Clinical significance of cytomegalovirus infection in patients with inflammatory bowel disease
Clinical significance of cytomegalovirus infection in patients with inflammatory bowel disease作者机构：Inflammatory Bowel Disease ClinicDepartment of GastroenterologyUniversity Hospital Ramón y Cajal28034 MadridSpain Department of GastroenterologyUniversity Hospital of Guadalajara19002 GuadalajaraSpain Department of GastroenterologyHospital Sureste28500 MadridSpain
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2013年第19卷第1期
页 面：17-25页
核心收录：
主 题：Cytomegalovirus Inflammatory bowel disease Crohn’s disease Ulcerative colitis Hematoxylin and eosin Immunohistochemical Polymerase chain reaction Ganciclovir Infectious colitis
摘 要：Cytomegalovirus(CMV) infection is common in humans.The virus then enters a latency phase and can reactivate to different stimuli such as immunosuppression.The clinical significance of CMV infection in inflammatory bowel disease is different in Crohn s disease(CD) and ulcerative colitis(UC).CMV does not interfere in the clinical course of CD.However,CMV reactivation is frequent in severe or steroid-resistant UC.It is not known whether the virus exacerbates the disease or simply appears as a bystander of a severe disease.Different methods are used to diagnose CMV colitis.Diagnosis is classically based on histopathological identification of viral-infected cells or CMV antigens in biopsied tissues using haematoxylin-eosin or immunohistochemistry,other tests on blood or tissue samples are currently being investigated.Polymerase chain reaction performed in colonic mucosa has a high sensitivity and a positive result could be associated with a worse prognosis disease;further studies are needed to determine the most appropriate strategy with positive CMV-DNA in colonic mucosa.Specific endoscopic features have not been described in active UC and CMV infection.CMV colitis is usually treated with ganciclovir for several weeks,there are different opinions about whether or not to stop immunosuppressive therapy.Other antiviral drugs may be used.Multicenter controlled studies would needed to determine which subgroup of UC patients would benefit from early antiviral treatment.
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