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SARS-CoV-2 Antibody Seroprevalence in Children and Workers from Belgian French-Speaking Primary Schools

Health 2023年第9期15卷 917-937页

作者： Kelly Cremer Julie Frère Olga Chatzis Ricardo de mendonca Benoît Kabamba Florence renard Mathilde de Keukeleire Dimitri Van der linden Annie Robert Institut de recherche Expérimentale et Clinique Department of Epidemiology and Biostatistics Faculty of Public Health Université Catholique de Louvain Brussels Belgium Pediatric Infectious Diseases Pediatric Department CHU Liège Liège Belgium Pediatric Infectious Diseases Specialized Pediatric Service Pediatric Department Cliniques Universitaires Saint-Luc Brussels Belgium department of Pathology Erasme University Hospital Université Libre de Bruxelles (ULB) H&#244pital Universitaire de Bruxelles (HUB) CUB H&#244pital Erasme Brussels Belgium Institut de recherche Expérimentale et Clinique Université Catholique de Louvain Brussels Belgium department of Microbiology Cliniques Universitaires Saint-Luc Brussels Belgium Office de la Naissance et de l’enfance Brussels Belgium

Purpose: During the COVID-19 pandemic, closing schools was discussed to limit the virus transmission, despite a lack of evidence on the role of young children in the virus spread. We undertook a study among Belgian primary schools to assess the SARS-CoV-2 antibody seroprevalence and its relationship with local incidence, school size, and socioeconomic status (SES). methods: Schools were purposively selected using three criteria: an area with either a low or a high COVID-19 incidence, either a small or a large size, and either a low or a high SES. 932 (/2488, 38%) children and 242 (/444, 55%) staff signed informed consent. COVID-19 antibodies were tested using rapid finger prick tests. results: Children participation was positively correlated with staff (r = +0.33;95% CI [−0.34;0.78]), and strongly with SES (r = +0.81;95% CI [0.40;0.95]). Seroprevalence was 21% in children (191/922) and 25% in staff (61/240). Seroprevalence did not correlate with local cumulative incidence (children: r = +0.06;95% CI [−0.59;0.67];staff: r = +0.26;95% CI [−0.40;0.74]). In staff, seroprevalence was higher in schools with higher SES (r = +0.37;95% CI [−0.29;0.79]), but not in children (r = −0.10;95% CI [−0.66;0.53]). Conclusion:The lower seroprevalence in children suggests they are lower transmitters than adults, but poor socioeconomic levels were less representative.

关键词： SARS-CoV-2 Children Schools Seroprevalence Socioeconomic Status Belgium

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中国华东地区多发性肌炎／皮肌炎患者肿瘤坏死因子－α基因多态性研究

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中华风湿病学杂志 2010年第12期14卷 822-827页

作者：高香吕玲复旦大学附属华山医院风湿科上海200040

目的研究中国华尔地区中多发性肌炎／皮肌炎（PM／DM）患者肿瘤坏死因子（TNF）－α基因多态性。方法采用聚合酶链反应－限制性片段长度多态性（PCR—RFlP）测定69例PM／DM患者与57名健康对照TNF—α．基囚启动子区－238、－308、－103... 详细信息

目的研究中国华尔地区中多发性肌炎／皮肌炎（PM／DM）患者肿瘤坏死因子（TNF）－α基因多态性。方法采用聚合酶链反应－限制性片段长度多态性（PCR—RFlP）测定69例PM／DM患者与57名健康对照TNF—α．基囚启动子区－238、－308、－1031位点的基凶型，比较各位点的基因型、等位基因及单倍体型频率在2组中差异有无统计学意义？2组比较采用χ2或者Fisherexact检验：结果－238、－308、－1031位点基因型及等位基因频率在PM／DM组或DM组与健康对照组之间比较差异无统计学意义。单倍体型AGT在PM／DM组和DM组中的频率都为0，在健康对照组中的频率为5．6％，差异具有统计学意义（P值分别为0．01，0．02）：单倍体型AGC在PM／DM组中的频率为4．3％，在DM组中的频率为5．80％，在健康对照组中的频率为0．6％，DM组与对照组相比，差异具有统计学意义（P=0．04，OR=9．84，95％C11．39～69．57），PM／DM组与对照组相比，差异无统计学意义（P=O．09，OR=7．22，95％C11．02～50．90）：单倍体型GGC在PM／DM组中的频率为14．6％，在DM组巾的频率为12．3％，在健康对照组中的频率为23．5％，DM组与健康对照组相比，差异有统计学意义（P=0．04，OR=0．47，95％C10．23～0．99）：结论TNF—α基因－238、－308、－1031位点单倍体型AGC是DM的易感因素。

关键词：皮肌炎肿瘤坏死因子α 多态性单核苷酸

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Children and Workers Well-Being in Belgian French-Speaking Primary Schools during the COVID-19 Pandemic

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Health 2023年第6期15卷 676-694页

作者： Kelly Cremer Julie Frère Olga Chatzis Benoît Kabamba Florence renard Mathilde de Keukeleire Ricardo de mendonca Dimitri Van der linden Annie Robert department of Epidemiology and Biostatistics Institut de Recherche Expérimentale et Clinique Faculty of Public Health UCLouvain Brussels Belgium department of Pediatric Pediatric Infectious Diseases CHU Liège Liège Belgium department of Pediatric Pediatric Infectious Diseases Specialized Pediatric Service Cliniques Universitaires Saint-Luc Brussels Belgium Institut de recherche Expérimentale et Clinique UCLouvain Brussels Belgium department of Microbiology Cliniques Universitaires Saint-Luc Brussels Belgium Office de la Naissance et de l’Enfance Brussels Belgium department of Pathology Erasme University Hospital Université Libre de Bruxelles (ULB) H&#244pital Universitaire de Bruxelles (HUB) CUB H&#244pital Erasme Brussels Belgium

Purpose: During the COVID-19 pandemic, a significant number of measures were taken worldwide to limit the transmission of SARS-CoV-2, and in many ways, changed human life. All these measures had harmful consequences and impacted the well-being of many people. Children were one of the most vulnerable groups. We conducted the present study to assess children’s and staff’s well-being in French-speaking primary schools in Belgium during the COVID-19 pandemic. methods: A 37-question questionnaire for each child based on the revised Children’s Manifest Anxiety Scale (RCMAS), and a 14-question questionnaire for each staff based on the Hospital Anxiety and depression (HAD) scale was undertaken in order to assess the well-being. Multiple logistic regressions were performed to assess the relationship between RCMAS or HAD and other explanatory variables. Staff reported their perception of their current life and their future life in 5 years on a Visual Analogue Scale (VAS). results: A total of 231 children and 221 staff in 11 primary schools answered the well-being questionnaire between January and May 2021. 53% (122/231) of children had symptoms of anxiety. Girls reported more anxiety symptoms than boys (≥10: 59%;Adj OR = 2.25;95% CI [1.28;4.03]). 52% (120/231) of children had a definite state of social desirability. According to age, the youngest (6 - 7 years) children were more likely to have social desirability (≥5: 71%;Adj OR = 3.44;95% CI [1.53;8.09]) compared to the oldest (10 - 12 years). Children who did not practice outdoor/street activities were more likely to have social desirability (≥5: 60%;Adj OR = 2.59;95% CI [1.38;4.99]). In schools with a higher local incidence of SARS-CoV-2, children were more likely to have social desirability (≥5: 64%;Adj OR = 2.15;95% CI [1.13;4.17]). In schools with a lower socioeconomic status, children were more likely to have social desirability (≥5: 72%;Adj OR = 2.74;95% CI [1.23;6.37]). Higher RCMAS anxiety (r = −0.18;p −0.23;p −0.20

关键词： COVID-19 Well-Being Children Schools

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Unraveling one billion years of geological evolution of the southeastern Amazonia Craton from detrital zircon analyses

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Geoscience Frontiers 2022年第5期13卷 129-152页

作者： Camille Rossignol Paul Yves Jean Antonio Francesco Narduzzi Eric Siciliano rego lívia Teixeira Romário Almeida de Souza Janaína N.Ávila Marco A.l.Silva Cristiano lana Ricardo I.F.Trindade Pascal Philippot departamento de Geofísica Instituto de AstronomiaGeofísica e Ciências Atmosféricas da Universidade de São PauloRua do Matão1226-Cidade UniversitáriaSão Paulo 05508-090Brazil Institut de Physique du Globe de Paris Universitéde ParisCNRSParisFrance Géosciences Montpellier Universitéde MontpellierCNRSUniversitédes AntillesMontpellierFrance Instituto de Geociências Universidade de São PauloRua do Lago562-Cidade UniversitáriaSão Paulo 05508-080Brazil Instituto de Geociências e Engenharias Universidade Federal do Sul e Sudeste do Pará–UNIFESSPAFolha 17Quadra 04Lote especialNova MarabáMarabáPará68505-080Brazil research School of Earth Sciences The Australian National University142 Mills RoadCanberraACT 2601Australia Applied Isotope research Group Departamento de GeologiaEscola de MinasUniversidade Federal de Ouro PretoRua Diogo de Vasconcelos12235400-000 Ouro PretoMGBrazil

despite representing one of the largest cratons on Earth,the early geological evolution of the Amazonia Craton remains poorly known due to relatively poor exposure and because younger metamorphic and tectonic events have obscured initial *** this study,we investigated the sedimentary archives of the Carajás Basin to unravel the early geological evolution of the southeastern Amazonia *** Carajás Basin contains sedimentary rocks that were deposited throughout a long period spanning more than one billion years from the mesoarchean to the *** oldest archives preserved in this basin consist of a few ca.3.6 ga detrital zircon grains showing that the geological roots of the Amazonia Craton were already formed by the *** the Paleoarchean or the early mesoarchean(ga),the Carajás Basin was large and rigid enough to sustain the formation and preservation of the Rio Novo Group greenstone ***,during the Neoarchean,at ca.2.7 ga,the southeastern Amazonia Craton witnessed the emplacement of the Parauapebas large Igneous Province(lIP)that probably covered a large part of the craton and was associated with the deposition of some of the world largest iron *** emplacement of this lIP immediately preceded a period of continental extension that formed a rift infilled first by iron formations followed by terrigenous *** major change of sedimentary regime might have been controlled by the regional tectonic evolution of the Amazonia Craton and its emergence above *** the Paleoproterozoic,at ca.2.1 ga,the Rio Fresco Group,consisting of terrigenous sediments from the interior of the Amazonia Craton,was deposited in the Carajás *** that time,the Amazonian lithosphere could have either underwent thermal subsidence forming a large intracratonic basin or could have been deformed by long wavelength flexures that induced the formation of basins and swells throughout the craton under the influence of

关键词： Carajás Basin Chemical Abrasion–lA-ICP-MS analyses Age distribution comparison Parauapebas large Igneous Province Transamazonian orogeny

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Pulsed laser Annealed ga Hyperdoped Poly-Si/SiO_(x)Passivating Contacts for High-Efficiency Monocrystalline Si Solar Cells

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Energy & Environmental Materials 2023年第3期6卷 388-399页

作者： Kejun Chen Enrico Napolitani Matteo de Tullio Chun-Sheng Jiang Harvey Guthrey Francesco Sgarbossa San Theingi William Nemeth Matthew Page Paul Stradins Sumit Agarwal David l.Young Colorado School of Mines 1500 Illinois StGolden Colorado 80401USA Dipartimento di Fisica e Astronomia and CNR-IMM Universit`a degli Studi di Padovavia Marzolo 8PadovaItaly National renewable Energy laboratory 15013 Denver West ParkwayGolden Colorado 80401USA

Polycrystalline Si(poly-Si)-based passivating contacts are promising candidates for high-efficiency crystalline Si solar *** show that nanosecond-scale pulsed laser melting(PlM)is an industrially viable technique to fabricate such contacts with precisely controlled dopant concentration profiles that exceed the solid solubility *** demonstrate that conventionally doped,hole-selective poly-Si/SiO_(x)contacts that provide poor surface passivation of c-Si can be replaced with ga-or B-doped contacts based on non-equilibrium *** overcome the solid solubility limit for both dopants in poly-Si by rapid cooling and recrystallization over a timescale of∼25 *** show an active ga dopant concentration of∼3×10^(20)cm^(−3)in poly-Si which is six times higher than its solubility limit in c-Si,and a B dopant concentration as high as∼10^(21) cm^(−3).We measure an implied open-circuit voltage of 735 mV for ga-doped poly-Si/SiO_(x)contacts on Czochralski Si with a low contact resistivity of 35.5±2.4 mΩcm^(2).Scanning spreading resistance microscopy and Kelvin probe force microscopy show large diffusion and drift current in the p-n junction that contributes to the low contact *** results suggest that PlM can be extended for hyperdoping of other semiconductors with low solubility atoms to enable high-efficiency devices.

关键词： ga hyperdoping ga passivating contacts poly-Si/SiO_(x) pulsed laser melting silicon solar cell

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Assessment of earthquake location uncertainties for the design of local seismic networks

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Earthquake Science 2024年第5期37卷 415-433页

作者： Antonio Fuggi Simone re Giorgio Tango Sergio del gaudio Alessandro Brovelli Giorgio Cassiani Isamgeo Italia S.r.l. Gallarate 21013Italy STOGIT S.p.A. UnitàGiacimentiCrema 26013Italy Dipartimento di Geoscienze Universitàdegli Studi di PadovaPadova 35131Italy

The ability to estimate earthquake source locations,along with the appraisal of relevant uncertainties,is paramount in monitoring both natural and human-induced *** this purpose,a monitoring network must be designed to minimize the location errors introduced by geometrically unbalanced *** this study,we first review different sources of errors relevant to the localization of seismic events,how they propagate through localization algorithms,and their impact on *** then propose a quantitative method,based on a Monte Carlo approach,to estimate the uncertainty in earthquake locations that is suited to the design,optimization,and assessment of the performance of a local seismic monitoring *** illustrate the performance of the proposed approach,we analyzed the distribution of the localization uncertainties and their related dispersion for a highly dense grid of theoretical hypocenters in both the horizontal and vertical directions using an actual monitoring network *** results expand,quantitatively,the qualitative indications derived from purely geometrical parameters(azimuthal gap(AG))and classical detectability *** proposed method enables the systematic design,optimization,and evaluation of local seismic monitoring networks,enhancing monitoring accuracy in areas proximal to hydrocarbon production,geothermal fields,underground natural gas storage,and other subsurface *** approach aids in the accurate estimation of earthquake source locations and their associated uncertainties,which are crucial for assessing and mitigating seismic risks,thereby enabling the implementation of proactive measures to minimize potential *** an operational perspective,reliably estimating location accuracy is crucial for evaluating the position of seismogenic sources and assessing possible links between well activities and the onset of seismicity.

关键词： network design earthquake localization detectability localization uncertainties local seismic network

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Expert group syndrome at high altitude

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Sports medicine and Health Science 2022年第3期4卷 215-218页

作者： Jean-Paul Richalet Marie-Anne Magnan Alice gavet Pierre lafère UniversitéSorbonne Paris Nord Laboratoire Hypoxie et PoumonUMR INSERM U1272BobignyFrance Institut National des Sports de l’Expertise et de la PerformancePôle médicalParisFrance Hôpitaux universitaires de Genève Département de médecine aiguëUnitéde médecine subaquatique et hyperbareGenevaSwitzerland Hôpitaux du Mont-Blanc Soins de suite et réadaptationChamonixFrance Universitéde Bretagne Occidentale Laboratoire ORPHYEA 44324BrestFrance HauteÉcole Bruxelles-Brabant(HE2B) EnvironmentalOccupationalAgeing(Integrative)Physiology LaboratoryBrusselsBelgium

During a training session for the university diploma of Mountain medicine delivered by University Sorbonne Paris Nord for medical doctors,one of the participants developed signs of maladaptation to high altitude at 3600 m,the severity of which was incorrectly *** was sparingly given by the patient(an anesthetist)to several of his colleagues and no one was in charge to collect clinical data,take a history,and provide appropriate *** combination of the absence of designation of a supervising doctor and the difficulty of communicating with the patient led to a lack of coordinated management and to an evolution of the symptoms towards severe acute mountain ***,the very rapid management of the patient and a rapid helicopter evacuation,as soon as the symptoms worsened towards the onset of a suspected high altitude cerebral and/or pulmonary edema,allowed rapid resolution without ***,medical,psychological,and managerial factors led to this Expert Group Syndrome.

关键词： Acute mountain sickness High altitude cerebral edema Psychology Group management

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CURlY lEAF regulates MicroRNA Activity by Controlling ARGONAUTE 1 degradation in Plants

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Molecular Plant 2020年第1期13卷 72-87页

作者： delfina A.re Damian A.Cambiagno Agustin lArce Ariel HTomassi Marisol Giustozzi Paula Casati Federico DAriel Pablo A.Manavella lnstituto de Agrobiotecnologia del litoral(CONICET-UNl) Catedra de Biologia Celulary MolecularFacultad de Bioquimica y Ciencias BiologicasUniversidad Nacional del Litoral3000 Santa FeArgentina Centro de Estudios Fotosinteticos y Bioquimicos(CEFOBI) Universidad Nacional de RosarioRosarioArgentina

CURlY lEAF ( ClF) encodes the methyltransferase subunit of the Polycomb repressor Complex 2 (PRC2), which regulates the expression of target genes through H3K27 trimethylation. We isolated a new ClF mutant allele ( clf-78) using a genetic screen designed to identify microRNA (miRNA) deficient mutants. ClF mutant plants showed impaired miRNA activity caused by increased ubiquitination and enhanced degradation of ARGONAUTE 1 (AGO1) in specific tissues. Such ClF-mediated AGO1 regulation was evident when plants were exposed to UV radiation, which caused increased susceptibility of clf mutants to some UV-induced responses. Furthermore, we showed that ClF directly regulates FBW2, which in turn triggers AGO1 degradation in the clf mutants. Interestingly, AGO1 bound to a target appeared particularly prone to degradation in the mutant plants, a process that was exacerbated when the complex bound a non-cleavable target. Thus, prolonged AGO1–target interaction seems to favor AGO1 degradation, suggesting that non-cleavable miRNA targets may overcome translation inhibition by modulating AGO1 stability in plants.

关键词： CURlY lEAF ARGONAUTE Arabidopsis UV FBW2

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The Conversion relationship between the local Earthquake Magnitude and Surface Wave Magnitude in the Inner Mongolia Digital Seismic Network

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Earthquake research in China 2019年第1期33卷 86-96页

作者： lIU Fang SU Riya XU Xiquan lI Hui NA re Earthquake Agency of Inner Mongolia Autonomous region

Using 116 earthquakes over M_l3.8 in the Inner Mongolia region from 2008 to 2015, the local earthquake magnitude M_l and surface wave magnitude M_S are remeasured. Based on norm linear regression(SR1 and SR2) and norm(OR) orthogonal regression method, we established the conversion relationship between M_l and M_S. The results were tested with gaussian disturbance. The result shows that the orthogonal regression method(OR) result has the best fitting curve, and the conversion relation is M_S=0.96 M_l-0.10. The difference between our result and Guo lücan's(M_S=1.13 M_l-1.08) may be caused by regional tectonic characteristics. M_(S Inner Mongolia) value is significantly higher than the M_(S empirical) value, with an average difference of 0.23, the difference distribution of empirical relation and the rectified relation is in the range of 0.2-0.3.

关键词： local earthquake magnitude Ml Surface wave magnitude MS gauss perturbation Magnitude conversion

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Penetrating and Basilic Trauma of the Thorax in a Context of Difficult Diagnosis at the Pediatric Hospital of Bangui (Central African republic)

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Open Journal of Pediatrics 2023年第5期13卷 657-662页

作者： Daniel Sylvère Ouaïmon Jacob Israël Junior Sopio Nathan Gbanade Packo Oumarou Youssof Center Hospitalier Universitaire Pediatrique de Bangui (CHUPB) Bangui Central African Republic Faculty of Health Sciences Bangui University Bangui Central African Republic

Appropriate management of penetrating trauma to the thorax requires knowledge of vulnating agents, as well as the principles of ballistic injury. The importance of the approach’s choice for surgical exploration of these injuries, and parietal damage, is an essential factor in decision making in the management and definition of the therapeutic strategy for these injuries. The authors report a clinical case of a penetrating traumatic ballistic wound of the thorax managed in a context of difficult diagnosis in the surgical Unit of the CHUPB.

关键词： Firearm Wound Thorax Trauma Child CAR

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