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Solid-Pseudopapillary Tumor: Case Report and Literature Review

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Open journal of Pathology（病理学期刊） 2024年第1期

作者： Nomenjanahary Lalaina Rabarison Manoahasina Ranaliarinosy razafimahefa vahatra joëlle Randrianjafisamindrakotroka Nantenaina Soa

Primary Digestive Lymphoma: Anatomical, Clinical and Epidemiological Study

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Open journal of Pathology 2023年第1期13卷 46-53页

作者： Razafindrafara Herilalao Elisabeth razafimahefa vahatra joëlle Rabarison Manoahasina Ranaliarinosy Andriamampionona Tsitohery Francine Randrianjafisamindrakotroka Nantenaina Soa Department of Pathology Hospital Center of Soavinandriana Antananarivo Madagascar Department of Pathology Andrainjato University Hospital Fianarantsoa Madagascar Department of Pathology Joseph Ravoahangy Andrianavalona University Hospital Antananarivo Madagascar

Gastrointestinal lymphoma is a non-Hodgkin’s lymphoma that develops from MALT (Mucosa Associated Lymphoid Tissue). It is a rare entity representing 1% of tumors of the gastrointestinal tract. In Madagascar, few studies have been performed on these lymphomas. Our objective is to report a series of digestive lymphoma in order to evaluate the epidemiological and anatomical-clinical aspects. This was a retrospective, cross-sectional, descriptive bicentric study conducted at the Department of Pathology at the Soavinandriana Hospital Center (CENHOSOA) and the Department of Pathology at the University Hospital Center of Andrainjato over a period of 4 years from January 1st, 2016 to December 31st, 2019. During the study period, we collected 14 cases of primary digestive lymphoma representing 16% of all lymphomas. We noted a female predominance with a sex ratio of 0.75. The mean age of the patients was 35.64 years with extremes of 3 and 78 years. The clinical signs were dominated by occlusive syndrome (57.14%), abdominal pain (21.44%), digestive hemorrhage (7.14%), intestinal invagination (7.14%) and lingual swelling (7.14%). Regarding the location, the ileum was the most frequently affected (42.85%), followed by the stomach (14.29%), the ileo-caecal area (14.29%), the sigmoid (14.29%), the colon (7.14%) and we also noted a lingual location (7.14%). The most frequent histological type was diffuse large B cell lymphoma (42.86%) followed by MALT lymphoma (35.71%), Burkitt’s lymphoma (14.29%) and diffuse small cell lymphoma (unclassified) (7.14%). We did not observe a significant association (p > 0.05) between the site involvement and the histological subtypes. Among the 14 cases, 3 were confirmed by immunohistochemistry. Primary lymphomas of the gastrointestinal tract include several anatomic entities with different presentation and prognosis. Pathological examination is essential for diagnosis. Immunohistochemical examination is a valuable aid for immuno

关键词： Lymphoma Gastrointestinal Tract Madagascar

Demons-Meigs Syndrome with a High CA 125 Level: A Case Report at Soavinandriana Center Hospital Antananarivo

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Open journal of Pathology 2023年第2期13卷 73-78页

作者： Razafindrafara Herilalao Elisabeth razafimahefa vahatra joëlle Rakotondrainibe Fenohery Nalisoa Randimbinirina Zakarimanana Lucas Rabarison Manoahasina Ranaliarinosy Randrianjafisamindrakotroka Nantenaina Soa Department of Pathology Soavinandriana Center Hospital (CENHOSOA) Antananarivo Madagascar Department of Pathology University Hospital Andrainjato Fianarantsoa Madagascar Department of Pathology Anosiala University Hospital Antananarivo Madagascar Department of Surgery Soavinandriana Center Hospital (CENHOSOA) Antananarivo Madagascar Department of Pathology Joseph Ravoahangy Andrianavalona University Hospital Antananarivo Madagascar

Introduction: Demons-Meigs syndrome combines a benign tumor of the ovary with ascites and pleural effusion. It is a rare disease and the pathophysiological mechanism is not yet well understood. The aim of our study is to report a case of Demons-Meigs syndrome, to determine its different characteristics and to make clinicians aware of the malignant predictive value of CA 125 in front of an ovarian tumor. Observation: The patient was 42 years old and had no previous history. She presented with intense abdominal pain of sudden onset, prompting a medical consultation. On clinical examination, the abdomen was distended with signs of peritoneal effusion and right pleural effusion. Ultrasound revealed a well-circumscribed, ovarian mass with an internal fluid component and hypervascularization on Doppler. The CA 125 level was elevated (293.9 U/ml). Exploratory laparotomy revealed two bilateral, firm, solid ovarian tumors without vegetation or peritoneal lesions. Macroscopically, one of the tumors was well circumscribed, lobulated with a smooth outer surface. It measured 20 × 17 × 8 cm and weighed 1400 g. The other tumor measured 19 × 11 × 5 cm, weighed 1090 g and had the same characteristics as the other tumor. Histologically, both tumors were a proliferation of fibroblastic spindle cells organized in short intersecting or storiform bundles, without cyto-nuclear atypia or excess mitoses. The diagnosis retained was bilateral ovarian fibroma in the context of a Demons-Meigs syndrome. Conclusion: Demons-Meigs syndrome is a rare entity. The concomitant elevation of the CA 125 level is not always an indicator of ovarian cancer. The curative treatment is surgical based on tumor removal ensuring the disappearance of peritoneal and pleural effusions.

关键词： Ovarian Tumor Demons-Meigs Syndrome Ascite Pleural Effusion CA 125 Madagascar

Superficial Angiomyxoma of the Vulva: A Case Report

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Open journal of Pathology 2024年第2期14卷 64-68页

作者： Zo Irène Raivoherivony Herilalao Elisabeth Razafindrafara vahatra joëlle razafimahefa Romuald Randriamahavonjy Nantenaina Soa Randrianjafisamindrakotroka Department of Pathology Joseph Ravoahangy Andrianavalona University Hospital Antananarivo Madagascar Department of Pathology Soavinandriana University Hospital Antananarivo Madagascar Department of Pathology Andrainjato University Hospital Fianarantsoa Madagascar Gyneco-Obstetrics Department Soavinandriana University Hospital Antananarivo Madagascar

Superficial angiomyxoma is a rare benign mesenchymal tumor that mainly occurs in the genital region. We report the case of a 51-year-old woman with a painless vulvar mass, well circumscribed on ultrasound. On gross finding, it was a polypoid and bilobed mass, partially encapsulated. On histological examination, it was a proliferation of non-atypical spindle cells with an abundant, myxoid stroma and numerous medium-sized blood vessels. The diagnosis was superficial angiomyxoma. The clinical features do not often lead to the diagnosis of superficial vulvar angiomyxoma. It is based on histological examination and immunohistochemistry is helpful to differentiate it from other myxoid tumors.

关键词： Angiomyxoma Mesenchymal Tumor Myxoïd Stromal Tumor of Vulva

Primary Digestive Lymphoma: Anatomical, Clinical and Epidemiological Study

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Open journal of Pathology（病理学期刊） 2023年第1期

作者： Razafindrafara Herilalao Elisabeth razafimahefa vahatra joëlle Rabarison Manoahasina Ranaliarinosy Andriamampionona Tsitohery Francine Randrianjafisamindrakotroka Nantenaina Soa

Demons-Meigs Syndrome with a High CA 125 Level: A Case Report at Soavinandriana Center Hospital Antananarivo

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Open journal of Pathology（病理学期刊） 2023年第2期

Superficial Angiomyxoma of the Vulva: A Case Report

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Open journal of Pathology（病理学期刊） 2024年第2期 64页

作者： Zo Irène Raivoherivony Herilalao Elisabeth Razafindrafara vahatra joëlle razafimahefa Romuald Randriamahavonjy Nantenaina Soa Randrianjafisamindrakotroka

Mesenchymal Tumors in Gastrointestinal Tract

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Open journal of Pathology 2022年第4期12卷 171-176页

作者： Lalaina Nomenjanahary Manoahasina Ranaliarinosy Rabarison vahatra joëlle razafimahefa Nantenaina Soa Randrianjafisamindrakotroka Department of Pathology Joseph Ravoahangy Andrianavalona University Hospital Antananarivo Madagascar Department of Pathology Andrainjato University Hospital Fianarantsoa Madagascar Chairman of the Department of Pathology Medical School of Antananarivo Antananarivo Madagascar

Mesenchymal neoplasms arising in the digestive tract are rare compared to adenomas and carcinomas [1]. They include several entities with histomorphological similarity and immunohistochemistry helps to confirm the diagnosis [2]. Our goals are to study the epidemiological aspect of mesenchymal tumors, and to compare the histological diagnoses before and after the use of immunochemistry. This is a retrospective, descriptive, single-center study performed on all cases of mesenchymal tumors in gastrointestinal tract, diagnosed at the laboratory of Pathological Anatomy Unit of joseph Ravoahangy Andrianavalona University Hospital from January 1, 2007 to December 31, 2018. We included 29 cases. The mean age was 43.28 years. The sex ratio was 1.07. After immunohistochemical examination, 24.14% of tumors changed diagnosis to GISTs which are the most common mesenchymal tumor involving the gastrointestinal tract. In all cases of mesenchymal tumors of the gastrointestinal tract GIST should first be ruled out before making other diagnoses. Histologic and immunophenotypic features are thereby essential. According to the literature review, if c-Kit and DOG-1 are negative, molecular biology must be used.

关键词： Stromal Tumor Gastrointestinal Epidemiology Diagnosis

Duodenal Endoscopic and Histopathologic Findings in a COVID-19 Patient: A Case Report and Literature Review

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Open journal of Pathology 2022年第4期12卷 156-166页

作者： vahatra joëlle razafimahefa jocia Fenomanana Manoahasina Ranaliarinosy Rabarison Soloniaina Hélio razafimahefa Tsitohery Francine Andriamampionona Department of Pathology CHU Andrainjato Fianarantsoa Madagascar Department of Biology CHU Andrainjato Fianarantsoa Madagascar Department of Pathology CHU Joseph Ravoahangy Andrianavalona Antananarivo Madagascar Department of Internal Medicine and Gastroenterology CHU Andrainjato Fianarantsoa Madagascar

Although COVID-19 clinical manifestations are mostly respiratory gastrointestinal manifestations may also be encountered in some instances. However, at the time of our writing, little is known about COVID-19, associated pathologic changes in the digestive system. We describe a case of COVID-19 disease with digestive manifestations that demonstrated specific pathologic changes in the gastrointestinal tract. Histological examination of endoscopic biopsy samples from duodenum was performed in combination with a review of the literature. According to our literature review, digestive histopathologic changes have been reported in 14 cases of COVID-19 patients. Pathological findings were generally nonspecific in all these cases and ranged from epithelial damage, lymphoplasmacytic and macrophages infiltrates, prominent endothelitis and ischemic enterocolitis. In our patient, histological features were more specific, characterized by several viral cytopathic effects associated with mucosal damage, numerous microthrombi and positive staining of ACE2 on various enterocytes. Histological analysis is not a practical option for the diagnosis of SARS-CoV-2 infections but could help to elucidate pathophysiology of the disease. Those changes may be specific in the GI tract and related clinical manifestations should not be overlooked. Furthermore, preventive measures for oral-fecal transmission should not be minimized.

关键词： COVID-19 SARS-CoV-2 Histopathologic Findings Duodenum Endoscopy Biopsy