Demons-Meigs Syndrome with a High CA 125 Level: A Case Report at Soavinandriana Center Hospital Antananarivo

作     者：Razafindrafara Herilalao Elisabeth Razafimahefa Vahatra Joëlle Rakotondrainibe Fenohery Nalisoa Randimbinirina Zakarimanana Lucas Rabarison Manoahasina Ranaliarinosy Randrianjafisamindrakotroka Nantenaina Soa Razafindrafara Herilalao Elisabeth;Razafimahefa Vahatra Joëlle;Rakotondrainibe Fenohery Nalisoa;Randimbinirina Zakarimanana Lucas;Rabarison Manoahasina Ranaliarinosy;Randrianjafisamindrakotroka Nantenaina Soa

作者机构：Department of Pathology Soavinandriana Center Hospital (CENHOSOA) Antananarivo Madagascar Department of Pathology University Hospital Andrainjato Fianarantsoa Madagascar Department of Pathology Anosiala University Hospital Antananarivo Madagascar Department of Surgery Soavinandriana Center Hospital (CENHOSOA) Antananarivo Madagascar Department of Pathology Joseph Ravoahangy Andrianavalona University Hospital Antananarivo Madagascar 

出 版 物：《Open Journal of Pathology》 (病理学期刊（英文）)

年 卷 期：2023年第13卷第2期

页      面：73-78页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Ovarian Tumor Demons-Meigs Syndrome Ascite Pleural Effusion CA 125 Madagascar 

摘      要：Introduction: Demons-Meigs syndrome combines a benign tumor of the ovary with ascites and pleural effusion. It is a rare disease and the pathophysiological mechanism is not yet well understood. The aim of our study is to report a case of Demons-Meigs syndrome, to determine its different characteristics and to make clinicians aware of the malignant predictive value of CA 125 in front of an ovarian tumor. Observation: The patient was 42 years old and had no previous history. She presented with intense abdominal pain of sudden onset, prompting a medical consultation. On clinical examination, the abdomen was distended with signs of peritoneal effusion and right pleural effusion. Ultrasound revealed a well-circumscribed, ovarian mass with an internal fluid component and hypervascularization on Doppler. The CA 125 level was elevated (293.9 U/ml). Exploratory laparotomy revealed two bilateral, firm, solid ovarian tumors without vegetation or peritoneal lesions. Macroscopically, one of the tumors was well circumscribed, lobulated with a smooth outer surface. It measured 20 × 17 × 8 cm and weighed 1400 g. The other tumor measured 19 × 11 × 5 cm, weighed 1090 g and had the same characteristics as the other tumor. Histologically, both tumors were a proliferation of fibroblastic spindle cells organized in short intersecting or storiform bundles, without cyto-nuclear atypia or excess mitoses. The diagnosis retained was bilateral ovarian fibroma in the context of a Demons-Meigs syndrome. Conclusion: Demons-Meigs syndrome is a rare entity. The concomitant elevation of the CA 125 level is not always an indicator of ovarian cancer. The curative treatment is surgical based on tumor removal ensuring the disappearance of peritoneal and pleural effusions.