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Role of hepatitis A virus in diabetes mellitus

World Journal of Diabetes 2021年第11期12卷 1928-1941页

作者： James Lin Horng-Yih Ou Rudruidee Karnchanasorn raynald samoa Lee-Ming Chuang Ken C Chiu Department of Gastroenterology City of Hope National Medical CenterDuarteCA 91010United States Division of Endocrinology and Metabolism Department of Internal MedicineNational Cheng-Kung University Medical College and HospitalTainan 700Taiwan Division of Endocrinology Metabolism and GeneticsDepartment of Internal MedicineUniversity of Kansas Medical CenterKansas CityKS 66160United States Department of Clinical Diabetes Endocrinologyand MetabolismDiabetes and Metabolism Research InstituteCity of Hope National Medical CenterDuarteCA 91010United States Division of Endocrinology Metabolism and NutritionDepartment of Internal MedicineHarbor-UCLA Medical CenterTorranceCA 90502United States of America Department of Internal Medicine National Taiwan University HospitalTaipei 102Taiwan Graduate Institute of Preventive Medicine School of Public HealthTaipei 102Taiwan

BACKGROUND Although much information is available regarding hepatitis C virus infection and diabetes,less is known about the relationship between hepatitis A virus(HAV)infection and *** To examine the roles of HAV in diabetes *** This cross-sectional study population included data from the National Health and Nutrition Examination Survey collected between *** subjects(≥20 years old)with available body mass index measurements,defined diabetes status,history of HAV vaccination,and HAV serology were *** vaccination was based on self-reported *** HAV immunization was defined as the presence of both vaccination and anti-HAV *** infection was defined by the absence of vaccination but presence of anti-hepatitis A *** odds ratio(OR)for diabetes with 95%confidence intervals(95%CI)was calculated for each HAV status and then adjusted for *** tests,based on different definitions of diabetes,were performed to verify the *** Among 19942 subjects,4229 subjects(21.21%)received HAV vaccination and HAV antibody was present in 9224 subjects(46.25%).Although HAV infection was associated with an increased risk of diabetes(OR:1.13;95%CI:1.08-1.18),HAV vaccination was not associated with diabetes(OR:1.06;95%CI:0.95-1.18),and successful HAV immunization had no impact on the risk of diabetes(OR:1.11;95%CI:0.97-1.27).Thus,HAV infection was an unlikely cause of ***,in non-vaccinated subjects,diabetes increased the risk of HAV infection by 40%(OR:1.40,95%CI:1.27-1.54).CONCLUSION An association between HAV infection and diabetes is observed which is best explained by an increased risk of HAV infection in diabetic *** subjects are more susceptible to ***,HAV vaccination is highly recommended in diabetic patients.

关键词： Vaccination Immunization Viral hepatitis Liver Glucose metabolism Diabetes mellitus

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Association of insulin resistance with serum ferritin and aminotransferases-iron hypothesis

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World Journal of Experimental Medicine 2015年第4期5卷 232-243页

作者： Jean Huang Rudruidee Karnchanasorn Horng-Yih Ou Wei Feng Lee-Ming Chuang Ken C Chiu raynald samoa Department of Clinical Diabetes Endocrinology and Metabolism City of Hope National Medical Center Division of Endocrinology Metabolism and Nutrition Department of Internal Medicine Harbor-UCLA Medical Center Division of Endocrinology Department of Medicine University of Kansas Medical Center Division of Endocrinology and Metabolism Department of Internal Medicine National Cheng Kung University Hospital College of Medicine National Cheng Kung University Department of Internal Medicine National Taiwan University Hospital Graduate Institute of Preventive Medicine School of Public Health National Taiwan University

AIM: To investigate the relationship of iron indices with diabetes mellitus(DM) in those without ***: This cross-sectional study examined data collected during the Third National Health and Nutrition Examination Survey(NHANES III). Only those who fasted properly and were not anemic with transferrin saturation < 45% were included(n = 6849). Insulin sensitivity and beta cell function were calculated from fasting glucose and insulin concentrations. Indices of iron metabolism were examined in the presence or absence of DM. We examined the relationship of insulin sensitivity and beta cell function with serum ferritin concentration. The influence of C-reactive protein and liver enzymes was also ***: Serum ferritin concentration was significantly higher in diabetic subjects(P = 0.0001 to< 0.000001). The difference remained significant after adjustment for age, body mass index, alcohol consumption, and mineral/iron supplement(P = 0.03 to< 0.000001). In those who did not take insulin, serum ferritin concentration was negatively associated with insulin sensitivity(P = 0.05 to 0.00001), but not with beta cell function. The alanine aminotransferase was correlated with serum ferritin concentration(P = 0.02 to< 0.000001) but not with insulin sensitivity, suggesting the role of the liver in iron-associated insulin ***: As most of diabetes is type 2 diabetes and insulin resistance is a cardinal feature of type 2diabetes, disordered iron metabolism could play a role in the pathogenesis of insulin resistance and type 2diabetes through its effect on liver function.

关键词： Diabetes mellitus Insulin sensitivity Beta cell function Ferritin Liver

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