Role of hepatitis A virus in diabetes mellitus

作     者：James Lin Horng-Yih Ou Rudruidee Karnchanasorn Raynald Samoa Lee-Ming Chuang Ken C Chiu 

作者机构：Department of GastroenterologyCity of Hope National Medical CenterDuarteCA 91010United States Division of Endocrinology and MetabolismDepartment of Internal MedicineNational Cheng-Kung University Medical College and HospitalTainan 700Taiwan Division of EndocrinologyMetabolism and GeneticsDepartment of Internal MedicineUniversity of Kansas Medical CenterKansas CityKS 66160United States Department of Clinical DiabetesEndocrinologyand MetabolismDiabetes and Metabolism Research InstituteCity of Hope National Medical CenterDuarteCA 91010United States Division of EndocrinologyMetabolism and NutritionDepartment of Internal MedicineHarbor-UCLA Medical CenterTorranceCA 90502United States of America Department of Internal MedicineNational Taiwan University HospitalTaipei 102Taiwan Graduate Institute of Preventive MedicineSchool of Public HealthTaipei 102Taiwan 

出 版 物：《World Journal of Diabetes》 (世界糖尿病杂志（英文版）（电子版）)

年 卷 期：2021年第12卷第11期

页      面：1928-1941页

核心收录：

学科分类：1002[医学-临床医学] 10[医学] 

主　　题：Vaccination Immunization Viral hepatitis Liver Glucose metabolism Diabetes mellitus 

摘      要：BACKGROUND Although much information is available regarding hepatitis C virus infection and diabetes,less is known about the relationship between hepatitis A virus(HAV)infection and diabetes.AIM To examine the roles of HAV in diabetes risk.METHODS This cross-sectional study population included data from the National Health and Nutrition Examination Survey collected between 2005-2012.Adult subjects(≥20 years old)with available body mass index measurements,defined diabetes status,history of HAV vaccination,and HAV serology were included.HAV vaccination was based on self-reported history.Successful HAV immunization was defined as the presence of both vaccination and anti-HAV antibody.HAV infection was defined by the absence of vaccination but presence of anti-hepatitis A antibody.The odds ratio(OR)for diabetes with 95%confidence intervals(95%CI)was calculated for each HAV status and then adjusted for covariates.Sensitivity tests,based on different definitions of diabetes,were performed to verify the results.RESULTS Among 19942 subjects,4229 subjects(21.21%)received HAV vaccination and HAV antibody was present in 9224 subjects(46.25%).Although HAV infection was associated with an increased risk of diabetes(OR:1.13;95%CI:1.08-1.18),HAV vaccination was not associated with diabetes(OR:1.06;95%CI:0.95-1.18),and successful HAV immunization had no impact on the risk of diabetes(OR:1.11;95%CI:0.97-1.27).Thus,HAV infection was an unlikely cause of diabetes.Alternatively,in non-vaccinated subjects,diabetes increased the risk of HAV infection by 40%(OR:1.40,95%CI:1.27-1.54).CONCLUSION An association between HAV infection and diabetes is observed which is best explained by an increased risk of HAV infection in diabetic patients.Diabetic subjects are more susceptible to HAV.Thus,HAV vaccination is highly recommended in diabetic patients.