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species richness and similarity of the flora on four lajedos in Boa Nova, Bahia, Brazil

Journal of Mountain science 2023年第6期20卷 1526-1539页

作者： Morgana Maria DO CARMO BARBOsA Anderson FERREIRA PINTO MACHADO Andrea Karla ALMEIDA DOs sANTOs raymundo joséde sá-neto Michele MARTINs CORRêA Graduate Program in Environmental sciences State University of Southwest BahiaUniversity Campus“Juvino Oliveira”BR 415km 0445700-000ItapetingaBahiaBrazil secretary of Education of the state of Bahia Military Police College Eraldo TinocoBrasilia Avenue273Kadija45650-120Vitoria da ConquistaBahiaBrazil Mongoyós Herbarium Multidisciplinary Institute in HealthCampus Anísio TeixeiraFederal University of BahiaRua Hormindo Barros58Bairro Candeias45029-094Vitoria da ConquistaBahiaBrazil department of Natural sciences State University of Southwest BahiaEstrada do Bem Querers/nBairro Candeias45083-900Vitoria da ConquistaBahiaBrazil

The municipality of Boa Nova,in northeastern Brazil,is in an ecotone zone between the Caatinga and Atlantic Forest phytogeographic *** transition phytophysiognomy is seasonal forest and known locally as mata de cipó.In these phytophysiognomies there are lajedos,which are rock outcrops colonized by vegetation welladapted to extreme microclimatic variation and vegetation diversity is affected by the vegetation types of the surrounding *** to the singularity of these environments and the relevance of floristic studies for conservation,this work aimed to identify the species richness and compare the similarity of the flora on four rock outcrops in Boa *** flora was surveyed during exploratory walks along lajedos between 2016 and *** total,162 species were identified on the Boa Nova *** flora has a composition and structure similar to semiarid outcrops,as well as endemic species that also occur in surrounding *** the proximity,a similarity index revealed there is floristic dissimilarity between the *** new occurrences were recorded for the region,five species are threatened with extinction(Aosa gilgiana,Ficus cyclophylla,Hippeastrum stigmovittatum,Pleroma caatingae and Trixis pruskii),and 43 species are common in anthropogenic *** reinforces the importance of actions to conserve these areas.

关键词： Ecotone Flora Inselberg Rock outcrops semiarid similarity

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Modelling the test, trace and quarantine strategy to control the COVID-19 epidemic in the state of são Paulo, Brazil

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Infectious Disease Modelling 2021年第1期6卷 46-55页

作者： Marcos Amaku Dimas Tadeu Covas Francisco Antonio Bezerra Coutinho raymundo soares Azevedo neto Claudio struchiner Annelies Wilder-smith Eduardo Massad school of Medicine University of Sao Paulo and LIM01-HCFMUSPSao PauloBrazil Instituto Butantan Sao PauloBrazil school of Applied Mathematics Fundacao Getulio VargasRio de JaneiroBrazil school of Veterinary Medicine University of Sao PauloSao PauloBrazil department Public Health and Clinical Heidelberg Institute of Global HealthUniversity of HeidelbergGermany Medicine Epidemiology and Global HealthUmeåUniversitySE-90185UmeåSweden department of Disease Control London School of Hygiene and TropicalMedicineUK

Testing for detecting the infection by sARs-CoV-2 is the bridge between the lockdown and the opening of *** this paper we modelled and simulated a test-trace-andquarantine strategy to control the COVID-19 outbreak in the state of são Paulo,*** state of são Paulo failed to adopt an effective social distancing strategy,reaching at most 59%in late March and started to relax the measures in late June,dropping to 41%in 08 ***,são Paulo relies heavily on a massive testing strategy in the attempt to control the *** alternative strategies combined with economic evaluations were *** strategy included indiscriminately testing the entire population of the state,reaching more than 40 million people at a maximum cost of 2.25 billion UsD,that would reduce the total number of cases by the end of 2020 by 90%.The second strategy investigated testing only symptomatic cases and their immediate contacts e this strategy reached a maximum cost of 150 million UsD but also reduced the number of cases by 90%.The conclusion is that if the state of são Paulo had decided to adopt the simulated strategy on April the 1st,it would have been possible to reduce the total number of cases by 90%at a cost of 2.25 billion Us dollars for the indiscriminate strategy but at a much smaller cost of 125 million Us dollars for the selective testing of symptomatic cases and their contacts.

关键词： COVID-19 sARs-CoV-2 Testing Cost-analysis Modelling

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Bayesian optimization with active learning of design constraints using an entropy-based approach

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npj Computational Materials 2023年第1期9卷 1866-1879页

作者： Danial Khatamsaz Brent Vela Prashant singh Duane D.Johnson Douglas Allaire raymundo Arróyave J.Mike Walker’66 department of Mechanical Engineering Texas A&M UniversityCollege StationTX 77843USA department of Materials science and Engineering Texas A&M UniversityCollege StationTX 77843USA Ames Laboratory U.S.Department of EnergyIowa State UniversityAmesIA 50011USA department of Materials science&Engineering Iowa State UniversityAmesIA 50011USA department of Industrial and systems Engineering Texas A&M UniversityCollege StationTX 77843USA

The design of alloys for use in gas turbine engine blades is a complex task that involves balancing multiple objectives and *** alloys must be ductile at room temperature and retain their yield strength at high temperatures,as well as possess low density,high thermal conductivity,narrow solidification range,high solidus temperature,and a small linear thermal expansion *** Integrated Computational Materials Engineering(ICME)methods are not sufficient for exploring combinatorially-vast alloy design spaces,optimizing for multiple objectives,nor ensuring that multiple constraints are *** this work,we propose an approach for solving a constrained multi-objective materials design problem over a large composition space,specifically focusing on the Mo-Nb-Ti-V-W system as a representative Multi-Principal Element Alloy(MPEA)for potential use in next-generation gas turbine *** approach is able to learn and adapt to unknown constraints in the design space,making decisions about the best course of action at each stage of the *** a result,we identify 21 Pareto-optimal alloys that satisfy all *** proposed framework is significantly more efficient and faster than a brute force approach.

关键词： alloys solidification alloy

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A physics informed bayesian optimization approach for material design: application to NiTi shape memory alloys

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npj Computational Materials 2023年第1期9卷 85-95页

作者： Danial Khatamsaz Raymond Neuberger Arunabha M.Roy sina Hossein Zadeh Richard Otis raymundo Arróyave Materials science and Engineering department Texas A&M UniversityCollege StationTX 77843USA Engineering and science Directorate Jet Propulsion LaboratoryCalifornia Institute of TechnologyPasadenaCA 91109USA Mechanical Engineering department Texas A&M UniversityCollege StationTX 77843USA department of Industrial&systems Engineering Texas A&M UniversityCollege StationTX 77843USA

The design of materials and identification of optimal processing parameters constitute a complex and challenging task,necessitating efficient utilization of available *** Optimization(BO)has gained popularity in materials design due to its ability to work with minimal ***,many BO-based frameworks predominantly rely on statistical information,in the form of input-output data,and assume black-box objective *** practice,designers often possess knowledge of the underlying physical laws governing a material system,rendering the objective function not entirely black-box,as some information is partially *** this study,we propose a physics-informed BO approach that integrates physics-infused kernels to effectively leverage both statistical and physical information in the decision-making *** demonstrate that this method significantly improves decision-making efficiency and enables more data-efficient *** applicability of this approach is showcased through the design of NiTi shape memory alloys,where the optimal processing parameters are identified to maximize the transformation temperature.

关键词： alloys shape approach

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Functional traits shape size-dependent growth and mortality rates of dry forest tree species

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Journal of Plant Ecology 2017年第6期10卷 895-906页

作者： Jamir A.Prado-Junior Ivan schiavini Vagner s.Vale Diego raymundo sergio F.Lopes Lourens Poorter Biology Institute Federal University of UberlandiaUberlandiaBrazil Forest Ecology and Forest Management Group Wageningen UniversityPO Box 476700 AA WageningenThe Netherlands Forestry department State University of Goias-Ipameri CampusRoad GO-330 Km 24175780-000 IpameriBrazil Biological sciences Institute Federal University of Juiz de Fora 36036-900Juiz de ForaBrazil Biology department State University of ParaibaBaraunas street 58429-500Campina GrandeBrazil

Aims Functional traits have emerged as an important tool to evaluate plant ***,the environmental conditions and ecological pressures that plants face change with their size,and the relationship between traits and plant performance should therefore be size-dependent,which has rarely been *** Here,we evaluated over a broad range of tree sizes the interspe-cific relationship between tree growth and mortality and eight func-tional stem,leaf and seed *** did so across 59 tree species in Brazilian dry forests and evaluated whether the relationships found for wet forest types in the literature also hold for dry forests,where water rather than light might limit tree *** Findings We indeed found a strong size-dependent relationship between demographic rates and functional *** small sizes,when trees are in the shaded understory,species with functional trait values that enhance light capture or shade tolerance(*** maximum adult stature,taller heights,wider crowns,higher seed mass)have higher growth and/or lower mortality rates(MR).This relationship disappears at larger sizes when trees attain better light conditions in the *** adaptations play only a role at larger tree sizes;once trees are in the dry and exposed canopy,species with higher wood density(an indicator of cavitation resistance)have lower *** study shows that both drought and shade adaptations are important in this dry forest,and that the relationships between func-tional traits and plant performance changes with plant *** size should therefore explicitly be included as an axis of variation in functional analyses,to better understand the relationship between functional traits and demographic rates.

关键词： demographic rates leaf traits seed mass tree architecture wood density

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Bayesian optimization with adaptive surrogate models for automated experimental design

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npj Computational Materials 2021年第1期7卷 1800-1811页

作者： Bowen Lei Tanner Quinn Kirk Anirban Bhattacharya debdeep Pati Xiaoning Qian raymundo Arroyave Bani K.Mallick department of statistics Texas A&M UniversityCollege StationTXUSA department of Mechanical Engineering Texas A&M UniversityCollege StationTXUSA department of Electrical&Computer Engineering Texas A&M UniversityCollege StationTXUSA department of Computer science&Engineering Texas A&M UniversityCollege StationTXUSA department of Materials science&Engineering Texas A&M UniversityCollege StationTXUSA

Bayesian optimization(BO)is an indispensable tool to optimize objective functions that either do not have known functional forms or are expensive to ***,optimal experimental design is always conducted within the workflow of BO leading to more efficient exploration of the design space compared to traditional *** can have a significant impact on modern scientific discovery,in particular autonomous materials discovery,which can be viewed as an optimization problem aimed at looking for the maximum(or minimum)point for the desired materials *** performance of BO-based experimental design depends not only on the adopted acquisition function but also on the surrogate models that help to approximate underlying objective *** this paper,we propose a fully autonomous experimental design framework that uses more adaptive and flexible Bayesian surrogate models in a BO procedure,namely Bayesian multivariate adaptive regression splines and Bayesian additive regression *** can overcome the weaknesses of widely used Gaussian process-based methods when faced with relatively high-dimensional design space or non-smooth patterns of objective *** simulation studies and real-world materials science case studies demonstrate their enhanced search efficiency and robustness.

关键词： functions properties optimization

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Environment-dependent attack rates of cryptic and aposematic butterflies

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Current Zoology 2018年第5期64卷 663-669页

作者： Brett M. sEYMOURE Andrew raymundo Kevin J. MCGRAW W. OWEN MCMILLAN Ronald L, RUTOWsKI department of Biology Colorado State University Fort Collins CO 80523 USA school of Life sciences Arizona State University Tempe AZ 85287 USA smithsonian Tropical Research Institute Panama City Panama

Many organisms have evolved adaptive coloration that reduces their risk of predation. Cryptic colo- ration reduces the likelihood of detection/recognition by potential predators, while warning or aposematic coloration advertises unprofitability and thereby reduces the likelihood of attack. Although some studies show that aposematic coloration functions better at decreasing attack rate than crypsis, recent work has suggested and demonstrated that crypsis and aposematism are both successful strategies for avoiding predation. Furthermore, the visual environment （e.g., ambient lighting, background） affects the ability for predators to detect prey. We investigated these 2 related hypoth- eses using 2 well-known visually aposematic species of Heliconius butterflies, which occupy differ- ent habitats （open-canopy vs. closed-canopy）, and one palatable, cryptic, generalist species Junonia coenia. We tested if the differently colored butterflies differ in attack rates by placing plasti- cine models of each of the 3 species in 2 different tropical habitats where the butterflies naturally occur： disturbed, open-canopy habitat and forested, closed-canopy habitat. The cryptic model had fewer attacks than one of the aposematic models. Predation rates differed between the 2 habitats, with the open habitat having much higher predation. However, we did not find an interaction between species and habitat type, which is perplexing due to the different aposematic phenotypes naturally occurring in different habitats. Our findings suggest that during the Panamanian dry sea- son avian predation on perched butterflies is not a leading cause in habitat segregation between the 2 aposematic species and demonstrate that cryptically colored animals at rest may be better than aposematic prey at avoiding avian attacks in certain environments.

关键词： avian attacks camouflage Heliconius Junonia light environment plasticine models predation warning coloration.

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Temozolomide and capecitabine regimen as first-line treatment in advanced gastroenteropancreatic neuroendocrine tumors at a Latin American reference center

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World Journal of Gastrointestinal Oncology 2024年第12期16卷 4675-4684页

作者： Wagner Eduardo Cruz-Diaz Victor Paitan Jersinho Medina raymundo Flores Juan Haro-Varas Raul Mantilla Victor Castro-Oliden department of Oncology Instituto Nacional de Enfermedades NeoplásicasLima 15038Perú department of Pathology Instituto Nacional de Enfermedades NeoplásicasLima 15038Perú department of Radiology Instituto Nacional de Enfermedades NeoplásicasLima 15038Perú

BACKGROUND Numerous studies have indicated that the temozolomide and capecitabine regimen(TEMCAP)exhibits a certain level of efficacy in treating advanced,welldifferentiated gastroenteropancreatic neuroendocrine tumors(GEP-NET).However,published data from Peru are *** hypothesize that this regimen could be a viable therapeutic option for advanced GEP-NET in the Peruvian *** To evaluate overall survival(Os)in patients diagnosed with advanced GEP-NET treated with TEMCAP at the Instituto Nacional de Enfermedades Neoplásicas(INEN)in Lima-Perú.METHODs A retrospective review was conducted to identify patients with GEP-NEN treated with the TEMCAP regimen between 2011 and 2021 at the INEN.A total of thirtyeight patients were included in the final analysis:Thirty-five received TEMCAP as a first-line treatment,and three as a second-line *** primary objective was to evaluate *** efficacy and safety of TEMCAP were assessed until the occurrence of unacceptable toxicity or disease *** outcomes were estimated using the Kaplan-Meier *** The median age of the patients was 52 years(range 24-77 years),and 53.3%were *** most common symptoms at diagnosis were abdominal pain in 31 patients(81.6%).Primary tumors included 12 in the rectum(31.6%),11 in the pancreas(28.9%),3 in the ileum(7.9%),2 in the mesentery(5.3%),2 in the small intestine(5.3%),1 in the appendix(2.6%),1 in the stomach(2.6%)and 6 cases of liver metastasis of unknown primary(15.8%).Five were neuroendocrine tumors(NET)G1(13.2%),33 were NET G2(86.8%),five had Ki67s administered to 35(92.1%)patients as first-line *** at 12,36,and 60 months was estimated in 80%,66%,and 42%,respectively,with a median Os of 49 *** TEMCAP therapy is a viable first-line option regarding efficacy and tolerability in areas where standard therapy is inaccessible.

关键词： Well-differentiated Gastroenteropancreatic neuroendocrine tumors Capecitabine Temozolomide Retrospective study Treatment Chemotherapy

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Major Existing Classification Matrices and Future Directions for Internet of Things

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Advances in Internet of Things 2017年第4期7卷 112-120页

作者： Kedir Mamo Basher Juan-Ivan Nieto-Hipolito Maria de Los Angeles Cosio Leon Mabel Vazquez-Briseno Juan de Dios sánchez López raymundo Buenrostro Mariscal Facultad de Ingeniería Arquitectura y Dise&#241 o UABC Ensenada México

Classification method is a formula, logical description generalizing characteristics of objects of related area. Nowadays, billions of smart objects are immersed in the environment, sensing, interacting, and cooperating with each other to enable efficient services. When we think about IoT, classification is a major challenge particularly if our technology is international level applicable. so, this limitation needs clear and deep analysis of the existing classification matrixes and gives some future directions depending on the different researches in the area. The paper surveys the current state-of-art in the classification of IoT. First, we try to explain commonly existing classification matrixes;second, cooperation of different methods defending on classification matrixes used. Then analyses challenges that IoT faced from classification angle and finally we give some direction for future IoT classification.

关键词： Internet of Things Classification of IoT IoT Overview Future of IoT smart Objects

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The role of microglia in depression

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Microenvironment & Microecology Research 2023年第3期5卷 10-15页

作者： Lester raymundo Dominguez Huarcaya María Fernanda Dominguez Ríos Faculty of Pharmacy and Biochemistry National University of San MarcosLima 01Peru Faculty of Psychology Pontifical Catholic University of Peru1801 Universitaria AvenueSan MiguelLima 32Peru.

According to studies,neuroinflammation is increasingly being linked to the development of major depressive disorder(MDD).In response to inflammatory stimuli,brain microglia,which are immune cells,can change into reactive *** of this,microglia play an essentiall role in the early stages of *** have shown that microglia are able to detect infected or damaged cells,which then activates a cytotoxic response that further exacerbates the harm to brain *** has been proven that microglia are quite good at recognizing infections and damaged ***,on the other hand,have been found to respond in a number of ways to injury and may even help regenerate damaged *** activation of microglia has been observed in persons with *** in neuroplasticity have been linked to depression,and recent studies show that this may be related to changes in microglia shape and function brought on by either excessive inflammatory activity or the natural aging *** the phenotype of microglia by regulation of inflammatory pathways may be necessary for harnessing neuroinflammation in *** research has linked several microglial phenotypes to individual metabolic pathways,showing that energy metabolism plays a pivotal role in coordinating microglial *** this study,we investigate whether or not traditional pro-inflammatory,anti-inflammatory,and metabolic pathways in microglia can be used as novel therapeutic routes for regulating neuroinflammation in brain *** focus of this essay is on MDD,although we will also discuss related mental health issues.

关键词： anti-inflammatory pathway major depressive disorder metabolic pathway microglia microglial pathways as therapeutic targets neuroinflammation pro-inflammatory pathway

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