检索结果-南通市图书馆

Optic neuropathy and increased retinal glial fibrillary acidic protein due to microbead-induced ocular hypertension in the rabbit

在线全文

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2016年第12期9卷 1732-1739页

作者： Jun Zhao Tian-hui Zhu Wen-Chie Chen Shi-Ming Peng Xiao Sheng Huang kin-Sang Cho Dong Feng Chen Guer-Sheung Liu School of Ophthalmology & Optometry Affiliated to Shenzhen University Shenzhen 518040 Guangdong Province China Shenzhen Eye Hospital Affiliated to Jinan University Shenzhen Key Laboratory of Ophthalmology Shenzhen 518040 Guangdong Province China Department of Ophthalmology Schepens Eye Research Institute Massachusetts Eye and Ear Harvard Medical School Boston 02114 USA Centre for Eye Research Australia Royal Victorian Eye and Ear Hospital East Melbourne 3002 Australia Ophthalmology Department of Surgery University of Melbourne East Melbourne 3002 Australia

AIM： To characterize whether a glaucoma model with chronic elevation of the intraocular pressure （IOP） was able to be induced by anterior chamber injection of microbeads in ***： In order to screen the optimal dose of microbead injection, IOP was measured every 3d for 4wk using handheld applanation tonometer after a single intracameral injection of 10 μL, 25 μL, 50 μL or 100 μL microbeads （5×10^6 beads/mL; n=6/group） in New Zealand White rabbits. To prolong IOP elevation, two intracameral injections of 50 μL microbeads or phosphate buffer saline （PBS） were made respectively at days 0 and 21 （n=24/group）. The fellow eye was not treated. At 5wk after the second injection of microbeads or PBS, bright-field microscopy and transmission electron microscopy （TEM） were used to assess the changes in the retina. The expression of glial fibrillary acidic protein （GFAP） in the retina was evaluated by immunofluorescence, quantitative real-time polymerase chain reaction and Western blot at 5wk after the second injection of ***： Following a single intracameral injection of 10 μL, 25 μL, 50 μL or 100 μL microbead, IOP levels showed a gradual increase and a later decrease over a 4wk period after a single injection of microbead into the anterior chamber of rabbits. A peak IOP was observed at day 15 after injection. No significant difference in peak value of IOP was found between 10 μL and 25 μL groups （17.13±1.25 mm Hg vs 17.63±0.74 mm Hg; P=0.346）. The peak value of IOP from 50 μL group （23.25±1.16 mm Hg） was significantly higher than 10 μL and 25 μL groups （all P〈0.05）. Administration of 100 μL microbead solution （23.00±0.93 mm Hg） did not lead to a significant increase in IOP compared to the 50 μL group （P=0.64）. A prolonged elevated IOP duration up to 8wk was achieved by administering two injections of 50 μL microbeads （20.48±1.21 mm Hg vs 13.60±0.90 mm Hg in PBS-injected group; P〈0.05）. The bright-field and TEM were used to assess the changes of retinal

关键词： microbead ocular hypertension optic neuropathy glial fibrillary acidic protein rabbit

面向复杂工况的液力变矩器与变速箱效能优化协同控制策略

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

西安交通大学学报 2024年第2期58卷 146-156页

作者：张泽宇惠记庄许仕伟耿麒卜正锋长安大学道路施工技术与装备教育部重点实验室西安710064 西藏天路股份有限公司博士后工作站拉萨850000 陕西航天动力高科技股份有限公司西安710077

针对工程机械在复杂工况下能源利用率不高的问题,提出了一种液力变矩器与变速箱效能优化协同控制策略。首先,在装载机功率与力学平衡的基础上,构造了基于牵引性能理论的装载机动力传动系统仿真平台,并通过装载机循环工况采集到的实验数... 详细信息

针对工程机械在复杂工况下能源利用率不高的问题,提出了一种液力变矩器与变速箱效能优化协同控制策略。首先,在装载机功率与力学平衡的基础上,构造了基于牵引性能理论的装载机动力传动系统仿真平台,并通过装载机循环工况采集到的实验数据验证了其有效性和可靠性;其次,基于发动机与液力变矩器台架实验,研究了ZL50型装载机的牵引特性,对比了其在起步、举升、铲掘、匀速4种不同牵引阶段的动力性能,分析了液力变矩器的闭锁点对装载机动力性、平顺性和经济性的影响;最后,提出了面向复杂工况的液力变矩器与变速箱效能优化协同控制策略,并对优化前后的装载机效能进行了对比分析。研究结果表明:在相同的V型循环工况下,采用所提出的控制策略,装载机等油耗输出能量从372.69 kW·h·mL^(-1)提高到420.51 kW·h·mL^(-1),整机效能提高了约12.8%。所提策略可为大型工程机械传动效率低、燃料消耗大、污染排放严重等问题提供解决方案。

关键词：装载机传动系统液力变矩器变速箱协同控制

Real-time transition dynamics and stability of chipscale dispersion-managed frequency microcombs

在线全文

学校读者我要写书评

暂无评论

Light(Science & Applications) 2020年第1期9卷 1520-1529页

作者： Yongnan Li Shu-Wei Huang Bowen Li Hao Liu Jinghui Yang Abhinav Kumar Vinod Ke Wang Mingbin Yu Dim-Lee Kwong hui-Tian Wang Kenneth kin-Yip Wong Chee Wei Wong Fang Lu Mesoscopic Optics and Quantum Electronics Laboratory University of CaliforniaLos AngelesCA 90095USA School of Physics and The MOE Key Laboratory of Weak Light Nonlinear Photonics Nankai UniversityTianjinChina Department of Electrical Computer and Energy EngineeringUniversity of Colorado BoulderBoulderCO 80309USA Department of Electrical and Electronic Engineering The University of Hong KongHong KongChina Institute of Microelectronics A*STARSingapore 117865Singapore

Femtosecond mode-locked laser frequency combs have served as the cornerstone in precision spectroscopy,alloptical atomic clocks,and measurements of ultrafast *** frequency microcombs based on nonlinear microresonators have been examined,exhibiting remarkable precision approaching that of laser frequency combs,on a solid-state chip-scale platform and from a fundamentally different physical *** recent successes,to date,the real-time dynamical origins and high-power stabilities of such frequency microcombs have not been fully ***,we unravel the transitional dynamics of frequency microcombs from chaotic background routes to femtosecond mode-locking in real time,enabled by our ultrafast temporal magnifier metrology and improved stability of dispersion-managed dissipative *** our dispersion-managed oscillator,we further report a stability zone that is more than an order-of-magnitude larger than its prior static homogeneous counterparts,providing a novel platform for understanding ultrafast dissipative dynamics and offering a new path towards high-power frequency microcombs.

关键词： dispersion stability dynamics

Tumor necrosis factor-α-induced protein 1 and immunity to hepatitis B virus

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2005年第48期11卷 7564-7568页

作者： Marie C Lin Nikki P Lee Ning Zheng Pai-Hao Yang Oscar G Wong Hsiang-Fu Kung Chee-kin hui John M Luk George Ka-Kit Lau Institute of Molecular Biology The University of Hong KongHong Kong SAR China Department of Surgery The University of Hong Kong Hong Kong SAR China Center for the Study of Liver Diseases The University of Hong Kong Hong Kong SAR China Department of Medicine The University of Hong Kong Hong Kong SAR China

AIM: To compare the gene expression profile in a pair of HBV-infected ***: The gene expression profile was compared in a pair of HBV-infected ***: The twins displayed different disease outcomes. One acquired natural immunity against HBV,whereas the other became a chronic HBV carrier. Eightyeight and forty-six genes were found to be up- or downregulated in their PBMCs, respectively. Tumor necrosis factor-alpha-induced protein 1 (TNF-αIP1) that expressed at a higher level in the HBV-immune twins was identified and four pairs of siblings with HBV immunity by RTPCR. However, upon HBV core antigen stimulation,TNF-αIP1 was downregulated in PBMCs from subjects with immunity, whereas it was slightly upregulated in HBV carriers. Bioinformatics analysis revealed a K+channel tetramerization domain in TNF-αIP1 that shares a significant homology with some human, mouse, and C elegan ***: TNF-αIP1 may play a role in the innate immunity against HBV.

关键词： TNF-α HBV Immunity

Remarkable synergistic effect in cobalt-iron nitride/alloy nanosheets for robust electrochemical water splitting

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2022年第2期31卷 405-414页

作者： Mingpeng Chen Di Liu Baoye Zi Yuyun Chen Dong Liu Xinyu Du Feifei Li Pengfei Zhou Ye Ke Jielei Li kin Ho Lo Chi Tat Kwok Weng Fai Ip Shi Chen Shuangpeng Wang Qingju Liu hui Pan Institute of Applied Physics and Materials Engineering University of MacaoMacaoChina Yunnan Key Laboratory for Micro/Nano Materials&Technology National Center for International Research on Photoelectric and Energy MaterialsSchool of Materials and EnergyYunnan UniversityKunming 650091YunnanChina Department of Electromechanical Engineering Faculty of Science and TechnologyUniversity of MacaoMacaoChina Department of Physics and Chemistry Faculty of Science and TechnologyUniversity of MacaoMacaoChina

Design and synthesis of noble-metal-free bifunctional catalysts for efficient and robust electrochemical water splitting are of significant importance in developing clean and renewable energy sources for sustainable energy ***,a simple three-step strategy is reported to construct cobalt-iron nitride/alloy nanosheets on nickel foam(CoFe-NA/NF)as a bifunctional catalyst for both hydrogen evolution reaction(HER)and oxygen evolution reaction(OER).The electrocatalyst with optimized composition(CoFe-NA2/NF)can achieve ultralow overpotentials of 73 mV and 250 mV for HER and OER,respectively,at a current density of 10 mA cm^(-2) in 1 M ***,the electrolyzer based on this electrocatalyst is able to boost the overall water splitting with a cell voltage of 1.564 V to deliver 10 mA cm^(-2) for at least 50 h without obvious performance ***,our experiment and theoretical calculation demonstrate that the combination of cobalt-iron nitride and alloy can have low hydrogen adsorption energy and facilitate water dissociation during *** addition,the surface reconstruction introduces metal oxyhydroxides to optimize the OER *** work may pave a new pathway to design bifunctional catalysts for overall water splitting.

关键词： Bifunctional electrocatalyst Metal nitride/alloy nanocomposite Overall water splitting high performance

Macroblock-level decoding and deblocking method and its pipeline implementation in H.264 decoder SOC design

在线全文

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第1期8卷 36-41页

作者： WANG Shu-hui LIN Tao LIN Zheng-hui Department of Electronic Engineering Shanghai Jiao Tong University Shanghai 200030 China

This paper presents a macroblock-level (MB-level) decoding and deblocking method for supporting the flexible macroblock ordering (FMO) and arbitrary slice ordering (ASO) bit streams in H.264 decoder and its SOC/ASIC implementation. By searching the slice containing the current macroblock in the bit stream and switching slices correctly, MBs can be decoded in the raster scan order, while the decoding process can immediately begin as long as the slice containing the current MB is available. This architectural modification enables the MB-level decoding and deblocking 3-stage pipeline, and saves about 20% of SDRAM bandwidth. Implementation results showed that the design achieves real-time decoding of 1080HD (1920×1088@30 fps) at a system clock of 166 MHz.

关键词： Flexible macroblock ordering (FMO) Arbitrary slice ordering (ASO) System-on-chip (SOC) Raster scan order Pipeline

论《营造法式》开间、柱高的取值比例及其形式关联

在线全文

学校读者我要写书评

暂无评论

建筑史学刊 2024年第1期5卷 121-135页

作者：喻梦哲惠盛健西安建筑科技大学

关于中国古代建筑是否存在复杂精密、成熟稳定且可理性解析的立面构成法则,是建筑历史研究中一个经典的命题。本文在前人研究基础之上,进一步借由作图验算,以铺作层与柱高、间广赋值间的联动方式为考察对象,探索固有数理比例耦合特定图... 详细信息

关于中国古代建筑是否存在复杂精密、成熟稳定且可理性解析的立面构成法则,是建筑历史研究中一个经典的命题。本文在前人研究基础之上,进一步借由作图验算,以铺作层与柱高、间广赋值间的联动方式为考察对象,探索固有数理比例耦合特定图形关系的内因。提出以分°值控制铺作总高,继而以其作为基准、以檐高的■定出柱高,再由柱高间广关系扩展至整个立面设计的操作模型,并结合《营造法式》料例、功限章节所载数据,验证了该算法的可行性,以期将利用几何或代数方法分别解析宋式建筑立面的两种既有工作统合于同一逻辑框架之内。

关键词：立面构成法则形式关联数理比例 “白银比”

Real-time Feed-forward Force Compensation for Active Magnetic Bearings System Based on H∞ Controller

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Mechanical Engineering 2011年第1期24卷 58-66页

作者： GAO hui XU Longxiang College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and Astronautics Nanjing 210016 China

There are two kinds of unbalance vibrations—force vibration and displacement vibration due to the existence of unbalance excitation in active magnetic bearings（AMB） system. And two unbalance compensation methods—closed-loop feedback and open loop feed-forward are presented to reduce the force vibration. The transfer function order of the control system directly influencing the system stability will be increased when the closed-loop method is adopted, which makes the real-time compensation not easily achieved. While the open loop method would not increase the primary transfer function order, it provides conditions for real-time compensation. But the real-time compensation signals are not easy to be obtained in the open loop method. To implement real-time force compensation, a new method is proposed to reduce the force vibration caused by the rotor unbalance on the basis of AMB active control. The method realizes real-time and on-line force auto-compensation based on H∞ controller and one novel feed-forward compensation controller, which makes the rotor rotate around its inertia axis. The time-variable feed-forward compensatory signal is provided by a modified adaptive variable step-size least mean square（VSLMS） algorithm. And the relevant least mean square（LMS） algorithm parameters are used to solve the H∞ controller weighting functions. The simulation of the new method to compensate some frequency-variable and sinusoidal signals is completed by MATLAB programming, and real-time compensation is implemented in the actual AMB experimental system. The simulation and experiment results show that the compensation scheme can improve the robust stability and the anti-interference ability of the whole AMB system by using H∞ controller to achieve close-loop control, and then real-time force unbalance compensation is implemented. The proposed research provides a new control strategy containing real-time algorithm and H∞ controller for the force compensation of AMB system. And

关键词： active magnetic bearings H∞ robust controller sensitivity and complementary sensitivity VSLMS algorithm feed-forward compensation

Epididymis cell atlas in a patient with a sex development disorder and a novel NR5A1 gene mutation

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2023年第1期25卷 103-112页

作者： Jian-Wu Shi Yi-Wen Zhou Yu-Fei Chen Mei Ye Feng Qiao Jia-Wei Tian Meng-Ya Zhang Hao-Cheng Lin Gang-Cai Xie kin Lam Fok hui Jiang Yang Liu Hao Chen Institute of Reproductive Medicine Medical School of Nantong UniversityNantong 226000China Department of Plastic and Reconstructive Surgery Shanghai Ninth People's HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China Department of Urology Peking University Third HospitalBeijing 100191China School of Biomedical Sciences Faculty of MedicineThe Chinese University of Hong KongHong Kong SARChina

This study aims to characterize the cell atlas of the epididymis derived from a 46,XY disorders of sex development(DSD)patient with a novel heterozygous mutation of the nuclear receptor subfamily 5 group A member 1(NR5A1)***-generation sequencing found a heterozygous c.124C>G mutation in NR5A1 that resulted in a p.Q42E missense mutation in the conserved DNA-binding domain of *** patient demonstrated feminization of external genitalia and Tanner stage 1 breast *** surgical procedure revealed a morphologically normal epididymis and vas deferens but a dysplastic ***-based single-cell RNA sequencing(scRNA-seq)analysis found that the fibroblast cells were significantly increased(approximately 46.5%),whereas the number of main epididymal epithelial cells(approximately 9.2%),such as principal cells and basal cells,was dramatically *** analysis of cell–cell communications and gene regulatory networks at the single-cell level inferred that epididymal epithelial cell loss and fibroblast occupation are associated with the epithelial-to-mesenchymal transition(EMT)*** present study provides a cell atlas of the epididymis of a patient with 46,XY DSD and serves as an important resource for understanding the pathophysiology of DSD.

关键词： disorders of sex development human epididymis NR5A1 scRNA-seq