Tumor necrosis factor-α-induced protein 1 and immunity to hepatitis B virus
Tumor necrosis factor-α-induced protein 1 and immunity to hepatitis B virus作者机构：Institute of Molecular Biology The University of Hong KongHong Kong SAR China Department of Surgery The University of Hong Kong Hong Kong SAR China Center for the Study of Liver Diseases The University of Hong Kong Hong Kong SAR China Department of Medicine The University of Hong Kong Hong Kong SAR China
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2005年第11卷第48期
页 面：7564-7568页
核心收录：
学科分类：1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100102[医学-免疫学] 10[医学]
摘 要：AIM: To compare the gene expression profile in a pair of HBV-infected ***: The gene expression profile was compared in a pair of HBV-infected ***: The twins displayed different disease outcomes. One acquired natural immunity against HBV,whereas the other became a chronic HBV carrier. Eightyeight and forty-six genes were found to be up- or downregulated in their PBMCs, respectively. Tumor necrosis factor-alpha-induced protein 1 (TNF-αIP1) that expressed at a higher level in the HBV-immune twins was identified and four pairs of siblings with HBV immunity by RTPCR. However, upon HBV core antigen stimulation,TNF-αIP1 was downregulated in PBMCs from subjects with immunity, whereas it was slightly upregulated in HBV carriers. Bioinformatics analysis revealed a K+channel tetramerization domain in TNF-αIP1 that shares a significant homology with some human, mouse, and C elegan ***: TNF-αIP1 may play a role in the innate immunity against HBV.
维普期刊数据库