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Drought Tolerance Enhancement with Co-Overexpression of DREB2A and APX in Indica Rice (<i>Oryza sativa</i>L.)

American Journal of Plant Sciences 2021年第2期12卷 234-258页

作者： Jagtap Sandhya Talakayala Ashwini ravula manisha Mahankali Vinodha Ankanagari Srinivas Department of Genetics & Biotechnology Osmania University Hyderabad India

Rice is a major cereal crop providing food and energy to more than half of world’s population and drought is a challenging abiotic stress limiting rice production. Engineering drought tolerance trait is a major bottle neck because of multigenic control and complex nature. Two promising candidate genes utilized in engineering drought tolerance include DREB2A transcription factor (a master regulator of downstream stress inducible genes) and APX (an important ROS scavenging enzyme). Overexpression of DREB genes has shown encouraging results but with a negative impact on plant morphology and production. Moreover, co-expression of DREB2A and APX genes’ influence on drought stress has not been studied. Hence, in the present study, overexpression of single genes DREB2A or APX and co-expression of these genes were studied for enhancement of drought tolerance in indica rice. Both genes under control of CaMV 35S promoter were transferred by Agrobacterium transformation into rice variety BPT5204 popular for slender grains in South India. Confirmation of T-DNA integration into rice genome was done with PCR analysis of transgenes. Homozygous transgenic lines of DREB2A, APX and DREB2A-APX generated in T3 generation were evaluated for

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Effect of minocycline and its nano-formulation on central auditory system in blast-induced hearing loss rat model

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Journal of Otology 2023年第1期18卷 38-48页

作者： Venkatesan Perumal Arun Reddy ravula Ningning Shao Namas Chandra Center for Injury Biomechanics Materialsand MedicineDepartment of Biomedical EngineeringNew Jersey Institute of TechnologyNewarkNJ07102USA

Blast injuries are common among the military service members and *** of the devastating effects of blast wave induced TBI is either temporary or permanent hearing *** hearing loss using minocycline is restricted by optimal drug concentration,route of administration,and its ***,therapeutic approach using novel therapeutic delivery method is in great *** the different delivery methods,nanotechnology-based drug delivery is desirable,which can achieve longer systemic circulation,pass through some biological barriers and specifically targets desired *** current study aimed to examine therapeutic effect of minocycline and its nanoparticle formulation in moderate blast induced hearing loss rat model through central auditory *** *** nanoparticle at reduced dose and frequency than regularly administered toxic *** moderate blast exposure,rats had hearing impairment as determined by ABR at 7-and 30-days post *** chronic condition,free minocycline also showed the significant reduction in ABR *** central auditory system,it is found in this study that minocycline nanoparticles ameliorate excitation in inferior colliculus;and astrocytes and microglia activation after the blast exposure is reduced by minocycline nanoparticles *** study demonstrated that in moderate blast induced hearing loss,minocycline and its nanoparticle formulation exhibited the optimal therapeutic effect on the recovery of the ABR impairment and a protective effect through central auditory *** conclusion,targeted and non-targeted nanoparticle formulation have therapeutic effect on blast induced hearing loss.

关键词： Minocycline Nanoparticle Hearing loss Blast injury and targeted drug delivery

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Anisocoria in a 10-month old girl in the immediate preoperative setting: can you proceed with surgery?

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The Journal of Biomedical Research 2011年第3期25卷 224-226页

作者： Zoel A Quinonez Niroop R ravula Department of Anesthesiology and Pain Medicine University of California Davis Health System

We report the case of a 10-month old girl with a significant past medical history who presented for elective sur-gery with a new-onset fixed, dilated pupil. We briefly review the diagnostic approach to such patients a... 详细信息

关键词： anisocoria anticholinergics ipratropium

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A Modified Method for the Synthesis of Tetradentate Ligand Involving Peptide Bond

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International Journal of Organic Chemistry 2014年第2期4卷 122-134页

作者： Pulimamidi Rabindra Reddy ravula Chandrashekar Hussain Shaik Battu Satyanarayana Department of Chemistry Osmania University Hyderabad India

In view of the importance of picolinic acid (Pa) in preventing cell growth and arresting cell cycle, attempts were made to design, synthesize and characterize two new Pa based tetradentate ligands (DPPTR and DPPTY) wi... 详细信息

关键词： Amide Bond Formation Tetradentate Ligand Peptide Bond Coupling Reagent

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