检索结果-南通市图书馆

Biotransformation of drugs mediated by brain-specific splice variants of the drug-metabolizing enzyme, Cytochrome P450

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Biotransformation of drugs mediated by brain-specific splice...

亚太地区国际脑研究研讨会

作者： Reddy P.Kommaddi Harish V.Pai Shankar J.Chinta Vijayalakshmi ravindranath Division of Molecular and Cellular Neuroscience National Brain Research CentreManesarGurgaon-122050HaryanaIndia Division of Molecular and Cellular Neuroscience National Brain Research CentreManesarGurgaon-122050HaryanaIndia Division of Molecular and Cellular Neuroscience National Brain Research CentreManesarGurgaon-122050HaryanaIndia Division of Molecular and Cellular Neuroscience National Brain Research CentreManesarGurgaon-122050HaryanaIndia

＜正＞ Cytochromes P450 （P450） is a family of heme proteins that functions as mono oxygenase and metabolizes a variety of xenobiotics, including drugs. Liver is quantitatively the major organ involved in P450 mediated metabolism. However, presence of P450 and associated mono-oxygenase activities in extrahepatic tissues such as lung, kidney and brain has been demonstrated. P450-mediated metabolism of psychoactive drugs in brain leads to pharmacological modulation at site of action and results in variable drug response. A frame

关键词：

兰布尔阿古查铅锌矿(印度最大的复合矿床)——选矿流程的发展

在线全文

cnki会议

学校读者我要写书评

暂无评论

国外金属矿选矿 1989年第5期26卷 7-13,14页

作者： K.ravindranath H.V.Palinwal 方群英

七十年代末印度发现的最富的贱金属硫化矿矿床具有重要的意义。根据1982年完成的18095米钻探结果,铅锌矿石的储量估计为6100万吨。矿石含锌13.4%,铅1.93%。矿石矿化最富的是闪锌矿,其次是黄铁矿、磁黄铁矿、方铅矿、毒砂和黄铜矿。矿化... 详细信息

七十年代末印度发现的最富的贱金属硫化矿矿床具有重要的意义。根据1982年完成的18095米钻探结果,铅锌矿石的储量估计为6100万吨。矿石含锌13.4%,铅1.93%。矿石矿化最富的是闪锌矿,其次是黄铁矿、磁黄铁矿、方铅矿、毒砂和黄铜矿。矿化围岩是石墨-硅线石片岩或片麻岩。1980—1983年间,曾全力以赴地进行旨在能生产出适于冶炼厂处理的铅锌精矿的选矿流程的研究。本文将介绍印度斯坦锌有限公司研究与发展中心以及某些印度的和国际的实验室为发展这一流程所作的贡献。考虑到综合试验厂已经用硫化物矿化在独特的围岩中的兰布尔阿古查复合矿石进行过4000吨的验证试验,对于生产铅-锌精矿来说,采用优先浮选流程是合适的。

关键词：铅锌矿选矿选矿流程

Building theoretical pictures from phenomenology:mechanics of polymers above and below Tg

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Building theoretical pictures from phenomenology:mechanics o...

2015年全国高分子学术论文报告会

作者： Shi-Qing Wang P.Boukany S.ravindranath Y.Y.Wang S.W.Cheng P.P.Lin Department of Polymer Science University of Akron

＜正＞This talk describes the establishment of theoretical foundations for melt rheology and molecular mechanics of polymers in disordered state.A brief review of the emergent paradigm of molecular network for nonlinear rheology of entangled polymer solutions and melts set the stage for a first attempt to formulate a molecular model for

关键词：

Advances in management of type 1 diabetes mellitus

在线全文

cnki会议

学校读者我要写书评

暂无评论

World Journal of Diabetes 2014年第5期5卷 689-696页

作者： ravindranath Aathira Vandana Jain Department of Pediatrics All India Institute of Medical Sciences Ansari Nagar New Delhi 110029 India

Treatment of type 1 diabetes mellitus has always posed a challenge to balance hyperglycemia control with hypoglycemia episodes. The quest for newer therapies is continuing and this review attempts to outline the recent developments. The insulin molecule itself has got moulded into different analogues by minor changes in its structure to ensure well controlled delivery, stable half-lives and lesser side effects. Insulin delivery systems have also consistently undergone advances from subcutaneous injections to continuous infusion to trials of inhalational delivery. Continuous glucose monitoring systems are also becoming more accurate and user friendly. Smartphones have also made their entry into therapy of diabetes by integrating blood glucose levels and food intake with calculated adequate insulin required. Artificial pancreas has enabled to a certain extent to close the loop between blood glucose level and insulin delivery with devices armed with meal and exercise announcements, dual hormone delivery and pramlintide infusion. Islet, pancreas-kidney and stem cells transplants are also being attempted though complete success is still a far way off. Incorporating insulin gene and secretary apparatus is another ambitious leap to achieve insulin independence though the search for the ideal vector and target cell is still continuing. Finally to stand up to the statement, prevention is better than cure, immunological methods are being investigated to be used as vaccine to prevent the onset of diabetes mellitus.

关键词： Type 1 diabetes advances Insulin analogues Closed loop system Continuous glucose monitors Insulin gene therapy

两种成像软件在预测下颌前徙术后软组织改变的比较性研究

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国口腔医学继续教育杂志 2013年第4期16卷 244-249页

作者： Sneha ravindranath Nathamuni Rengarajan Krishnaswamy Venkateswaran Sundaram 邓金荣(译) 高雪梅(审) 不详北京大学口腔医学院第三门诊部北京市海淀区花园东路10号100191

对既定的正畸正[牙合]联合治疗建立共同的目标和期望值是矫治设计中的一个重要部分．成像软件使之得到了大大简化。本研究的目的就是研究两个外科成像软件—Dolphin Imaging 10和Vistadent OC模拟真实的下颌前徙术后结果的可靠性。使用... 详细信息

对既定的正畸正[牙合]联合治疗建立共同的目标和期望值是矫治设计中的一个重要部分．成像软件使之得到了大大简化。本研究的目的就是研究两个外科成像软件—Dolphin Imaging 10和Vistadent OC模拟真实的下颌前徙术后结果的可靠性。使用的方法为组织一个由正畸医师、外科医师和普通人群的团队．使用视觉模拟量表（VAS）进行评价。预测图像同时还被用于头影测量软组织评价分析。本研究的结果显示使用VAS量表评价两个软件在预测外科效果时都表现一般。根据3个评价组的整体评价．其中一个软件稍优于另一个。不同区域评价显示下唇区域精确性最差．颏下区精确性最好，得分最高。软组织的头影测量显示两组软件除下唇区域指标外差别均较小。因此Dolphin Imaging 10和Vistadent OC在预测下颌前徙手术结果方面较可靠，精确性差的主要存在于下唇区域。

关键词：计算机手术模拟图像预测软件

Quantitative Analysis of a Panel of Gene Expression in Matched Benign and Neoplastic Prostate Epithelial Cells from Patients with“Aggressive”and“Nonaggressive”Prostate Cancer

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Quantitative Analysis of a Panel of Gene Expression in Match...

中华医学会病理学分会2005年学术年会

作者：刘爱军 Bungo Furusato Lakshmi ravindranath Syed Shaheduzzaman Vasantha Srikantan Iabell A.Sesterhenn David G.McLeod Judd W.Moul Shiv Srivastava Gyorgy Petrovics Centerfor Prostate Disease Research Uniformed Services University of the Health Sciences Center for Prostate Disease Research Uniformed Services University of the Health Sciences Department of Genitourinary Pathology Armed Forces Institute of Pathology Urology Service Walter Reed Army Medical Center Center for Prostate Disease Research Uniformed Services University of the Health Sciences Urology ServiceWalter Reed Army Medical Center

Prostate cancer (CaP) is a complex, multifactorialdisease with heterogeneous tumor types, making the prediction of the clinical course for individual CaP patients a challenge. To better understand the molecular basis of CaP and potentially provide information toward more accurate prognosis/diagnosis, we have defined a set of laser capture microdissected (LCM) specimens that are being used for quantitative parallel expression analysis of a panel of genes frequently altered in CaP. Experimental Design: From 300 CaP patients undergo-

关键词：

Frequent Expression Alterations of ETS Related Gene-1(ERG1)in Prostate Cancer Transcriptome Reveal Diagnostic and Prognostic Biomarker Potential

在线全文

cnki会议

学校读者我要写书评

暂无评论

Frequent Expression Alterations of ETS Related Gene-1(ERG1)i...

中华医学会病理学分会2005年学术年会

作者：刘爱军 Gyorgy Petrovics Syed Shaheduzzaman Bungo Furasato Martin Nau Lakshmi ravindranath Albert Dobi Vasantha Srikantan Isabell A Sesterhenn David G McLeod Maryanne Vahey Judd W Moul Shiv Srivastava Centerfor Prostate Disease Research US Military Cancer InstituteUniformed Services University Center for Prostate Disease Research US Military Cancer InstituteUniformed Services University Department of Genitourinary Pathology Armed Forces Institute of Pathology Laboratory of Functional Genomics Walter Reed Army Institute of Research Urology Service Walter Reed Army Medical Center

Transcription factors encoded by the ETS family of genes are central in integrating signals that regulate cell growth and differentiation, stress responses and tumorigenesis. This study, using laser microdissected paired benign and malignant prostate epithelial cells from prostate cancer (CaP) patients (n=114), identifies ERG, a member of the ETS transcription factor family, as the most frequently overexpressed poto-oncogene in the transcriptome of malignant prostate epithelial cells. Combined quantitative expression analysis of ERG with two other genes commonly overexpressed in CaP, AMACR and DD3, revealed overexpression of at least one of these three genes in virtually all cancer specimen (54 of 55). Therefore,

关键词：

Comparative Efficacy of Polyamine-Based Scavenger Resins

在线全文

cnki会议

学校读者我要写书评

暂无评论

Impact of Climate Change on Vegetation Distribution and Net Primary Productivity of Forests of Himalayan River Basins: Brahmaputra, Koshi and Indus

International Journal of Organic Chemistry（有机化学国际期刊） 2012年第1期

作者： Krishnarao Sandhya Bhagavathula ravindranath

来源：评论

学校读者我要写书评

暂无评论

American Journal of Climate Change 2018年第2期7卷 271-294页

作者： A. Chaitra S. Upgupta L. D. Bhatta J. Mathangi D. S. Anitha K. Sindhu Vidya Kumar N. K. Agrawal M. S. R. Murthy F. Qamar Indu K. Murthy J. Sharma R. K. Chaturvedi G. Bala N. H. ravindranath Centre for Sustainable Technologies Indian Institute of Science Bengaluru India International Centre for Integrated Mountain Development (ICIMOD) Kathmandu Nepal Divecha Centre for Climate Change Centre for Atmospheric Sciences Indian Institute of Science Bengaluru India

The impacts of climate change in terms of forest vegetation shifts and Net Primary Productivity (NPP) changes are assessed for Brahmaputra, Koshi and Indus river basins for the mid (2021-2050) and long (2071-2100) terms for RCP4.5 and RCP8.5 scenarios. Two Dynamical Global Vegetation Models (DGVMs), Integrated BIosphere Simulator (IBIS) and (Lund Postdam and Jena (LPJ), have been used for this purpose. The DGVMs are driven by the ensemble mean climate projections from 5 climate models that contributed to the CMIP5 data base. While both DGVMs project vegetation shifts in the forest areas of the basins, there are large differences in vegetation shifts projected by IBIS and LPJ. This may be attributed to differing representation of land surface processes and to differences in the number of vegetation types (Plant Functional Types) defined and simulated in the two models. However, there is some agreement in NPP changes as projected by both IBIS and LPJ, with IBIS mostly projecting a larger increase in NPP for the future scenarios. Despite the uncertainties with respect to climate change projections at river basin level and the differing impact assessments from different DGVMs, it is necessary to assess the “vulnerability” of the forest ecosystems and forest dependent communities to current climate risks and future climate change and to develop and implement resilience or adaptation measures. Assessment of the “vulnerability” and designing of the adaptation strategies could be undertaken for all the forested grids where both IBIS and LPJ project vegetation shifts.

关键词： Climate Change Forests Himalayan River Basins Impacts NPP Change Forest Type Shift