Frequent Expression Alterations of ETS Related Gene-1(ERG1)in Prostate Cancer Transcriptome Reveal Diagnostic and Prognostic Biomarker Potential
作者单位：Centerfor Prostate Disease ResearchUS Military Cancer InstituteUniformed Services University Center for Prostate Disease ResearchUS Military Cancer InstituteUniformed Services University Department of Genitourinary PathologyArmed Forces Institute of Pathology Laboratory of Functional GenomicsWalter Reed Army Institute of Research Urology ServiceWalter Reed Army Medical Center
会议名称：《中华医学会病理学分会2005年学术年会》
会议日期：2005年
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
摘 要：Transcription factors encoded by the ETS family of genes are central in integrating signals that regulate cell growth and differentiation, stress responses and tumorigenesis. This study, using laser microdissected paired benign and malignant prostate epithelial cells from prostate cancer (CaP) patients (n=114), identifies ERG, a member of the ETS transcription factor family, as the most frequently overexpressed poto-oncogene in the transcriptome of malignant prostate epithelial cells. Combined quantitative expression analysis of ERG with two other genes commonly overexpressed in CaP, AMACR and DD3, revealed overexpression of at least one of these three genes in virtually all cancer specimen (54 of 55). Therefore,