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A review on emerging materials with focus on BiI_(3) for room-temperature semiconductor radiation detectors

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Radiation Detection Technology and Methods 2023年第4期7卷 465-483页

作者： Ritu Chaudhari Chhaya ravi kant Alka Garg Surender Kumar Sharma Department of Applied Sciences and Humanities Indira Gandhi Delhi Technical University for WomenKashmere GateDelhi110006India Gargi College University of DelhiSiri Fort RoadNew Delhi110049India Delhi Skill and Entrepreneurship University New DelhiIndia

Purpose Considerable advances in the fundamental knowledge and applications of radiation science have led to significant progress and development of room-temperature semiconductor radiation detectors(RTSD).The RTSDs technologies are continuously evolving with accelerated research and material engineering in the last *** scientific and technological advancements have led to development of high-performance radiation detectors with high signal-to-noise ratio(SNR),better sensitivity,faster response and higher-resolution with capability of desired room-temperature *** paper is a review on emerging semiconductor radiation detector materials with a deeper insight into the prospective role of Bismuth tri-iodide(BiI_(3))for room-temperature radiation *** An introduction of the state of art of most developed semiconductor materials,i.e.,cadmium telluride(CdTe),mercury iodide(HgI_(2)),lead iodide(PbI_(2)),etc.,and a critical examination of properties,shortcomings and challenges related to their synthesis have been ***-semiconductor composites with desirable properties and their integration into detector devices is also *** sections discuss the role of BiI_(3) as an emerging radiation detector material for room-temperature operation with an in-depth discussion on the role of defects in charge transportation and electrode ***,the current challenges along with the future prospects of these materials for radiation detection to promote continuous innovation and practical applications are also *** The comprehensive review on latest developments in room-temperature radiation detector materials is expected to help establish a technological roadmap for the synthesis,fabrication and commercialization of novel materials for development of efficient radiation detectors.

关键词： Radiation detector Defects Electrical properties Bismuth tri-iodide Semiconductor Toxicity

High Cholesterol Disorders, Myocardial Infarction and Its Therapeutics

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World Journal of Cardiovascular Diseases 2023年第8期13卷 433-469页

作者： ravi kant Upadhyay Department of Zoology Deen Dayal Upadhyaya Gorakhpur University Gorakhpur India

The current review article discusses several conditions linked to high cholesterol, including their causes, diagnoses, and treatments. Cardiovascular disease is one of the leading causes of death worldwide, and hypercholesterolemia is a standalone risk factor for the condition. Numerous cardiovascular illnesses (CVDs) and disorders, including myocardial infarction, hypertension, peripheral vascular diseases, and coronary heart diseases, were highlighted in this article. Low density lipoprotein (LDL) is the key factor in the majority of CVDs. It adheres to fatty deposits and forms plaques inside artery lumen, preventing the heart and other body organs from receiving enough blood and oxygen. Cardiomyopathies and dyslipidemias are the most common causes of morbidity and mortality in men and place a considerable health cost on society. Age, hypertension, obesity-induced blood pressure, and a rise in plasma cholesterol are all factors that raise the risk of coronary heart disease (CHD). Calorie intake must be controlled, meal composition must be changed, a natural cycle must be established, and circadian timeliness must be maintained in order to live a healthy life. To lower the risks of metabolic and cardiovascular diseases, try to go vegetarian and always consume traditional plant-based diets and herbal remedies. Exercise yoga and aerobics every day to stay physically healthy, and have your blood pressure, blood sugar, and cholesterol levels checked on a regular basis. Follow your family doctor’s recommendations for managing high cholesterol risks and diagnosing CVD, obtain a lipid profile, take the recommended medications, maintain composure, and adopt a positive outlook for a long and healthy life.

关键词： Hypercholestemia Coronary Heart Diseases (CHD) Cardiovascular Diseases. Hypercholestemia Cardiomyopathy Cardiac Infarction Risks Diagnosis Lipoproteins Lipid Profile Polyunsaturated Fatty Acids Antioxidants

Biochemical Alterations and Termiticidal Activity of Combinatorial Essential Oil Ingredients of Citrus maxima on Indian White Termite Odontotermes obesus

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Journal of Biosciences and Medicines 2023年第4期11卷 60-81页

作者： Lokpriy Pandey ravi kant Upadhyay Department of Zoology (Environmental Science) Deen Dayal Upadhyaya Gorakhpur University Gorakhpur India

Essential oils are better alternative for synthetic termiticides with the inherent resistance by insects, environmental and health effects on humans. In present investigation, various bio-molecules i.e. glycogen, protein, amino acid, DNA, RNA and lipid were evaluated to determine the anti-termite efficacy of Citrus maxima essential oil based combinatorial formulations against Indian white termite Odontotermes obesus. For this purpose, termites were treated topically with 40% and 80% of 24 hr LD50 values of various combinatorial formulations. A significant (p > 0.05) alteration was noted in all the above biomolecules at various time intervals. Both dose response and time period was found important in physiological alteration in levels of various bio-molecules. Combinatorial mixtures of Citrus essential oils have shown synergistic activity against termites. The research outcomes of present investigation would help to open sustainable way to termite control in crop field, gardens and houses.

关键词： Citrus maxima Essential Oils Odontotermes obesus Bio-Molecules Inhibition Termiticidal Action

Effect of Purified Paper Wasp Ropalidia marginata Venom Toxins on Different Biomolecules in Mice Serum

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Journal of Biosciences and Medicines 2023年第5期11卷 55-75页

作者： Simran Sharma ravi kant Upadhyay Department of Zoology Deen Dayal Upadhyaya Gorakhpur University Gorakhpur India

This study evaluated the effects of purified paper wasp Ropalidia marginata venoms on various biomolecules in the blood serum of albino mice. Changes in the concentration of some important macromolecules, i.e., proteins, free amino acids, uric acid, cholesterol, pyruvic acid, total lipids and glucose were noted down. These alterations were measured after intraperitoneal injection of 40% and 80% 24-hour LD50 purified Ropalidia marginata venom toxin. Serum total protein levels were found to decrease to 78% after 6 hrs, while serum free amino acid levels were significantly increased to 117% 6 hrs after venom injection compared to control. It was also found that serum uric acid levels increased to 138% after 8 hrs of venom injection compared to control. The increase in serum cholesterol i.e. (101% and 106%) and pyruvic acid increased significantly to a maximum value of 106% after 6 hrs of treatment at 40% LD50. Glycogen levels in the gastrocnemius muscle were found to decrease significantly (p-0.05) to 43% and 92% at LD50 after injection of purified Ropalidia marginata venom after 8 h and 80% at LD50 compared to control. Moreover, up to 71% and 81% were obtained at 10 hrs of treatment with the same dose. In the present study, the purified toxins significantly changed the levels of biomolecules in blood serum, indicating their wider effects on cellular physiology due to toxic effects and stress on the animal. These toxins can be good antigens and stimulate immune responses in experimental mice.

关键词： Paper Wasp Venom and Toxin Lethal Effects Blood Serum Biomolecules

Effect of Purified Paper Wasp Ropalidia marginata Venom Toxin Enzyme Activity in Blood Serum, Liver, and Gastrocnemius Muscle of Albino Mice

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Advances in Enzyme Research 2023年第3期11卷 113-145页

作者： Simran Sharma ravi kant Upadhyay Department of Zoology Deen Dayal Upadhyaya Gorakhpur University Gorakhpur India

In the present, investigation effects of sub-lethal dose of purified paper wasp Ropalidia marginata venom toxins were evaluated on important metabolic enzymes i.e. ALP ACP, GPT, GOT, LDH, and AchE enzyme activity in serum, liver, and gastrocnemius muscles of albino mice. Alkaline phosphatase was found to be increased up to 119.9% at the 6th hr of the toxin injection in comparison to control. This elevation may be due to cytolysis. Maximum increase i.e., 153.33% level of glutamate pyruvate transaminase (GPT) was found at 6 hrs of 40% of 24-h LD50 treatment while it was found to be 151.1% at 6 hrs of 24 hr 80% of LD50, venom injection. A significant elevation was observed in LDH activity in serum, liver, and muscles, while the activity of AchE was decreased in serum, liver, and gastrocnemius muscles of albino mice after injecting the sub-lethal dose of Ropalidia marginata venom. This increase in the activity of LDH produces liver damage, massive disintegration and necrosis of hepatic cells. This elevation in LDH level led to a significant increase in the glucose catabolism and elevated oxidative stress in muscle and liver cells. It also displays insufficient oxygen supply and consequently leads to cell death. In experimental animals, venom toxin treatment decreased AchE level, and animals showed muscular paralysis. When mice were treated with 40% and 80% of 24-h LD50 of purified venom caused a significant (p < 0.05) elevation in the level of ACP, GOT, GPT, and LDH while the reduction in ALP and AChE level. Present study will be useful in the development of prototypes for study of pharmacological and therapeutic effects of various venom toxins. For this purpose structure activity relationship of enzyme and venom toxin, its due interaction to various metabolic enzymes and receptors must be explored.

关键词： Ropalidia marginata Serum Liver and Rectus Abdominis Gastrocnemius Muscle Atria and Ventricle Acid Phosphatase (ACP) Alkaline Phosphatase (ALP) Glutamate Pyruvate Transaminase (GPT) and Glutamate Oxaloacetate Transaminase (GOT) Lactic Dehydrogenase (LDH) Acetylcholinesterase (AchE)

Termiticidal and Biochemical Activity of Combinatorial Essential Oil Ingredients of Tagetes erecta on Indian White Termite Odontotermes obesus

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Journal of Biosciences and Medicines 2023年第4期11卷 114-136页

作者： Susheel Kumar ravi kant Upadhyay Department of Zoology Deen Dayal Upadhyaya Gorakhpur University Gorakhpur India

In present investigation, various bio-molecular parameters i.e. glycogen, protein, amino acid, DNA, RNA and lipid, were determined for evaluation of anti-termite efficacy of Tagetes erecta essential oil based combinatorial formulations against Indian white termite Odontotermes obesus. For this purpose, 40% and 80% of 24 hrs of LD50 values of various formulations were provided for treatment of termite workers. Observations were taken at 4 hrs time interval up to 16 hrs to know inhibitory activity of these combinatorial mixtures on termite species Odontotermes obesus. Significant (p > 0.05) alterations were observed in the level above mentioned bio-molecules when termites were treated with different combinatorial essential oils ingredients of Citrus maxima. Combinatorial mixtures of Tagetes erecta essential oils have shown synergistic activity against termites. This study will provide an overall sustainable way to termite control in crop field, gardens and houses. It also suggests use of essential oils as better alternative of synthetic termiticides as these are safer for environmental and human health.

关键词： Tagetes erecta Odontotermes obesus Plant Essential Oils Termiticides Bio-Molecules Inhibition Sustainable

Toxicity of Tagetes erecta Essential Oil Based Combinatorial Formulations on Various Metabolic Enzymes in Indian White Termite Odontotermes obesus

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Advances in Enzyme Research 2023年第2期11卷 58-81页

作者： Susheel Kumar ravi kant Upadhyay Department of Zoology (Environmental Science) Deen Dayal Upadhyaya Gorakhpur University Uttar Pradesh India

Plant essential oils and their constituents have proven to be very effective against insects, especially termites. They are the best alternative to synthetic pesticides that are harmless to the environment and human health. In the present study, different enzymes, namely alkaline phosphatase, acid phosphatase, glutamate-oxaloacetate transaminase, glutamate-pyruvate transaminase and acetylcholinesterase, were evaluated in Indian termite Odontotermes obesus in a combination preparation based on Tagetes erecta essential oil. For the study of anti-termite effects against worker termites were treated topically with 40% and 80% of the 24-hour LD50 values of various combination formulations. Subsequent bioassays at 40% and 80% of LD50 of combinatorial preparations S-AST-A, S-AST-B, and S-AST-C resulted in a significant (p > 0.05) decrease in glutamate-oxaloacetate transaminase. After 16 hours of treatment, they were 87.92%, 80.17%, 89.30%, 79.17%, 81.92% and 73.17% respectively. In vivo exposures of 40% and 80% of the LD50 of the combination formulation caused a highly significant (p > 0.05) reduction (p > 0.05) of all test enzymes tested compared to controls. The effects of different oil formulations exhibited time- and dose-dependent responses, resulting in physiological changes in the concentrations of various enzymes. The combined mixture of Tagetes erecta essential oils has significantly better anti-termite ability compared to inorganic insecticides. Findings from this study will help support termite control in fields, gardens and homes in a sustainable way, without the downsides of insecticide resistance and pollution. These could potentially be used to produce commercial formulations for use against pests.

关键词： Tagetes erecta Essential Oils Odontotermes obesus Enzymes Inhibition Termiticidal Action

Toxic Effects of Citrus maxima Based Combinatorial Formulations on Important Metabolic Enzymes in Indian White Termite Odontotermes obesus

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Advances in Enzyme Research 2023年第2期11卷 11-33页

作者： Lokpriy Pandey ravi kant Upadhyay Department of Zoology (Environmental Science) Deen Dayal Upadhyaya Gorakhpur University Gorakhpur India

In the present study, Citrus maxima essential crude oil extract was used to prepare combinatorial formulations and workers of Indian white termite Odontotermes obesus were treated topically with 40% and 80% of 24 hr LD50 values of these formulations. In subsequent bioassays levels of various enzymes i.e. alkaline phosphatase, acid phosphatase, glutamate oxaloacetate transaminase, glutamate pyruvate transaminase and acetylcholinesterase were evaluated to determine the anti-termite efficacy of Citrus maxima essential oil based combinatorial formulations. S-RET-A, S-RET-B and S-RET-C caused significant (p > 0.05) decrease in glutamate oxaloacetate transaminase i.e. 87.47%, 86.81% and 81.77% & 82.04%, 79.39% and 74.75% respectively at 16 h treatment. In vivo exposure of 40% and 80% of LD50 of combinatorial formulations caused very significant (p > 0.05) reduction in all the test enzymes i.e. alkaline phosphatase, acid phosphatase, glutamate oxaloacetate transaminase and glutamate pyruvate transaminase expect acetylcholinesterase levels after 16 h all tested treatments in comparison to control. Both dose-response and time period were found important in physiological alteration in levels of various enzymes. Combinatorial mixtures of Citrus essential oils have shown synergistic activity against termites. The research findings of the present study would help termite control in crop fields, gardens and houses in a sustainable way.

关键词： Citrus maxima Essential Oils Odontotermes obesus Enzymes Inhibition Termiticidal Action

Effects of Purified Indian Cattle Tick Rhipicephalus microplus Saliva Toxins on Various Enzymes in Blood Serum, Liver and Muscles of Albino Mice

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Advances in Enzyme Research 2023年第2期11卷 82-112页

作者： Nidhi Yadav ravi kant Upadhyay Department of Zoology Deen Dayal Upadhyaya Gorakhpur University Gorakhpur India

In the present investigation, in vivo effects of purified ticks’ saliva toxin were evaluated on the level of certain important cellular metabolic enzymes i.e. acid phosphatase (ACP), alkaline phosphatase (ALP), glutamate pyruvate transaminase, glutamate oxaloacetate transaminase and lactic dehydrogenase. For this purpose, sub-lethal doses, 40% and 80% of 24 h LD50 purified saliva toxins of Rhipicephalus microplus (Canestrini, 1888) were injected subcutaneously in the albino mice. In treated mice saliva toxins targeted membrane-bound enzymes i.e. serum acid phosphatase and alkaline phosphatase, its level was increased from 118.30% to 163.63% at the 6th hr in comparison to the control. Besides this, the levels of serum glutamate pyruvate transaminase (GPT) and glutamate oxaloacetate transaminase (GOT) and lactic dehydrogenase (LDH) also increased up to 161.11% (at 6th hr), 148.27 (at 8th hr) and 125.45% (at 6th hr) respectively in comparison to control. An increase in the level of LDH showed insufficient oxygen supply, massive disintegration of cells and leakage of the enzyme into the circulation. It clearly indicated the toxic effects of saliva toxins on the membrane of blood cells, hepatocytes and myocardial muscle cell functions in albino mice. On the other hand activity of acetyl cholinesterase was reduced by 65.51% at the 6th hr of the saliva toxin injection in comparison to the control. This inhibition of acetyl cholinesterase activity caused the accumulation of acetylcholine molecules at the synaptic junctions and led to prolonged activation of acetylcholine receptors. It caused permanent stimulation of nerves and muscle cells that may result in muscular paralysis and finally death of the animal.

关键词： Rhipicephalus microplus Serum Liver and Rectus Abdominis Gastrocnemius Muscle Atria and Ventricle Acid Phosphatase (ACP) Alkaline Phosphatase (ALP) Glutamate Pyruvate Transaminase (GPT) and Glutamate Oxaloacetate Transaminase (GOT) Lactic Dehydrogenase (LDH) and Acetylcholinesterase (AchE)