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3D Bioprinted Spheroidal Droplets for Engineering the Heterocellular Coupling between Cardiomyocytes and Cardiac Fibroblasts

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Cyborg and Bionic Systems 2021年第1期2021卷 206-221页

作者： raven el khoury Naveen Nagiah Joel A.Mudloff Vikram Thakur Munmun Chattopadhyay Binata Joddar Inspired Materials&Stem-Cell Based Tissue Engineering Laboratory(IMSTel) The University of Texas at El PasoEl PasoTX 79968USA Department of Metallurgical Materialsand Biomedical EngineeringM201 EngineeringThe University of Texas at El Paso500 W.University AvenueEl PasoTX 79968USA Department of Molecular and Translational Medicine Center of Emphasis in Diabetes and MetabolismTexas Tech University Health Sciences Center5001 El Paso DriveEl PasoTX 79905USA Border Biomedical Research Center The University of Texas at El Paso500 W.University AvenueEl PasoTX 79968USA

Since conventional human cardiac two-dimensional(2D)cell culture and multilayered three-dimensional(3D)models fail in recapitulating cellular complexity and possess inferior translational capacity,we designed and developed a high-throughput scalable 3D bioprinted cardiac spheroidal droplet-organoid model with cardiomyocytes and cardiac fibroblasts that can be used for drug screening or regenerative engineering *** study helped establish the parameters for bioprinting and cross-linking a gelatin-alginate-based bioink into 3D spheroidal droplets.A flattened disk-like structure developed in prior studies from our laboratory was used as a *** microstructural and mechanical stability of the 3D spheroidal droplets was assessed and was found to be ideal for a cardiac *** human cardiac fibroblasts and AC16 cardiomyocytes were mixed in the bioink and ***-dead assay and flow cytometry analysis revealed robust biocompatibility of the 3D spheroidal droplets that supported the growth and proliferation of the cardiac cells in the long-term ***,the heterocellular gap junctional coupling between the cardiomyocytes and cardiac fibroblasts further validated the 3D cardiac spheroidal droplet model.

关键词： linking printing printed

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Deep Morphea in an Immunosuppressed Patient With Anti-U1RNP Myositis:A Case Report

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International Journal of Dermatology and Venereology 2024年第2期7卷 111-114页

作者： Ahmad Berjawi Laure L.Irani Jinane R.el khoury Department of Dermatology Gilbert and Rose Marie Chagoury School of MedicineLebanese American UniversityBeirut 1100Lebanon Department of Rheumatology Division of Internal MedicineGilbert and Rose Marie Chagoury School of MedicineLebanese American University Medical CenterBeirut 1100Lebanon

Introduction:Morphea is an inflammatory skin disease characterized by skin thickening due to increased collagen deposition in the dermis or subcutaneous ***-U1RNP myositis is a newly described entity characterized by myositis,arthritis,interstitial lung disease,and Raynaud *** present a case of a unique combination of deep morphea in a patient with anti-U1RNP *** presentation:A 64-year-old male with 5-year history of proximal muscle weakness,polyarthritis,Raynaud phenomenon,and dyspnea on multiple immunosuppressives presented with localized infiltrated,tight,and hyperpigmented plaques over the posterior thighs and mid-to-lower back developing over the last 2 years and limiting his *** workup revealed a positive ANA,anti-U1RNP antibody,anti-Jo1 antibody,and anti-Ro52 *** workup showed restrictive lung disease,kidney disease,and *** was diagnosed with anti-U1RNP *** biopsy of the back lesion showed deep ***:Association of deep morphea with anti-U1RNP myositis is not described prior in the *** of morphea is challenging since the patient is already on immunosuppressive *** patient failed methotrexate prior and is currently on Mycophenolate mofetil and Deflazacort which are reported as potential treatment for ***,physical therapy plus topical Tacrolimus were suggested as an initial measure to preserve the range of motion of his posterior thighs and *** is a case of progressive deep morphea developing in a patient with a unique autoimmune profile on immunosuppressive ***:Anti-U1RNP myositis is a challenging diagnosis and should be always thought of in patients with positive anti-U1RNP,myositis,interstitial lung disease,arthritis,kidney disease,and Raynaud ***,deep morphea treatment in immunosuppressed patients is challenging and different measures should be considered.

关键词： deep morphea immunosuppression anti-U1RNP myositis case report

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Results of selective decontamination with oral neomycin and metronidazole for major colorectal surgery in Australia:A cohort study

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Laparoscopic, Endoscopic and Robotic Surgery 2024年第2期7卷 72-78页

作者： James Wei Tatt Toh Devansh Shah Henry Wang Charlotte Kwik Joseph Do Woong Choi Chelsie Leonie Beinke Paul Morris eleni Baird-Gunning Geoffrey Peter Collins Fiona Gavegan Karen Shedden Toufic el-khoury Nimalan Pathma-Nathan Kerry Hitos Department of Colorectal Surgery Westmead HospitalWestmeadNew South WalesAustralia The University of Sydney Westmead HospitalWestmeadNew South WalesAustralia Western Sydney University New South WalesAustralia University of Notre Dame New South WalesAustralia Westmead Research Centre for Evaluation of Surgical Outcomes Westmead HospitalSydneyAustralia

Objective The role of selective decontamination with oral antibiotics(OABs)and mechanical bowel preparation(MBP)prior to elective colorectal surgery is still widely *** objective of this study was to compare the outcomes of selective decontamination with neomycin,metronidazole and MBP compared to those of decontamination with MBP alone or with no *** Selective decontamination with neomycin and metronidazole combined with bowel preparation was introduced prior to elective colorectal surgery as part of an enhanced recovery after surgery program at Westmead Hospital,a major Australian tertiary referral hospital,between June 2017 and January *** between short-term outcomes of OAB+MBP and MBP/no preparation were made using prospectively collected data on length of stay(LOS),readmission,mortality within 30 days,anastomotic leakage(AL),surgical site infection(SSI),urinary tract infection,deep venous thrombosis and/or pulmonary embolism,pneumonia,and ***-up was limited to hospital stays and subsequent presentations within the health district within thirty days of *** Mann-Whitney U test was used to analyse continuous data,and the chi-square test was used for categorical *** and multivariate regression modelling was performed to identify risk factors associated with an increased likelihood of SSI and *** Patients with oral neomycin and metronidazole combined with bowel preparation had reduced superficial SSI(2.7%vs.7.6%,p=0.043)and overall complications(32.7%vs.44.6%,p=0.020),particularly Clavien-Dindo 1 complications(7.3%vs.16.5%,p=0.009).However,the differences in AL(2.7%vs.4.5%,p=0.369)and organ/space SSI(1.3%vs.3.7%,p=0.327)were not statistically *** median LOS(6 d vs.6 d,p=0.370)was not different between the *** Selective decontamination with neomycin and metronidazole reduces the risk of SSIs and overall *** was a trend to toward a lower AL,but this differ

关键词： Neomycin Metronidazole Colorectal surgery Anastomotic leakage Surgical site infection

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Determination and assessment of total mercury levels in local, frozen and canned fish in Lebanon

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Journal of Environmental Sciences 2011年第9期23卷 1564-1569页

作者： Pierre J Obeid Bilal el-khoury Joanne Burger Samer Aouad Mira Younis Amal Aoun John Hanna el-Nakat University of Balamand Faculty of SciencesDepartment of Chemistry Nelson Biological Laboratory Division of Life SciencesRutgers University

Fish is an important constituent of the Lebanese ***,very little attention in our area is given to bring awareness regarding the effect of the toxicity of mercury （Hg） mainly through fish *** study aimed to report analytical data on total mercury levels in several fish species for the first time in thirty years and to also made individuals aware of the presence and danger from exposure to mercury through fish *** samples were selected from local Lebanese markets and fisheries and included 94 samples of which were fresh,frozen,processed,and canned *** values were reported as microgram of mercury per gram of fish based on wet *** level of mercury ranged from 0.0190 to 0.5700 μg/g in fresh samples,0.0059 to 0.0665 μg/g in frozen samples,and 0.0305 to 0.1190 μg/g in canned *** data clearly showed that higher levels of mercury were detected in local fresh fish as opposed to other types thus placing consumers at higher risk from mercury ***,the data revealed that Mallifa （yellowstripe barracuda/Sphyraena chrysotaenia）,Sargous （white seabream/Diplodus sargus）,Ghobbos （bogue/Boops boops）,and shrimp （Penaeus sp.） were among the types containing the highest amounts of *** the other hand,processed fish such as fish fillet,fish burger,small shrimp and crab are found to contain lower levels of mercury and are associated with lower exposure risks to *** population should therefore,be aware to consume limited amounts of fresh local fish to minimize exposure to mercury.

关键词： total mercury fish Lebanon

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Transanal minimally invasive surgery to rescue anastomosis following leak after low anterior resection: A case report

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Laparoscopic, Endoscopic and Robotic Surgery 2021年第4期4卷 121-124页

作者： James Wei Tatt Toh Henry Wang Geoffrey Collins Chelsea Beinke elissa Zhang Alistair Escott Toufic el-khoury Nimalan Pathma-Nathan Discipline of Surgery Sydney Medical SchoolThe University of SydneySydneyAustralia Colorectal Department Westmead HospitalSydneyAustralia The University of Notre Dame SydneyAustralia

Restorative low anterior resection(LAR)for rectal cancer carries a significant risk of anastomotic leak:One of the most feared complications in colorectal *** management may include takedown of the anastomosis and end colostomy which,in some cases,is *** contemporary operative measures include over the scope clips and ***,there have been case reports and a Society of American Endoscopic and Gastrointestinal Surgeons video on the novel use of transanal minimally invasive surgery(TAMIS)in the management of anastomotic *** present a 59-year-old female who underwent LAR after declining radiotherapy for a bulky 9 cm rectal tumour 9-10 cm from the anal *** clinical deterioration,computed tomography demonstrated an anastomotic leak communicating with a 5-cm pelvic collection containing *** laparoscopy,pus and faeculent material were washed from the pelvic cavity and drains were ***-operative endoscopy demonstrated a 7-8 mm dehiscence at the *** defect(approximately 7 cm from the anal verge)was successfully closed using TAMIS and a running V-lock *** patient recovered well and was discharged home on post-operative day *** this case,a low colorectal anastomotic leak was successfully rescued with *** novel technique may be useful in the armamentarium of colorectal surgeons experienced in TAMIS.

关键词： Transanal minimally invasive surgery Anastomotic leak Low anterior resection Colorectal cancer

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Incidence and prevalence of hepatitis B and hepatitis C viruses in hemodialysis patients in Lebanon

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World Journal of Nephrology 2016年第1期5卷 101-107页

作者： Antoine Abou Rached Lara el khoury Talal el Imad Abdallah S Geara Josette Jreijiry Walid Ammar National Hepatitis Program Ministry of Public HealthBeirut 1106 9800Lebanon Department of Internal Medicine Division of GastroenterologyLebanese UniversityBeirut 2903 1308Lebanon Faculty of Medical Sciences Lebanese UniversityBeirut 2903 1308Lebanon School of Medicine West Virginia UniversityMorgantownWV 26506-9100United States Ministry of Public Health Beirut 1106 9800Lebanon

AIM： To determine the incidence and the prevalence of hepatitis B and C viral infections in patients on hemodialysis （HD） across ***： We reviewed the data registry at the Lebanese Ministry of Public Health where records of monthly hepatitis B surface antigen （HBsAg） and hepatitis C virus （HCV） serology are reported from 60 affiliated HD centers across Lebanon. All patients who were on HD or who started HD between October 2010 and July 2012 were included in the study. Patients from seven HD centers were excluded due to inadequate and incomplete results reporting. During the selected period, HBsAg and HCV serology were available for 3769 patients from 53 HD centers distributed at all Lebanese governorates. The prevalence was calculated by dividing the number of patients with positive HBsAg or HCV serology to the total number of patients. The Incidence was calculated by dividing the number of newly acquired infection to number of patients-years （p-y）. Incidence rates at different governorates were compared to each other using two tailed Z test and a P value of 〈 0.05 was considered ***： Sixty out of 3769 HD patients were found to have positive HBS Ag and 177 out of 3769 were positive for HCV Antibodies. The prevalence of hepatitis B virus （HBV） and HCV in HD patients across Lebanon was 1.6%, and 4.7%, respectively. The comparison of prevalence according to geographic distribution could not be done accurately due to the frequent shift of patients between dialysis centers at different governorates. The incidence rate was 0.27 per 100 p-y for HBV and 0.37 per 100 p-y for HCV. There was no signifcant difference concerning the incidence of HBV between HD centers at different governorates （all P values 〉 0.1）, but this difference was highly significant concerning the incidence rates of HCV which occurred predominantly in the southern centers （1.47 per 100 p-y） with a P value of 0.00068 and 0.00374 when compared to Mount Lebanon （0.21 per 100 p-y

关键词： Hemodialysis Prevalence Hepatitis C virus Incidence Hepatitis B virus Lebanon

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高速电流反馈型放大器驱动并均衡最长100米的VGA电缆

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世界电子元器件 2010年第11期 42-43页

作者： Charly el-khoury ADI公司高速放大器部门

在课堂、演讲厅和会议室,PC通过VGA电缆连接到投影仪,以传输红绿蓝（RGB）视频信号。平均电缆长度取决于房间大小和天花板高度,但多数电缆不超过1 00米。本文介绍集成电荷泵的三通道高速电流反馈型运算放大器ADA4858-3（见附录）如何能... 详细信息

在课堂、演讲厅和会议室,PC通过VGA电缆连接到投影仪,以传输红绿蓝（RGB）视频信号。平均电缆长度取决于房间大小和天花板高度,但多数电缆不超过1 00米。本文介绍集成电荷泵的三通道高速电流反馈型运算放大器ADA4858-3（见附录）如何能驱动并均衡最长达1 00米的VGA电缆。这种解决方案用在PC与电缆之间,便于使用,成本低廉,易于实施,

关键词：电缆连接电流反馈型运算放大器 VGA 驱动视频信号电缆长度会议室

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安森美:聚焦电动汽车和可再生能源市场打造可持续生态系统

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变频器世界 2023年第1期 27-28页

作者： Hassane el-khoury 安森美

安森美是领先的功率分立器件和模块半导体供应商,具备阵容广泛的分立IGBT和SiC MOSFET以及功率集成模块(PIM),先进的差异化封装技术,端到端的供货能力(尤其是在碳化硅领域的垂直整合模式为我们带来独特的竞争优势),并致力于通过整合提... 详细信息

安森美是领先的功率分立器件和模块半导体供应商,具备阵容广泛的分立IGBT和SiC MOSFET以及功率集成模块(PIM),先进的差异化封装技术,端到端的供货能力(尤其是在碳化硅领域的垂直整合模式为我们带来独特的竞争优势),并致力于通过整合提升智能水平,让客户不用做选择,就可以同时拥有高能效、低重量和出色的成本控制,结合相辅相成的智能感知方案,助客户实现最先进功能的设计。

关键词：供货能力半导体供应商整合提升可再生能源分立器件智能感知集成模块成本控制

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The Role of Accountants in Decision-Making in Lebanese Firms

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Journal of Modern Accounting and Auditing 2014年第2期10卷 155-163页

作者： Pierre Al khoury Marwan Al Kotob Batoul Al Mohammad Dima Shamsedeen Hanan el Khodr Hibatullah E1 Bsat Rania el Khatib Yasmina Chaar Rafik Hariri University Mechref Lebanon

The issue of accountants＇ role in decision-making has been the center of attention of lots of studies in the last decade but never did it get the adequate coverage in Lebanon. This paper studies to what extent accountants are involved in the managerial decision-making in Lebanon. Two hundred experienced accountants from all over the country were randomly selected for a questionnaire survey. This survey provides evidence as to what factors contribute to the variance of influence accountants have in managerial decision-making. The results from the questionnaires varied, but we conclude that accountants＇ involvement in new product development （NPD）, the skills that accountants have, their role in the financial analysis of the firm, and how much the finn they work for encourages them to advice on business decisions affect the degree of contribution an accountant has to decision-making. The findings of this research could be used as a reference to help in understanding the role of accounting in Lebanon by various finns and organizations.

关键词： accounting decision-making skills new product development (NPD) executive information system (EIS)

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锌营养状况评价方法研究进展

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微量元素与健康研究 1993年第2期10卷 62-64页

作者： Antoine E el-khoury 施正学

微量元素营养状况评价对决定微量元素需要量,保证人体有足量的微量元素摄取具有重要意义。锌与许多代谢过程有关。当研究病人或表现健康个体的营养状况时必须考虑锌,而且评价的方法应随评价对象的年龄和生理状况而异;例如,对表现健康。

关键词：营养状况评价锌缺乏症缺锌必需营养素摄取量红细胞膜分泌入血大鼠细胞免疫反应脂肪酸代谢

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