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Polyvinylpyrrolidone-based bioink:influence of bioink properties on printing performance and cell proliferation during inkjet-based bioprinting

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Bio-Design and Manufacturing 2023年第6期6卷 676-690页

作者： Wei Long Ng Xi Huang Viktor Shkolnikov ratima suntornnond Wai Yee Yeong HP-NTU Digital Manufacturing Corporate Lab Nanyang Technological University(NTU)Singapore 637460Singapore Singapore Centre for 3D Printing(SC3DP) School of Mechanical and Aerospace EngineeringNanyang Technological University(NTU)Singapore 639798Singapore HP Inc. Palo AltoCA 94304USA

Among the different bioprinting techniques,the drop-on-demand(DOD)jetting-based bioprinting approach facilitates contactless deposition of pico/nanoliter droplets ofmaterials and cells for optimal cell–matrix and cell–cell *** bioinks play a critical role in the bioprinting process,there is a poor understanding of the influence of bioink properties on printing performance(such as filament elongation,formation of satellite droplets,and droplet splashing)and cell health(cell viability and proliferation)during the DOD jetting-based bioprinting *** inert polyvinylpyrrolidone(PVP360,molecular weight=360 kDa)polymerwas used in this study to manipulate the physical properties of the bioinks and investigate the influence of bioink properties on printing performance and cell *** experimental results showed that a higher bioink viscoelasticity helps to stabilize droplet filaments before rupturing from the nozzle *** highly stretched droplet filament resulted in the formation of highly aligned“satellite droplets,”which minimized the displacement of the satellite droplets away from the predefined ***,a significant increase in the bioink viscosity facilitated droplet deposition on the wetted substrate surface in the absence of splashing and significantly improved the accuracy of the deposited main *** analysis showed that cell-laden bioinks with higher viscosity exhibited higher measured average cell viability(%),as the presence of polymer within the printed droplets provides an additional cushioning effect(higher energy dissipation)for the encapsulated cells during droplet impact on the substrate surface,improves the measured average cell viability even at higher droplet impact velocity and retains the proliferation capability of the printed *** the influence of bioink properties(e.g.,bioink viscoelasticity and viscosity)on printing performance and cell proliferation is important for the formulation

关键词： Biofabrication 3D bioprinting Drop-on-demand bioprinting Bioink properties Polyvinylpyrrolidone

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Design and 3D Printing of Scaffolds and Tissues

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Engineering 2015年第2期1卷 261-268页

作者： Jia An Joanne Ee Mei Teoh ratima suntornnond Chee Kai Chua Singapore Centre for 3D Printing School of Mechanical and Aerospace Engineering Nanyang Technological University

A growing number of three-dimensional(3D)-print- ing processes have been applied to tissue engineering. This paper presents a state-of-the-art study of 3D-printing technologies for tissue-engineering applications, with particular focus on the development of a computer-aided scaffold design system; the direct 3D printing of functionally graded scaffolds; the modeling of selective laser sintering(SLS) and fused deposition modeling(FDM) processes; the indirect additive manufacturing of scaffolds, with both micro and macro features; the development of a bioreactor; and 3D/4D bioprinting. Technological limitations will be discussed so as to highlight the possibility of future improvements for new 3D-printing methodologies for tissue engineering.

关键词： rapid prototyping 3D printing additive manufacturing tissue engineering bioprinting

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A facile method to fabricate cell-laden hydrogel microparticles of tunable sizes using thermal inkjet bioprinting

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Droplet 2024年第4期3卷 29-38页

作者： ratima suntornnond Wei Long Ng Viktor Shkolnikov Wai Yee Yeong HP-NTU Digital Manufacturing Corporate Lab Nanyang Technological University(NTU)Singapore Singapore Centre for 3D Printing(SC3DP) School of Mechanical and Aerospace EngineeringNanyang Technological University(NTU)Singapore HP Inc. Palo AltoCaliforniaUSA

This study investigates the application of a drop-on-demand(DOD)thermal inkjet(TIJ)-based bioprinting system for the fabrication of cell-laden hydrogel microparticles(HMPs)with tunable *** TIJ bioprinting technique involves the formation of vapor bubbles within the print chamber through thermal energy,expelling small droplets of bio-ink onto a *** study employs a heat-treated saponified gelatin-based bio-ink,*** bio-ink is modified through methacrylic anhydride functionalization and undergoes subsequent saponification and heat treatment *** concentrations of SPAN 80 surfactant in mineral oil were evaluated to assess their influence on HMP size and *** results indicate a direct correlation,with higher SPAN 80 concentrations resulting in smaller and more stable *** study further investigates the influence of jetting volume on HMP size distribution,revealing that larger jetting volumes lead to increased HMP sizes,attributed to droplet *** is supported by our further study via a Monte Carlo simulation,which shows that the mean droplet diameter grows approximately linear with the number of dispensed *** addition,the study demonstrates the capability of the TIJ bioprinting system to achieve multimaterial encapsulation within HMPs,exemplified by staining living cells with distinct cytoplasmic membrane *** presented approach provides insights into the controlled fabrication of cell-laden HMPs,highlighting the versatility of the TIJ bioprinting system for potential applications in tissue engineering and drug delivery.

关键词： printing thermal sizes

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支架与组织的设计及3D打印

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Engineering 2015年第2期 200-215页

作者：安佳 Joanne Ee Mei Teoh ratima suntornnond Chee Kai Chua Singapore Centre for 3D Printing School of Mechanical and Aerospace EngineeringNanyang Technological University

目前,组织工程学中应用3D打印工艺的情况越来越多。本文介绍3D打印技术在组织工程学应用领域的最前沿研究,尤其侧重于计算机辅助支架设计系统的开发、功能梯度支架的直接3D打印、选择性激光烧结(SLS)和熔融沉积成型(FDM)工艺建模、利用... 详细信息

目前,组织工程学中应用3D打印工艺的情况越来越多。本文介绍3D打印技术在组织工程学应用领域的最前沿研究,尤其侧重于计算机辅助支架设计系统的开发、功能梯度支架的直接3D打印、选择性激光烧结(SLS)和熔融沉积成型(FDM)工艺建模、利用微观和宏观特征进行支架间接增材制造、生物反应器的开发,以及3D/4D生物打印。本文还讨论3D打印的技术限制,进而突出新3D打印方法在组织工程学领域得到进一步改善的可能性。

关键词：快速原型制造 3D打印增材制造组织工程生物打印

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