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Evaluating the Importance of Environmental Variables on Spatial Distribution of Caspian cobra Naja oxiana(Eichwald, 1831) in Iran

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Asian Herpetological Research 2019年第2期10卷 129-138页

作者： Elmira KAZEMI Mohammad KABOLI rasoul khosravi Nematollah KHORASANI Department of Environment Faculty of Natural Recources and EnvironmentScience and Research BranchIslamic Azad UniversityTehranIran Department of Environmental Science Faculty of Natural ResourcesUniversity of TehranKarajIran Department of Natural Resources and Environmental Engineering School of AgricultureShiraz UniversityShirazIran

Over recent years, the population of Caspian cobra Naja oxiana has declined in its distribution range in Iran due to habitat destruction and overhunting. Consequently, their small and isolated populations in fragmented landscapes are facing genetic and demographic threats. Evaluating the spatial distribution pattern of Naja oxiana, identifying core habitat patches and improving landscape connectivity among the patches have a significant role in the long-term survival of the species. This study predicts the spatial distribution map of the Caspian cobra considering the factors affecting the predictive power of the distribution models, including sampling bias in presence points, correct selection of background locations, and input model parameters. The sampling bias in presence points was removed using spatial filtering. Several models were run using 19 environmental variables that eventually led to the selection of the effective habitat variables and best MaxEnt distribution model. We also used an ensemble model(EM) of habitat suitability methods to predict the potential habitats of the species. Topographical roughness, shrublands, average annual precipitation, and sparse rangeland with a density of ≤ 20% had the most effect on the spatial distribution of Caspian cobra. The evaluation of models confirmed that the EM has more predictive performance than MaxEnt in predicting the distribution of Naja oxiana.

关键词： Naja oxiana MaxEnt habitat suitability landscape connectivity distribution modelling

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Niosome-encapsulated auraptene reduced the mRNA expression of VEGF-A and PDGFs genes in human retinaderived RPE cell line

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International Journal of Ophthalmology(English edition) 2024年第6期17卷 1028-1035页

作者： Akram Vahidi Teymoor khosravi Farzad Dastaviz Mehdi Sheikh Arabi Ayyoob khosravi Morteza Oladnabi Student Research Committee Golestan University of Medical SciencesGorgan ***Iran Department of Medical Nanotechnology Faculty of Advanced Medical TechnologiesGolestan University of Medical SciencesGorgan ***Iran Stem Cell Research Center Golestan University of Medical SciencesGorgan ***Iran Department of Molecular Medicine Faculty of Advanced Medical TechnologiesGolestan University of Medical SciencesGorgan ***Iran Gorgan Congenital Malformations Research Center Golestan University of Medical SciencesGorgan ***Iran

AIM:To evaluate the effect of auraptene(AUR)treatment in forms of free and encapsulated in niosome nanoparticles by investigating the mRNA expression level of vascular endothelium growth factor(VEGF)-A and platelet-derived growth factors(PDGFs)in human retinal pigment epithelium(RPE)cell ***:Niosome nanocarriers were produced using two surfactants Span 60 and Tween *** cell line was treated with both free AUR and *** dosage of treatments was calculated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)*** of VEGF-A and PDGF-A,PDGF-B,PDGF-C,PDGF-D genes was measured after total RNA extraction and cDNA synthesis,using real-time polymerase chain reaction(RT-PCR).RESULTS:The highest entrapment efficiency(EE)was achieved by Span 60:cholesterol(1:1)with 64.3%.The half maximal inhibitory concentration(IC50)of free and niosome-encapsulated AUR were 38.5 and 27.78µg/mL,*** study revealed that niosomal AUR had more gradual delivery to the ***-PCR results showed reduced expression levels of VEGF-A,PDGF-A,PDGF-B,PDGF-C,and PDGF-D after treatment with both free and niosomal ***:Niosomal formulation of Span 60:cholesterol(1:1)is an effective drug delivery approach to transfer AUR to RPE ***-A,PDGF-A,PDGF-B,PDGF-C,and PDGF-D are four angiogenic factors,inhibiting which by niosomal AUR may be effective in age-related macular degeneration.

关键词： auraptene niosome age-related macular degeneration angiogenesis nanocarrier

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Zoning of Nitrite and Nitrate Concentration in Groundwater Using Geografic Information System (GIS), Case Study: Drinking Water Wells in Yazd City

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Journal of Geoscience and Environment Protection 2016年第3期4卷 91-96页

作者： Reza Ali Fallahzadeh Seyed Ali Almodaresi Mohamad Mehdi Dashti Ahmad Fattahi Mojtaba Sadeghnia Hadi Eslami rasoul khosravi Roya Peirovi Minaee Mahmoud Taghavi Department of Environmental Health Engineering Faculty of Public Health Shahid Sadoughi University of Medical Sciences Yazd Iran Department of GIS & RS Engineering College Yazd Branch Islamic Azad University Yazd Iran Department of Occupational Health Engineering School of Public Health Shahid Sadoughi University of Medical Sciences Yazd Iran Department of Environmental Health Engineering Zabol University of Medical Sciences Zabol Iran

Studies have demonstrated that the presence of nitrate and nitrite in drinking water can cause some disease such as cancer and blu baby in the infant. The Environmental Protection Agency (EPA) has since adopted the 10 mg/L standard as the maximum contaminant level (MCL) for nitrate-nitrogen and 1 mg/L for nitrite-nitrogen for regulated public water systems. Given the importance of nitrate and nitrite in drinking water as well as GIS ability in spatial analysis of various factors in the groundwater, this study aimed to evaluate concentration of nitrate and nitrite in the drinking water wells of Yazd using two IDW (Inverse Distance Weighting) and Kriging models. In this descriptive study, the applied data on the water quality of underground water of Yazd Environmental Health Office and the average annual nitrate and nitrite in 2015 were related to 24 wells in the studied area. The nitrate and nitrite rate in groundwater in wells was compared to the standard amount of Institute of Standard and Industrial Researches and then was analyzed via Arc GIS software using IDW and Kriging interpolation methods. The mean concentration of nitrate was 17.62 ± 3.08 mg/l and for nitrite was 0.011 ± 0.003 mg/l in the wells. In the all studied zone, the nitrate and nitrite rate was in the standard range according to the National Standard of Iran (No. 1053). In this study, Kriging interpolation method was more efficient than IDW method.

关键词： Drinking Water Nitrite and Nitrate Concentration Geographic Information Systems Interpolation

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Impact of umbelliprenin-containing niosome nanoparticles on VEGF-A and CTGF genes expression in retinal pigment epithelium cells

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 7-15页

作者： Farzad Dastaviz Akram Vahidi Teymoor khosravi Ayyoob khosravi Mehdi Sheikh Arabi Abouzar Bagheri Mohsen Rashidi Morteza Oladnabi Stem Cell Research Center Golestan University of Medical SciencesGorgan ***Iran Department of Medical Genetics School of Advanced Technologies in MedicineGolestan University of Medical SciencesGorgan ***Iran Student Research Committee Golestan University of Medical SciencesGorgan ***Iran Department of Molecular Medicine Faculty of Advanced Medical TechnologiesGolestan University of Medical SciencesGorgan ***Iran Department of Medical Nanotechnology Faculty of Advanced Medical TechnologiesGolestan University of Medical SciencesGorgan ***Iran Department of Clinical Biochemistry and Genetics Faculty of MedicineMazandaran University of Medical SciencesSari ***Iran Department Pharmacology Faculty of MedicineMazandaran University of Medical SciencesSari ***Iran Gorgan Congenital Malformations Research Center Golestan University of Medical SciencesGorgan ***Iran

AIM:To investigate the impact of niosome nanoparticles carrying umbelliprenin(UMB),an anti-angiogenic and anti-inflammatory plant compound,on the expression of vascular endothelial growth factor(VEGF-A)and connective tissue growth factor(CTGF)genes in a human retinal pigment epithelium(RPE)-like retina-derived cell ***:UMB-containing niosomes were created,optimized,and ***-like cells were treated with free UMB and UMB-containing *** IC_(50)values of the treatments were determined using an MTT *** expression of VEGF-A and CTGF was evaluated using real-time polymerase chain reaction after RNA extraction and cDNA ***’characteristics,including drug entrapment efficiency,size,dispersion index,and zeta potential were *** UMB had an IC_(50)of 96.2μg/mL,while UMB-containing niosomes had an IC_(50)of 25μg/***:Treatment with UMB-containing niosomes and free UMB resulted in a significant reduction in VEGF-A expression compared to control cells(P=0.001).Additionally,UMB-containing niosomes demonstrated a significant reduction in CTGF expression compared to control cells(P=0.05).However,there was no significant reduction in the expression of both genes in cells treated with free ***:Both free UMB and niosome-encapsulated UMB inhibits VEGF-A and CTGF genes ***,the latter demonstrates significantly greater efficacy,potentially due to the lower UMB dosage and gradual *** findings have implications for anti-angiogenesis therapeutic approaches targeting age-related macular degeneration.

关键词： umbelliprenin niosome age-related macular degeneration vascular endothelial growth factor-A connective tissue growth factor

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Advancing sandstone reservoir compressibility prediction:A correlation-driven methodology

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Petroleum Research 2024年第2期9卷 273-279页

作者： Tarek Ganat Meftah Hrairi Amr Badawy Vahid khosravi Mohammed Abdalla Department of Petroleum Chemical Engineering Sultan Qaboos UniversityP.O.Box 50Al-Khod123MuscatOman Department of Mechanical and Aerospace Engineering International Islamic University MalaysiaP.O.Box 1050728Kuala LumpurMalaysia Reservoir Engineering Section Petronas Carigali SDN BHDP.O.Box 10500088Kuala LumpurMalaysia Department of Chemical and Petroleum Engineering Faculty of EngineeringTechnologyand Built EnvironmentUCSI University56000Kuala LumpurMalaysia Chemical&Petroleum Engineering United Arab Emirates UniversityP.O.Box No.15551Al AinUAE

This study presents a correlation-based approach for predicting the compressibility of sandstone reservoir *** study proposes a matrix of new empirical equations that significantly improve the precision of measuring the pore volume compressibility,with the most optimal fit of results based on a cubic polynomial *** accuracy of the calculations was validated through comparison with actual data using root mean square method,and the suggested correlations significantly enhance the precise prediction of rock compressibility in sandstone *** this study,the source of data collection is consolidated and unconsolidated sandstone from East Asia offshore ***,variations in compressibility with net overburden pressure over the course of the field's lifespan have been *** results demonstrate the application of regression analysis in establishing a network of linkages between independent and dependent *** proposed correlations for consolidated and unconsolidated sandstones offer a remarkable improvement in the accurate calculation of rock compressibility compared to traditional laboratory procedures,with an average error of 2.5%compared to 5-10%for laboratory *** approach of this study offers a cost-effective and time-efficient alternative to remarkedly enhance the overall performance of sandstone reservoirs in the oil and gas industry.

关键词： Compressibility Consolidated and unconsolidated sandstone Rock properties Rock mechanics

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An Electrical Impedance Imaging System Towards Edge Intelligence for Non-Destructive Testing of Concrete

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Tsinghua Science and Technology 2024年第3期29卷 883-896页

作者： Abolfazl Roshanpanah Mahdi Abbasi Hani Attar Ayman Amer Mohammad R.khosravi Ahmed A.Solyman Department of Electrical Engineering Islamic Azad UniversityScience and Research BranceTehran ***Iran Department of Computer Engineering Bu-Ali Sina UniversityHamedan ***Iran Department of Energy Engineering Zarqa UniversityZarqa 13110Jordan Department of Computer Engineering Persian Gulf UniversityBushehr ***Iran Department of Electrical and Electronics Engineering Faculty of Engineering and ArchitectureNişantaşıUniversityIstanbul 34398Turkey

In the construction industry,to prevent accidents,non-destructive tests are necessary and *** impedance tomography is a new technology in non-invasive imaging in which the image of the inner part of conductive bodies is reconstructed by the arrays of external electrodes that are connected on the periphery of the *** equipment is cheap,fast,and edge *** this imaging method,the image of electrical conductivity distribution(or its opposite;electrical impedance)of the internal parts of the target object is *** image reconstruction process is performed by injecting a precise electric current to the peripheral boundaries of the object,measuring the peripheral voltages induced from it and processing the collected *** an electrical impedance tomography system,the voltages measured in the peripheral boundaries have a non-linear equation with the electrical conductivity *** paper presents a cheap Electrical Impedance Tomography(EIT)instrument for detecting impurities in the concrete.A voltage-controlled current source,a micro-controller,a set of multiplexers,a set of electrodes,and a personal computer constitute the structure of the *** conducted tests on concrete with impurities show that the designed EIT system can reveal impurities with a good accuracy in a reasonable time.

关键词： non-destructive testing system concrete electrical impedance tomography

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Heating-Cooling Monitoring and Power Consumption Forecasting Using LSTM for Energy-Efficient Smart Management of Buildings: A Computational Intelligence Solution for Smart Homes

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Tsinghua Science and Technology 2024年第1期29卷 143-157页

作者： Omid Akbarzadeh Sahand Hamzehei Hani Attar Ayman Amer Nazanin Fasihihour Mohammad R.khosravi Ahmed A.Solyman Department of Electronics and Telecommunications Politecnico di TorinoTurin 10129Italy Department of Energy Engineering Zarqa UniversityZarqa 13110Jordan Shandong Provincial University Laboratory for Protected Horticulture Weifang University of Science and TechnologyWeifang 262799China Department of Electrical and Electronics Engineering Faculty of Engineering and ArchitectureNisantası UniversityIstanbul 25370The Republic of Turkiye

Energy management in smart homes is one of the most critical problems for the Quality of Life(QoL)and preserving energy *** of the relevant issues in this subject is environmental contamination,which threatens the world's *** computing-enabled Artificial Intelligence(Al)algorithms can provide impactful solutions to this *** research proposes using one of the Recurrent Neural Network(RNN)algorithms known as Long Short-Term Memory(LSTM)to comprehend how it is feasible to perform the cloud/fog/edge-enabled prediction of the building's *** parameters of power electricity,power heating,power cooling,and total power in an office/home in cold-climate cities are considered as our features in the *** on the collected data,we evaluate the LSTM approach for forecasting parameters for the next year to predict energy consumption and online monitoring of the model's performance under various *** implementing the Al predictive algorithm,several existing tools are *** results have been generated through simulations,and we find them promisingforfutureapplications.

关键词： design-builder Besos smart cities smart building neural network Long Short-Term Memory(LSTM)

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Introducing a new rock abrasivity index using a scaled down disc cutter

Rock Mechanics Bulletin

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Rock Mechanics Bulletin 2024年第3期3卷 24-37页

作者： Maziar Moradi Mohammad Hossein khosravi Jafar Khademi Hamidi Department of Civil and Environmental Engineering University of StrathclydeGlasgowG11XQUK Department of Mining Engineering Faculty of EngineeringUniversity of BirjandBirjand ***Iran

Rock abrasivity influences wear of cutting tools and consequently,performance of mechanized tunneling *** methods have been proposed to evaluate rock abrasivity in recent decades,each one has its own *** this paper,a new method is introduced to estimate wear of disc cutters based on rock cutting tests using scaled down discs(i.e.54 and 72 mm diameter).The discs are made of H13 steel,which is a common steel type in producing real-scale discs,with hardness of 32 and 54 *** small-scale linear rock cutting machine and a new abrasion test apparatus,namely University of Tehran abrasivity test machine,are utilized to perform the *** width of the worn discs is monitored and presented as the function of the accumulated test run to classify the rock *** tests show that by increasing the uniaxial compressive strength(UCS)of the rock samples,wear rate is doubled gradually that reveals the sensitivity of the test procedure to the main pa-rameters affecting the abrasivity of hard *** the rocks with the highest UCS,the normal wear stops after performing 5 to 10 rounds of the tests,and then,deformation of the disc tip is *** abrasivity indices are defined based on the abrasivity tests results and their correlations with Cerchar Abrasivity Index(CAI)and UCS are *** of the established correlations in this study with previous investigations dem-onstrates the sensitivity of the indices to the parameters affecting wear of the disc cutters and repeatability of the outputs obtained from abrasivity tests using scaled down *** of this study can be used to enhance the accuracy of rock abrasivity classifications.

关键词： Mechanized tunneling Rock cutting Rock abrasivity classification University of Tehran abrasivity test Wear

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Immunologic tumor microenvironment modulators for turning cold tumors hot

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Cancer Communications 2024年第5期44卷 521-553页

作者： Gholam-Reza khosravi Samaneh Mostafavi Sanaz Bastan Narges Ebrahimi Roya Safari Gharibvand Nahid Eskandari Department of Medical Immunology School of MedicineIsfahan University of Medical SciencesIsfahanIran Department of Immunology Faculty of Medical SciencesTarbiat Modares UniversityTehranIran Department of Immunology School of MedicineAhvaz Jundishapur University of Medical SciencesAhvazIran

Tumors can be classified into distinct immunophenotypes based on the presence and arrangement of cytotoxic immune cells within the tumor microenvironment(TME).Hot tumors,characterized by heightened immune activity and responsiveness to immune checkpoint inhibitors(ICIs),stand in stark contrast to cold tumors,which lack immune infiltration and remain resistant to *** overcome immune evasion mechanisms employed by tumor cells,novel immunologic modulators have emerged,particularly ICIs targeting cytotoxic T-lymphocyte-associated protein 4(CTLA-4)and programmed cell death protein 1/programmed death-ligand 1(PD-1/PD-L1).These agents disrupt inhibitory signals and reactivate the immune system,transforming cold tumors into hot ones and promoting effective antitumor ***,challenges persist,including primary resistance to immunotherapy,autoimmune side effects,and tumor response *** these challenges requires innovative strategies,deeper mechanistic insights,and a combination of immune interventions to enhance the effectiveness of *** the landscape of cancer medicine,where immune cold tumors represent a formidable hurdle,understanding the TME and harnessing its potential to reprogram the immune response is *** review sheds light on current advancements and future directions in the quest for more effective and safer cancer treatment strategies,offering hope for patients with immune-resistant tumors.

关键词： cold tumor hot tumor immunologic modulator immunotherapy therapeutic strategy tumor microenvironment

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High-Performance Flow Classification of Big Data Using Hybrid CPU-GPU Clusters of Cloud Environments

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Tsinghua Science and Technology 2024年第4期29卷 1118-1137页

作者： Azam Fazel-Najafabadi Mahdi Abbasi Hani H.Attar Ayman Amer Amir Taherkordi Azad Shokrollahi Mohammad R.khosravi Ahmed A.Solyman Department of Computer Engineering Faculty of EngineeringBu-Ali Sina UniversityHamedan ***Iran Department of Energy Engineering Zarqa UniversityZarqa 13132Jordan Department of Informatics University of OsloOslo 0316Norway Department of Computer Science MalmöUniversityMalmö20506Sweden Shandong Provincial University Laboratory for Protected Horticulture Weifang University of Science and TechnologyWeifang 261100China Department of Electrical and Electronics Engineering NişantaşıUniversityIstanbul 34481742Türkiye

The network switches in the data plane of Software Defined Networking (SDN) are empowered by an elementary process, in which enormous number of packets which resemble big volumes of data are classified into specific flows by matching them against a set of dynamic rules. This basic process accelerates the processing of data, so that instead of processing singular packets repeatedly, corresponding actions are performed on corresponding flows of packets. In this paper, first, we address limitations on a typical packet classification algorithm like Tuple Space Search (TSS). Then, we present a set of different scenarios to parallelize it on different parallel processing platforms, including Graphics Processing Units (GPUs), clusters of Central Processing Units (CPUs), and hybrid clusters. Experimental results show that the hybrid cluster provides the best platform for parallelizing packet classification algorithms, which promises the average throughput rate of 4.2 Million packets per second (Mpps). That is, the hybrid cluster produced by the integration of Compute Unified Device Architecture (CUDA), Message Passing Interface (MPI), and OpenMP programming model could classify 0.24 million packets per second more than the GPU cluster scheme. Such a packet classifier satisfies the required processing speed in the programmable network systems that would be used to communicate big medical data.

关键词： OpenMP Compute Unified Device Architecture(CUDA) Message Passing Interface(MPI) packet classification medical data tuple space algorithm Graphics Processing Unit(GPU)cluster

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