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每日一次他达拉非对男性勃起功能障碍的作用及伴侣评估报告

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中华男科学杂志 2010年第8期16卷 766-766页

作者： Althof SE rubio-Aurioles E Kingsberg S 白文俊北京大学人民医院男性健康管理研究所

此研究旨在评估他达拉非每日1次5mg对勃起功能障碍(ED)患者的疗效(达到勃起以及插入阴道)以及患者夫妇的总体性生活满意度。这是一项回顾性分析,汇总了两项多中心、随机化、双盲、安慰剂对照临床研究的数据,研究对象为505对夫妇(他达拉... 详细信息

此研究旨在评估他达拉非每日1次5mg对勃起功能障碍(ED)患者的疗效(达到勃起以及插入阴道)以及患者夫妇的总体性生活满意度。这是一项回顾性分析,汇总了两项多中心、随机化、双盲、安慰剂对照临床研究的数据,研究对象为505对夫妇(他达拉非组n=373对;安慰剂组n=132对)。两组中的男性受试者分别服用5mg他达拉非或安慰剂1次/d,共12周。男性受试者及其女性伴侣在每次性交活动尝试后分别独立完成各自的“性活动日志”(SEP)。计算各受试者/伴侣对SEP日志问题“阳性”答复百分率的平均值,并对受试者及其伴侣的答复一致性进行评估。[第一段]

关键词：男性勃起功能障碍他达拉非女性伴侣评估报告安慰剂对照性生活满意度受试者临床研究

既往有西地那非治疗史的勃起功能障碍患者服用他达拉非与性交尝试之间的相对时间间隔:来自单组开放式研究的地理因素比较

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中华男科学杂志 2010年第8期16卷 767-767页

作者： rubio-Aurioles E Glina S Abdo CH 黄晓军浙江中医药大学附属第二医院泌尿外科

既往研究发现,接受枸橼酸西地那非治疗的勃起功能障碍(ED)患者在改服他达拉非后会改变服药一性交尝试行为。而现有的研究尚未能对5型磷酸二酯酶(PDE5)抑制剂治疗过程中的地理以及文化因素对性行为的影响进行深入的研究。本研究收集了200... 详细信息

既往研究发现,接受枸橼酸西地那非治疗的勃起功能障碍(ED)患者在改服他达拉非后会改变服药一性交尝试行为。而现有的研究尚未能对5型磷酸二酯酶(PDE5)抑制剂治疗过程中的地理以及文化因素对性行为的影响进行深入的研究。本研究收集了2002年11月至2004年5月期间在全球21个国家进行的单组开放式临床试验的研究数据,对服用枸橼酸西地那非患者与服用他达拉非患者的服药.性交尝试行为变化进行了分析以及比较。患者按照地理来源区域分为4组,即亚洲区、澳大利亚/新西兰(ANZ)区、中东欧/中东区(CEE/ME)以及拉美区(LA)。[第一段]

关键词：枸橼酸西地那非勃起功能障碍地理因素他达拉非治疗史开放式患者时间间隔

Mercury in Canned Tuna in *** Light Tuna Really Light?

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Food and Nutrition Sciences 2013年第7期4卷 48-54页

作者： Montserrat González-Estecha María JoséMartínez-García Manuel Fuentes-Ferrer Andrés Bodas-Pinedo Alfonso Calle-Pascual JoséMaría Ordóñez-Iriarte Cristina Fernández-Pérez Nieves Martell-Claros MiguelÁngel rubio-Herrera Emilia Gómez-Hoyos JoséJesús Guillén-Pérez Trace Element Unit and Laboratory Medicine Department Instituto de Investigación SanitariaHospital Clínico San CarlosMadridSpain Universidad Politécnica CartagenaSpain Universidad Camilo Jose Cela MadridSpain Department of Epidemiology Instituto de Investigación SanitariaHospital Clínico San CarlosMadridSpain Department of Pediatrics Instituto de Investigación SanitariaHospital Clínico San CarlosMadridSpain Department of Endocrinology Instituto de Investigación SanitariaHospital Clínico San CarlosMadridSpain Consejería de Sanidad y Consumo MadridSpain Hypertension Unit Instituto de Investi-gación SanitariaHospital Clínico San CarlosMadridSpain Publich Health Department CartagenaSpain Universidad de Murcia MurciaSpain

In Spain, certain population-based studies have shown high blood mercury (Hg) levels due to the high consumption of fish. Some studies have stated that one of the most consumed fish in Spain is canned tuna. Different Spanish organisms consider that it is safe to consume canned tuna as it supposedly has a low mercury content, particularly in so-called light tuna. However, in Spain light tuna is mainly yellowfin and bigeye tuna, while in other countries it is mainly skipjack tuna. This study analyzed 36 cans of the most popular brands in Spain and examined the influence of the type of tuna, packaging medium (olive oil, sunflower seed oil, water or marinade), different brands, prices and expiration dates. Mercury concentrations (mg/kg) were measured by atomic absorption spectrometry and thermal decomposition amalgamation. The medians observed were (mg/kg): light tuna: 0.314;IQR: 0.205 - 0.594, white tuna: 0.338;IQR: 0.276 - 0.558, skipjack: 0.311;IQR: 0.299 - 0.322, frigate tuna: 0.219;IQR 0.182 - 0.257 and mackerel: 0.042;IQR 0.029 -?0.074. We found statistically significant differences between white tuna, light tuna and mackerel (p = 0.004);light tuna and mackerel (p = 0.002) and white tuna and mackerel (p = 0.006). However, we found no differences between white tuna and light tuna, or among packaging medium, brands, prices or expiration dates. The limit of 0.500 mg/kg of mercury in canned tuna was exceeded by the following percentages of the cans: 33.3% of light tuna, 16.7% of white tuna, and 0% of Skipjack, frigate tuna and mackerel. The mercury content of the cans of Spanish light tuna that were analyzed was variable and high. The results of this study indicate that stricter regulation of Hg in canned tuna is necessary. Until then, it is safer to recommend that vulnerable populations such as children and pregnant women consume canned mackerel, which has a markedly lower mercury content.

关键词： Mercury Canned Tuna Spain

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地中海不同林火强度影响下的水蚀趋势

中国水土保持 2002年第7期 33-33页

作者： V.Andreu,J.L.rubio,E.Gimeno-Garcia,R.Cerni Centro de Investigaciones sobre Desertificación-CIDE CSIC Universitat de Valncia GeneralitatValencianaCamèdelaMarjal s/n Centro de Investigaciones sobre Desertificación-CIDE CSIC Universitat de Valncia GeneralitatValencianaCamèdelaMarjal s/n Centro de

New insights to occult gastrointestinal bleeding: From pathophysiology to therapeutics

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World Journal of Gastrointestinal Pathophysiology 2014年第3期5卷 271-283页

作者： Antonio Damián Sánchez-Capilla Paloma De La Torre-rubio Eduardo Redondo-Cerezo Department of Gastroenterology University Hospital Virgende Las Nieves 18014 Granada Spain Department of Gastroenterology University Hospital Virgen deLas Nieves 18014 Granada Spain Endoscopy Unit Department of Gastroenterology University Hospital Virgen de Las Nieves 18014 Granada Spain

Obscure gastrointestinal bleeding is still a clinical challenge for gastroenterologists. The recent development of novel technologies for the diagnosis and treatment of different bleeding causes has allowed a better management of patients, but it also determines the need of a deeper comprehension of pathophysiology and the analysis of local expertise in order to develop a rational management algorithm. Obscure gastrointestinal bleeding can be divided in occult, when a positive occult blood fecal test is the main manifestation, and overt, when external sings of bleeding are visible. In this paper we are going to focus on overt gastrointestinal bleeding, describing the physiopathology of the most usual causes, analyzing the diagnostic procedures available, from the most classical to the novel ones, and establishing a standard algorithm which can be adapted depending on the local expertise or availability. Finally, we will review the main therapeutic options for this complex and not so uncommon clinical problem.

关键词： Obscure gastrointestinal bleeding Angiodysplasia Wireless capsule endoscopy Double balloon enteroscopy

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地中海不同林火强度影响下的水蚀趋势

中国水土保持 2002年第7期 29-29页

作者： V.Andreu J.L.rubio E.Gimeno-Garcia R.Cerni Centro de Investigaciones sobre Desertificación-CIDE CSICUniversitat de ValnciaGeneralitatValencianaCamèdelaMarjals/nCentro de Investigaciones sobre Desertificación-CIDECSICUniversitat de ValnciaGeneralitatValencianaCamèdelaMarjals/nCentro de

心血管MRI评估静力运动对主动脉反流病人的急性效应:左心室重构的作用

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国际医学放射学杂志 2017年第3期 362-363页

作者： J.M.Alegret N.Martinez-Micaelo A.L.Gerche L.Franco-Bonafonte F.rubio-Pérez N.Calvo 郭小琴 Departments of Cardiology and Sports Medicine Hospital Universitari de Sant Joan Institut d ’Investigació Sanitària Pere Virgili Universitat Rovira i Virgili

摘要目的对于主动脉反流(AR)的病人,静力运动(SE)对其全心室功能和反流程度的影响尚未见报道。方法前瞻性地对23例无症状的AR病人行静息及SE状态下的心血管MR(CMR)成像。结果 SE过程中,两心室的舒张末期(EDV)和收缩末期(ESV)容量均存在... 详细信息

摘要目的对于主动脉反流(AR)的病人,静力运动(SE)对其全心室功能和反流程度的影响尚未见报道。方法前瞻性地对23例无症状的AR病人行静息及SE状态下的心血管MR(CMR)成像。结果 SE过程中,两心室的舒张末期(EDV)和收缩末期(ESV)容量均存在反流量的下降,同时LV射血分数(EF)轻度下降,且上述变化的幅度取决于LV重构的程度。对于有较大程度LV重构的病人,由于LV ESV的下降幅度较小(相对于LV EDV)导致LV EF有所下降(静息时

关键词：心血管主动脉大动脉静力运动 MRI

Pedigree analysis of 220 almond genotypes reveals two world mainstream breeding lines based on only three different cultivars

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Horticulture Research 2021年第1期8卷 72-82页

作者： Felipe Perez de los Cobos Pedro J.Martinez-Garcia Agusti Romero Xavier Miarnau Iban Eduardo Werner Howad Mourad Mnejja Federico Dicenta Rafel Socias i Company Maria J.rubio-Cabetas Thomas M.Gradziel Michelle Wirthensohn Henri Duval Doron Holland Pere Arus Francisco J.Vargas Ignasi Batlle Institut de Recerca i Tecnologia Agroalimentaries(IRTA) Mas BoveCtra.Reus-El Morell Km 3843120 ConstantiTarragonaSpain Institut de Recerca i Tecnologia Agroalimentaries(IRTA) Centre de Recerca en Agrigenomica(CRAG)CSIC-IRTA-UAB-UB.Cerdanyola del Valles(Bellaterra)08193 BarcelonaSpain Centro de Edafologia y Biologia Aplicada del Segura Consejo Superior de Investigaciones Cientificas(CEBAS-CSIC)P.O.Box 16430100 EspinardoMurciaSpain Institut de Recerca i Tecnologia Agroalimentaries(IRTA) FruitcentrePCiTALGardeny ParkFruitcentre Building25003 LleidaSpain Centro de Investigacion y Tecnologia Agroalimentaria de Aragon(CITA) Avda.Montanana 93050059ZaragozaInstituto Agroalimentario de Aragon IA2(CITA-Universidad de Zaragoza)ZaragozaSpain University of California 1 Shields AvenueDavisCA 95616USA University of Adelaide Waite ResearchSchool of AgricultureFood and WinePMB 1Glen OsmondAdelaideSA 5064Australia Institut National de la Recherche Agronomique(INRA) Domain St.Maurice CS 6009484143 Montfavet CedexFrance Agricultural Research Organization Newe-Ya’ar Research CenterP.O.Box 1021Ramat Yishad 30095Israel

Loss of genetic variability is an increasing challenge in tree breeding programs due to the repeated use of a reduced number of founder ***,in almond,little is known about the genetic variability in current breeding stocks,although several cases of inbreeding depression have been *** gain insights into the genetic structure in modern breeding programs worldwide,marker-verified pedigree data of 220 almond cultivars and breeding selections were *** coefficients,pairwise relatedness,and genetic contribution were calculated for these *** results reveal two mainstream breeding lines based on three cultivars:“Tuono”,“Cristomorto”,and“Nonpareil”.Descendants from“Tuono”or“Cristomorto”number 76(sharing 34 descendants),while“Nonpareil”has 71 *** mean inbreeding coefficient of the analyzed genotypes was 0.041,with 14 genotypes presenting a high inbreeding coefficient,over *** programs from France,the USA,and Spain showed inbreeding coefficients of 0.075,0.070,and 0.037,*** to their genetic contribution,modern cultivars from Israel,France,the USA,Spain,and Australia trace back to a maximum of six main founding *** the group of 65 genotypes carrying the S f allele for self-compatibility,the mean relatedness coefficient was 0.125,with“Tuono”as the main founding genotype(24.7%of total genetic contribution).The results broaden our understanding about the tendencies followed in almond breeding over the last 50 years and will have a large impact into breeding decision-making process *** current genetic variability is required in almond breeding programs to assure genetic gain and continuing breeding progress.

关键词： breeding cultivar founding

瑞典5000人植入NFC芯片,再也不担心手机被偷了

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中外管理 2020年第8期 26-26页

作者： Isabel rubio 赵嘉怡(译) 不详

在瑞典,一家名为Dsruptive的公司研发了一种可植入体内的NFC芯片。芯片有米粒大小,可以在手的虎口部位植入。目前瑞典已经有5000人植入该设备,主要用于乘坐交通工具,进入健身房等场所,以及存储私人信息等。该设备可在体内至少使用25年,... 详细信息

在瑞典,一家名为Dsruptive的公司研发了一种可植入体内的NFC芯片。芯片有米粒大小,可以在手的虎口部位植入。目前瑞典已经有5000人植入该设备,主要用于乘坐交通工具,进入健身房等场所,以及存储私人信息等。该设备可在体内至少使用25年,并在任何时候都可以卸下或更换。而除了瑞典,该公司还收到来自英国、美国、日本、西班牙等国家的订单。据悉,未来还可以将其应用于远程医疗领域。

关键词：远程医疗 NFC 健身房私人信息交通工具植入瑞典芯片