检索结果-南通市图书馆

From oral formulations to drug-eluting implants:using 3D and 4D printing to develop drug delivery systems and personalized medicine

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bio-Design and Manufacturing 2022年第1期5卷 85-106页

作者： Niels G.A.Willemen Margaretha A.J.Morsink Devin Veerman Classius F.da Silva Juliana C.cardoso Eliana B.Souto Patrícia Severino Center for Biomedical Engineering Department of MedicineBrigham and Women&HospitalHarvard Medical School65 Landsdowne StreetMA 02139 CambridgeUSA Department of Developmental BioEngineering Faculty of Science and TechnologyTechnical Medical CentreUniversity of TwenteEnschedeThe Netherlands Translational Liver Research Department of Medical Cell BioPhysicsTechnical Medical CentreFaculty of Science and TechnologyUniversity of TwenteEnschedeThe Netherlands Targeted Therapeutics Department of Biomaterials Science and TechnologyFaculty of Science and TechnologyUniversity of TwenteEnschedeThe Netherlands Department of Chemical Engineering Institute of EnvironmentalChemical and Pharmaceutical SciencesFederal University of São PauloRua São Nicolau210Diadema 09913‑030Brazil University of Tiradentes(Unit) and Institute of Technology and Research(ITP)Av.Murilo Dantas300Aracaju 49010‑390Brazil Faculty of Pharmacy University of CoimbraPólo das Ciências da SaúdeAzinhaga de Santa Comba3000‑548 CoimbraPortugal CEB‑Centre of Biological Engineering University of MinhoCampus de Gualtar4710‑057 BragaPortugal Tiradentes Institute 150 Mt Vernon StDorchesterMA 02125USA

Since the start of the Precision Medicine Initiative by the United States of America in 2015,interest in personalized medicine has grown *** short,personalized medicine is a term that describes medical treatment that is tuned to the *** possible way to realize personalized medicine is 3D *** using materials that can be tuned upon stimulation,4D printing is *** recent years,many studies have been exploring a new field that combines 3D and 4D printing with *** has resulted in many concepts of pharmaceutical devices and formulations that can be printed and,possibly,tailored to an ***,the first 3D printed drug,Spritam®,has already found its way to the *** review gives an overview of various 3D and 4D printing techniques and their applications in the pharmaceutical field as drug delivery systems and personalized medicine.

关键词： Drug delivery systems 3D/4D printing Drug-eluting implants Microneedles Oral formulations

New approach for obtaining the C-factor of RUSLE considering the seasonal effect of rainfalls on vegetation cover

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

International Soil and Water Conservation Research 2021年第2期9卷 207-216页

作者： Pietro Menezes Sanchez Macedo Paulo Tarso Sanches Oliveira Mauro Antonio Homem Antunes Valdemir Lucio Durigon Elaine Cristina cardoso Fidalgo Daniel Fonseca de Carvalho Agronomy-Soil Science Post Graduate Program Federal Rural University of Rio de JaneiroBR 465km 723897-000SeropedicaRJBrazil Federal University of Mato Grosso do Sul CxP.549Campo GrandeMS79070-900Brazil Federal Rural University of Rio de Janeiro Engineering DepartmentBR 465km 723897-000SeropedicaRJBrazil Technical College of the Federal Rural University of Rio de Janeiro BR 465km 723897-000SeropedicaRJBrazil National Center for Soil Research Brazilian Agricultural Research CorporationRio de JaneiroBrazil

We present a new approach for calculating the C-factor of RUSLE considering the effect of low-reflectance vegetation cover areas on the reduction of the effects on erosion caused by rainfall *** this,we propose the coefficients Cr2(rescaled 2)and C-PC(Precipitation Correction),which represent the Cfactor,and an adaptation in NDVI calculation,according to the seasonality of precipitation(NDVI-PC).The Cr2 factor is used when there is no seasonal effect of rainfall on vegetation,while the C-PC factor is calculated for localities under the influence of seasonality,from *** proposed approaches were tested using different satellites images in the Palmares-Ribeir~ao do Saco watershed,Rio de Janeiro,*** values of Cr2 and C-PC factors were compared to the Cr factor(rescaled)and to mean values from the literature for different land *** results indicated that the Cr2 factor represents an improvement in accuracy in relation to Cr by considering specific values of the studied area to normalize the data without ***,the C-PC factor is able to simulate the effect of seasonality,providing more realistics values of soil loss by the RUSLE as a function of the proportion of area affected by the rainfall seasonality obtained from *** conclude that both Cr2 and C-PC factors generate values similar of the C-factor observed in the literature,and therefore are able to provide better soil loss estimation than that using the Cr factor.

关键词： Soil erosion Land cover Soil use and management factor Vegetation seasonality NDVI

Leukocyte-technetium-99m uptake in Crohn's disease:Does it show subclinical disease?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2010年第3期16卷 365-371页

作者： Luciene G Mota Luiz GV Coelho Carlos JR Simal Maria LA Ferrari Clodomiro Toledo Josep Martin-Comin Simone OF Diniz Valbert N cardoso Nuclear Engineering Department Federal University of Minas Gerais Gastro-enterology ALFA Institute Clinical HospitalFederal University of Minas Gerais Nuclear Medicine Felício Rocho HospitalMedicine FacultyFederal University of Minas Gerais Medicine Nuclear Center Bellvitge Hospital Radioisotope Laboratory Pharmacy FacultyFederal University of Minas Gerais

AIM:To evaluate inflammatory activity in patients with Crohn's disease (CD) using technetium-99m-hexamethylpropyleneamine oxime (99mTc-HMPAO) granulocyte ***: Twenty patients (7 male and 13 female) with CD and five healthy volunteers were selected for 99mTc-HMPAO granulocyte scintigraphy. The Crohn's Disease Activity Index (CDAI), blood tests and C-reactive protein (CRP) of each patient were performed 7 d before the scintigraphic images. The leukocytes were labeled according to the International Society of Radiolabeled Blood Elements (ISORBE) consensus protocol and the scintigraphic images, including single photon emission computed tomography, were obtained 30 min and 2 h after injection of the radiolabeled ***:The labeling yield of the leukocytes with the lipophilic complex 99mTc-HMPAO was 55.0%±10%. Six of the 20 patients (30%) presented congruent results for the three parameters investigated (CDAI, Scintigraphic Index and CRP). On the other hand, 14 patients (70%) did not show congruent results. There was no significant correlation between the indices analyzed according to the Spearman test (P>0.05,n=20).CONCLUSION: The results suggest that 99mTc-HMPAO-labeled leukocyte scintigraphy could be important for determining inflammatory activity in CD even in the absence of clinical symptoms.

关键词： Technetium-99m Hexamethylpropyleneamine oxime Leukocytes Inflammatory bowel disease Scintigraphy

XEN^(■) implant and trabeculectomy medium-term quality of life assessment and comparison of results

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2018年第12期11卷 1941-1944页

作者： Ana Luisa Basilio Nuno Moura-Coelho Ines Passos Mariana Sa cardoso Isabel Domingues Maria Reina Rita Flores Teresa Gomes Ophthalmology Department Central Lisbon Hospital Center Lisbon 1169050Portugal

AIM: To evaluate and compare the quality of life of patients submitted to XEN~? implant or trabeculectomy and the relationship with potentially involved ***: A cross-sectional study of patients with advanced open-angle glaucoma who underwent implantation of XEN~?(group 1) and trabeculectomy(group 2) between October 2015 and February 2017. The studied variables were: age, gender, follow-up time, need of topical anti-hypertensive therapy, visual acuity and intraocular pressure(IOP). The quantification of the quality of life was attained through the Glaucoma Symptom Scale(GSS) questionnaire. RESULTS: Totally 34 eyes(34 patients) were included, 17 in each group. The mean GSS scores for group 1 were 42.6±6.8(median, 47; p25, 36.5; p75, 48.5) and for group 2 it was 41.6±7.0(median, 43; p25, 36.5; p75, 47.0; P=0.34). There was a strong negative correlation between the need for topical anti-hypertensive drugs and the GSS result in both groups(r=-0.88, P<0.01, r=-0.59, P=0.01, respectively) and a moderate negative correlation with IOP in group 1(r=-0.50, P=0.03).CONCLUSION: The analysis demonstrates the noninferiority of medium-term quality of life of one group in relation to the other(XEN~? implant and trabeculectomy). The number of topical anti-hypertensive drugs and IOP negatively influenced the quality of life.

关键词： quality of life XEN^(■) trabeculectomy

Hyperbaric oxygen therapy as a complementary treatment for radiation proctitis:Useless or useful?-A literature review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2021年第27期27卷 4413-4428页

作者： Diogo Alpuim Costa Carla Espiney Amaro Ana Nunes Joana Santos cardoso Pedro Modas Daniel Isabel Rosa João Vieira Branco Department of Haematology and Oncology CUF OncologiaLisboa 1998-018Portugal Centro de Medicina Subaquática e Hiperbárica(CMSH) Portuguese NavyLisboa 1649-020Portugal Centro de Investigação Naval(CINAV) Portuguese NavyBase Naval do AlfeiteAlmada 2810-001Portugal OVA Medical School Faculdade de Ciências MédicasLisboa 1169-056Portugal Department of Otorhinolaryngology Hospital das Forças Armadas(HFAR)Lisboa 1649-020Portugal Department of Gastroenterology Hospital das Forças Armadas(HFAR)Lisboa 1649-020Portugal Department of Vascular Surgery Centro Hospitalar Universitário de Lisboa CentralHospital de Santa MartaLisboa 1169-024Portugal Department of Intensive Care Unit Hospital das Forças Armadas(HFAR)Lisboa 1649-020Portugal Department of General Surgery Hospital das Forças Armadas(HFAR)Lisboa 1649-020Portugal

Radiotherapy(RT)is the backbone of multimodality treatment of more than half of cancer *** new modern RT techniques,late complications may occur such as radiation proctitis(RP).The natural history of RP is *** symptoms may resolve spontaneously or require conservative *** the other hand,for similar and uncomplicated clinical contexts,symptoms may persist and can even be refractory to the progressive increase in treatment *** the last decades,an enormous therapeutic armamentarium has been considered in RP,including hyperbaric oxygen therapy(HBOT).Currently,the evidence regarding the impact of HBOT on RP and its benefits is *** prospective and randomised studies are necessary to validate HBOT’s effectiveness in the‘real world’clinical *** article reviewed the relevant literature on pathophysiology,clinical presentation,different classifications and discuss RP management including a proposal for a therapeutic algorithm with a focus on HBOT.

关键词： Radiation proctitis Radiation proctopathy Radiotherapy Radio-induced lesion Late radiation tissue injury Delayed radiation injury Late sequelae Hyperbaric oxygen therapy Hyperbaric oxygen Review

Using Magnetic Method for the Identification of Anomalies Due to Kimberlite Pipes, Luando Area, Bié, Angola

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Geosciences 2020年第11期11卷 745-755页

作者： Gerson Itembo João Baptista Ageu cardoso Department of Geosciences Instituto Superior Politécnico de Tecnologias e Ciências (ISPTEC) Talatona Luanda Angola Department of Geophysics Universidade Agostinho Neto (UAN) Camama Luanda Angola

One of the measurement geophysical methods to investigate kimberlite pipes is by using the magnetic method. The acquired field data in this study uses two proton-precession magnetometers for the mapping of magnetic anomalies due to kimberlites. Three different magnetic maps are obtained from the result of total magnetic field data processing on Oásis Montaj software programme. These maps include magnetic anomaly maps through statistical analyses, total magnetic field intensity map and map of the analytic signal. Based on the interpretation of these maps a structure is identified with SWW-NEE directions in which magnetic signatures that indicate the presence of kimberlite pipes are observed. As the interpretation of the magnetic anomalies is a complicated process due to their dipolar nature, the analytic signal is generated, where is possible to observe the typical shape of these anomalies.

关键词： Near-Surface Geophysical Study Magnetic Anomalies Kimberlite Pipes Total Magnetic Field Anomalies Analytic Signal Map

Araucaria angustifolia Aboveground Roots Presented High Arbuscular Mycorrhizal Fungal Colonization and Diversity in the Brazilian Atlantic Forest

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pedosphere 2016年第4期26卷 561-566页

作者： Milene MOREIRA Maria I. ZUCCHI Jose E. GOMES Siu M. TSAI Alessandro ALVES-PEREIRA Elke J. B. N. cardoso Sao Paulo State Agency for Agribusiness Technology CP 28 Piracicaba 13400-970 Center for Nuclear Energy in Agriculture University of Sao Paulo Piracieaba 13416-000 Genetics Department Luiz de Queiroz College of Agriculture University of Sao Paulo Piraeieaba 13418-900 Soil Science Department Luiz de Queiroz College of Agriculture University of Sao Paulo Piracicaba 13418-900

30 different arbuscular mycorrhizal fungi （AMF） species, distributed in different genera such as Glomus, Acaulospora, Scutellospora, Entrophospora, Ambisporu, Kuklospora, Gigaspora, and Archeospora, have been identified in the root zone of Araucaria angustifolia, known as Brazil Pine. During our AMF survey in this ecosystem, our attention was called to the presence of many superficially growing Araucaria roots. Our hypothesis was that these roots were colonized with AMF because of the presence of AMF spores in organic material aboveground. Samples of these superficial roots and the organic substrate they were growing on were evaluated for their mycorrhizal status. DNA was extracted from the AMF-colonized superficial roots and submitted to polymerase chain reaction （PCR） amplification using the NS31-AM1 primer pair, followed by cloning and sequencing. We found that the root colonization percentages were between 31% and 52%, and the number of AMF spores in the substrate ranged from 27 to 164 spores per 50 g dry substrate. The phylogenetic analyses and tree construction using maximum parsimony （MP） and neighbor-joining （N J） methods identified 13 different species of the phylum Glomeromycota belonging to the genera Glomus, Funneliformis, Rhizophagus, Gigaspora, Acaulospora, and Archaeospora, and five isolates were identified only at the genus level. To our knowledge, this is the first report on Araucaria angustifolia with roots growing aboveground, producing runner roots that develop on dead tree trunks and organic material. The higher colonization of the aboveground roots than those commonly found in belowground Araucaria roots suggests that they may present active metabolic uptake of nutrients.

关键词： AMF spores fungal taxonomy mycorrhizal status nutrient uptake organic substrate root colonization superficial roots

Clinical implication of 14-3-3 epsilon expression in gastric cancer

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2012年第13期18卷 1531-1537页

作者： Mariana Ferreira Leal Danielle Queiroz Calcagno Smia Demachki Paulo Pimentel Assumpo Roger Chammas Rommel Rodríguez Burbano Marília de Arruda cardoso Smith Genetics Division Department of Morphology and GeneticFederal University of So PauloSo Paulo 04023-900Brazil Pathology Service Joo de Barros Barreto University HospitalFederal University of ParáBelém 60673-000Brazil Surgery Service Joo de Barros Barreto University HospitalFederal University of ParáBelém 60673-000Brazil Laboratory of Experimental Oncology School of MedicineUniversity of So PauloSo Paulo 01246-903Brazil Human Cytogenetics Laboratory Institute of Biological SciencesFederal University of ParáBelém 66073-000Brazil

AIM:To evaluate for the first time the protein and mRNA expression of 14-3-3εin gastric ***:14-3-3εprotein expression was determined by western blotting,and mRNA expression was examined by real-time quantitative RT-PCR in gastric tumors and their matched non-neoplastic gastric tissue ***:Authors observed a significant reduction of 14-3-3εprotein expression in gastric cancer(GC)samples compared to their matched non-neoplastic *** levels of 14-3-3εwere also associated with diffuse-type GC and early-onset of this *** data suggest that reduced 14-3-3εmay have a role in gastric carcinogenesis ***:Our results reveal that the reduced 14-3-3εexpression in GC and investigation of 14-3-3ε interaction partners may help to elucidate the carcino-genesis process.

关键词： Gastric cancer 14-3-3 epsilon YWHAE Geneexpression Protein expression

Notice on a Case Study on the Utilization of Wind Energy Potential on a Remote and Isolated Small Wastewater Treatment Plant

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Smart Grid and Renewable Energy 2011年第3期2卷 293-299页

作者： Joao Fernando Pereira Gomes Pedro Manuel cardoso Ddepartment Eng^(a) Quimica Instituto Superior de Engenharia de LisboaLisboaPortugal Ddepartment Eng^(a) Quimica e Biologica Instituto Superior TecnicoLisboaPortugal Sustainable Development Instituto de Soldadura e QualidadePorto-SalvoPortugal

Small wastewater treatment plants (WWTP) are frequently located, by necessity, in remote and isolated sites, which increases the difficulty of its energy supply. Some of them are located near the seaside, in environmental sensible zones, and due to tourism activity of these sites, seasonal effects related with population size fluctuation can occur, which can originate certain inefficiencies concerning WWTP design and energy supply. The objective of this paper is to describe a step by step procedure for evaluation of the wind potential of sites that are dependent of in-situ energy generation, as well as, a case study on the utilization of the potential wind energy in Magoito WWTP (5000 p.e.). The employed methodology comprised the collection of one year of in-situ wind data and its validation by comparison with historical data of about 10 years of a nearby anemometric station. The data provided by the two anemometric stations was statistically treated. It allowed the analysis of the results from the two stations are promissory in terms of wind availability and velocity. Finally, it comprised the simulation of the local wind conditions for a considerable larger area in order to find the best site for locating a wind turbine.

关键词： Wind Energy Wastewater Treatment Plants