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Distribution of DNA damage in the human sperm nucleus:implications of the architecture of the sperm head

Asian Journal of Andrology 2020年第4期22卷 401-408页

作者： Silvia González-Rojo Cristina Fernández-Díez Marta Lombó María Paz Herráez Department of Molecular Biology Faculty of BiologyUniversidad de LeónCampus de Vegazana s/n LeónLeón 24071Spain

The sperm nucleus is prone to sustain DNA damage before and after *** of the damage is not homogeneous,and the factors determining differential sensitivity among nuclear regions have not yet been *** sperm chromatin contains three structural domains,two of which are considered the most susceptible to DNA damage:the histone bound domain,harboring developmental related genes,and the domain associated with nuclear matrix *** a quantitative polymerase chain reaction(qPCR)approach,we analyzed the number of lesions in genes homeobox A3(HOXA3),homeobox B5(HOXB 5),sex-determining region Y(SRY)-box 2(SOX2),β-GLOBIN,rDNA 18S,and rDNA 28S in human sperm after ultraviolet irradiation(400μW cm−2,10 min),H2O2treatment(250 mmol l−1,20 min),and cryopreservation,which showed differential susceptibility to genetic *** vulnerability is dependent on the genotoxic agent and independent of the sperm nuclear proteins to which the chromatin is bound and of accessibility to the transcription *** of 8-hydroxy-2'-deoxyguanosine(8-OHdG)showed that the highest level of oxidation was observed after *** distribution of oxidative lesions also differed depending on the genotoxic agent.8-OHdG did not colocalize either with histone 3(H3)or with type IIα+βtopoisomerase(TOPO IIα+β)after H2O2treatment but matched perfectly with peroxiredoxin 6(PRDX6),which is involved in *** study reveals that the characteristics of the sperm head domains are responsible for access of the genotoxicants and cause differential degree of damage to nuclear areas,whereas chromatin packaging has a very limited *** histone-enriched genes analyzed cannot be used as biomarkers of oxidative DNA damage.

关键词： biomarkers DNA damage human sperm oxidative stress sperm chromatin sperm quality

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Energy level engineering of charge selective contact and halide perovskite by modulating band offset:Mechanistic insights

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Journal of Energy Chemistry 2021年第3期30卷 822-829页

作者： Yassine Raoui Hamid ez-Zahraouy Samrana Kazim Shahzada Ahmad BCMaterials Basque Center for MaterialsApplications and NanostructuresBld.Martina CasianoUPV/EHU Science ParkBarrio Sarriena s/n48940 LeioaSpain IKERBASQUE Basque Foundation for ScienceBilbao 48013Spain Laboratory of Condensed Matter and Interdisciplinary Sciences Faculty of SciencesMohammed V UniversityRabatMorocco

Mixed cation and anion based perovskites solar cells exhibited enhanced stability under outdoor conditions,however,it yielded limited power conversion efficiency when TiO_(2) and Spiro-OMeTAD were employed as electron and hole transport layer(ETL/HTL)*** inevitable interfacial recombination of charge carriers at ETL/perovskite and perovskite/HTL interface diminished the efficiency in planar(n-i-p)perovskite solar *** employing computational approach for uni-dimensional device simulator,the effect of band offset on charge recombination at both interfaces was *** noted that it acquired cliff structure when the conduction band minimum of the ETL was lower than that of the perovskite,and thus maximized interfacial ***,if the conduction band minimum of ETL is higher than perovskite,a spike structure is formed,which improve the performance of solar *** optimum value of conduction band offset allows to reach performance of 25.21%,with an open circuit voltage(VOC)of 1231 mV,a current density JSC of 24.57 mA/cm^(2) and a fill factor of 83.28%.Additionally,we found that beyond the optimum offset value,large spike structure could decrease the *** an optimized energy level of Spiro-OMeTAD and the thickness of mixed-perovskite layer performance of 26.56% can be *** results demonstrate a detailed understanding about the energy level tuning between the charge selective layers and perovskite and how the improvement in PV performance can be achieved by adjusting the energy level offset.

关键词： Device modelling Electron affinity Conduction band offset Valence band offset Charge recombination Perovskite solar cell

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Electrochemically assisted production of biogenic palladium nanoparticles for the catalytic removal of micropollutants in wastewater treatment plants effluent

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Journal of Environmental Sciences 2023年第6期128卷 203-212页

作者： Cindy Ka Y Law Kankana Kundu Luiza Bonin Lorena Peñcoba-Antona Eduardo Bolea-Fernandez Frank Vanhaecke Korneel Rabaey Abraham Esteve-Nez Bart De Gusseme Nico Boon Center for Microbial Ecology and Technology(CMET) Ghent UniversityCoupure Links 653B-9000 GentBelgium Centre for Advanced Process Technology for Urban Resource recovery(CAPTURE) P.O.Frieda Saeysstraat 1B-9000 GentBelgium METfilter S.L. Autovía A49 Sevilla-Huelva Km 2841820 Carrión de los CéspedesSevillaSpain IMDEA Water Institute Av.Punto Com2Parque Científico Tecnológico28805 Alcaláde HenaresMadridSpain Atomic&Mass Spectrometry(A&MS)research group Department of ChemistryGhent UniversityCampus SterreKrijgslaan 281-S12B-9000 GhentBelgium Universidad de Alcalá Department of Analytical ChemistryPhysical Chemistry and Chemical EngineeringCtra.Madrid-Barcelona Km 33.60028871 Alcaláde HenaresMadridSpain

Biogenic palladium nanoparticles(bio-Pd NPs)are used for the reductive transformation and/or dehalogenation of persistent *** this work,H2(electron donor)was produced in situ by an electrochemical cell,permitting steered production of differently sized bio-Pd *** catalytic activity was first assessed by the degradation of methyl *** NPs showing the highest catalytic activity were selected for the removal of micropollutants from secondary treated municipal *** synthesis at different H2 flow rates(0.310 L/hr or 0.646 L/hr)influenced the bio-Pd NPs *** NPs produced over 6 hr at a lowH2 flow rate had a larger size(D50=39.0 nm)than those produced in 3 hr at a high H2 flow rate(D50=23.2 nm).Removal of 92.1%and 44.3%of methyl orange was obtained after 30 min for the NPs with sizes of 39.0 nm and 23.2 nm,***-Pd NPs of 39.0 nm were used to treat micropollutants present in secondary treated municipal wastewater at concentrations ranging fromμg/L to ng/*** removal of 8 compounds was observed:ibuprofen(69.5%)94.3%)ibiotics occurred at>90%***,these data indicate that the size,and thus the catalytic activity of the NPs can be steered and that the removal of challengingmicropollutants at environmentally relevant concentrations can be achieved through the use of bio-Pd NPs.

关键词： Antibiotics Adsorption Biogenic palladium nanoparticles Catalytic activity H2 Secondary treated municipal wastewater

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Ligninolytic enzymes production by endophytic fungus Diaporthe phaseolorum(Desm.)*** the influence of different carbon and nitrogen sources

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Studies in Fungi 2021年第1期6卷 531-542页

作者： Kumar V Prasher ib Mycology and Plant Pathology Lab. Department of BotanyPanjab University ChandigarhChandigarh-160014India

Endophytic fungi are being investigated for their ability to create industrially relevant secondary *** recent years,there has been a surge in interest in these fungi as a source of novel enzymes,particularly hydrolytic *** present study investigated the effect of different carbon,organic and inorganic nitrogens on the growth and ligninolytic enzyme production by the endophytic fungus Diaporthe *** fungus was isolated from the leaves of Dillenia indica and analyzed by morpho-molecular *** fungus showed promising results for in vitro production of ligninolytic *** was the most favorable carbon compound for growth among all the carbon compounds *** displayed maximum lignin peroxidase(Lip)activity in fructose(3.5 U/ml),followed by pectin(2.60 U/ml)and glucose(2.53 U/ml).Glucose gave the highest manganese peroxidase(MnP)activity i.e.,6.88 U/ml followed by starch,sucrose and ***,the maximum laccase activity was 44.5 U/ml in *** nitrate and L-asparagine were the best inorganic and organic nitrogen for *** the case of ligninolytic enzyme production,ammonium acetate and ammonium phosphate were the best media for LiP and MnP,whereas laccase production was highest in ammonium nitrate supplemented *** organic nitrogen sources,medium supplemented with DL-tryptophan gave the highest Lip production,whereas MnP and laccase production was observed in the medium containing L-tyrosine and *** the best of our knowledge,this is the first report related to the growth and ligninolytic enzyme production by Diaporthe *** findings from the study will assist researchers in improving the production of ligninolytic enzymes by this fungus under in vitro conditions on an industrial scale.

关键词： Hydrolytic enzymes Industrially In vitro Manganese peroxidase Morpho molecular analysis

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Availability of elements for heterogeneous catalysis: Predicting the industrial viability of novel catalysts

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Chinese Journal of Catalysis 2018年第1期39卷 16-26页

作者： Anders B. Laursen Jens Sehested ib Chorkendorff Peter C. K. Vesborg Department of Physics Technical University of DenmarkFysikvej bygn.307DK‐2800 Kgs.LyngbyDenmark Haldor Topsoe A/S Haldor Topsoe Alle 1DK乚2800 Kgs.LyngbyDenmark

Growing concern regarding the sustainability of the chemical industry has driven the developmentof more efficient catalytic ***‐generation estimates of catalyst viability are based oncrustal abundance,which has severe ***,we propose a second‐generation approachto predicting the viability of novel catalysts prior to industrial implementation to benefit the globalchemical *** this prediction,we found that a correlation exists between catalyst consumptionand the annual production or price of the catalyst element for11representative industrialcatalytic *** on this correlation,we have introduced two new descriptors for catalystviability,namely,catalyst consumption to availability ratio per annum(CCA)and consumed catalystcost to product value ratio per annum(CCP).Based on evaluations of CCA and CCP for selected industrial reactions,we have grouped catalysts from the case studies according to viability,allowing the identification of general limits of viability based on CCA and *** the CCA and CCP and their comparing with the general limits of viability provides researchers with a novel framework for evaluating whether the cost or physical availability of a new catalyst could be *** have extended this analysis to calculate the predicted limits of economically viable production and product cost for new catalysts.?2018,Dalian Institute of Chemical Physics,Chinese Academy of *** by Elsevier *** rights reserved.

关键词： Heterogeneous catalysis Industrial catalysis Sustainability Element availability Catalyst Catalyst design Element abundance Scalability

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海南岛成土母质的地形多样性分析

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土壤学报 2004年第2期41卷 170-175页

作者：张学雷陈杰张甘霖檀满枝 Juan José ibáez 中国科学院南京土壤研究所南京210008 Centrode Ciencias Medioambientales

多样性指数、多度分布模型等统计手段长时间以来在生态学领域被用于分析不同生态体的发生规律。本研究中将类似手段用于地形多样性 (作为地多样性的研究案例 )分析中 ,讨论基于海南岛土壤—地形体数字化数据库 (SOTER) ,通过对不同成土... 详细信息

多样性指数、多度分布模型等统计手段长时间以来在生态学领域被用于分析不同生态体的发生规律。本研究中将类似手段用于地形多样性 (作为地多样性的研究案例 )分析中 ,讨论基于海南岛土壤—地形体数字化数据库 (SOTER) ,通过对不同成土母质上地形类别的丰富度指数 (S)、多样性指数 (Shannon指数H′)和均匀度指数 (PielouE)的计算 ,不同成土母质上地形类别多度分布模型的建立与应用。

关键词：海南岛成土母质地形多样性丰富度指数多样性指数均匀度指数多度分布模型地理信息系统

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Fear of COVID-19 and emotional dysfunction problems:Intrusive,avoidance and hyperarousal stress as key mediators

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World Journal of Psychiatry 2022年第8期12卷 1088-1101页

作者： raquel Falcó Verónica Vidal-Arenas Jordi Ortet-Walker Juan C Marzo JoséA Piqueras PSICO-RECURSOS COVID-19 Study Group Department of Health Psychology and Center for Applied Psychology Universidad Miguel HernándezElche 03202AlicanteSpain Department of Basic and Clinical Psychology and Psychobiology Universitat Jaume ICastellóde la Plana 12071CastellónSpain

BACKGROUND There is mounting empirical evidence of the detrimental effects of the coronavirus disease 2019(COVID-19)outbreak on mental *** research has underscored the effects of similar destabilizing situations such as war,natural disasters or other pandemics on acute stress levels which have been shown to exacerbate current and future psychopathological *** To explore the role of acute stress responses(intrusive,avoidance and hyperarousal)as mediators in the association between fear of COVID-19 and emotional dysfunction-related problems:Depression,agoraphobia,panic,obsessivecompulsive,generalized anxiety,social anxiety and health anxiety *** A sample of 439 participants from a university community in Spain(age:mean±SD:36.64±13.37;73.1%females)completed several measures assessing their fear of COVID-19,acute stress responses and emotional dysfunction syndromes through an online *** collection was carried out from the start of home confinement in Spain until May 4,2020,coinciding with initial de-escalation *** of the dataset included descriptive and frequency analyses,Mann-Whitney U Test of intergroup comparisons and path analysis for direct and indirect *** is an observational,descriptive-correlational and crosssectional *** The prevalence of clinical symptoms in our sample,reported since the beginning of the pandemic,reached 31.44%.The female group presented higher scores although the effect size was ***,the participants who exceeded the clinical cut-off points in emotional problems showed higher levels of fear of COVID-19 and of cognitive,motor and psychophysiological responses of acute stress,unlike the group with normative *** addition,the results show significant mediated effects of hyperarousal stress among fear of COVID-19 and emotional dysfunction ***,the clinical syndromes most related to the consequences of the pandemic(e.g.,social contact avoi

关键词： Fear of COVID-19 Acute stress Emotional dysfunction Psychophysiological activation Mediated effects

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Challenges in estimating ancestral state reconstructions:the evolution of migration in Sylvia warblers as a study case

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Integrative Zoology 2020年第3期15卷 161-173页

作者： raquel PONTI Angel ARCONES David R.VIEITES National Museum of Natural Sciences MadridSpain Department of Evolutionary Biology Ecology and Environmental SciencesFaculty of BiologyUniversity of BarcelonaBarcelonaSpain Biodiversity Research Institute(IRBIO) University of BarcelonaBarcelonaSpain

Our current understanding of how species have evolved is mainly based on comparative phylogenetic methods,which use phylogenies to infer the evolution of *** development of ancestral state reconstruction(ASR)methods has provided the tools to reconstruct trait evolution,which are widely used in fields like evolutionary biology,macroecology and *** there are different elements involved in those analyses,with different levels of uncertainty(*** to branch length estimation,trait coding,statistical framework,taxon sampling or software),the various combinations of these elements likely have a strong impact on the reconstruction of the evolution of traits,potentially leading to opposite *** assess the impact of these different elements in ASR,we performed a set of analyses,including all possible combinations of such elements and using the evolution of migratory behavior in Sylvia warblers as a case study,which was coded as a continuous or as a discrete *** results show that taxon sampling,character coding,tree shape,statistical framework and software all significantly affect ASR,both individually and in *** all reconstructed tree nodes show discrepancies,but in the critical ones most pairwise comparisons between analyses lead to conflicting and unexpectedly antagonistic results(zero migration vs fully migratory),thus challenging interpretations of trait *** propose some possible solutions to partly inform decisions,involving the method selection and the incorporation of biological or fossil evidence regarding how traits evolve,but our results demand serious rethinking about how the research community currently uses ASR.

关键词： ancestral state reconstruction conflicting methods evolution of migration Sylvia warblers

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Atrial fibrillation in the elderly

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Journal of Geriatric Cardiology 2019年第1期16卷 49-53页

作者： Pablo Díez-Villanueva Fernando Alfonso Department of Cardiology Hospital Universitario de la Princesa

Atrial fibrillation(AF)is the most common arrhythmia in elderly population,with age being one of the most important factors involved in its *** disturbances may be present on the surface electrocardiogram before AF onset in some *** this arrhythmia is diagnosed,antithrombotic therapy is mandatory in most cases,as this is the only treatment that has demonstrated to improve *** increases both the risk of thromboembolic and bleeding complications,while benefits from anticoagulant therapy outweigh that from bleeding in most scenarios,also in very elderly ***,elderly patients with AF are often ***-vitamin K antagonist oral anticoagulants have emerged as an alternative to vitamin K antagonists,with significant less adverse events and better profile in terms of efficacy and *** conditions related to age should be carefully evaluated in these patients(including frailty,comorbidity and polypharmacy)to ensure an individualized clinical and therapeutic approach.

关键词： Atrial fibrillation Antithrombotic therapy Frailty Non-vitamin K antagonist oral anticoagulants The elderly

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Denitrification-nitrification process in permeable coastal sediments: An investigation on the effect of salinity and nitrate availability using flow-through reactors

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Acta Oceanologica Sinica 2021年第9期40卷 1-12页

作者： Shan Jiang Mark Kavanagh Juan Severino Pino ibánhez Carlos Rocha State Key Laboratory of Estuarine and Coastal Research East China Normal University School of Natural Sciences Trinity College Dublin Trinity Centre for the Environment School of Natural Sciences Trinity College Dublin Instituto de Investigacións Mari?as Consejo Superior de Investigaciones Científicas

Permeable coastal sediments act as a reactive node in the littoral zone,transforming nutrients via a wide range of biogeochemical *** rates are controlled by abiotic factors,e.g.,salinity,temperature or solute ***,a series of incubation experiments,using flow-through reactors,were conducted to simulate the biogeochemical cycling of nitrate (NO3~?) and phosphorus (P) in permeable sediments under differentNO3~?availability conditions (factor I) along a salinity gradient (admixture of river and seawater,factor II).In an oligotrophic scenario,i.e.,unamendedNO3~?concentrations in both river and seawater,sediments acted as a permanent net source ofNO3~?to the water *** peak production rate occurred at an intermediate salinity(20).IncreasingNO3~?availability in river water significantly enhanced netNO3~?removal rates within the salinity range of 0 to 30,likely via the denitrification pathway based on the sediment microbiota *** this scenario,the most active removal was obtained at salinity of *** both river and seawater were spiked with NO3~?,the highest removal rate switched to the highest salinity (36).It suggests the salinity preference of theNO3~?removal pathway by local denitrifiers (e.g.,Bacillus and Paracoccus) and thatNO3~?removal in coastal sediments can be significantly constrained by the dilution relatedNO3~?*** with the obtained variation forNO3~?reactions,permeable sediments acted as a sink of soluble reactive P in all treatments,regardless of salinity andNO3~?input concentrations,indicating a possibility of P-deficiency for coastal water from the intensive cycling in permeable ***,the net production of dissolved organic carbon (DOC) in all treatments was positively correlated with the measuredNO3~?reaction rates,indicating that the DOC supply may not be the key factor forNO3~?removal rates due to the consumption by intensive aerobic *** the intensive pr

关键词： NO − 3 production and removal flow-through reactors salinity stable isotopes permeable sediments

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