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MicroRNAs:Role in hepatitis C virus pathogenesis

Genes & Diseases 2015年第1期2卷 35-45页

作者： Shubham Shrivastava Robert Steele ranjit ray Ratna B.ray Department of Pathology Saint Louis UniversitySt.LouisMOUSA Department of Internal Medicine Saint Louis UniversitySt.LouisMOUSA

Hepatitis C virus(HCV)is a global health burden with an estimated 170e200 million peoples chronically infected *** infection remains as an independent risk factor for chronic hepatitis,liver cirrhosis,hepatocellular carcinoma,and a major reason for liver *** of direct acting antiviral(DAA)drugs have shown promising results with more than 90%success rate in clearing the HCV RNA in patients,although long-term consequences remain to be ***(miRNAs)are important players in establishment of HCV infection and target crucial host cellular factors needed for productive HCV replication and augmented cell *** expression of miRNAs is involved in the pathogenesis associated with HCV infection by controlling signaling pathways such as immune response,proliferation and *** is emerging as a means of communication between various cell types inside the *** is likely possibility of developing circulating miRNAs as biomarkers of disease progression and can also serve as diagnostic tool with potential of early therapeutic intervention in HCV associated end stage liver *** review focuses on recent studies highlighting the contribution of miRNAs in HCV life cycle and their coordinated regulation in HCV mediated liver disease progression.

关键词： Circulatory miRNAs HCV Interferon signaling Liver disease MicroRNA

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Hepatitis C virus infection and insulin resistance

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World Journal of Diabetes 2014年第1期5卷 52-58页

作者： Sandip K Bose ranjit ray Department of Molecular Microbiology and Immunology Saint Louis University Division of Infectious Diseases Allergy and ImmunologyEdward A Doisy Research Center Department of Internal Medicine Saint Louis University

Approximately 170 million people worldwide are chronically infected with hepatitis C virus(HCV).Chronic HCV infection is the leading cause for the development of liver fibrosis,cirrhosis,hepatocellular carcinoma(HCC)and is the primary cause for liver transplantation in the western *** resistance is one of the pathological features in patients with HCV infection and often leads to development of typeⅡ*** resistance plays an important role in the development of various complications associated with HCV *** evidence indicates that HCV associated insulin resistance may result in hepatic fibrosis,steatosis,HCC and resistance to anti-viral ***,HCV associated insulin resistance is a therapeutic target at any stage of HCV *** modulates normal cellular gene expression and interferes with the insulin signaling *** mechanisms have been proposed in regard to HCV mediated insulin resistance,involving up regulation of inflammatory cytokines,like tumor necrosis factor-α,phosphorylation of insulin-receptor substrate-1,Akt,up-regulation of gluconeogenic genes like glucose 6 phosphatase,phosphoenolpyruvate carboxykinase 2,and accumulation of lipid *** this review,we summarize the available information on how HCV infection interferes with insulin signaling pathways resulting in insulin resistance.

关键词： Hepatitis C virus Insulin resistance Insulin receptor substrate 1 Protein kinase B mammalian tar-get of rapamycin/S6K1 Suppressor of cytokine signal-ing 3 Glucose transporter-4 Lipid metabolism Anti-viral therapy

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