MicroRNAs:Role in hepatitis C virus pathogenesis

作     者：Shubham Shrivastava Robert Steele Ranjit Ray Ratna B.Ray 

作者机构：Department of PathologySaint Louis UniversitySt.LouisMOUSA Department of Internal MedicineSaint Louis UniversitySt.LouisMOUSA 

出 版 物：《Genes & Diseases》 (基因与疾病（英文）)

年 卷 期：2015年第2卷第1期

页      面：35-45页

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：supported by research grant DK081817(RBR)and DK080812(RR)from the National Institutes of Health and SLU Liver Center Seed Grant(RBR) 

主　　题：Circulatory miRNAs HCV Interferon signaling Liver disease MicroRNA 

摘      要：Hepatitis C virus(HCV)is a global health burden with an estimated 170e200 million peoples chronically infected *** infection remains as an independent risk factor for chronic hepatitis,liver cirrhosis,hepatocellular carcinoma,and a major reason for liver *** of direct acting antiviral(DAA)drugs have shown promising results with more than 90%success rate in clearing the HCV RNA in patients,although long-term consequences remain to be ***(miRNAs)are important players in establishment of HCV infection and target crucial host cellular factors needed for productive HCV replication and augmented cell *** expression of miRNAs is involved in the pathogenesis associated with HCV infection by controlling signaling pathways such as immune response,proliferation and *** is emerging as a means of communication between various cell types inside the *** is likely possibility of developing circulating miRNAs as biomarkers of disease progression and can also serve as diagnostic tool with potential of early therapeutic intervention in HCV associated end stage liver *** review focuses on recent studies highlighting the contribution of miRNAs in HCV life cycle and their coordinated regulation in HCV mediated liver disease progression.