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Inhibitive effect of TAK-242 on Tenon’s capsule fibroblasts proliferation in rat eyes

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International Journal of Ophthalmology(English edition) 2019年第11期12卷 1699-1707页

作者： Liang Liang Meng-Nan Zhu Bao-Ji Chen Zheng Wang Li-Ye He rang zhang Department of Ophthalmology The First College of Clinical Medical ScienceChina Three Gorges UniversityYichang 443003Hubei ProvinceChina Department of Ophthalmology Yichang Central People’s HospitalYichang 443003Hubei ProvinceChina Department of Ophthalmology Xianning Central HospitalXianning 437100Hubei ProvinceChina

AIM: To study the inhibition effect of TAK-242 on the proliferation of rat eye Tenon's capsule fibroblasts via the toll-like receptor 4(TLR4) signaling ***: SD rat Tenon's capsule fibroblasts were extracted and cultured, then the cells were divided into normal control group, lipopolysaccharide(LPS) group(10 g/m L LPS) and TAK-242 group(1 μmol/L TAK-242, and 10 μg/m L LPS after 30 min). The expressions of TLR4, transforming growth factor-β1(TGF-β1) and interleukin-6(IL-6) in each group were detected by Western blot and reverse transcriptase-polymerase chain reaction(RT-PCR). Cell proliferation was detected by cell counting kit-8(CCK-8).RESULTS: Double immunofluorescent labeling in the extracted cells showed negative keratin staining and positive vimentin staining. Western blot showed that the LPS group had the highest expression of TLR4 and TGF-β1(P0.05). RT-PCR showed that the IL-6 m RNA expression in LPS group was the highest in the three groups(P<0.01). CONCLUSION: TAK-242 inhibits the proliferation of LPSinduced Tenon's capsule fibroblasts and the release of inflammatory factors by regulating the TLR4 signalingpathway, providing a new idea for reducing the scarring of the filter passage after glaucoma filtration surgery.

关键词： Tenon's capsule fibroblasts fibrosis TAK-242 rat

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长三角快速客运网城际公共交通分担率模型

同济大学学报（自然科学版） 2008年第9期36卷 1210-1215,1240页

作者：张戎吴晓磊同济大学交通运输工程学院上海200092

分析了快速客运线投入运营后长江三角洲城际公共交通类型,设计了确定城际间合理公共交通选择枝的方法;根据影响中短途旅客出行的因素,构造了城际公共交通选择枝的广义成本函数;通过对该地区不同出行距离上的旅客进行RP(基于观察到的并... 详细信息

分析了快速客运线投入运营后长江三角洲城际公共交通类型,设计了确定城际间合理公共交通选择枝的方法;根据影响中短途旅客出行的因素,构造了城际公共交通选择枝的广义成本函数;通过对该地区不同出行距离上的旅客进行RP(基于观察到的并已发生的行为选择)及SP(在预设的假定条件下获得的被调查者的行为选择)调查,标定了出行距离别的出发地到车站、候车、在车、车站到目的地四种行为时间价值.在此基础上,运用Logit模型,预测各类城际公共交通的客流分担率.最后,分析了上海到嘉兴、杭州、宁波、南京、扬州等城市的各类城际公共交通客流分担率,验证了本模型的合理性,得出了不同出行条件下城际公共交通客流分担率的特点.

关键词：城际公共交通分担率快速客运网 Logit模型 RP/SP调查行为时间价值

Association between the Epidermal Growth Factor Gene and Intelligence in Major Depression Patients

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Chinese Medical Sciences Journal 2010年第2期25卷 105-108页

作者： Wen-min Tian Ke-rang zhang Juan zhang Yan Shen Qi Xu National Laboratory of Medical Molecular Biology Institute of Basic Medica Sciences Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100005 China Department of Psychiatry the First Hospital of Shanxi Medical University Taiyuan 030001 China

Objective To study the association between the epidermal growth factor(EGF) gene and intelligence in patients with major *** Intelligence measurement using Wechsler Adult Intelligence Scale(WAIS) was perfor-med on 120 unrelated patients with major depression and 46 control *** was collected from all subjects for extraction of genomic *** single nucleotide polymorphisms(SNPs) in the EGF gene were genotyped using polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry(MALDI-TOF-MS).Results Mean scores of both score lang and score task,two subtests in WAIS,differed significantly between major depression patients and controls(P<0.0001).Quantitative trait analysis showed that the genetype of rs2250724 was closely associated with score lang and score task in major depression *** associations were still significant after 10 000 *** Although preliminary,our results provide evidence for association between the EGF gene and intelligence in patients with major *** variation in the EGF gene may increase the susceptibility of major depression.

关键词： epidermal growth factor intelligence major depression

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跨坐式单轨车辆的临界横向力与曲线限速

铁道学报 2020年第2期42卷 50-56页

作者：张让任利惠季元进同济大学铁道与城市轨道交通研究院

在离心力的作用下,跨坐式单轨车辆走行部一侧的稳定轮减载。根据稳定轮刚刚脱离轨面这一临界状态,定义此时车体离心力为临界横向力。采用达朗贝尔原理将跨坐式单轨车辆通过曲线的动力学问题转换为静力学问题,推导出临界横向力和稳定轮... 详细信息

在离心力的作用下,跨坐式单轨车辆走行部一侧的稳定轮减载。根据稳定轮刚刚脱离轨面这一临界状态,定义此时车体离心力为临界横向力。采用达朗贝尔原理将跨坐式单轨车辆通过曲线的动力学问题转换为静力学问题,推导出临界横向力和稳定轮预压力之间的关系公式,并利用多体动力学软件UM验证了公式的准确性。依据临界横向力公式,从舒适度角度计算稳定轮预压力的合理取值,得到曲线最高限制速度和最低限制速度与稳定轮预压力、轨道梁超高率以及曲线半径之间的关系。结果表明:临界横向力与稳定轮和导向轮的预压力成线性关系;考虑运行安全性和舒适度要求,本文中车辆的稳定轮和导向轮预压力设置为7kN时,轨道梁最大超高率设置为6%比较合适。

关键词：跨坐式单轨车辆临界横向力曲线限速舒适度安全性

A Novel Method of Using Chaotic Sequences in MIMO Radar for Multiple Targets Detection

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A Novel Method of Using Chaotic Sequences in MIMO Radar for ...

Genetic Diversity of Recurrent Selection Populations with Ms2 Gene Assessed by Gliadins in Common Wheat (Triticum aestivum L.)

2012 IEEE 14th International Conference on Communication Technology

作者： Dong Shen Lin-rang zhang Xin Liu Nan Liu School of Electronic and Information Engineering Lanzhou Jiaotong UniversityLanzhouChina National Key Lab of Radar Signal Processing Xidian University

ISBN: (纸本)9781467321006

Based on the sensitive dependence on initial conditions and good auto-correlation of chaotic sequences,a method is proposed to increase the resolution of multiple-input multiple-output （MIMO） radar for multiple targets detection with chaotic *** waveform set can be generated by chaotic sequences from different initial *** is uncorrelated between auto-correlation sidelobes of different chaotic waveforms,at the same time,it is uncorrelated between cross-correlation of different chaotic waveforms ***,multiple pulse compression accumulation can help to reduce auto-correlation sidelobes and cross-correlation effects in MIMO radar effectively,the output has low peak sidelobe value and the resolution of multiple targets detection is ***,simulation results show the effectiveness of this method.

关键词： MIMO radar chaos multiple targets detection waveform design

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Agricultural Sciences in China 2010年第5期9卷 615-625页

作者： JIANG Hui, GAO Qing-rong, LI Luo-jiang, KONG Ling-rang, zhang Wei-dong, WU Shi-wen and YANG Ya-li State Key Laboratory of Crop Biology, Department of Agronomy, Shandong Agricultural University, Tai’an 271018, P.R.China [a] State Key Laboratory of Crop Biology Department of Agronomy Shandong Agricultural University Tai'an 271018 P.R.China

The male-sterile lines with Ms2 gene were highly evaluated in recurrent selection in wheat （Triticum aestivum L.）. Three populations C6 （population after six cycles of selection）, C7 （population after seven cycles of selection）, and C8 （population after eight cycles of selection） were constructed through recurrent selection with 12 parental materials （P）. Acid polyacrymide gel electrophoresis （A-PAGE） analysis was used to identify gliadin patterns and evaluate the genetic diversity in 12 parents and three populations. A total of 63 bands were identified, of which 17 polymorphic bands and 7 unique bands were present in populations and seven polymorphic bands and four unique bands were present in parents. The number of polymorphic and unique bands decreased gradually from C6 to C8, especially for to- and y-gliadins. The genetic distances in C6, C7, and C8 were calculated. The distributions of genetic distance were different in three recurrent selection populations. From C6 to C8, the genetic distance was 0.2687, 0.2652 and 0.1987, respectively. Statistically significant differences were detected between C7 and C8 with the T value of 37.9718. The result of cluster analysis based on genetic similarity matrix of three populations fitted well to those of principle coordinates analysis （PCoA）. Compared with 12 parents, almost all individuals of three populations are new genotypes. Most of the individuals from C6 and C7 could be divided into two groups, while most individuals of C8 were in one cluster. In conclusion, the results indicated that the genetic diversity was decreased severely according to the information revealed by A-PAGE, although some variations could be created in the recurrent selection. It was necessary to introduce diverse germplasm based on the genetic database of recurrent population to maintain and improve the breeding efficiency in the further program.

关键词： genetic diversity recurrent selection gliadins Ms2 gene Triticum aestivum L

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基于单片机的自动化炊事锅监控系统研发

武汉理工大学学报 2008年第2期30卷 146-148,164页

作者：张让莘山东交通职业学院机械系潍坊261206

介绍了全自动电加热炊具监控系统的硬软件的设计开发过程。针对传统炊事器具存在的不足和诸多安全隐患,提出合理的解决方案。然后,以AT89C52单片机为核心,采用嵌入式系统的设计方法与计算机测控技术,实现了全方位、多层次的安全监测和... 详细信息

介绍了全自动电加热炊具监控系统的硬软件的设计开发过程。针对传统炊事器具存在的不足和诸多安全隐患,提出合理的解决方案。然后,以AT89C52单片机为核心,采用嵌入式系统的设计方法与计算机测控技术,实现了全方位、多层次的安全监测和控制体系,形成了一套全自动电加热炊具设计的实用方法。

关键词：电炊锅单片机自动监控

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汽车流动真空环保厕所系统设计

武汉理工大学学报 2008年第4期30卷 142-145页

作者：张让莘山东交通职业学院机械系潍坊261206

在对传统重力冲水而厕所与真空环保厕所进行比较的基础上,提出了汽车真空环保厕所系统的设计方案及构成。汽车流动真空环保厕所主要由汽车移动系统、真空便器系统、真空纳污系统和控制系统组成。详细介绍了各组成部分的主要零部件的功能... 详细信息

在对传统重力冲水而厕所与真空环保厕所进行比较的基础上,提出了汽车真空环保厕所系统的设计方案及构成。汽车流动真空环保厕所主要由汽车移动系统、真空便器系统、真空纳污系统和控制系统组成。详细介绍了各组成部分的主要零部件的功能,同时提出了设计要点及安装调试的关键。通过对样机的试用和性能检测表明,所研制的汽车流动真空环保厕所是一种结构新颖、节水降耗、卫生安全、使用方便、工艺简单的环保设备。

关键词：汽车真空环保厕所设计

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医院药学服务品牌的设计与传播

现代医院 2008年第5期8卷 113-114页

作者：章蓉深圳职业技术学院广东深圳518055

品牌营销是医院管理的重要环节,在此过程中,医院不仅要宣传医学优势,还要将药学服务等方面作为品牌的有机组成部分,构筑完善的医院品牌价值体系。从医院的核心健康服务特色出发,通过SWOT分析,对每一项药学服务功能进行系统整合,是进行... 详细信息

品牌营销是医院管理的重要环节,在此过程中,医院不仅要宣传医学优势,还要将药学服务等方面作为品牌的有机组成部分,构筑完善的医院品牌价值体系。从医院的核心健康服务特色出发,通过SWOT分析,对每一项药学服务功能进行系统整合,是进行药学服务品牌功能价值设计的重要方法;将所有可能与病患者接触的场所和过程当作一个传播载体进行整体规划,通过就医接触、社区等多种途径传播,有利于提高公众对药学服务功能的认知。

关键词：药学服务服务品牌品牌管理品牌营销