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Two-Stent Strategy for Bifurcation Lesions in Percutaneous Transluminal Coronary Angioplasty: Real-World Evidence

World Journal of Cardiovascular Diseases 2024年第3期14卷 140-156页

作者： Dilip Kumar Amit Malviya Animesh Mishra Rabin Chakraborty Sanjeev S. Mukherjee Soumya Patra Arindam Pande rana Rathor Roy Debopriyo Mondal Ashesh Halder Sumit Shanker Medica Superspecialty Hospital 127 Eastern Metropolitan Bypass Nitai Nagar Mukundapur Kolkata West Bengal India North Eastern Indira Gandhi Regional Institute of Health & Medical Sciences (NEIGRIHMS) Mawdiangdiang Shillong Meghalaya India

Background: Bifurcation lesions pose a high risk for adverse events after percutaneous coronary intervention (PCI). Evidence supporting the benefits of the two-stent strategy (2SS) for treating coronary bifurcation lesions in India is limited. This study aimed to evaluate the clinical outcomes of various 2SSs for percutaneous transluminal coronary angioplasty for bifurcation lesions in India. Materials and Methods: This retrospective, observational, multicentric, real-world study included 64 patients over 8 years. Data on demographics, medical history, PCI procedures, and outcomes were recorded. Descriptive statistics were computed using the SPSS software. Results: Patients (n = 64) had an average age of 65.3 ± 11.1 years, with 78.1% males. Acute coronary syndrome was reported in 18.8%, chronic stable angina in 40.6%, and unstable angina in 34.4% of participants. Two-vessel disease was observed in 98.4% of patients, and 99.4% had true bifurcation lesions. The commonly involved vessels were the left anterior descending artery (50%), left circumflex coronary artery (34.4%), and first diagonal artery (43.8%). Mean percent diameter stenosis was 87.2% ± 10.1%. The mean number of stents used was 2.00 ± 0.34. The 2SS techniques included the T and small protrusion (TAP) (39.1%), double kissing (DK) crush (18.8%), and the culotte techniques (14.1%). Procedural and angiographic success rate was 92.18%. Major adverse cardiovascular events at 1-year follow-up occurred in 7.8% of cases. Conclusion: The 2SS for bifurcation lesions showed favorable in-hospital and follow-up outcomes. Findings can serve as a resource for bifurcation angioplasty in India. Larger real-world studies with robust methodology are needed to validate these results.

关键词： Bifurcation Stenting Coronary Bifurcation Lesions Percutaneous

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Focus on current and emerging treatment options for glioma:A comprehensive review

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World Journal of Clinical Oncology 2024年第4期15卷 482-495页

作者： Brandon Lucke-Wold Burhanuddin Sohail Rangwala Muhammad Ashir Shafique Mohammad Arham Siddiq Muhammad Saqlain Mustafa Fnu Danish rana Muhammad Umer Nasrullah Noor Zainab Abdul Haseeb Department of Neurosurgery University of FloridaGainesvilleFL 32608United States Department of Neurosurgery Jinnah Sindh Medical UniversityKarachi 75510Pakistan Department of Neurosurgery Army Medical CollegeRawalpindi 46000Pakistan

This comprehensive review delves into the current updates and challenges associated with the management of low-grade gliomas(LGG),the predominant primary tumors in the central nervous *** a general incidence rate of 5.81 per 100000,gliomas pose a significant global concern,necessitating advancements in treatment techniques to reduce mortality and *** review places a particular focus on immunotherapies,discussing promising agents such as Zotiraciclib and ***,a CDK9 inhibitor,has demonstrated efficacy in glioblastoma treatment in preclinical and clinical studies,showing its potential as a therapeutic ***,a viral immunotherapy,induces inflammation in glioblastoma and displays positive outcomes in both adult and pediatric *** of immunotherapy extends to Pembrolizumab,Nivolumab,and Entrectinib,revealing the challenges and variabilities in patient *** promising preclinical data,the monoclonal antibody Depatuxizumab has proven ineffective in glioblastoma treatment,emphasizing the critical need to understand resistance *** review also covers the success of radiation therapy in pediatric LGG,with evolving techniques,such as proton therapy,showing potential improvements in patient quality of *** treatment is discussed in the context of achieving a balance between preserving the patient’s quality of life and attaining gross total resection,with the extent of surgical resection significantly influencing the survival *** addition to advancements in cancer vaccine development,this review highlights the evolving landscape of LGG treatment,emphasizing a shift toward personalized and targeted *** research is essential for refining strategies and enhancing outcomes in the management of LGG.

关键词： Low-grade gliomas Monoclonal antibody Lerapolturev Glioblastoma CDK9 inhibitor

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基于BSG深度学习模型的中医药智能问答系统研究:以方剂和中药为例

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Digital Chinese Medicine 2024年第1期7卷 47-55页

作者：李冉任高晏峻峰邹北骥刘青萍湖南中医药大学信息科学与工程学院湖南长沙410208 中南大学计算机学院湖南长沙410083

目的基于深度学习的方法,利用知识图谱构建中医药知识库,探寻联合模型在中医药智能问答系统的应用。方法以《方剂学》和《中药学》规划教材为基础建立知识图谱,作为智能问答系统的知识来源,本研究提出一种BERT+Slot-Gated(BSG)深度学习... 详细信息

目的基于深度学习的方法,利用知识图谱构建中医药知识库,探寻联合模型在中医药智能问答系统的应用。方法以《方剂学》和《中药学》规划教材为基础建立知识图谱,作为智能问答系统的知识来源,本研究提出一种BERT+Slot-Gated(BSG)深度学习模型,获取用户自然问题中包含的中医药实体和问句意图,通过实体和意图在知识图谱检索答案返回给用户,运用Flask框架和BSG模型研发中医药智能问答系统。结果构建了包含3149个实体和6891个关系三元组的中医药知识图谱,通过问题语料测试,本系统在回答中医药20类问题的实体识别F1值为0.9969,意图识别准确率为99.75%,表明本系统具有较高的实用性和可行性,并通过微信公众号平台实现了用户与系统交互。结论本文所提出的BSG模型通过提高向量维度在实验中取得了较好的结果,表明联合模型方法的有效性,可为实现中医药智能问答系统提供新的研究思路。

关键词：中医药深度学习知识图谱智能问答系统 BERT+Slot-Gated模型

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多维广义朗之万方程的解析精确解

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曲阜师范大学学报（自然科学版） 2024年第4期50卷 95-98页

作者： Mushtaq rana Imran 王春阳支世超赵曾轩鲁东大学物理与光电工程学院山东省烟台市264039

采用拉普拉斯变换和矩阵运算相结合的方法解析求解了多维朗之万方程,并将所得结果与已有的二维解析研究进行了比较,验证了该方法的可行性和正确性,为将来在理论上使用多维朗之万方程研究复合核的形变等复杂随机问题奠定了基础.

关键词：矩阵拉普拉斯变换多维广义朗之万方程

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Exploring the Prevalence and Contributing Factors of Depression among Sickle Cell Anemia Patients in Saudi Arabia’s Jazan Region

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International Journal of Mental Health Promotion 2024年第5期26卷 351-359页

作者： Abdullah A.Alharbi Ahmad Y.Alqassim Mohammed A.Muaddi Najat H.Aldubayyan rana I.Abuhadi Futon A.Akoor Sarah J.Mobarki Imtenan A.Oberi Ghaidaa H.Alharbi Yara Ajeebi Adnan M.Alkhayat Hafiz Malhan Mohammed Bakkar Anwar M.Makeen Family and Community Medicine Department Faculty of MedicineJazan UniversityJazan45142Saudi Arabia Laboratory Department King Fahd Central HospitalMinistry of HealthJazan45142Saudi Arabia Internal Medicine Department Prince Mohammad bin Nasser HospitalMinistry of HealthJazan45142Saudi Arabia Hematology Department King AbdulAziz Medical City for National GuardRiyadh11426Saudi Arabia

Sickle Cell Anemia(SCA)is a prevalent genetic condition in Saudi Arabia,particularly in the Jazan *** study’s purpose was to assess the prevalence of de-pression among individuals with SCA in this area and to identify the factors associated with this *** study involved 391 adult participants,all patients in the hematology center of Prince Mohammed bin Nasser Hospital(PMNH).Data was collected through an anonymous interview questionnaire–the Arabic version of the Patient Health Questionnaire-9(PHQ-9)–between March–May *** questionnaire covered socio-demographic information and variables related to the participant’s SCA history,such as pain levels,frequency of pain,hospitalization duration,and frequency of blood *** variables underwent Chi-square and One-way ANOVA testing,followed by multivariate *** study found a 42%prevalence of depression among the SCA *** significantly linked with heightened depression levels included being widowed or divorced,experiencing frequent and severe pain,and longer duration of hospital *** educational level of at least a bachelor’s degree was also a significant *** study reveals a high prevalence of depression among SCA patients in the Jazan *** underscores the need for policymakers to educate both physicians and patients about the importance of mental health in SCA *** study also highlights the need for more research into the specific causes and effects of depressive symptoms in SCA patients to inform the creation of effective management plans.

关键词： Sickle cell anemia prevalence depression public health policy Jazan region Saudi Arabia

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Etchability of Latent Fission Fragment Tracks in CR-39

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Chinese Physics Letters 2007年第11期24卷 3107-3110页

作者： Mukhtar Ahmed rana Physics Division Directorate of Science PINSTECH P.O. Nilore Islamabad Pakistan

We report the chemical etching behaviour of the CR-39 polymer detector exposed to fission fragments of 252Cf describing etchability of latent tracks, which are like nanocylinders. The fission fragment exposed detectors were etched in 1-7 N NaOH water solutions at temperatures 50-80℃ for 45 min in the case of track length and 180 min in the case of track diameter measurements. The reduced etch rate S （called here etchability） is determined using experimental results for all etching conditions and the etching conditions with the highest reduced etch are obtained. Physics and energetics of bulk and track etching are discussed. Possible effects causing spurious changes in determination of activation energy of etching are investigated.

关键词： coated conductor buffer layer self-epitaxy CeO2

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基于蜂窝网络的D2D通信中的资源管理

基于蜂窝网络的D2D通信中的资源管理

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作者： rana zeeshan Ahmad 西安电子科技大学

学位级别：硕士

设备到设备(D2D)通信是指终端设备之间的直接通信,无需eNB传输,被认为是下一代无线通信的关键技术之一。该技术的“直接短距离”通信功能不仅可以节省频谱资源,而且可以减少传输延迟,降低功耗,提高传输速率。有效的资源管理是保证这些... 详细信息

设备到设备(D2D)通信是指终端设备之间的直接通信,无需eNB传输,被认为是下一代无线通信的关键技术之一。该技术的“直接短距离”通信功能不仅可以节省频谱资源,而且可以减少传输延迟,降低功耗,提高传输速率。有效的资源管理是保证这些优势获得的关键。本文主要研究通过博弈论实现D2D通信中的资源管理,论文的主要工作如下。1.提出了基于非合作博弈论的联合功率和资源分配方案。通过对蜂窝用户和D2D用户进行适当的功率控制,可以减少干扰,以便有效地分配资源块。文中利用非合作博弈来解决资源分配问题。在此博弈模型中,eNB被视为卖家,D2D对被视为需要这些资源进行通信的购买者,并且需要有偿获取这些资源。D2D在复用资源过程中会引入干扰,通过D2D功率的调节,使D2D用户引起的干扰可降低在定义的干扰阈值下。通过使买家的收益最大化,计算其最佳传输功率后,卖家通过使其效益最大化来决定如何复用资源。在此场景中,一个D2D对一次只能与一个蜂窝用户共享资源,同样,一个蜂窝用户一次只能与一个D2D共享资源。结果表明,该方案可以为D2D用户分配较佳传输功率,在最小化干扰的情况下,提高系统容量。2.提出了同时进行了上行传输模式和下行传输模式下D2D通信的资源分配,允许D2D用户在上行传输模式或下行传输模式下与一个蜂窝用户共享资源。在确保蜂窝用户和D2D用户的基本数据速率要求的同时,最大限度地提高系统的整体数据速率,提出了一种功率控制和频率复用方案。文中通过将功率优化和频率复用分解为两个子优化问题,并通过迭代实现资源分配。首先,通过解决非线性优化问题为D2D用户和蜂窝用户找到一组最佳功率,D2D用户将在上行链路或下行链路中共享蜂窝资源。然后通过匹配方法实现D2D用户与可用蜂窝用户间资源共享,使用最大匹配算法来最大化系统的整体数据速率。仿真结果表明,所提算法与单独复用上行或下行方法相比可以提高系统的吞吐量。

关键词： D2D 干扰缓解资源复用蜂窝网络功率控制

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The Effect of Wastewater Treatment Plants on Retainment of Plastic Microparticles to Enhance Water Quality—A Review

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Journal of Environmental Protection 2021年第3期12卷 161-195页

作者： rana zeeshan Habib Ruwaya Al Kendi Thies Thiemann Department of Biology College of Science United Arab Emirates University Al Ain United Arab Emirates Department of Chemistry College of Science United Arab Emirates University Al Ain United Arab Emirates

Microplastics, plastic pieces of ≤5 mm in size, are ubiquitous in ther environment and can be found in both terrestrial and aquatic ecosystems. This manuscript reviews the literature on the fate of microplastics in w... 详细信息

关键词： Microplastics Nanoplastics Wastewater Treatment Plants Sludge Treatment Plastic Retainment

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Planar Channelling Criticalities of MeV Protons in Si Crystal： Simulations, Evaluation and Applications

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Chinese Physics Letters 2008年第10期25卷 3724-3727页

作者： Mukhtar Ahmed rana Methodology Applications Initiative Physics Division PINSTECH Post Office Nilore Islamabad Pakistan

We reports a phase-space structure of MeV proton beam planar channelled along {110} planes in Si crystal using simulation results with the help of a computer code FLUX. The aim is to understand channelling conditions suitable for disorder measurement in crystals. Phase-space distribution of a planar channelled proton beam evolutes in a systematic fashion when it travels into the crystal. Planar channelled beam oscillates between phase-like and space-like conditions in which a part of the beam becomes under phase and space criticalities. These criticality conditions in planar channelling are analysed, explained and discussed with the perspective of defect measurement in crystals.

关键词： the power-law exponents precipitation durative abrupt precipitation change

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Formation of Charged Particle Tracks in Solids

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Chinese Physics Letters 2006年第6期23卷 1448-1451页

作者： Mukhtar A. rana Physics Research Division PINSTECH PO Nilore Islamabad Pakistan

A criterion for formation of etchable tracks in solids is suggested using the well-known concepts of ionization and thermal spikes, diffusion process with useful and justified assumptions, and present or published experimental and theoretical investigations on the same subject. The suggested criterion is useful for a wide spectrum of researchers including development and applications of track recording materials, ions implantation, sputtering and other areas, which include interactions of charged particles with solids.

关键词： RADIATION-DAMAGE ACTIVATION-ENERGY AUGER ELECTRONS CR-39 DETECTORS

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