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Sickle cell nephropathy:A review of novel biomarkers and their potential roles in early detection of renal involvement

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World Journal of Clinical Pediatrics 2022年第1期11卷 14-26页

作者： Osama Y Safdar rana m baghdadi Sereen A Alahmadi Bana E Fakieh Amaal m Algaydi of Pediatric King Abdulaziz UniversityJEDDAH 21414Saudi Arabia College of medicine King Abdulaziz UniversityJEDDAH 21422Saudi Arabia

Whether the underlying mutations are homozygous,heterozygous,or coinherited with other hemoglobinopathies,sickle cell disease is known to afflict the kidneys,leading to the clinical entity known as sickle cell nephropathy(SCN).Although common,SCN remains diagnostically *** studies performed in the context of renal disorders often fail to detect early stage *** makes the quest for early diagnosis and treatment more challenging,and it increases the burden of chronic kidney disease-related morbidity among *** diagnostic tools have been employed to overcome this *** this study,we discuss various biomarkers of SCN,including those employed in clinical practice and others recently identified in experimental settings,such as markers of vascular injury,endothelial dysfunction,tubulo-glomerular damage,and oxidative *** include kidney injury molecule-1,monocyte chemoattractant protein-1,N-acetyl-B-D-glucosaminidase,ceruloplasmin,orosomucoid,nephrin,and cation channels,among ***,we explore the potential of novel biomarkers for refining diagnostic and therapeutic approaches and describe some obstacles that still need to be *** highlight the importance of a collaborative approach to standardize the use of promising new ***,we outline the limitations of conventional markers of renal damage as extensions of the pathogenic process occurring at the level of the organ and its functional subunits,with a discussion of the expected pattern of clinical and biochemical progression among patients with SCN.

关键词： Sickle cell disease Sickle cell nephropathy Chronic kidney disease Kidney injury molecule-1 monocyte chemoattractant protein-1 N-acetyl-B-D-glucosaminidase

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Unraveling the nature of sensing in electrostatic mEmS gas sensors

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microsystems & Nanoengineering 2024年第3期10卷 109-117页

作者： Yasser S.Shama Sasan Rahmanian Hamza mouharrar rana Abdelrahman Alaaeldin Elhady Eihab m.Abdel-Rahman Systems Design Engineering University of Waterloo200 University Ave WWaterloo N2L 3G1 ONCanada mechanical Engineering Benha Faculty of EngineeringBenha UniversityBenha 13511Egypt

This paper investigates the fundamental sensing mechanism of electrostatic mEmS gas *** compares among the responsivities of a set of mEmS isopropanol sensors before and after functionalization,and in the presence and absence of electrostatic fields when operated in static and dynamic detection *** the static mode,we found that the sensors do not exhibit a measurable change in displacement due to added *** the other hand,bare sensors showed a clear change in displacement in response to isopropanol *** the dynamic mode,functionalized sensors showed a measurable frequency shift due to the added mass of isopropanol *** the presence of strong electrostatic fields,the measured frequency shift was found to be threefold larger than that in their absence in response to the same concentration of isopropanol *** enhanced responsivity of dynamic detection allows the sensors to measure the vapor mass captured by the functional material,which is not the case for static *** detection of isopropanol by bare sensors in static mode shows that change in the medium permittivity is the primary sensing *** enhanced responsivity of dynamic mode sensors when operated in strong electrostatic fields shows that their sensing mechanism is a combination of a weaker added mass effect and a stronger permittivity *** findings show that electrostatic mEmS gas sensors are independent of the direction of the gravitational field and are,thus,robust to changes in *** is erroneous to refer to them as‘gravimetric’sensors.

关键词： mechanism electrostatic measurable

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Gradient Optimizer Algorithm with Hybrid Deep Learning Based Failure Detection and Classification in the Industrial Environment

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Computer modeling in Engineering & Sciences 2024年第2期138卷 1341-1364页

作者： mohamed Zarouan Ibrahim m.mehedi Shaikh Abdul Latif md.masud rana Department of Electrical and Computer Engineering(ECE) King Abdulaziz UniversityJeddah21589Saudi Arabia Center of Excellence in Intelligent Engineering Systems(CEIES) King Abdulaziz UniversityJeddah21589Saudi Arabia Department of Nuclear Engineering King Abdulaziz UniversityJeddah21589Saudi Arabia Department of Electrical and Electronic Engineering Rajshahi University of Engineering and TechnologyRajshahiBangladesh

Failure detection is an essential task in industrial systems for preventing costly downtime and ensuring the seamlessoperation of the system. Current industrial processes are getting smarter with the emergence of Industry ***, various modernized industrial processes have been equipped with quite a few sensors to collectprocess-based data to find faults arising or prevailing in processes along with monitoring the status of *** diagnosis of rotating machines serves a main role in the engineering field and industrial production. Dueto the disadvantages of existing fault, diagnosis approaches, which greatly depend on professional experienceand human knowledge, intellectual fault diagnosis based on deep learning (DL) has attracted the researcher’sinterest. DL reaches the desired fault classification and automatic feature learning. Therefore, this article designs a Gradient Optimizer Algorithm with Hybrid Deep Learning-based Failure Detection and Classification (GOAHDLFDC)in the industrial environment. The presented GOAHDL-FDC technique initially applies continuous wavelettransform (CWT) for preprocessing the actual vibrational signals of the rotating machinery. Next, the residualnetwork (ResNet18) model was exploited for the extraction of features from the vibration signals which are thenfed into theHDLmodel for automated fault detection. Finally, theGOA-based hyperparameter tuning is performedtoadjust the parameter valuesof theHDLmodel *** experimental result analysis of the GOAHDL-FD Calgorithm takes place using a series of simulations and the experimentation outcomes highlight the better resultsof the GOAHDL-FDC technique under different aspects.

关键词： Fault detection Industry 4.0 gradient optimizer algorithm deep learning rotating machineries artificial intelligence

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Assessment of Online Transgender Healthcare Teaching modules for Internal medicine Residents and Fellows

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Open Journal of Internal medicine 2024年第2期14卷 259-268页

作者： Elizabeth m. Lamos rana malek Department of medicine University of Maryland School of Medicine Baltimore MD USA

Background: Transgender healthcare is not a formal learning requirement in Internal medicine residency or fellowship. The National LGBTQ Task Force appealed to urgently train clinicians on the effective care of transgender patients. Few studies address the successful implementation of transgender healthcare teaching and education in graduate medical education. Purpose: The purpose was to design an online asynchronous curriculum to address the need for improved transgender healthcare education in graduate medical education and assess change in knowledge and comfort in transgender healthcare for residents and fellow learners. methods: A 6-module curriculum was developed using established guidelines and ACGmE competencies as a framework for content. To assess curriculum effectiveness, participants received anonymous pre- and post-curriculum surveys which included a multiple-choice knowledge assessment, Likert scale comfort questions focusing on healthcare skills, and open-ended feedback questions. Results: Twenty-six internal medicine residents and fellows participated in the curriculum (2022-2023). There was a 69% post-survey response rate. Participants improved their gender-affirming knowledge after completing the curriculum (p Conclusion: This online curriculum was successful in increasing knowledge and comfort in transgender care for Im residents and fellows. It provides a promising framework to address this gap in curricular content.

关键词： Education Fellow Resident Transgender

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Enhancing cotton resilience to challenging climates through genetic modifications

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Journal of Cotton Research 2024年第2期7卷 196-206页

作者： AHmED Ali Ijaz KHAN Azeem Iqbal NEGm mohamed A.m. IQBAL Rida AZHAR muhammad Tehseen KHAN Sultan Habibullah rana Iqrar Ahmad Department of Plant Breeding and Genetics University of AgricultureFaisalabadFaisalabad 38000Pakistan Cotton Research Institute-Giza GizaEgypt Centre for Advanced Studies in Agriculture and Food Security University of AgricultureFaisalabadFaisalabad 38000Pakistan Centre of Agricultural Biochemistry and Biotechnology University of AgricultureFaisalabadFaisalabad 38000Pakistan School of Agriculture Sciences Zhengzhou UniversityZhengzhou 450000China

Cotton is one of the most important fiber crops that plays a vital role in the textile *** production has been unstable over the years due to climate change induced biotic stresses such as insects,diseases,and weeds,as well as abiotic stresses including drought,salinity,heat,and *** breeding methods have been used to breed climate resilient cotton,but it requires a considerable amount of time to enhance crop tolerance to insect pests and changing climatic conditions.A promising strategy for improving tolerance against these stresses is genetic *** review article discusses the role of genetic engineering in cotton *** essential concepts and techniques include genome editing via clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein 9(CRISPR-Cas9),overexpression of target genes,downregulation using RNA interference(RNAi),and virus-induced gene silencing(VIGS).Notably,the Agrobacterium-mediated transformation has made significant contributions to using these techniques for obtaining stable transgenic plants.

关键词： Cotton Genome editing Drought Salinity Heat

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Exploring the Prevalence and Contributing Factors of Depression among Sickle Cell Anemia Patients in Saudi Arabia’s Jazan Region

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International Journal of mental Health Promotion 2024年第5期26卷 351-359页

作者： Abdullah A.Alharbi Ahmad Y.Alqassim mohammed A.muaddi Najat H.Aldubayyan rana I.Abuhadi Futon A.Akoor Sarah J.mobarki Imtenan A.Oberi Ghaidaa H.Alharbi Yara Ajeebi Adnan m.Alkhayat Hafiz malhan mohammed Bakkar Anwar m.makeen Family and Community medicine Department Faculty of MedicineJazan UniversityJazan45142Saudi Arabia Laboratory Department King Fahd Central HospitalMinistry of HealthJazan45142Saudi Arabia Internal medicine Department Prince Mohammad bin Nasser HospitalMinistry of HealthJazan45142Saudi Arabia Hematology Department King AbdulAziz Medical City for National GuardRiyadh11426Saudi Arabia

Sickle Cell Anemia(SCA)is a prevalent genetic condition in Saudi Arabia,particularly in the Jazan *** study’s purpose was to assess the prevalence of de-pression among individuals with SCA in this area and to identify the factors associated with this *** study involved 391 adult participants,all patients in the hematology center of Prince mohammed bin Nasser Hospital(PmNH).Data was collected through an anonymous interview questionnaire–the Arabic version of the Patient Health Questionnaire-9(PHQ-9)–between march–may *** questionnaire covered socio-demographic information and variables related to the participant’s SCA history,such as pain levels,frequency of pain,hospitalization duration,and frequency of blood *** variables underwent Chi-square and One-way ANOVA testing,followed by multivariate *** study found a 42%prevalence of depression among the SCA *** significantly linked with heightened depression levels included being widowed or divorced,experiencing frequent and severe pain,and longer duration of hospital *** educational level of at least a bachelor’s degree was also a significant *** study reveals a high prevalence of depression among SCA patients in the Jazan *** underscores the need for policymakers to educate both physicians and patients about the importance of mental health in SCA *** study also highlights the need for more research into the specific causes and effects of depressive symptoms in SCA patients to inform the creation of effective management plans.

关键词： Sickle cell anemia prevalence depression public health policy Jazan region Saudi Arabia

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Fallopian tube assessment of the peristaltic-ciliary flow of a linearly viscous fluid in a finite narrow tube

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Applied mathematics and mechanics(English Edition) 2018年第3期39卷 437-454页

作者： H.ASHRAF A.m.SIDDIQUI m.A.rana Department of mathematics and Statistics Riphah International University Department of mathematics York CampusPennsylvania State University

The present theoretical assessment deals with the peristaltic-ciliary trans- port of a developing embryo within a fallopian tubal fluid in the human fallopian tube. A mathematical model of peristalsis-cilia induced flow of a linearly viscous fluid within a fallopian tubal fluid in a finite two-dimensional narrow tube is developed. The lubrica- tion approximation theory is used to solve the resulting partial differential equation. The expressions for axial and radial velocities, pressure gradient, stream function, volume flow rate, and time mean volume flow rate are derived. Numerical integration is performed for the appropriate residue time over the wavelength and the pressure difference over the wavelength. moreover, the plots of axial velocity, the appropriate residue time over wavelength, the vector, the pressure difference over wavelength, and the streamlines are displayed and discussed for emerging parameters and constants. Salient features of the pumping characteristics and the trapping phenomenon are discussed in detail. Yhrther- more, a comparison between the peristaltic flow and the peristaltic-ciliary flow is made as the special case. Relevance of the current results to the transport of a developing embryo within a fallopian tubal fluid from ampulla to the intramural in the fallopian tube is also explored. It reveals the fact that cilia along with peristalsis helps to complete the required mitotic divisions while transporting the developing embryo within a fallopian tubal fluid in the human fallopian tube.

关键词： peristaltic-ciliary flow linearly viscous fluid analytic solution human fal-lopian tube

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Bulk etch rates of CR-39 at high etchant concentrations:diffusionlimited etching

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Nuclear Science and Techniques 2020年第12期31卷 41-49页

作者： E.m.Awad m.A.rana mushtaq Abed Al-Jubbori Physics Department Faculty of ScienceMenoufia UniversityShebin El-KoomMenoufia 32511Egypt mERADD Instrumentation Control and Computer Complex(ICCC)PARAS Building18-KM Multan RoadP.O.ChungLahorePakistan Department of Physics College of Education for Pure SciencesUniversity of MosulMosul 41001Iraq

Systematic CR-39 bulk etching experiments were conducted over a wide range of concentrations(2–30 N)of NaOH-based *** analysis and a deep discussion of the results are presented.A comprehensive nuclear track chemical etching data bank was *** regimes of CR-39 bulk etching were *** I spans etchant concentrations from 2 to 12 *** II spans concentrations from 12 to 25 *** call this the dynamic bulk etching *** III is for concentrations greater than 25 *** this regime,the bulk etch rate is saturated with respect to the etchant *** classification is discussed and *** role of ethanol in NaOH-based etchants is explored and discussed.A parameter called the “reduced bulk etch rate” is defined here,which helps in analyzing the dependence of bulk etching on the amount of ethanol in the *** bulk etch rate shows a natural logarithmic dependence on the density of ethanol in the etchant.

关键词： CR-39 detector Ethanol Bulk etch rate Reduced bulk etch rate Diffusion-limited etching Concentration-limited etching

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microstructural evolution,dislocation density and tensile properties of Al–6.5Si–2.1Cu–0.35mg alloy produced by different casting processes

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Journal of materials Science & Technology 2021年第36期95卷 145-157页

作者： S.Samat m.Z.Omar A.H.baghdadi I.F.mohamed A.Rajabi A.m.Aziz Department of mechanical and manufacturing Engineering Faculty of Engineering and Built EnvironmentUniversiti Kebangsaan MalaysiaBangiUKM 43600Malaysia

Al–Si–Cu–mg foundry alloys are used in casting process ***,their strength properties remain low due to their microstructural characteristics and *** this work,the microstructural characteristics,dislocation densities,and mechanical properties of Al–Si–Cu–mg cast alloys prepared through different casting methods were studied *** casting processes,namely,gravity casting(GC),rheocasting(RC),thixoforming(Thixo),and Thixo with heat treatment,were *** GC and RC samples had mainly dendriticα-Al phase microstructures and exhibited coarse Si particles and intermetallic compounds in their interdendritic *** contrast,the Thixo and heat-treated Thixo(HT-Thixo)samples exhibited microstructural refinement with uniformly distributedα-Al globules,fine fibrous Si particles,and fragmented intermetallic compounds amongα-Al *** accumulation of dislocation densities increased in the Thixo sample as the strain was increased due to plastic ***,the ultimate tensile strength and yield strength of the HT-Thixo sample increased by 87%and 63%,respectively,relative to those of the GC *** cleavage fracture displayed by the GC and RC samples led to brittle ***,the Thixo and HT-Thixo samples presented dimple-based ductile fracture.

关键词： Al–Si–Cu–mg alloy Thixoforming microstructure mechanical property Dislocation density

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A Variant of the Classical Von Kármán Flow for a Couple Stress Fluid

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Chinese Physics Letters 2012年第8期29卷 164-167页

作者： A.A.Farooq A.m.Siddiqui m.A.rana T.Haroon Department of mathematics COMSATS University of Science and TechnologyAbbottabadPakistan Department of mathematics York CampusPennsylvania State UniversityYorkPA 17403USA Department of Basic Sciences Riphah International UniversityIslamabadPakistan Department of mathematics COMSATS University of Science and TechnologyIslamabadPakistan

We present an attempt to study the influence of couple stresses on the flow induced by an infinite disk rotating with a constant angular *** governing equations of motion in three dimensions are treated analytically yielding the derivation of exact solutions which differ from those corresponding to the classical Von Kármán's *** analysis reveals that a boundary layer structure develops near the surface of the disk,whose far-field behaviour is distinct from the near-wall *** velocity and vorticity components for various values of the dimensionless parameters,associated with the flow,are presented graphically.

关键词： solution flow Von

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