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Altered profiles of fecal bile acids correlate with gut microbiota and inflammatory responses in patients with ulcerative colitis

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World Journal of Gastroenterology 2021年第24期27卷 3609-3629页

作者： Zhen-Huan Yang Fang Liu xiao-ran Zhu Fei-Ya Suo Zi-jun Jia Shu-Kun Yao Graduate School Beijing University of Chinese MedicineBeijing 100029China Department of Gastroenterology China-Japan Friendship HospitalBeijing 100029China

BACKGROUND Gut microbiota and its metabolites may be involved in the pathogenesis of inflammatory bowel *** clinical studies have recently shown that patients with ulcerative colitis(UC)have altered profiles of fecal bile acids(BAs).It was observed that BA receptors Takeda G-protein-coupled receptor 5(TGR5)and vitamin D receptor(VDR)participate in intestinal inflammatory responses by regulating NF-ĸB *** hypothesized that altered profiles of fecal BAs might be correlated with gut microbiota and inflammatory responses in patients with *** To investigate the changes in fecal BAs and analyze the relationship of BAs with gut microbiota and inflammation in patients with *** The present study used 16S rDNA sequencing technology to detect the differences in the intestinal flora between UC patients and healthy controls(HCs).Fecal BAs were measured by targeted metabolomics *** TGR5 and VDR expression was analyzed using immunohistochemistry,and serum inflammatory cytokine levels were detected by *** Thirty-two UC patients and twenty-three HCs were enrolled in this *** was found that the diversity of gut microbiota in UC patients was reduced compared with that in ***,Clostridium IV,Butyricicoccus,Clostridium XlVa,Faecalibacterium,and Roseburia were significantly decreased in patients with UC(P=3.75E-05,P=8.28E-07,P=0.0002,P=0.003,P=0.0003,and P=0.0004,respectively).Proteobacteria,Escherichia,Enterococcus,Klebsiella,and Streptococcus were significantly enriched in the UC group(P=2.99E-09,P=3.63E-05,P=8.59E-05,P=0.003,and P=0.016,respectively).The concentrations of fecal secondary BAs,such as lithocholic acid,deoxycholic acid,glycodeoxycholic acid,glycolithocholic acid,and taurolithocholate,in UC patients were significantly lower than those in HCs(P=8.1E-08,P=1.2E-07,P=3.5E-04,P=1.9E-03,and P=1.8E-02,respectively)and were positively correlated with Butyricicoccus,Roseburia,Clostridium IV,Faecalibacterium,and

关键词： Ulcerative colitis Gut microbiota Bile acids Takeda G-protein-coupled receptor 5 Vitamin D receptor

Association between Polymorphisms in Telomere-Associated Protein Genes and the Cholinesterase Activity of Omethoate-Exposed Workers

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Biomedical and Environmental Sciences 2022年第5期35卷 448-452页

作者： FAN Ya Hui LI Xin Ling LIU xiao Hua GUO Zhi Feng YAN Meng Qing DUAN xiao ran MIAO Wen Bin WANG Wei Department of Occupational Health and Occupational Diseases College of Public HealthZhengzhou UniversityZhengzhou 450001HenanChina Biotherapy Center The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhou 450052HenanChina Director of Efficacy and Safety Evaluation Laboratory Pony Testing Group Shanghai Co.Ltd.Shanghai 201600China

Organophosphorus pesticides(OPs)are extensively used for their high efficiency,broad spectrum,and low ***,the health hazards caused by long-term,low-dose exposure to OPs are easily *** is a large class of OPs that is widely used in *** inhibition of the cholinesterase(ChE)activity is the main toxicity mechanism of OPs,and such an activity is used as a biomarker of exposure to OPs.

关键词： pesticides China. residue

某固废资源综合利用项目产生水淬渣的危险特性鉴别研究

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世界有色金属 2024年第13期 208-210页

作者：王真顾茗心刘军杨兆青杜晓冉河南省岩石矿物测试中心河南郑州450012 河南省矿物加工及生物选矿工程技术研究中心河南郑州450012

为明确某固废资源综合利用项目中产生水淬渣的危险特性,通过属性判断、腐蚀性鉴别、急性毒性初筛、易燃性鉴别、浸出毒性鉴别、反应性鉴别、毒性物质含量鉴别等手段对水淬渣是否具有危险特性进行鉴别。鉴别结果表明,在生产工艺不变、原... 详细信息

为明确某固废资源综合利用项目中产生水淬渣的危险特性,通过属性判断、腐蚀性鉴别、急性毒性初筛、易燃性鉴别、浸出毒性鉴别、反应性鉴别、毒性物质含量鉴别等手段对水淬渣是否具有危险特性进行鉴别。鉴别结果表明,在生产工艺不变、原辅料来源稳定、原辅料配比稳定且相关生产设备运行良好,生产工况稳定的情况下,鉴别对象水淬渣不属于危险废物,可作为一般工业固体废物进行管理和处置。

关键词：危险特性鉴别水淬渣毒性物质含量

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Unveiling the promotion of accelerated water dissociation kinetics on the hydrogen evolution catalysis of NiMoO_(4) nanorods

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Journal of Energy Chemistry 2022年第4期31卷 805-813页

作者： Tuzhi Xiong Bowen Huang Jingjing Wei Xincheng Yao ran xiao Zhixiao Zhu Fang Yang Yongchao Huang Hao Yang M.-Sadeeq(Jie Tang)Balogun College of Materials Science and Engineering Hunan UniversityChangsha 410082HunanChina Institute of Environmental Research at Greater Bay Key Laboratory for Water Quality and Conservation of the Pearl River DeltaMinistry of EducationGuangzhou UniversityGuangzhou 510006GuangdongChina Guangxi Key Laboratory of Electrochemical Energy Materials School of Chemistry&Chemical EngineeringGuangxi UniversityNanning 530004GuangxiChina Hunan Joint International Laboratory of Advanced Materials and Technology for Clean Energy Hunan UniversityChangsha 410082HunanChina

Nickel molybdate(NiMoO_(4))attracts superior hydrogen desorption behavior but noticeably poor for efficiently driving the hydrogen evolution reaction(HER)in alkaline media due to the sluggish water dissociation ***,we successfully accelerate the water dissociation kinetics of NiMoO_(4)for prominent HER catalytic properties via simultaneous in situ interfacial engineering with molybdenum dioxide(MoO_(2))and doping with phosphorus(P).The as-synthesized P-doped NiMoO_(4)/MoO_(2)heterostructure nanorods exhibit outstanding HER performance with an extraordinary low overpotential of-23 m V at a current density of 10 m A cm^(-2),which is highly comparable to the performance of the state-of-art Pt/C coated on nickel foam(NF)*** density functional theory(DFT)analysis reveals the enhanced performance is attributed to the formation of MoO_(2)during the in situ epitaxial growth that substantially reduces the energy barrier of the Volmer pathway,and the introduction of P that provides efficient hydrogen desorption of Ni MoO_(2).This present work creates valuable insight into the utilization of interfacial and doping systems for hydrogen evolution catalysis and beyond.

关键词： NiMoO_(4)/MoO_(2) Water dissociation kinetics Interfacial and doping Density functional theory Hydrogen evolution reaction

Comparison of changes in land use and land cover in China and the USA over the past 300 years

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Journal of Geographical Sciences 2015年第9期25卷 1045-1057页

作者： HE Fanneng LI Meijiao LI Shicheng xiao ran Key Laboratory of Land Surface Pattern and Simulation Institute of Geographic Sciences and Natural Resources Research CAS Beijing 100101 China University of Chinese Academy of Sciences Beijing 100049 China

Comparative studies of changes in land use and land cover between different countries over a long time-scale are helpful in understanding the processes and driving forces of these changes in different situations. We compared and analyzed the temporal and spatial characteristics of cropland, forest and grassland between China＇s mainland and the conterminous USA over the past 300 years. We found that, over the past 300 years, the area of cropland showed an overall increasing trend both in China and in the USA. In China, the area of cropland increased by about 79.46×104 km2 from 1661 to the 1980s, and the per capita cropland decreased from 0.37×104 m2 in 1685 to 0.10×104 m2 in 2000. For the USA, the area of cropland increased by 190.87×104 km2 between 1700 and 1950. The per capita cropland area of each time slice for the past 300 years was greater than 0.60×104 m2 and the maximum value was 2.01×104 m2 in 1890. As a result of the expansion in land reclamation, the forest and grassland areas of the USA have decreased by about 136.98×104 km2 and 136.98×104 km2, respectively, over the past 300 years; the corresponding values for China are about 89.73×104 km2 and 40.00×104 km2, respectively. In terms of the spatial patterns, the expansion in cropland in China mainly occurred in the border areas （including the northeast, southwest and Inner Mongolia） and in the hilly areas. Cropland expansion in the USA mainly occurred in the mid-west regions. In China, population growth is the most important driving factor in changes in land use and land cover, whereas in the USA, government policy plays the most significant role.

关键词： land use/cover change historical comparisons past 300 years China the USA

Nab-paclitaxel plus capecitabine as first-line treatment for advanced biliary tract cancers:An open-label,non-randomized,phase II clinical trial

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World Journal of Gastroenterology 2024年第30期30卷 3564-3573页

作者： Ling-xiao Xu Jia-Jia Yuan ran Xue Jun Zhou Department of Gastrointestinal Oncology Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing)Peking University Cancer Hospital and InstituteBeijing 100142China

BACKGROUND Biliary tract cancers(BTCs)are a heterogeneous group of tumors with high malignancy,poor prognosis,and limited treatment *** To explore the efficacy and safety of nab-paclitaxel plus capecitabine as first-line treatment for advanced and metastatic *** This open-label,non-randomized,double-center,phase II clinical trial recruited systemic therapy-naive patients with unresectable or metastatic BTCs between April 2019 and June 2022 at Beijing Cancer Hospital and the First Hospital of China Medical *** patients were administered nab-paclitaxel(150 mg/m^(2),day 1)and capecitabine(2000 mg/m^(2),twice daily,days 1-7)in 14-day cycles until experiencing intolerable toxicity or disease *** primary outcome was the objective response rate(ORR).The secondary outcomes included the disease control rate(DCR),overall survival(OS),progression-free survival(PFS),and *** A total of 44 patients successfully completed the trial,with a median age of 64.00 years(interquartile range,35.00-76.00),and 26(59.09%)were *** response assessment was impeded for one patient due to premature demise from tumor *** the remaining 43 patients undergoing at least one imaging assessment,the ORR was 23.26%[95%confidence interval(CI):11.80%-38.60%],and the DCR was 69.77%(95%CI:53.90%-82.80%).The median OS was 14.1 months(95%CI:8.3-19.9),and the median PFS was 4.4 months(95%CI:2.5-6.3).A total of 41 patients(93.18%)experienced at least one adverse event(AE),with 10 patients(22.73%)encountering grade≥3 AEs,and the most frequent AEs of any grade were alopecia(79.50%),leukopenia(54.55%),neutropenia(52.27%),and liver dysfunction(40.91%),and no treatment-related deaths were *** Nab-paclitaxel plus capecitabine may be an effective and safe first-line treatment strategy for patients with advanced or metastatic BTCs.

关键词： Nab-paclitaxel Capecitabine Biliary tract cancer Objective response rate Phase II clinical trial

肝癌细胞中NME1功能研究及调控的pHis修饰底物发现

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现代生物医学进展 2024年第13期24卷 2401-2407页

作者：刘萧然邢美宁陈沛渝孙薇应万涛军事科学院军事医学研究院生命组学研究所、医学蛋白质组全国重点实验室、北京蛋白质组研究中心、国家蛋白质科学中心(北京) 北京102206 广东药科大学药学院广东广州510006

目的:研究核苷二磷酸激酶1(Nucleoside diphosphate kinase A,NME1)在肝癌细胞HCCLM3中的功能作用及其调控的组氨酸磷酸化(Histidine phosphorylation,pHis)修饰底物。方法:采用划痕愈合实验和Transwell小室实验以及蛋白质组学和磷酸化... 详细信息

目的:研究核苷二磷酸激酶1(Nucleoside diphosphate kinase A,NME1)在肝癌细胞HCCLM3中的功能作用及其调控的组氨酸磷酸化(Histidine phosphorylation,pHis)修饰底物。方法:采用划痕愈合实验和Transwell小室实验以及蛋白质组学和磷酸化蛋白质组学分析方法,对NME1敲除后细胞表型与分子水平变化进行分析。结果:在肝癌细胞中敲除组氨酸激酶NME1能降低细胞运动能力,全蛋白组差异分析发现NME1敲除后差异表达蛋白主要参与细胞底物黏附调控、细胞周期调节及蛋白激酶活性调控等生命活动过程。Western blot检测发现敲除NME1表达使细胞整体pHis修饰水平显著下调。随后使用整合pHis修饰位点鉴定策略,即通过双甲基标记、强阳离子交换色谱(Strong cation exchange,SCX)分离磷酸化修饰肽段与非修饰肽段、铜珠(Cu-iminodiacetic acid,Cu-IDA)富集组氨酸肽段以及质谱检测等过程,首次在肝癌细胞系中鉴定到242个pHis修饰位点及206个pHis修饰蛋白。大约25%的pHis修饰蛋白为首次发现,其中NME1敲低组pHis修饰水平显著下调的蛋白有(Cell adhesion molecule 3,CADM3)、(Cytochrome C,CYCS)、(Glyceraldehyde-3-phosphate dehydrogenase,GAPDH)及(Phosphofructokinase,PFKM)等近30个,表明NME1可能通过这些蛋白及代谢酶的组氨酸磷酸化修饰水平的变化影响肿瘤细胞间的黏附及代谢能力。结论:肿瘤细胞中NME1表达水平的变化会影响肿瘤细胞的运动能力,细胞内pHis修饰水平的失调可能全面参与疾病进程。

关键词：肝细胞癌 NME1 组氨酸磷酸化细胞表型蛋白质组学磷酸化蛋白质组学

Effects of regenerated tissue extracts after liver injury on the proliferation,differentiation,migration and invasion of SK-HEP1 cells

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Asian Pacific Journal of Tropical Medicine 2018年第3期11卷 235-239页

作者： Na Cheng xiao-ran Liu Da-Wei Liu Fang Liu Jin Xiang Di Yang Guo-Qiang Zhao Department of Pathology The Third Affiliated HospitalSun Yat-sen University Emergency Department The First Affiliated Hospital of Hainan Medical University Department of Pathology The First Affiliated HospitalSun Yat-sen University Department of Oncology Nanfang HospitalSouthern Medical University Department of Pathology Sun Yat-sen University Cancer Center Department of Pathology Nanhai District People's Hospital Pathology Teaching and Research Section Sun Yat-sen University Zhongshan School of Medicine

Objective: To study the effects of regenerated tissue extracts after liver injury on the proliferation, differentiation, migration and invasion of SK-HEP1 cells. Methods: Regenerated tissue extracts after liver injury were used to induce SK-HEP1 cells after enrichment, their effects on the proliferation, differentiation, migration and invasion of SK-HEPI cells were observed through in vitro cell culture, MTT, flow cytometry and transwell assays. Results:In response to the action of regenerated tissue extracts after liver injury, SK-HEP1 cells were blocked in G_0/G_1 phase, their growth rate was distinctly reduced. The number of SK-HEP1^(-fj)colonies decreased. The migration ability of SK-HEPI cells showed a decreased trend on day7 and day 11 after induction. SK-HEPl's invasion ability clearly decreased on days 7 and11 after induction, especially on day 7. Conclusions: To a certain extent, regenerated tissue extracts after liver injury can inhibit the proliferation, differentiation, migration and invasion of hepatoma cells, showing an important potential of being a differentiating agent for the treatment of liver cancer.

关键词： SK-HEPI hepatoma cell Regenerated tissue extracts of liver injury Differentiation-inducing therapy SK-HEPI cell enrichment(SK-HEP1-fjr)

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机场停机位分配问题研究现状与展望

航空计算技术 2024年第4期54卷 130-134页

作者：潘肖然胡荣邓松武孙娇娇张军峰南京航空航天大学江苏南京211000 韶关丹霞机场有限公司广东韶关512000

为提高机场场面资源利用效率,大量文章研究停机位分配问题的优化模型与求解算法。首先,概述了停机位分配问题概念。其次,从旅客、机场、航空公司和鲁棒性等不同维度,梳理了停机位分配问题优化目标的研究现状,并归纳了停机位分配问题的... 详细信息

为提高机场场面资源利用效率,大量文章研究停机位分配问题的优化模型与求解算法。首先,概述了停机位分配问题概念。其次,从旅客、机场、航空公司和鲁棒性等不同维度,梳理了停机位分配问题优化目标的研究现状,并归纳了停机位分配问题的约束条件。从数学规划法、智能优化法两个维度综述了停机位分配问题的求解算法,并比较了不同算法优缺点。最后,从考虑交互关系的多目标优化、实现动态实时分配、多资源联合分配、创新优化算法和考虑不确定因素五个方面展望了停机位分配问题研究的发展趋势。

关键词：停机位分配优化目标约束条件算法设计联合分配