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Bronchiolar adenoma with unusual presentation:Two case reports

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World Journal of Clinical Cases 2022年第14期10卷 4541-4549页

作者： Ying du Zheng-Yan Wang Zheng Zheng Ying-Xue Li Xiu-Yu Wang ran du Department of Pathology The Affiliated Hospital of Shandong First Medical University(Liaocheng People’s Hospital)Liaocheng 252000Shandong ProvinceChina

BACKGROUND The clinicopathological features,immunohistochemical characteristics,and genetic mutation profile of two unusual cases of distal bronchiolar adenoma are retrospectively analyzed and the relevant literature is *** SUMMARY Case 1 was a 63-year-old female patient who had a mixed ground-glass nodule,with mild cells in morphology,visible cilia,and bilayer structures in focal *** staining for P63 and cytokeratin(CK)5/6 revealed the lack of a continuous bilayer structure in most areas,and no mutations were found in epidermal growth factor receptor,anaplastic lymphoma kinase,ROS1,Kirsten rat sarcoma,PIK3CA,BRAF,human epidermal growth factor receptor-2(HER2),RET,and neuroblastoma RAS *** 2 was a 58-year-old female patient who presented with a solid nodule,in which most cells were observed to be medium sized,the nuclear chromatin was pale and homogeneous,local cells had atypia,and cilia were found *** staining for P63 and CK5/6 showed no expression of these proteins in mild cell morphology whereas the heteromorphic cells showed a bilayer *** same nine genes as above were analyzed,and HER2 gene mutation was *** Some unresolved questions remain to be answered to determine whether the lesion is a benign adenoma or a part of the process of malignant transformation from benign adenoma of the bronchial ***,whether lesions with atypical bilayer structures are similar to atypical hyperplastic lesions of the breast remains to be ***,clarity on whether these lesions can be called atypical bronchiolar adenoma and whether they are invasive precursor lesions is *** studies should examine the diagnostic significance of HER2 gene mutation as a prognostic indicator.

关键词： Bronchiolar adenoma Human epidermal growth factor receptor-2 gene Thoracic tumors Cellular atypia Ciliated muconodular papillary tumor Case report

The phase separation of SGS3 regulates antiviral immunity and fertility in Arabidopsis

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Science China(Life Sciences) 2023年第8期66卷 1938-1941页

作者： Yujie Han Xiaolin Zhang ran du Xiaoyi Shan Daoxin Xie MOE Laboratory of Bioinformatics Tsinghua-Peking Center for Life SciencesSchool of Life SciencesTsinghua UniversityBeijing 100084China Peking University-Tsinghua University-National Institute of Biological Sciences Joint Graduate Program School of Life SciencesTsinghua UniversityBeijing 100084China Shenzhen Branch of Guangdong Laboratory for Lingnan Modern Agriculture Genome Analysis Laboratory of the Ministry of AgricultureAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518124China

Dear Editor,As a conserved mechanism among eukaryotic organisms,RNA silencing is vital for suppressing gene expression at the transcriptional or posttranscriptional level to regulate multiple biological *** interfering RNAs(si RNAs)generated by Dicer proteins integrate with Argonaute(AGO)to form an RNA-induced silencing complex(RISC),in which RNA/DNA could be degraded/methylated through a sequence-specific manner(Ding et al.,2004).

关键词： immunity separation

Hydrogel-Based Stimuli-Responsive Micromotors for Biomedicine

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Cyborg and Bionic Systems 2022年第1期2022卷 273-284页

作者： Huaijuan Zhou Guozhao Dong Ge Gao ran du Xiaoying Tang Yining Ma Jinhua Li Advanced Research Institute of Multidisciplinary Sciences Bejing Institute of TechnologyBeijing 100081China School of Medical Technology Beijing Institute of TechnologyBeijing 100081China School of Materials Science Engineering Key Laboratory of High Energy Density Materials of the Ministry of EducationBeijing Institute of TechnologyBeijing 100081China School of Life Science Beijing Institute of TechnologyBeijing 100081China Department of Forensic Science Jiangsu Police InstituteNanjing 210031China

The rapid development of medical micromotors draws a beautiful blueprint for the noninvasive or minimally invasive diagnosis and *** combining stimuli-sensitive hydrogel materials,micromotors are bestowed with new characteristics such as stimuli-responsive shape transformation/*** biocompatibility and biodegradability,and drug loading *** by chemical fuels or external fields(eg,magnetic field,ultrasound,light,and electric field),hydrogel-based stimuli-responsive(HBSR)micromotors can be utilized to load therapeutic agents into the hydrogel networks or directly grip the target cargos(eg.,drug-loaded partides,cells,and thrombus),transport them to sites of interest(e.g.,tumor area and diseased tissues),and unload the cargos or execute a specific task(e.g.,cell capture,targeted sampling,and removal of blood dots)in response to a stimulus(eg.,change of temperature,pH,ion strength,and chemicals)in the physiological *** high flexibility,adaptive capacity,and shape morphing property enable the H BSR micromotors to complete specific medical tasks in complex physiological scenarios,especially in confined,hard to-reach tissues,and vessels of the ***,this review summarizes the current progress in hydrogel-based medical micromotors with stimuli *** thermo-responsive,photothermal-responsive,magnetocaloric-responsive,pH-responsive,ionic strength-responsive,and chemoresponsive micromotors are discussed in ***,curent challenges and future perspectives for the development of HBSR micromotors in the biomedical field are discussed.

关键词： diagnosis utilized loaded

Biomembrane-inspired design of medical micro/nanorobots:From cytomembrane stealth cloaks to cellularized Trojan horses

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Aggregate 2023年第5期4卷 63-95页

作者： Jinhua Li Huaijuan Zhou Chun Liu Shuailong Zhang ran du Yulin Deng Xuenong Zou School of Medical Technology Beijing Institute of TechnologyBeijingChina Advanced Research Institute of Multidisciplinary Sciences Beijing Institute of TechnologyBeijingChina Center for Translational Medicine Precision Medicine InstituteThe First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina Guangdong Provincial Key Laboratory of Orthopedics and Traumatology Department of Spinal SurgeryThe First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina School of Mechatronical Engineering Beijing Institute of TechnologyBeijingChina School of Materials Science&Engineering Key Laboratory of High Energy Density Materials of the Ministry of EducationBeijing Institute of TechnologyBeijingChina School of Life Science Beijing Institute of TechnologyBeijingChina

Micro/nanorobots are promising for a wide range of biomedical applications(such as targeted tumor,thrombus,and infection therapies in hard-to-reach body sites)because of their tiny size and high maneuverability through the actuation of external fields(e.g.,magnetic field,light,ultrasound,electric field,and/or heat).However,fully synthetic micro/nanorobots as foreign objects are susceptible to phagocytosis and clearance by diverse *** address this issue,researchers have attempted to develop various cytomembrane-camouflaged micro/nanorobots by two means:(1)direct coating of micro/nanorobots with cytomembranes derived from living cells and(2)the swallowing of micro/nanorobots by living immunocytes via *** camouflaging with cytomembranes or living immunocytes not only protects micro/nanorobots from phagocytosis,but also endows them with new characteristics or functionalities,such as prolonging propulsion in biofluids,targeting diseased areas,or neutralizing bacterial *** this review,we comprehensively summarize the recent advances and developments of cytomembrane-camouflaged medical micro/*** first discuss how cytomembrane coating nanotechnology has been employed to engineer synthetic nanomaterials,and then we review in detail how cytomembrane camouflage tactic can be exploited to functionalize micro/*** aim to bridge the gap between cytomembrane-cloaked micro/nanorobots and nanomaterials and to provide design guidance for developing cytomembrane-camouflaged micro/nanorobots.

关键词： camouflage cell membranes immune cells medical micromotors targeted drug delivery

Risk factors for cognitive impairment in patients with chronic kidney disease

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World Journal of Psychiatry 2024年第2期14卷 308-314页

作者： Xiao-Hui Wang Yong He Huan Zhou Ting Xiao ran du Xin Zhang Department of Nephrology The Fifth Hospital of WuhanWuhan 430050Hubei ProvinceChina Department of Nephrology The Central Hospital of Enshi Tujia and Miao Autonomous PrefectureEnshi 445000Hubei ProvinceChina

BACKGROUND Chronic kidney disease(CKD)patients have been found to be at risk of concurrent cognitive dysfunction in previous studies,which has now become an important public health issue of widespread *** To investigate the risk factors for concurrent cognitive dysfunction in patients with *** This is a prospective cohort study conducted among patients with CKD between October 2021 and March 2023.A questionnaire was formulated by literature review and expert consultation and included questions about age,sex,education level,per capita monthly household income,marital status,living condition,payment method,and *** Logistic regression analysis showed that patients aged 60-79 years[odds ratio(OR)=1.561,P=0.015]and≥80 years(OR=1.760,P=0.013),participants with middle to high school education(OR=0.820,P=0.027),divorced or widowed individuals(OR=1.37,P=0.032),self-funded patients(OR=2.368,P=0.008),and patients with hypertension(OR=2.011,P=0.041)had a higher risk of cognitive *** risk of cognitive impairment was lower for those with a college degree(OR=0.435,P=0.034)and married *** The risk factors affecting cognitive dysfunction are age,60-79 years and≥80 years;education,primary school education or less;marital status,divorced or widowed;payment method,selffunded;hypertension;and CKD.

关键词： Cognitive impairment Cognitive dysfunction Chronic kidney disease

Examining the Trends and Influencing Factors of International Trade in the Era of New Economic Globalization

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Proceedings of Business and Economic Studies 2023年第6期6卷 45-49页

作者： ran du Széchenyi István University 9026 GyőrEgyetem tér 1Hungary

In the context of the new era of economic globalization,the development of international trade holds immense significance in fostering global economic recovery and advancing the process of global economic *** this backdrop,aspects such as trade liberalization,digital trade,trade in services,and the influence of multinational companies are becoming increasingly ***,factors encompassing economic,political,technological,and environmental considerations,as well as regional economic integration,will exert influence on the trajectory of international trade *** paper aims to comprehensively explore the development trends of international trade and the myriad influencing factors within the framework of the new economic globalization.

关键词： New economic globalization International trade Trade liberalization

Discrimination of Handlebar Grip Samples by Fourier Transform Infrared Microspectroscopy Analysis and Statistics

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Journal of Forensic Science and Medicine 2017年第2期3卷 63-67页

作者： Zeyu Lin Bing Li ran du Ziwei Wei Yuanfeng Wang Collaborative Innovation Center of Judicial Civilization Key Laboratory of Evidence ScienceCUPLMinistry of EducationChina

In this paper,the authors presented a study on the discrimination of handlebar grip samples,to provide effective forensic science service for hit and run traffic cases.50 bicycle handlebar grip samples,49 electric bike handlebar grip samples,and 96 motorcycle handlebar grip samples have been randomly collected by the local police in Beijing(China).Fourier transform infrared microspectroscopy(FTIR)was utilized as analytical ***,target absorption selection,data pretreatment,and discrimination of linked samples and unlinked samples were chosen as three steps to improve the discrimination of FTIR spectrums collected from different handlebar grip *** component analysis and receiver operating characteristic curve were utilized to evaluate different data selection methods and different data pretreatment methods,*** is possible to explore the evidential value of handlebar grip residue evidence through instrumental analysis and statistical *** will provide a universal discrimination method for other forensic science samples as well.

关键词： Evidential value Fourier transform infrared microscpectroscopy handlebar grip sample principal component analysis receiver operating characteristic

CircLphn3 protects the blood-brain barrier in traumatic brain injury

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Neural Regeneration Research 2022年第4期17卷 812-818页

作者： Yu-Qi Cheng Chen-Rui Wu Meng-ran du Qiang Zhou Bi-Ying Wu Jia-Yuan-Yuan Fu Ehab Balawi Wei-Lin Tan Zheng-Bu Liao Department of Neurosurgery The First Affiliated Hospital of Chongqing Medical UniversityChongqingChina

Circular RNAs(circRNAs)are a new and large group of non-coding RNA molecules that are abundantly expressed in the central nervous ***,very little is known about their roles in traumatic brain *** this study,we firstly screened differentially expressed circ RNAs in normal and injured brain tissues of mice after traumatic brain *** found that the expression of circ Lphn3 was substantially decreased in mouse models of traumatic brain injury and in hemin-treated b End.3(mouse brain cell line)*** overexpressing circ Lphn3 in b End.3 cells,the expression of the tight junction proteins,ZO-1,ZO-2,and occludin,was upregulated,and the expression of mi R-185-5 p was *** b End.3 cells transfected with mi R-185-5 p mimics,the expression of ZO-1 was ***-luciferase reporter assays showed that circ Lphn3 bound to mi R-185-5 p,and that mi R-185-5 p bound to ***,circ Lphn3 overexpression attenuated the hemin-induced high permeability of the in vitro b End.3 cell model of the blood-brain barrier,while mi R-185-5 p transfection increased the *** findings suggest that circ Lphn3,as a molecular sponge of mi R-185-5 p,regulates tight junction proteins'expression after traumatic brain injury,and it thereby improves the permeability of the blood-brain *** study was approved by the Animal Care and Use Committee of Chongqing Medical University of China(approval No.2021-177)on March 22,2021.

关键词： bioinformatics blood-brain barrier circ RNA mi RNA RNA-sequence tight junction protein traumatic brain injury ZO1

Calpain inhibition ameliorates scald burn-induced acute lung injury in rats

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Burns & Trauma 2018年第4期6卷 307-315页

作者： Peng-ran du Hong-Ting Lu Xi-Xiang Lin Li-Feng Wang Yan-Xia Wang Xiao-Ming Gu Xiao-Zhi Bai Ke Tao Jing-Jun Zhou Department of Physiology and Pathophysiology Fourth Military Medical UniversityNo.169 Changle West RoadXi'an 710032China Department of Biochemistry Fourth Military Medical UniversityXi'anShaanxiChina Department of Pathology Fourth Military Medical UniversityXi'anShaanxiChina Department of Burns and Cutaneous Surgery Xijing HospitalFourth Military Medical UniversityXi'anShaanxiChina

Background:The molecular pattern of severe burn-induced acute lung injury, characterized by cell structure damage and leukocyte infiltration, remains unknown. This study aimed to determine whether calpain, a protease involved in both processes, mediates severe burn-induced acute lung injury. Methods:Rats received ful-thickness scald burns covering 30%of the total body surface area, fol owed by instant fluid resuscitation. MDL28170 (Tocris Bioscience), an inhibitor of calpain, was given intravenously 1 h before or after the scald burn. The histological score, wet/dry weight ratio, and caspase-3 activity were examined to evaluate the degree of lung damage. Calpain activity and its source were detected by an assay kit and immunofluorescence staining. The proteolysis of membrane skeleton proteinsα-fodrin and ankyrin-B, which are substrates of calpain, was measured by Western blot. Results:Time-course studies showed that tissue damage reached a peak between 1 and 6 h post-scald burn and gradually diminished at 24 h. More importantly, calpain activity reached peak levels at 1 h and was maintained until 24 h, paralleled by lung damage to some extent. Western blot showed that the levels of the proteolyzed forms ofα-fodrin and ankyrin-B correlated well with the degree of damage. MDL28170 at a dose of 3 mg/kg b. w. given 1 h before burn injury not only antagonized the increase in calpain activity but also ameliorated scald burn-induced lung injury, including the degradation ofα-fodrin and ankyrin-B. Immunofluorescence images revealed calpain 1 and CD45 double-positive cel s in the lung tissue of rats exposed to scald burn injury, suggesting that leukocytes were a dominant source of calpain. Furthermore, this change was blocked by MDL28170. Final y, MDL28170 given at 1 h post-scald burn injury significantly ameliorated the wet/dry weight ratio compared with burn injury alone. Conclusions:Calpain, a product of infiltrating leukocytes, is a mediator of scald burn-induced acute l

关键词： Acute lung injury Burn Calpain Inflammation Membrane skeleton proteins Scald