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A Tutorial on Federated Learning from Theory to Practice:Foundations,Software Frameworks,Exemplary Use Cases,and Selected Trends

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IEEE/CAA journal of Automatica Sinica 2024年第4期11卷 824-850页

作者： M.Victoria Luzón Nuria Rodríguez-barroso Alberto Argente-Garrido Daniel jiménez-López jose M.Moyano javier Del Ser Weiping Ding Francisco Herrera Department of Software Engineering Andalusian Research Institute in Data Science and Computational Intelligence(DaSCI)University of GranadaGranada 18071Spain Department of Computer Science and Artificial Intelligence Andalusian Research Institute in Data Science and Computational Intelligence(DaSCI)University of GranadaGranada 18071Spain Department of Communications Engineering University of the Basque Country(UPV/EHU)and also with TECNALIABasque Research&Technology Alliance(BRTA)Spain School of Information Science and Technology Nantong UniversityNantong 226019China

When data privacy is imposed as a necessity,Federated learning(FL)emerges as a relevant artificial intelligence field for developing machine learning(ML)models in a distributed and decentralized *** allows ML models to be trained on local devices without any need for centralized data transfer,thereby reducing both the exposure of sensitive data and the possibility of data interception by malicious third *** paradigm has gained momentum in the last few years,spurred by the plethora of real-world applications that have leveraged its ability to improve the efficiency of distributed learning and to accommodate numerous participants with their data *** virtue of FL,models can be learned from all such distributed data sources while preserving data *** aim of this paper is to provide a practical tutorial on FL,including a short methodology and a systematic analysis of existing software ***,our tutorial provides exemplary cases of study from three complementary perspectives:i)Foundations of FL,describing the main components of FL,from key elements to FL categories;ii)Implementation guidelines and exemplary cases of study,by systematically examining the functionalities provided by existing software frameworks for FL deployment,devising a methodology to design a FL scenario,and providing exemplary cases of study with source code for different ML approaches;and iii)Trends,shortly reviewing a non-exhaustive list of research directions that are under active investigation in the current FL *** ultimate purpose of this work is to establish itself as a referential work for researchers,developers,and data scientists willing to explore the capabilities of FL in practical applications.

关键词： Data privacy distributed machine learning federated learning software frameworks

Development of peptide inhibitors of HIV transmission

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Bioactive Materials 2016年第2期1卷 109-121页

作者： Siyu Shi Peter K.Nguyen Henry j.Cabral ramon Diez-barroso Paul j.Derry Satoko M.Kanahara Vivek A.Kumar Department of Chemistry Rice UniversityHoustonTX 77030USA Baylor College of Medicine HoustonTX 77030USA Community Healthcare Network New YorkNY 10010USA Department of Biomedical Engineering New Jersey Institute of TechnologyUniversity HeightsNewarkNJ 07102USA Department of Chemical Biological and Pharmaceutical EngineeringNew Jersey Institute of TechnologyUniversity HeightsNewarkNJ 07102USA

Treatment of HIV has long faced the challenge of high mutation rates leading to rapid development of resistance,with ongoing need to develop new methods to effectively fight the ***,early HIV medications were designed to inhibit RNA replication and protein production through small molecular *** based therapeutics are a versatile,promising field in HIV therapy,which continues to develop as we expand our understanding of key protein-protein interactions that occur in HIV replication and *** review begins with an introduction to HIV,followed by the biological basis of disease,current clinical management of the disease,therapeutics on the market,and finally potential avenues for improved drug development.

关键词： HIV HIV treatment Drug development Peptide therapeutic Peptide inhibitor

The aryl hydrocarbon receptor and the gut–brain axis

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Cellular & Molecular Immunology 2021年第2期18卷 259-268页

作者： Andreia barroso joão Vitor Mahler Pedro Henrique Fonseca-Castro Francisco j.Quintana Ann Romney Center for Neurologic Diseases Brigham and Women’s HospitalHarvard Medical SchoolBostonMAUSA Faculdade de Medicina FMUSP Universidade de São PauloSão PauloSPBrazil Broad Institute of MIT and Harvard CambridgeMAUSA

The aryl hydrocarbon receptor(AHR)is a ligand-activated transcription factor initially identified as the receptor for *** half a century after its discovery,AHR is now recognized as a receptor for multiple physiological ligands,with important roles in health and *** this review,we discuss the role of AHR in the gut–brain axis and its potential value as a therapeutic target for immune-mediated diseases.

关键词： Aryl hydrocarbon receptor Autoimmune diseases Infectious diseases cancer

Hydrogen sulfide:A novel component in Arabidopsis peroxisomes which triggers catalase inhibition

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journal of Integrative Plant Biology 2019年第7期61卷 871-883页

作者： Francisco j.Corpas juan B.barroso Salvador Gonzalez-Gordo Maria A.Munoz-Vargas jose M.Palma Group of Antioxidants Free Radicals and Nitric Oxide in BiotechnologyFood and AgricultureDepartment of BiochemistryCell and Molecular Biology of PlantsEstacion Experimental del ZaidfnCSICC/Profesor Albareda 1E-18008 GranadaSpain Group of Biochemistry and Cell Signaling in Nitric oxide Department of Biochemistry and Molecular BiologyCampus"Las Lagunillas"E-23071University of JaenJaenSpain

Plant peroxisomes have the capacity to gen erate different reactive oxygen and nitrogen species(ROS and RNS),such as H2O2,superoxide radical(O2^·-),nitric oxide and peroxynitrite(ONOO^-).These organelles have an active nitrooxidative metabolism which can be exacerbated by adverse stress *** sulfide(H2S)is a new signaling gasotransmitter which can mediate the posttranslational modification(PTM)*** used Arabidopsis thaliana transgenic seedlings expressing cyan fluorescent protein(CFP)fused to a canonical peroxisome targeting signal 1(PTS1)to visualize peroxisomes in living cells,as well as a specific fluorescent probe which showed that peroxisomes contain H2S.H2S was also detected in chloroplasts under glyphosate-induced oxidative stress *** enzyme activities,including catalase,photorespiratory H2O2-generating glycolate oxidase(GOX)and hydroxypyruvate reductase(HPR),were assayed in vitro with a H2S *** line with the persulfidation of this enzyme,catalase activity declined significantly in the presence of the H2S *** corroborate the inhibitory effect of H2S on catalase activity,we also assayed pure catalase from bovine liver and pepper fruit-enriched samples,in which catalase activity was *** together,these data provide evidenee of the presence of H2S in plant peroxisomes which appears to regulate catalase activity and,consequently,the peroxisomal H2O2 metabolism.

关键词： Hydrogen sulfide triggers catalase inhibition

Approaches for handling high-dimensional cluster expansions of ionic systems

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npj Computational Materials 2022年第1期8卷 1254-1264页

作者： julia H.Yang Tina Chen Luis barroso-Luque Zinab jadidi Gerbrand Ceder Department of Materials Science and Engineering BerkeleyCA94720USA Materials Sciences Division Lawrence Berkeley National LaboratoryBerkeleyCA94720USA

Disordered multicomponent systems attract great interest due to their engineering design flexibility and subsequent rich space of ***,detailed characterization of the structure and atomic correlations remains challenging and hinders full navigation of these complex spaces.A lattice cluster expansion is one tool to obtain configurational and energetic *** in theory a cluster expansion can be applied to any system of any dimensionality,the method has primarily been used in binary systems or ternary *** we apply cluster expansions in high-component ionic systems,setting up the largest cluster expansion ever attempted to our *** doing so,we address and discuss challenges specific to high-component ionic systems,namely charge state assignments,structural relaxations,and rank-deficient *** introduce practical procedures to make the fitting and analysis of complex systems tractable,providing guidance for future computational studies of disordered ionic systems.

关键词： properties cluster ionic

CCL2-2518 A/G and CCR2 190 A/G do not influence the outcome of hepatitis C virus infection in the Spanish population

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World journal of Gastroenterology 2007年第15期13卷 2187-2192页

作者： MA Montes-Cano jR García-Lozano j Aguilar-Reina M Romero-Gómez N barroso A Nú(n|~)ez-Roldán MF González-Escribano Servicio de Inmunologia Hospital Universitario Virgen del Rocío Spain Servicio de Digestivo Hospital Universitario Virgen del Rocío Spain Sección Hepatología. Hospital Universitario de Valme. Servicio Andaluz de Salud Seville Spain

AIM： To assess whether CCL2 or interactions between this chemokine and its receptor （CCR2） are associated with outcomes of chronic hepatitis C and with responses to antiviral therapy. METHODS： Two hundred and eighty-four patients with chronic hepatitis C and 193 non-infected matched controls were included in this study. Patients were categorized according to their Scheuer score of hepatic fibrosis as F0-F2 （/7 = 202） or F3-F4 （/7 = 82） and according to their response to anti-Hepatitis C virus （HCV） therapy as sustained response （SR, n = 201） or non-sustained response （NSR, n = 98）. Genotyping of the -2518 （A/G） CCL2 was performed using PCR-RFLP, genotyping of the 190 （A/G） CCR2 using a PCR-ARMS system, and genotyping of the rs3138042 （G/A） CCR2 using Taqman probes. RESULTS： Univariate analyses identified 4 parameters （infection duration time, viral genotype, gender and AST levels） that tended to influence fibrosis and 7 parameters （CCL2G, CCL2ACCR2A, viremia levels, fibrosis stage, viral genotype, infection duration time and AST levels） that significantly influenced or tended to influence response to treatment. Multivariate analysis identified gender and AST levels as parameters that independently influenced fibrosis stage and viral genotype and infection duration time were the two parameters that independently influenced response to treatment. CONCLUSION： Our results indicate that the mutations studied in the gene pair CCL2/CCR2 do not play a major role in the outcome and response to treatment for HCV infection in the Spanish population.

关键词： CCL2 CCR2 Polymorphism Hepatitis C virus Treatment Fibrosis stage

Vegetative propagation of Apuleia leiocarpa(Vogel)***

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journal of Forestry Research 2022年第2期33卷 455-462页

作者： joséGabriel de Souza Silva Diêgo Faustolo Alves Bispo David Pessanha Siqueira Giovanna Campos Mamede Weiss de Carvalho Deborah Guerra barroso Laboratório de Fitotecnia Universidade Estadual do Norte Fluminense Darcy RibeiroAvenida Alberto LamegoCampos dos GoytacazesRJ 2000Brazil

Apuleia leiocarpa is an environmentally and economically significant Atlantic Forest species threat-ened by ongoing *** vegetative propagation of the species could be a step forward to enable implanta-tion of clonal seed orchards and multiplication of selected trees but remains unknown to *** study assessed the mini-cutting technique for propagation of *** and determined the time required for rooting and viable mini-cutting type and *** results show that it is possible to propagate *** with mini-cuttings derived from mini-stumps produced with seeds;the mini-stumps pre-sented regrowth capacity and remained constantly produc-tive for 1 year;10-cm *** mini-cuttings should remain under misting conditions for at least 40 days,and the vegetative propagation of *** with intermediate 7-to 10-cm mini-cuttings resulted in more vigorous clonal seedlings than smaller mini-cuttings.

关键词： Mini-cutting Tropical woody species Adventitious rooting Fabaceae

Fiber laser with simultaneous multi-wavelength Er/Yb passively Q-switched and single-wavelength Tm gain-switched operations

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Photonics Research 2019年第6期7卷 608-614页

作者： j.ALANIZ-BAYLON M.duran-SANCHEZ R.I.ALVAREZ-TAMAYO B.POSADA-RAMIREZ M.BELLO-jIMENEZ B.IBARRA-ESCAMILLA A.A.CASTILLO-GUZMAN E.A.KUZIN Instituto Nacional de Astrofísica óptica y Electrónica (INAOE)L. E. Erro 1 Sta. Ma. Tonantzintla Pue. 72824 Mexico CONACyT-Instituto Nacional de Astrofísica óptica y ElectrónicaA. P. 51 y 216 Pue. 72000 Mexico CONACyT-Universidad Autónoma de Nuevo León Av.Universidad S/NSan Nicolas de los Garza N. L. 66451 Mexico Instituto de Investigación en Comunicación óptica Universidad Autónoma de San Luis Potosí Av. Karakorum 1470 S. L. P. 78210 Mexico Universidad Autónoma de Nuevo León Av.Universidad S/NSan Nicolas de los Garza N. L. 66451 Mexico

We report the experimental investigation of an all-fiber multi-wavelength passively Q-switched Er/Yb laser with simultaneous gain-switched pulsed operation by using a thulium-doped fiber as a saturable *** emission is obtained in three wavelength regions with central peaks at around 1546 nm, 1561 nm, and1862 nm. Multi-wavelength emission with separation of approximately 1 nm is obtained around the wavelength regions of 1546 nm and 1561 nm. Stable laser pulses are generated in the pump power range from 3.6 W to7.3 W.

关键词： Fiber laser multi-wavelength

Experimental Study on Split-Ring Resonators with Different Slit Widths

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journal of Electromagnetic Analysis and Applications 2013年第9期5卷 366-370页

作者： Pedro j.Castro joaquim j.barroso joaquim P.Leite Neto Associated Plasma Laboratory National Institute for Space Research—INPESao Jose dos CamposBrazil

Metamaterial one-dimensional periodic structures are composed of split-ring resonators, which can display electric permittivity and magnetic permeability simultaneously negative, are studied experimentally. In the present study, each resonator is made up of two concentric circular copper rings patterned on a substrate of kapton, with slits diametrically opposite each other and with the line of the splits along the longitudinal direction of the periodic array containing seven split rings evenly spaced. The experiments consist in inserting the metamaterial slab into a square waveguide of side length 6 mm, corresponding to a cutoff frequency of 25 GHz. Transmission bands due to magnetic and electrical responses are identified for slits with aperture widths of 1 mm and 2 mm, centered at 5.67 and 6.12 GHz frequencies, respectively, values well below the 25 GHz frequency cutoff, so characterizing a medium with negative permeability and permittivity.

关键词： Metamaterials Split-Ring Resonators Magnetic Response Electric Response Left-Handed Transmission Band