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Response to Commentary by Dr. Matthew J. Clarkson on

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Journal of Sport and Health Science 2024年第5期13卷 670-671页

作者： Hugo de Luca Corrêa Lysleine Alves Deus Dahan da Cunha Nascimento Nicholas Rolnick Rodrigo Vanerson Passos Neves Andrea Lucena Reis Thais Branquinho de Araújo Carmen Tzanno-Martins Fernanda Silveira Tavares Luiz Sinésio silva Neto Cláudio Avelino Rodrigues Santos Paolo Lucas Rodrigues-silva Fernando Honorato Souza Vitória Marra da Motta Vilalva Mestrinho Rafael Lavarini dos Santos Rosangela Vieira Andrade Jonato Prestes Thiago dos Santos Rosa Post-graduate Program of Physical Education Catholic University of BrasıliaBrasılia 71966-700Brazil The Human Performance Mechanic Lehman CollegeNew YorkNY 10011USA Clinical Group Home Dialysis Center and RenalClass Sao Paulo 01239-040Brazil Department of Medicine Catholic University of BrasıliaBrasılia 71966-700Brazil Faculty of Medicine Federal University of TocantinsTocantins 77001-090Brazil Embrapa Genetic Resources and Biotechnology Brasılia 70770-917Brazil g Graduate Program of Genomic Sciences and Biotechnology Brasılia 71966-700Brazil

Dear editor:We sincerely thank Matthew *** for his insightful commentary1 on our recent publication in the Journal of Sport and Health Science.2 Clarkson's pioneering work in the development and application of blood flow restriction (BFR) exercise protocols has undeniably laid the groundwork for subsequent investigations in this field,including our own.(3-6)His commentary not only highlights the relevance and timeliness of our study but also offers valuable perspectives on refining safety considerations for intradialytic BFR exercise among hemodialysis patients.

关键词： patients application flow

Literature review of accessibility measures and models used in land use and transportation planning in last 5 years

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Journal of Geographical Sciences 2022年第3期32卷 560-584页

作者： Aviral MARWAL Elisabete silva Department of Land Economy University of CambridgeCambridgeUnited Kingdom

Since its inception accessibility has undergone various changes in the way it is defined,measured,and *** paper reviews the recent advancements made in the accessibility measures along with the models used in different applications of accessibility related to land use and *** measures of accessibility are grouped under infrastructure-based,location-based,and person-based *** paper finds that although the person-based measures are statistically robust and theoretically sound,they are less preferred than the location-based measure in the accessibility *** review finds recent development such as web based mapping and use of location based data;image mapping through convolutional neural networks;and activity-time constraints modeling in the measures of ***,the paper reviews literature from the last five years that have used accessibility to study travel mode choices and household location choices and finds the use of three types of modeling framework-Statistical,Neural Network,and Agent Based *** on the literature review,this paper suggests the inclusion of environmental sustainability and gender equity in the accessibility measurement framework and a shift towards model synthesis to enhance the model accuracy and to reduce the present complexities in model building.

关键词： accessibility travel behavior household location choices agent-based modeling artificial neural network

Calorie restriction or dietary restriction: how far they can protect the brain against neurodegenerative diseases?

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Neural Regeneration Research 2022年第8期17卷 1640-1644页

作者： Tayana silva de Carvalho Herz-und Diabeteszentrum NRW(HDZ NRW) Bad OeynhausenGermany

Finding the correct nutritional intervention is one of the biggest challenges in treating patients with neurodegenerative *** general,these patients develop strong metabolic alterations,resulting in lower treatment efficacy and higher mortality ***,there are still many open questions regarding the effectiveness of dietary interventions in *** studies have shown that a reduction in calorie intake activates key pathways that might be important for preventing or slowing down the progression of such ***,it is still unclear whether these neuroprotective effects are associated with an overall reduction in calories(hypocaloric diet)or a specific nutrient restriction(diet restriction).Therefore,here we discuss how commonly or differently hypocaloric and restricted diets modulate signaling pathways and how these changes can protect the brain against neurodegenerative diseases.

关键词： Alzheimer’s disease diet therapy dietary intervention epilepsy fasting glucose restriction hypocaloric diet multiple sclerosis Parkinson’s disease stroke

Soil and altitude drive diversity and functioning of Brazilian Páramos(campo de altitude)

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Journal of Plant Ecology 2017年第5期10卷 771-779页

作者： Andreza Viana Neri Gladson ramon Alves Borges João Augusto Alves Meira-Neto Luiz Fernando silva Magnago Ian Michael Trotter Carlos Ernesto GRSchaefer Stefan Porembski Departamento de Biologia Vegetal Laboratório de Ecologia e Evolução de PlantasUniversidade Federal de ViçosaPH RolfsS/NCampus UniversitárioViçosaMinas Gerais 36570-900Brazil Departamento de Biologia Setor de Ecologia e ConservaçãoUniversidade Federal de LavrasLavrasMinas Gerais 37200-000Brazil Departamento de Economia Rural Universidade Federal de ViçosaPH RolfsS/NCampus UniversitárioViçosaMinas Gerais 36570-900Brazil Departamento de Solos Universidade Federal de ViçosaPH RolfsS/NCampus UniversitárioViçosaMinas Gerais 36570-900Brazil Allgemeine und Spezielle Botanik Institut für BiowissenschaftenUniversität RostockWismarsche Str.8D-18051 RostockGermany

Aims the vegetation on Brazilian Páramos consists of assemblages that are driven mainly by the influence of strong environmental *** is very important to understand the effect of environmental varia-tion on taxonomic diversity and on functional *** the lack of information about the functional diversity in Brazilian Páramos,we analyzed for the first time the effects of altitude and edaphic attributes on functional traits,as well as on taxonomic and functional *** also wanted to answer the questions:Which ecological strategies are favorable in high-altitude grassland?Does soil attributes determine distributions of traits in high-altitude grassland?considering the studied altitudinal gradient is altitude an important variable in the community assembly?Methods the study was conducted on three mountains:Mammoth(1850 m),Elephant(1790 m)and totem(1690 m)in Serra do Brigadeiro State Park,Minas Gerais State,*** mountains represent the‘Serra das cabeças’,a smaller ridge that is surrounded by the Atlantic Forest,one of the 25 hotspot of *** samples were taken using 100 plots of 1 m2 per mountain that were randomly *** plants except mosses were *** taxonomic diversity was evaluated using richness,Shannon diversity,effective number of species and Pielou *** the functional diver-sity,we considered the functional richness,functional evenness and functional *** linear models(GLM/Poisson and quasi-Poisson)were used to evaluate the effect of abiotic variables(altitude,soil depth and soil chemical attributes)on biotic variables(number of species and individuals,life form,dispersal and fruit type)and ordinary least squares regression to evaluate the effect of abiotic variables on the functional and taxonomic *** Findingsthe soil variables presented a considerable edaphic gradient associated with *** soil in Serra das cabeças plays an important role for the

关键词： mountain conservation vegetation islands functional diversity life form highland grassland functional traits

Sarcopenia and Anemia Are Predictors of Poor Prognostic in Cervical Cancer Patients

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Open Journal of Obstetrics and Gynecology 2024年第5期14卷 693-704页

作者： Leandro Santos de Araujo Resende Francine Vilela de Amorim Miguel Soares Conceição Rodrigo Menezes Jales Patrick Nunes Pereira Luis Otávio Sarian Glauco Baiocchi Sophie Derchain Agnaldo Lopes da silva Filho Department of Gynecology and Obstetrics Botucatu Medical School S&#227o Paulo State University UNESP S&#227o Paulo Brazil Department of Health Sciences University of Sao Francisco S&#227o Paulo Brazil Department of Obstetrics and Gynecology School of Medical Science State University of Campinas (UNICAMP) Campinas Brazil Department of Gynecologic Oncology AC Camargo Cancer Center Sao Paulo Brazil Department of Gynecology and Obstetrics School of Medicine of the Federal University of Minas Gerais Belo Horizonte Brazil

Objective: Evaluate pretreatment sarcopenia and anemia as prognostic factors in women undergoing treatment for cervical cancer (CC) with concurrent chemoradiotherapy (CCRT). Methods: 151 women with CC were analysed in this cohort study. Pretreatment computed tomography (CT) images were analysed to assess skeletal muscle index (SMI). Hazard ratios (HR) and multivariate Cox proportional HR were used to analyse association between low SMI, age, body mass index (BMI), haemoglobin levels, histological type, and International Federation of Gynaecology and Obstetrics (FIGO) stage with PFS and OS. Results: A total of 151 patients were included, 53 (35.1%) presented pretreatment sarcopenia;51 (34%) stage I/II and 100 (66%) stage III/IV. Among those patients in advanced stage (III/IV) 37 (70%) (p = 0.28) were sarcopenic at the beginning of treatment. Sarcopenia was associated with worse progression-free survival (PFS) and overall survival (OS) in our cohort [HR 0.97 (p = 0.01)] [HR 0.73 (p = 0.001)], as well as anemia [HR 0.73 (p = 0.001)] [HR 0.78 (p = 0.001)]. Linear regression models indicated that despite showing no association with age, neutrophil or platelet counts, sarcopenia was associated with pretreatment anemia levels (p = 0.01). After a multivariate analysis, only haemoglobin (anemia) and complete CCRT remained associated with PFS and OS. Sarcopenia and anemia were associated with worse PFS and OS in FIGO stage I/II. Conclusion: Pretreatment sarcopenia was significantly associated with low haemoglobin levels. Anemia and incomplete CCRT were independently associated with poor prognosis in women with CC. Pretreatment sarcopenia, as low SMI, was a predictor of poor prognostic in early stages of CC.

关键词： Cervical Cancer Sarcopenia Anemia Chemoradiotherapy

Venopulmonary ECMO Improved Hypoxemia and Supported the Right Ventricle in a Patient with Decompensated Eisenmenger Syndrome

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World Journal of Cardiovascular Surgery 2024年第1期14卷 7-19页

作者： Daniel Manzur-Sandoval Gian Manuel Jiménez-Rodríguez Edgar García-Cruz Ramón Espinosa-Soto Erika Yamali Ramirez-Marcano Yessenia Máyory Téllez-López José Luis Elizalde-silva Gustavo Rojas-Velasco Cardiovascular Critical Care Unit Ignacio Ch&#225vez National Institute of Cardiology Mexico City Mexico Adult Congenital Heart Disease Unit Ignacio Ch&#225vez National Institute of Cardiology Mexico City Mexico Cardiology Department Ignacio Ch&#225vez National Institute of Cardiology Mexico City Mexico

Mechanical circulatory and/or respiratory assistance with extracorporeal membrane oxygenation (ECMO) has become a standard of care for patients with circulatory (venoarterial) and/or respiratory (venovenous) failure refractory to standard therapies. Adult patients with congenital heart disease are an increasingly recognized and growing population and include various groups, such as undiagnosed cases in childhood and palliated and/or corrected cases, which require subsequent care because of residual lesions, cardiac arrest/insufficiency, and arrhythmias, among other conditions. In addition, these patients are prone to developing pathologies that are typical of adulthood with a generally increased risk of morbidity and mortality because of their low reserves and organic damage associated with the underlying heart disease, which makes them candidates for ECMO. These patients represent an additional challenge in this therapy because malformations and the presence of a shunt can generally affect the usual cannulation methods and hemodynamic and oximetry monitoring. Thus, the configuration decision must be made on a case-by-case basis. Here, we present a cannulation method, venopulmonary artery ECMO, which provides hemodynamic and respiratory support, and may be ideal for patients with shunts and/or right ventricular dysfunction. To our knowledge, this is the first report of this configuration in patients with congenital heart diseases.

关键词： Eisenmenger Syndrome Venopulmonary Artery ECMO Refractory Hypoxemia Right Ventricular Dysfunction

Atmospheric Pollutants in a Commercial Region of Fortaleza, Ceará, Brazil: Integration of Health, Environment and Economy in Urban Planning to Improve Air Quality

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Journal of Geoscience and Environment Protection 2024年第5期12卷 92-112页

作者： Mônica Giovana Alves Cardoso Ratts Brenna Kessy silva Lima Gilvan Ribeiro dos Santos Fladimir de Lima Gondim Rinaldo Santos Araújo Mona Lisa Moura de Oliveira Francisco Sales Ávila Cavalcante Daniel Silveira Serra Science and Technology Center State University of Cear&#225 Cear&#225 Brazil Department of Chemistry and Environment Federal Institute of Cear&#225 Cear&#225 Brazil Center of Technological Sciences State University of Cear&#225 Cear&#225 Brazil

The accelerated growth of the vehicular fleet, the modernization of large urban centers, and the few adjustments to the road network in Fortaleza have intensified the problems of traffic and emissions of atmospheric pollutants, highlighting the necessity for strategic urban planning initiatives to address the escalating issues of traffic and pollution. With the objective of analyzing the indices of concentrations of atmospheric pollutants and estimating how these levels can affect human health, this work consists of a study of the analysis of air quality in the intense trade region of Fortaleza. For this, the analysis zone was divided into three perimeters (Major - Medium - Minor), where each perimeter was analyzed at 7 am, 12 noon and 5 pm. Concentrations of the type of O3, particulate matter (PM2.5 and PM10), CO2 and HCHO were collected. Our results demonstrate that most of the analyses are within the limits of current legislation;however, at certain times and perimeters, the analyses of CO2 and HCHO exceeded the established limits. In view of the above, we conclude that public policies to control air quality are necessary to reduce the damage to human health and the environment caused by pollutants.

关键词： Air Quality Urban Planning Particulate Material Health Impacts

Practical assessment of rock damage due to blasting

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International Journal of Mining Science and Technology 2019年第3期29卷 379-385页

作者： Jhon silva Tristan Worsey Braden Lusk Department of Mining Engineering University of KentuckyLexingtonKY 40508USA Department of Mining and Nuclear Engineering Missouri University of Science and TechnologyRollaMO 65409USA

Blasting is the most cost effective methodology to break rock for mining or civil engineering applications.A good production blast will break only the rock that is needed to be removed,leaving the host rock with minimal *** control of rock damage due to blasting is very important when it comes to mine or construction design,safety,and *** to the host rock due to a production blast could result in failures,overbreak and unstable *** how far the fractures generated by a production blast will go into the host rock is a valuable tool for engineers to design a safe highwall while keeping the actual excavation close to the ***,there are several methods available to predict damage due to *** accuracy of many of these methods is questionable,and in most cases,the methodologies over predict the *** often leads to inefficient mines and poor construction *** the current methodologies are reviewed,each one presents sound approaches,but in many cases they also lack consideration of other variables that,according to the authors,need to be included when predicting blast *** paper presents a practical methodology to assess the rock damage from blasting by combining other *** proposed method allows consideration of more variables when compared to available methods,resulting in a more accurate rock damage *** method uses the estimation of the generated levels of peak particle velocity with the distance from a production blast presented by Persson and Holmberg,the peak particle velocity damage ranges proposed by Forsyth and the relationship between the static compressive strength and dynamic compressive strength of rocks from *** new methodology was validated using the data published in a large-scale study performed in granite by Siskind.

关键词： Blasting Fracture Fracture extension Peak particle velocity

Adverse impact of industrial animal agriculture on the health and welfare of farmed animals

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Integrative Zoology 2006年第1期1卷 53-58页

作者： Joyce D’silva Compassion in World Farming PetersfieldHampshireUK

Industrial animal agriculture is grounded in the concept of maximizing productivity and *** breeding for maximum productivity in one characteristic of the animal(*** yield in cows,or breast meat in broiler chickens)has resulted in genotypes and phenotypes that may predispose the animals to poor health and *** conditions in which these individuals are kept may also frustrate many inherited behaviors that they are strongly motivated to *** order to curb the resulting harmful aberrant behaviors,such as feather-pecking in chickens,we sometimes resort to mutilating the *** many places chickens are routinely de-beaked by means of a hot metal *** in World Farming(an international organization that promotes the humane treatment of farm animals)believes that it is unethical to treat sentient beings in such *** have a duty to respect farm animals’sentience by providing them with housing conditions that take their needs and wants into account,and by reverting to the use of dual-purpose,slower-growing breeds that have the potential for good *** to current farming practices are available,and we owe it to the animals,and to our consciences,to pursue them.

关键词： animal welfare intensive animal husbandry selective breeding stereotypic behavior