Calorie restriction or dietary restriction: how far they can protect the brain against neurodegenerative diseases?

作     者：Tayana Silva de Carvalho Tayana Silva de Carvalho

作者机构：Herz-und Diabeteszentrum NRW(HDZ NRW)Bad OeynhausenGermany 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2022年第17卷第8期

页      面：1640-1644页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：supported by the Brazilian National Council for Scientific and Technological Development(CNPq)/German Academic Exchange Service(DAAD)(290076/2014-5 to TSC) 

主　　题：Alzheimer’s disease diet therapy dietary intervention epilepsy fasting glucose restriction hypocaloric diet multiple sclerosis Parkinson’s disease stroke 

摘      要：Finding the correct nutritional intervention is one of the biggest challenges in treating patients with neurodegenerative *** general,these patients develop strong metabolic alterations,resulting in lower treatment efficacy and higher mortality ***,there are still many open questions regarding the effectiveness of dietary interventions in *** studies have shown that a reduction in calorie intake activates key pathways that might be important for preventing or slowing down the progression of such ***,it is still unclear whether these neuroprotective effects are associated with an overall reduction in calories(hypocaloric diet)or a specific nutrient restriction(diet restriction).Therefore,here we discuss how commonly or differently hypocaloric and restricted diets modulate signaling pathways and how these changes can protect the brain against neurodegenerative diseases.