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Curcumin preconditioning enhances the efficacy of adipose-derived mesenchymal stem cells to accelerate healing of burn wounds

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Burns & Trauma 2021年第1期9卷 272-287页

作者： Maryam Azam Hafiz Ghufran Hira Butt Azra Mehmood ramla ashfaq Asad M.Ilyas Muhammad R.Ahmad Sheikh Riazuddin National Centre of Excellence in Molecular Biology 87-West Canal Bank RoadUniversity of the PunjabLahorePakistan Jinnah Burn and Reconstructive Surgery Centre Maulana Shaukat Ali RdQuaid-i-Azam CampusLahorePakistan

Background:Following recent findings from our group that curcumin preconditioning augments the therapeutic efficacy of adipose-derived stem cells in the healing of diabetic wounds in rats,we aimed to investigate the regenerative effects of curcumin preconditioned adipose-derived mesenchymal stem cells(ASCs)for better recovery of acid inflicted burns in this ***:ASCs were preconditioned with 5μM curcumin for 24 hours and assessed for proliferation,migration,paracrine release potential and gene expression comparative to naive ***,the healing capacity of curcumin preconditioned ASCs(Cur-ASCs)versus naive ASCs was examined using acidic wounds in *** this,acid inflicted burns of 20 mm in diameter were made on the back of male Wistar ***,2×10^(6) cells of Cur-ASCs and naive ASCs were intradermally injected in the wound periphery(n=6)for comparison with an untreated saline ***-transplantation,wounds were macroscopically analysed and photographed to evaluate the percentage of wound closure and period of *** wound biopsies were excised and used for histological evaluation and expression analysis of wound healing markers at molecular level by quantitative PCR and western ***:We found that Cur-ASCs exhibited greater proliferation,migration and paracrine potential in ***,Cur-ASCs showed more effective recovery than naive ASCs as exhibited by gross morphology,faster wound closure and earlier ***’s trichrome and hematoxylin and eosin staining demonstrated the improved architecture of the healing burns,as evidenced by reduced infiltration of inflammatory cells,compact collagen and marked granulation in Cur-ASC treated *** these findings,molecular assessment showed significantly reduced expressions of pro-inflammatory factors(interleukin-1 beta,interleukin-6,tumor necrosis factor alpha)a with striking upsurge of an oxidative marker(superoxide dismutase 1),p

关键词： Adipose-derived stem cells Curcumin preconditioning Acidic burn Wound healing

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小口径血管的生物打印进展

Engineering 2021年第6期7卷 282-308页

作者：曹霞 Sushila Maharjan ramla ashfaq Jane Shin Yu Shrike Zhang Division of Engineering in Medicine Department of Medicine Brigham and Women's Hospital Harvard Medical School

生物工程血管在再生医学和药物筛选等应用中的需求越来越大,但生物工程血管移植物的真正可用性仍然有限。三维(3D)生物打印技术为移植和再生提供了一种潜在的血管或血管化组织结构的制备方法。本文总结了不同血管的基本生物学特性,以及... 详细信息

生物工程血管在再生医学和药物筛选等应用中的需求越来越大,但生物工程血管移植物的真正可用性仍然有限。三维(3D)生物打印技术为移植和再生提供了一种潜在的血管或血管化组织结构的制备方法。本文总结了不同血管的基本生物学特性,以及用于制备血管和血管化组织结构的3D生物打印方法和生物墨水设计,重点探讨了小口径血管。

关键词：生物打印小口径血管生物墨水血管生物工程

Maximal operators of pseudo-differential operators with rough symbols

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Applied Mathematics(A Journal of Chinese Universities) 2024年第1期39卷 174-180页

作者： ramla Benhamoud ZHU Xiang-rong School of Mathematical Sciences Zhejiang Normal UniversityJinhua 321004China

Consider a pseudo-differential operator T_(a)f(x)=∫_(R^(n))e^(ix,ζ)a(x,ζ)f(ζ)dζwhere the symbol a is in the rough Hormander class L^(∞)S_(ρ)^(m)with m∈R andρ∈[0,1].In this note,when 1≤p≤2,if n(ρ-1)/p and a∈L^(∞)S_(ρ)^(m),then for any f∈S(R^(n))and x∈R^(n),we prove that M(T_(a)f)(x)≤C(M(|f|^(p))(x))^(1/p) where M is the Hardy-Littlewood maximal *** theorem improves the known results and the bound on m is sharp,in the sense that n(ρ-1)/p can not be replaced by a larger constant.

关键词： pseudo-differential operator rough Hormander class H-L maximal operator

Antimicrobial,hemagglutination and phytotoxic activity of crude ethanolic and aqueous extracts of Seriphidium kurramense

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Journal of Traditional Chinese Medicine 2018年第3期38卷 433-438页

作者： Kafeel Ahmad Amjad Ali Waqar Ahmed Afridi ramla Somayya Muhammad Jawad Ullah Centre of Biotechnology and Microbiology University of Peshawar

OBJECTIVE: To investigate the antimicrobial activity, hemagglutination and phytotoxic activity of crude ethanolic and aqueous extracts of Seriphidium ***: The extracts were analyzed by agar well diffusion assays against five bacterial species:Staphylococcus aureus(S. aureus), methicillin-resistant S. aureus, Escherichia coli, Klebsiella pneumoniae, Bacillus subtilis, and Salmonella typhi. The extracts were also screened against six fungal species — Aspergillus niger, Aspergillus flavus, Alternaria solani, Rhizoctonia solani, Fusarium solani and Pleurotus florida — using the agar tube diffusion method. Additionally, hemagglutination and phytotoxic activities of the crude ethanolic and aqueous extracts were ***: The crude ethanolic and aqueous extracts showed dose-dependent inhibition of the various tested fungal and bacterial strains. No hemagglutination activity was observed. Both the ethanolic and aqueous extracts showed dose-dependent phytotoxic activity toward Lemna ***: The crude ethanolic and aqueous extracts of Seriphidium kurramense possess good antimicrobial and phytotoxic activities, but no hemagglutination activity.

关键词： Anti-bacterial agents Antifungal agents Phytotoxic Seriphidium kurramense

Milk phospholipids-based nanostructures functionalized with rhamnolipids and bacteriocin:Intrinsic and synergistic antimicrobial activity for cheese preservation

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Food Bioscience 2022年第3期47卷 371-382页

作者： Ayesha Sardar Khalid Taskeen Niaz Bina Zarif Saima Shabbir Tayyaba Noor ramla Shahid Muhammad Imran Department of Biosciences Faculty of SciencesCOMSATS University IslamabadPark RoadIslamabad45550Pakistan Department of Materials Science and Engineering Institute of Space TechnologyIslamabad44000Pakistan School of Chemical and Materials Engineering (SCME) National University of Science and Technology (NUST)IslamabadPakistan

Milk fat globule membrane (MFGM) phospholipids-based nanostructures were developed and their functionalization with rhamnolipids (RLs) was carried out to enhance the preservation of cheese against resistant foodborne pathogens i.e.,Listeria monocytogenes and Escherichia coli .Void (without nisin) and nisin-loaded RLs functionalized MFGM nanostructures (RLs-MFGM-NS) were fabricated by ultrasonication-assisted self-assembly *** morphology of void and loaded RLs-MFGM-NS and pristine MFGM nanostructures (MFGM-NS) was observed under scanning electron microscopy (SEM),which indicated uniform size ranging from 43 nm (void RLs-MFGM-NS) to 194 nm (loaded RLs-MFGM-NS).FTIR analyses confirmed the electrostatic interaction,predominantly H-bonding and linkage of carboxyl ester group of MFGM with C–H group in RLs after functionalization of ***,quantitative antimicrobial assay on cheese slices confirmed the broad-spectrum potential of intrinsically active nanostructures (due to RLs) having synergistic activity with nisin against *** and *** .Hence,nisin-loaded RLs-MFGM-NS can be applied as promising bioactive additives for sustained preservation of cheese.

关键词： Rhamnolipids Nisin MFGM Functionalized nanostructures Foodborne pathogens

Antifungal, phytotoxic and hemagglutination activity of methanolic extracts of Ocimum basilicum

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Journal of Traditional Chinese Medicine 2016年第6期36卷 794-798页

作者： Kafeel Ahmad Ali talha Khalil Yusra ramla Somayya Centre of Biotechnology and Microbiology University of Peshawar

OBJECTIVE: To report some of the pharmacological features of the medicinal plant Ocimum ***: In the current studies, Antifungal activity of crude methanolic fraction of Ocimum basilicum was determined against eight pathogenic fungal strains using tube dilution assay. The methanolic fraction was also investigated for phytotoxic and hemagglutination ***: Of the eight strains investigated only Candida albicans and Curvilaria lunata were found to be least affected by plant extract while the rest were significantly inhibited. Moderate phytotoxic activity was observed against lemna minor. Hemagglutination activity showed absence of phytolectins and hence no agglutination of ***: The crude extract of Ocimum basilicum has significant properties against fungi and phytotoxic substances.

关键词： Plants,toxic Antifungal agents Pathogenicity Ocimum basilicum

Variations of Natural Soil Salinity in an Arid Environment Using Underground Watertable Effects on Salinization of Soils in Irrigated Perimeters in South Tunisia

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International Journal of Geosciences 2012年第5期3卷 1040-1047页

作者： Ajmi Boulbaba Lazzez Marzouk ramla ben Rabah Shimi Najet Faculty of Science of Tunis Department of Geology Tunis Tunisia Tunisian Oil Company Tunis Tunisia

In arid and semi-arid regions, salinity is a serious and chronic problem for agriculture. The aim of this study is to evaluate the hydromorphical and salinity risks, and to evaluate the relationship and the possible interfering between the water table and the soil on the oasis of Gabes. The topic is very important, especially for nations around the oceans in arid and semi-arid regions. The effect of the gypsum alkalinity in the soil salinity has investigated. The chemical characteristic of used water irrigation (salinity saturation) and their impact factor in the productivity area. Moreover, in this study the program of examination need to put fifteen piesometres by CRAD (Regional Commissariat of Agriculture Development) in the city of Gabes to controlling the variation of water levels in the superficial water table and their change chemical quality. The experimental measure of this program needs a yearly observation and investigation during April and May to evaluate the hydromorphical and salinity risks on the oasis of Gabes. The relationship and the possible interfering between the water table and the soil has evaluate in such condition.

关键词： Oasis Irrigation Water Superficial Water Table Salinity Drainage Tunisia

Identifying Brain Characteristics of Bright Students

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Journal of Intelligent Learning Systems and Applications 2018年第3期10卷 93-103页

作者： ramla Ghali Hamdi Ben Abdessalem Claude Frasson Roger Nkambou Department of Computer Science Université du Québec à Montréal Montréal Canada Department of Computer Science and Operations Research Université de Montréal Montréal Canada

Gifted students have different ways of learning. They are characterized by a fitful level of attention and intuitive reasoning. In order to distinguish gifted students from normal students, we conducted an experiment with 17 pupils, willing participants in this study. We collected different types of data (gender, age, performance, initial average in math and EEG mental states) in a web platform called NetMath intending for the learning of mathematics. We selected ten tasks divided into three difficulty levels (easy, medium and hard). Participants were invited to respond to top-level exercises on the four basic operations in decimals. Our first results confirmed that the student’s performance has no relation with age. A younger 9-year-old student achieved a higher score than the group with an average of 68.18%. This student can be considered as a gifted one. The gifted students can be also characterized by a mean value of attention (around 60%). They also can be defined by slightly weaker values of their mental states of attention and workload in comparison with the weak pupils.

关键词： NetMath Platform Performance Workload Attention Relaxation Decimal Numbers

Prevention of H2O2 Induced Oxidative Damages of Rat Testis by Thymus algeriensis

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Biomedical and Environmental Sciences 2016年第4期29卷 275-285页

作者： Fatma Guesmi Hamida Beghalem Amit K Tyagi Manel Ben Ali ramla Ben Mouhoub Houda Bellamine Ahmed Landoulsi Laboratory of Biochemistry and Molecular Biology Faculty of Sciences of Bizerte Zarzouma Bizerte 7021 Tunisia Cytokine Research Laboratory Department of Experimental Therapeutics The University of Texas M. D. Anderson Cancer Center 1515 Holcombe Boulevard Houston TX 77030 USA Laboratory of Biomonitoring of the Environment (LRO1/ES14) Faculty of Sciences of Bizerte Zarzouma Bizerte 7021 Tunisia Service of Anatomo-Pathology of Menzel Bourguiba Bizerte 7050 Tunisia

Objective We evaluate the effects of Thymus algeriensis （TEO） against hydrogen peroxide （H202） toxicity on body and testis weight, testis sperm count, testis lipid peroxidation, and antioxidant enzyme activities in rats. Methods Rats were treated with low （LD） and high dose （HD） of H202 （0.1 and 1 mmol/L） in the presence or absence of TEO （150 mg/kg）. Results The results exhibited a significant decrease in body weight and testis weight, in total sperm number decrease （P〈0.05）, sperm motility and percentage of sperm viability, leading to complete arrest, in sperm flagellar beat frequency by the gavage of 1 mmol/L H202 compared to controls. The administration of H2O2 resulted in a significant reduction in testis GSH, GPx, CAT, SOD, and GST activity and significant increase （P〈0.05） in MDA concentration compared with the untreated control animals. TEO pre-treatment protected testis from the H2O2 generated oxidative stress. These results were confirmed by histological architecture examinations. Conclusion H2O2 has the ability to alter the sperm function, characteristics and development of testis. However, TEO is an efficient natural agent, which can prevent the testis from H2O2-induced oxidative damage in rats.

关键词： Testis Hydrogen peroxide TEO Antioxidants Infertility