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Navigating the intersection of psychiatry and ophthalmology:A comprehensive review of depression and anxiety management in glaucoma patients

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World Journal of Psychiatry 2024年第3期14卷 362-369页

作者： Prasanna venkatesh ramesh Arvind Kumar Morya Ashik Azad Pavithra Pannerselvam Aji Kunnath Devadas Sai Thaejesvi Gopalakrishnan Shruthy Vaishali ramesh Ajanya K Aradhya Department of Glaucoma and Research Mahathma Eye Hospital Private LimitedTrichy 620017Tamil NaduIndia Department of Ophthalmology All India Institute of Medical SciencesHyderabad 508126TelanganaIndia Department of Optometry and Visual Science Mahathma Eye Hospital Private LimitedTrichy 620017Tamil NaduIndia Junior Resident Mahathma Eye Hospital Private LimitedTrichy 620017Tamil NaduIndia Department of Cataract and Refractive Surgery Mahathma Eye Hospital Private LimitedTrichy 620017Tamil NaduIndia

Glaucoma,a prevalent and debilitating eye disease,has long been associated with vision impairment and ***,recent research has shed light on the often-underestimated psychological dimensions of this *** and depression,two pervasive psychiatric comorbidities,have been increasingly recognized among glaucoma *** comprehensive review aims to explore the intricate relationship between psychiatry and ophthalmology,in the context of managing depression and anxiety in glaucoma *** meticulously examining peer-reviewed literature,we synthesize current knowledge on the prevalence,risk factors,and underlying mechanisms of anxiety and depression in *** evidence reveals that glaucoma patients face an elevated risk of experiencing these mood *** such as progressive vision loss,complex medication regimens,and the fear of further visual deterioration contribute to their ***,we delve into the bidirectional relationship between glaucoma and mood disorders,shedding light on the complex interplay between ocular and emotional *** review investigates the implications of anxiety and depression on glaucoma management,including their potential impact on treatment adherence,disease progression,and overall quality of *** also explore the neurobiological pathways linking glaucoma and mood disorders,providing a foundation for future research and potential therapeutic *** conclusion,recognizing the psychological burden carried by glaucoma patients is essential for holistic and patient-centered *** review underscores the pressing need for integrated approaches that bring together ophthalmological and psychiatric expertise to optimize the well-being of individuals facing the challenges of *** addressing anxiety and depression in glaucoma care,healthcare providers can enhance the overall quality of life for these patients,ultimately leading to improved outcomes and a brighter

关键词： Glaucoma Psychiatry Depression Anxiety Risk factors Bidirectional relationship

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Intraocular lens selection in diabetic patients:How to increase the odds for success

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World Journal of Diabetes 2024年第6期15卷 1199-1211页

作者： Arvind Kumar Morya Prateek Nishant Prasanna venkatesh ramesh Sony Sinha Aarti Heda Sarika Salodia Ripunjay Prasad Department of Ophthalmology All India Institute of Medical SciencesHyderabad 508126TelanganaIndia Department of Ophthalmology ESIC Medical CollegePatna 801113BiharIndia Department of Glaucoma and Research Mahathma Eye Hospital Private LimitedTrichy 620017Tamil NaduIndia Department of Ophthalmology-Vitreo-Retina Neuro-Ophthalmology and OculoplastyAll India Institute of Medical SciencesPatnaPatna 801507BiharIndia Department of Ophthalmology National Institute of OphthalmologyPune 411000MaharashtraIndia Department of Safety Global Medical SafetyLundbeckSingapore 307591Singapore Department of Ophthalmology RP Eye InstituteDelhi 110001India

The incidence of cataracts is significantly higher in diabetic individuals,particularly in younger age groups,with rates quadrupled in those under 65 and doubled in those over 65 compared to *** surgery in diabetic patients poses many challenges:Poor epithelial healing,decreased corneal sensitivity,increased central corneal thickness,decreased endothelial cell count,variable topography,poor pupillary dilatation,anterior capsular phimosis,posterior capsular opacification(PCO),chances of progression of diabetic retinopathy(DR),zonular weakness,and vitreous prolapse and diabetic macular *** of an appropriate intraocular lens(IOL)is crucial for visual rehabilitation and monitoring *** choice of IOL in diabetic cataract patients is a challenging ***-edge IOLs are favored for their capacity to mitigate PCO,whereas hydrophilic counterparts may incur calcification in the setting of proliferative *** advisability of premium IOLs for achieving spectacle independence warrants judicious evaluation,particularly in the presence of advanced *** IOL placement within the capsular bag is advocated to minimize postoperative *** preoperative assessment and informed patient counseling regarding IOL options are indispensable for optimizing surgical *** review article covers various aspects regarding the choice of IOLs in different case scenarios and complications in the diabetic population.

关键词： Diabetics Cataract Intraocular lens Diabetic retinopathy Diabetes mellitus

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Unveiling the silent link:Normal-tension glaucoma's enigmatic bond with cardiac blood flow

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World Journal of Cardiology 2024年第1期16卷 10-15页

作者： Prasanna venkatesh ramesh Arvind Kumar Morya Ajanya K Aradhya Pavithra Pannerselvam Sai Thaejesvi Gopalakrishnan Shruthy Vaishali ramesh Aji Kunnath Devadas Navaneeth Krishna Department of Glaucoma and Research Mahathma Eye Hospital Private LimitedTrichy 620017Tamil NaduIndia Department of Ophthalmology All India Institute of Medical SciencesHyderabad 508126TelanganaIndia Department of Optometry and Visual Science Mahathma Eye Hospital Private LimitedTrichy 620017Tamil NaduIndia Mahathma Eye Hospital Private Limited Trichy 620017Tamil NaduIndia Department of Cataract and Refractive Surgery Mahathma Eye Hospital Private LimitedTrichy 620017Tamil NaduIndia

This comprehensive review embarks on a captivating journey into the complex relationship between cardiology and normal-tension glaucoma(NTG),a condition that continues to baffle clinicians and researchers ***,characterized by optic nerve damage and visual field loss despite normal intraocular pressure,has long puzzled *** emerging perspective suggests that alterations in ocular blood flow,particularly within the optic nerve head,may play a pivotal role in its *** NTG shares commonalities with its high-tension counterpart,its unique pathogenesis and potential ties to cardiovascular health make it a fascinating subject of *** navigates through the complex web of vascular dysregulation,blood pressure and perfusion pressure,neurovascular coupling,and oxidative stress,seeking to uncover the hidden threads that tie the heart and eyes together in *** review explores into the intricate mechanisms connecting cardiovascular factors to NTG,shedding light on how cardiac dynamics can influence ocular health,particularly in cases where intraocular pressure remains within the normal ***'s enigmatic nature,often characterized by seemingly contradictory risk factors and clinical profiles,underscores the need for a holistic approach to patient *** parallels to cardiac health,we examine into the shared vascular terrain connecting the heart and the *** factors,including systemic blood flow,endothelial dysfunction,and microcirculatory anomalies,may exert a profound influence on ocular perfusion,impacting the delicate balance within the optic nerve *** elucidating the subtle clues and potential associations between cardiology and NTG,this review invites clinicians to consider a broader perspective in their evaluation and management of this elusive *** the understanding of these connections evolves,so too may the prospects for early diagnosis and tailored interventions,ultimately enhancing the qual

关键词： Normal tension glaucoma Vascular dysregulation Ocular blood flow Blood pressure Perfusion pressure Oxidative stress

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Novel automated non-invasive detection of ocular surface squamous neoplasia using artificial intelligence

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World Journal of Methodology 2024年第2期14卷 51-64页

作者： Sony Sinha Prasanna venkatesh ramesh Prateek Nishant Arvind Kumar Morya Ripunjay Prasad Department of Ophthalmology–Vitreo Retina Neuro Ophthalmology and OculoplastyAll India Institute of Medical SciencesPatna 801507India Department of Glaucoma and Research Mahathma Eye Hospital Private LimitedTrichy 620017India Department of Ophthalmology ESIC Medical CollegePatna 801113India Department of Ophthalmology All India Institute of Medical SciencesHyderabad 508126India Department of Ophthalmology RP Eye InstituteDelhi 110001India

Ocular surface squamous neoplasia(OSSN)is a common eye surface tumour,characterized by the growth of abnormal cells on the ocular *** includes invasive squamous cell carcinoma(SCC),in which tumour cells penetrate the basement membrane and infiltrate the stroma,as well as non-invasive conjunctival intraepithelial neoplasia,dysplasia,and SCC in-situ thereby presenting a challenge in early detection and *** identification and precise demarcation of the OSSN border leads to straightforward and curative treatments,such as topical medicines,whereas advanced invasive lesions may need orbital exenteration,which carries a risk of *** intelligence(AI)has emerged as a promising tool in the field of eye care and holds potential for its application in OSSN *** algorithms trained on large datasets can analyze ocular surface images to identify suspicious lesions associated with OSSN,aiding ophthalmologists in early detection and *** can also track and monitor lesion progression over time,providing objective measurements to guide treatment ***,AI can assist in treatment planning by offering personalized recommendations based on patient data and predicting the treatment *** manuscript highlights the role of AI in OSSN,specifically focusing on its contributions in early detection and diagnosis,assessment of lesion progression,treatment planning,telemedicine and remote monitoring,and research and data analysis.

关键词： Conjunctival neoplasm Early detection of cancer Machine learning Deep neural network Precision medicine

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Diabetic retinopathy:A review on its pathophysiology and novel treatment modalities

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World Journal of Methodology 2024年第4期14卷 61-76页

作者： Arvind Kumar Morya Prasanna venkatesh ramesh Prateek Nishant Kirandeep Kaur Bharat Gurnani Aarti Heda Sarika Salodia Head of the Department Department of OphthalmologyAll India Institute of Medical SciencesHyderabad 508126TelanganaIndia Glaucoma Medical Officer Department of Glaucoma and ResearchMahathma Eye Hospital Private LimitedTrichy 620017Tamil NaduIndia Department of Ophthalmology ESIC Medical CollegePatna 801103BiharIndia Department of Pediatric Ophthalmology and Strabismus Gomabai Netralaya and Research CentreNeemuch 458441Madhya PradeshIndia Cornea and Refractive Services Gomabai Netralaya and Research CentreNeemuch 458441Madhya PradeshIndia Department of Ophthalmology National Institute of OphthalmologyPune 411000MaharashtraIndia Global Medical Safety LundbeckSingapore 569933SingaporeSingapore

Diabetes mellitus(DM)is a chronic metabolic non-communicable disease with the ability to cause serious microvascular and macrovascular complications throughout the body,including in the *** retinopathy(DR),present in onethird of patients with diabetes,is a vision-threatening complication caused by uncontrolled diabetes,which greatly affects the retinal blood vessels and the lightsensitive inner retina,eventually leading to *** epidemiological studies elucidate that DR can vary by age of onset,duration,types of diabetes,and *** studies show that the pathogenesis of diabetic retinopathy has spread its roots beyond merely being the result of *** complexity of its etiopathology and diagnosis makes therapeutic intervention *** review throws light on the pathological processes behind DR,the cascade of events that follow it,as well as the available and emerging treatment options.

关键词： Diabetes Diabetic retinopathy Diabetic macular edema Intravitreal injection Laser photocoagulation

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Pharmacological adjuvants for diabetic vitrectomy surgery

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World Journal of Methodology 2024年第4期14卷 84-90页

作者： ramesh venkatesh Chaitra Jayadev Vishma Prabhu Priyanka Gandhi Rupal Kathare Naresh K Yadav Ayushi Choudhary Jay Chhablani Department of Ophthalmology Narayana NethralayaBangalore 560010India Department of Retina Narayana Nethralaya Eye InstituteBangalore 560010India Department of Vitreo Retina Narayana NethralayaRetina ServSuper Specialty Eye Hospital and Post Graduate Institute of OphthalmologyBangalore 560010India Department of Retina University of Pittsburg School of MedicinePittsburgPA 15213United States

Diabetic vitrectomy is a highly intricate surgical procedure performed during the advanced stages of diabetic retinopathy(DR).It is used to treat conditions such as tractional or combined retinal detachment,vitreous hemorrhage,and subhyaloid hemorrhage,which are all severe manifestations of proliferative *** results of the surgery are uncertain and *** surgery has made significant progress since the early stages of *** the past ten years,advancements in intravitreal pharmacotherapy have emerged,offering new possibilities to improve the surgical results for our *** the realm of medical terminology,an"adjunct"refers to a pharmaceutical or substance employed to aid or expedite the primary therapeutic intervention for a particular *** introduction has broadened the range of therapeutic choices that are accessible prior to,during,and following surgical *** review article will specifically analyze the pharmacological adjuncts used in diabetic vitrectomy surgery,with a focus on their role in facilitating or aiding specific steps of the *** implementation of this system of categorization offers benefits to the surgeon by allowing them to foresee potential difficulties that may occur during the surgical procedure and to choose the appropriate pharmacological agent to effectively tackle these challenges,thus enhancing surgical success rates.

关键词： Diabetic retinopathy Vitrectomy Intravitreal injections Anti-vascular endothelial growth factor Adjuvants Outcomes

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Diabetes more than retinopathy,it’s effect on the anterior segment of eye

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World Journal of Clinical Cases 2023年第16期11卷 3736-3749页

作者： Arvind Kumar Morya Prasanna venkatesh ramesh Kirandeep Kaur Bharat Gurnani Aarti Heda Karan Bhatia Aprajita Sinha Department of Ophthalmology All India Institute of Medical SciencesHyderabad 508126TelanganaIndia Glaucoma and Research Mahathma Eye Hospital Private LimitedTennurTrichy 620001Tamil NaduIndia Pediatric Ophthalmology and Strabismus Sadguru Netra ChikitsalayaSadguru Seva Sangh TrustJanaki-KundChitrakoot 485334Madhya PradeshIndia Cornea and Refractive Services Sadguru Netra ChikitsalayaSadguru Seva Sangh TrustJanaki-KundChitrakoot 485334Madhya PradeshIndia Department of Ophthalmology National Institute of OphthalmologyPune 411000MaharashtraIndia Department of Ophthalmology Manaktala Eye and Maternity HomeMeerut 250001Uttar PradeshIndia Department of Ophthalmology Worcestershire Acute HospitalWorcestershire 01601United Kingdom

Diabetes mellitus(DM)is one of the chronic metabolic noncommunicable diseases that has attained worldwide *** threatens healthy life around the globe,with mild-to-severe secondary complications and leads to significant illness including nephropathy,neuropathy,retinopathy,and macrovascular abnormalities including peripheral vasculopathy,and ischaemic heart *** into diabetic retinopathy(DR),which affects one-third of persons with diabetes,has made considerable strides in recent *** addition,it can lead to several anterior segment complications such as glaucoma,cataract,cornea,conjunctiva,lacrimal glands and other ocular surface *** DM also caused gradual damage to corneal nerves and epithelial cells,which raises the likelihood of anterior segment diseases including corneal ulcers,dry eye disease,and chronic epithelial *** DR and other associated ocular complications are well-known,the complexity of its aetiology and diagnosis makes therapeutic intervention *** glycaemic control,early detection and regular screening,and meticulous management is the key to halting the progression of the *** this review manuscript,we aim to provide an in-depth understanding of the broad spectrum of diabetic complications in the anterior segment of the ocular tissues and illustrate the progression of diabetes and its pathophysiology,epidemiology,and prospective therapeutic *** first such review article will highlight the role of diagnosing and treating patients with a plethora of anterior segment diseases associated with diabetes,which are often neglected.

关键词： Diabetes Ocular surface Cataract Glaucoma Lens Uvea

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Axenfeld-Reiger syndrome: A search for the missing links

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World Journal of Clinical Cases 2023年第29期11卷 7034-7042页

作者： Arvind Kumar Morya Prasanna venkatesh ramesh Sony Sinha Prateek Nishant Nazia Nain Ravi NaikRamavath Chetana Gone Ripunjay Prasad Department of Ophthalmology All India Institute of Medical SciencesBibi NagarHyderabad 508126TelanganaIndia Glaucoma Medical Officer Mahathma Eye Hospital Private LimitedThennurTrichy 620017Tamil NaduIndia Department of Ophthalmology-Vitreo-Retina and Oculoplasty All India Institute of Medical SciencesPatnaPatna 801507BiharIndia Department of Ophthalmology All India Institute of Medical SciencesPatnaPatna 801507BiharIndia Department of Ophthalmology RP Eye InstituteDelhi 110001DelhiIndia

BACKGROUND Axenfeld-Rieger syndrome(ARS)is a rare cause of congenital glaucoma and may result in loss of *** is mostly autosomal dominant in nature characterized by developmental abnormalities in the angle of anterior chamber and iris of the eye,also associated with structural abnormalities in the *** To study and observe the demographics and clinical findings in a very rare ocular disease known as *** Case records of symptomatic patients attending Ophthalmology outpatient department and diagnosed to have ocular hypertension or glaucoma in 3 years from March 2017 to March 2020 were evaluated to search for cases diagnosed with *** of all patients diagnosed with ARS were then analysed for demographic and clinical characterization as well as management and success of *** Eight out of ten patients with positive clinical signs were symptomatic and had *** of these patients had limbal stem cell deficiency and another had vernal *** Clinical characterization of ARS is important for making a definitive diagnosis and determining prognosis.

关键词： Axenfeld-Reiger Syndrome Glaucoma Limbal stem cell deficiency Vernal keratoconjuctivitis

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Nonparametric Statistical Feature Scaling Based Quadratic Regressive Convolution Deep Neural Network for Software Fault Prediction

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Computers, Materials & Continua 2024年第3期78卷 3469-3487页

作者： Sureka Sivavelu venkatesh Palanisamy School of Computer Science Engineering and Information Systems Vellore Institute of TechnologyVellore632014India

The development of defect prediction plays a significant role in improving software quality. Such predictions are used to identify defective modules before the testing and to minimize the time and cost. The software with defects negatively impacts operational costs and finally affects customer satisfaction. Numerous approaches exist to predict software defects. However, the timely and accurate software bugs are the major challenging issues. To improve the timely and accurate software defect prediction, a novel technique called Nonparametric Statistical feature scaled QuAdratic regressive convolution Deep nEural Network (SQADEN) is introduced. The proposed SQADEN technique mainly includes two major processes namely metric or feature selection and classification. First, the SQADEN uses the nonparametric statistical Torgerson–Gower scaling technique for identifying the relevant software metrics by measuring the similarity using the dice coefficient. The feature selection process is used to minimize the time complexity of software fault prediction. With the selected metrics, software fault perdition with the help of the Quadratic Censored regressive convolution deep neural network-based classification. The deep learning classifier analyzes the training and testing samples using the contingency correlation coefficient. The softstep activation function is used to provide the final fault prediction results. To minimize the error, the Nelder–Mead method is applied to solve non-linear least-squares problems. Finally, accurate classification results with a minimum error are obtained at the output layer. Experimental evaluation is carried out with different quantitative metrics such as accuracy, precision, recall, F-measure, and time complexity. The analyzed results demonstrate the superior performance of our proposed SQADEN technique with maximum accuracy, sensitivity and specificity by 3%, 3%, 2% and 3% and minimum time and space by 13% and 15% when compared with the two sta

关键词： Software defect prediction feature selection nonparametric statistical Torgerson-Gower scaling technique quadratic censored regressive convolution deep neural network softstep activation function nelder-mead method

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Performance of Bacillus tropicus on Mechanical,Durable and Crack Remediation Properties in Sustainable Vermiculite Concrete

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Journal of Bionic Engineering 2024年第4期21卷 1987-1999页

作者： Anbazhagan Rajesh venkatesh Sri Hariny Arunachalam Sumathi School of Civil Engineering SASTRA Deemed to be UniversityThirumalaisamudramThanjavurTamilnadu613401India

Sustainable cement-based concrete materials are primarily used for construction,among which vermiculite as lightweight fine aggregate gains more future development ***,a bacterial solution was sprayed over vermiculite and wrapped using calcium sulphoaluminate(CSA)cement to replace with fine aggregate in ***,based on a preliminary test on compressive strength results,10%of Ground Granulated Blast Furnace Slag(GGBS)and a healing solution proportion of 9:1 was selected for preparing self-healing *** fine aggregate was replaced in concrete using vermiculite in 0%,5%,10%and 15%and the findings suggest that bacterial vermiculite replacement should be at most 5%to achieve better results in strength and durable *** strength enhancement observed for compressive strength,strength regain,split tensile strength,flexural strength,and ultrasonic pulse velocity were 29.22%,45.5%,34.02%,28.03%and 41.4%*** crack healing at 7,14 and 28 days of BIVC was 38.23%,58.82%and 79.41%,which is 3–4%lower than internal crack *** analysis by Scanning Electron Microscopy(SEM),X-Ray Diffractometer(XRD),and Energy Dispersive Spectroscopy(EDS)reveals the existence of calcite,and it was formed due to the bio-mineral action of bacteria with available nutrients in sustainable concrete.

关键词： Bacillus tropicus Vermiculite Ground granulated blast furnace slag Mechanical properties Durable properties Crack healing Microstructural characterization

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