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Journal of Pharmaceutical Analysis 2014年第2期4卷 144-152页

作者： Bhupinder singh rama s.lokhandae Ashish Dwivedi sandeep sharma Naveen Dubey Jubiliant Clinsys Limited NoidaNew DelhiIndia Jaipur National University JaipurIndia

A validated ultra-performance liquid chromatography mass spectrometric method （UPLC-Ms/Ms） was used for the simultaneous quantitation of candesartan （CN） and hydrochlorothiazide （HCT） in human plasma. The analysis was performed on UPLC-Ms/Ms system using turbo ion spray interface. Negative ions were measured in multiple reaction monitoring （MRM） mode. The analytes were extracted using a liquid-liquid extraction （LLE） method by using 0.1 mL of plasma volume. The lower limit of quantitation for CN and HCT was 1.00 ng/mL whereas the upper limit of quantitation was 499.15 ng/mL and 601.61 ng/mL for CN and HCT respectively. CN d4 and HCT-13Cd2 were used as the internal standards for CN and HCT respectively. The chromatography was achieved within 2.0 min run time using a C18 Pheno-menex, Gemini NX （100 mm ~ 4.6 mm, 5 mm） column with organic mixture：buffer solution （80：20, v/v） at a flow rate of 0.800 mL/min. The method has been successfully applied to establish the bioequivalence of candesartan cilexetil （CNC） and HCT immediate release tablets with reference product in human subjects.

关键词： Candesartan cilexetil Hydrochlorothiazide UPLC Ms/Ms Bioequivalence Candcsartan cilexetil-hydrochlorothiazide(ATACAND HCT)

Velocity Form Calculations of Generalized Oscillator strengths for 3s→ (3p, 4p, 5p, 6p) Dipole Transitions of Atomic sodium in Debye Plasma

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Open Journal of Applied sciences 2024年第6期14卷 1512-1529页

作者： Louis Gomis Clement Diatta Moustapha sadibou Tall Ibrahima Gueye Faye rama Gomis Yande Diouf Mamadou Coulibaly Laboratoire de Physique des Plasmas et de Recherches Interdisciplinaires Departement de Physique Universite Cheikh Anta Diop Dakar Senegal

In this paper, the generalized oscillator strengths (GOss) of excitations of atomic sodium from ground state to 2p63s0 (3p, 4p, 5p, 6p) states, immersed in Debye plasma, were calculated by using wavefunctions which were obtained numerically from the restricted Hartree-Fock (RHF) equation. This RHF equation employs the local density approach for exchange interactions including plasma Debye screening. Theoretical RHF and random phase approximation with exchange (RPAE) velocity calculations have shown that the GOss for excitations to 3 s0(3 p,4 p,5 p,6 p)depend on the plasma Debye screening effects, as shown by the reduction in the GOs amplitude with decreasing Debye length λD. The agreement between the present RPAE V results for the transitions 3 s→3 s0(3 p,4 p,5 p)and the length calculations of Martínez-Flores was satisfactory. Correlation effects were found quite to be significant in the vicinity of the maxima of the GOs of the 3 s→3 s0(4 p,5 p,6 p)excitations by using the RPAE V approach. We note the poor influence of many electron correlations on the GOs of (3 s→3 p)transition with the same principal quantum number. Finally, we comment that the RPAE V calculations are useful in investigating electron correlation effects on the transition GOs of atomic sodium planted in Debye plasma. The present velocity results also reveal that the 3 s→3 s0(5p, 6p)transition GOss tend to be delocalized due to more significant screening effects at Debye lengths λD=20and 30 a.u. for excited subshells 5p and 6p, respectively. We report here novel results of GOs for 3 s→3 s06ptransition obtained from different Debye lengths.

关键词： Plasma screening Effect Correlation Effect sodium Atomic Velocity Form GOs Restricted Hatree-Fock Random Phase Approximation with Exchange

Epidemiological, Clinical, and Evolutionary Profile of Type 1 Diabetics in the Internal Medicine Department of the Abass Ndao Hospital from 2010 to 2021 (about 659 Cases)

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Journal of Diabetes Mellitus 2024年第1期14卷 69-79页

作者： sow Djiby Djiba Boundia Ndour Michel Assane Diedhiou Demba Dieng Mouhamed Diallo Ibrahima Mané Ndiaye rama saou Houleye Fall Ndiouga Ndiaye Matar Gadji Fatou Kiné sarr Anna Diop said Nourou Ndour Mbaye Maimouna Department of Internal Medicine and Medical specialties Hospital Abass Ndao Dakar Sénéga

Introduction: Type 1 diabetes can have acute complications, sometimes requiring hospitalization. The aim of this study was to describe the epidemiological, clinical and evolutionary aspects of type 1 diabetes in patients at the Abass Ndao National Hospital in Dakar. Patients and Methods: This was a cross-sectional, descriptive and analytical study conducted from January 01, 2010 to December 31, 2021. It focused on hospitalized type 1 diabetic patients. Epidemiological, clinical and evolutionary data were evaluated. Results: six hundred and fifty-nine (659) patients were enrolled, representing a frequency of 11.5%. The mean age was 29.47 years, giving a sex ratio (m/f) of 0.95. Average hospital stay was 6.1 days. One hundred and forty-four (144) patients (21.8%) had inaugural diabetes. The average consultation time was 14.89 days. Acute metabolic complications were ketoacidosis in 353 patients (56%), and hypoglycemia in 1.2%. simple hyperglycemia was noted in 113 patients (18.0%). Infection was present in 522 patients (58.3%), of whom 95 (28.2%) had a skin infection.55 patients (16.3%) had a respiratory infection. 12.3% had a dietary imbalance.176 cases (27.7%) had no imbalance.26 patients (3.9%) died, with infectious pathologies accounting for the majority of decompensation factors among the deceased (57.7%). Conclusion: Type 1 diabetes is a cause of morbidity and mortality. It is essential to develop and implement a prevention and management program.

关键词： Type 1 Diabetes Epidemiology Mortality senegal

Biological and mechanical investigation of novel flax/silk protein-based nanofibrous scaffold for bone regeneration

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Progress in Natural science:Materials International 2022年第4期32卷 443-455页

作者： M.rama U.Vijayalakshmi Department of Chemistry School of Advanced Sciences Vellore Institute of Technology

The process of bone tissue regeneration involves an intricate network of a biological macromolecules that includes proteins and peptides to support stimulation and healing response. Here, we have fabricated a novel flaxseed/silk fibroin based(dual protein) composite nanofibers using β-TCP to improve the biological properties and promote cartilage tissue regeneration along with a controllable rate of biodegradation. The physiochemical properties of PVA/β-TCP/FP:sF were characterized by FTIR, XRD, sEM, porosity, contact angle measurements and mechanical evaluation etc. This study demonstrates the biological performance of the developed nanofibers by using hemocompatibility, biodegradation ability, and apatite deposition in stimulated body fluid. Moreover, the cell viability assay was performed on MG-63 osteoblast cells and long-term antibacterial rate against E. coli and s. aureus was analysed. Docking results of flax protein and silk fibroin protein further confirmed the stable modes of intramolecular bonding and the most stable electrostatic values using theoretical calculations. Taken together,the experimental results proved that the dual protein-based fibrous scaffold was found to be up-regulated in terms of biological activity with enhanced cell adhesion and proliferation.

关键词： Flax protein silk fibroin β-TCP Electrospinning Docking Bone regeneration

Millimeter wave dielectric loaded exponentially tapered slot antenna array using substrate integrated waveguide for gigabit wireless communications

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红外与毫米波学报 2015年第5期34卷 513-519页

作者： s Ramesh T rama Rao Department of Electronics & communication Engineering Valliammai Engineering College RADMIC Department of Telecommunication EngineeringSRM University

A new and upcoming application is the use of 60 GHz antennas for high date rate point-to-point connections to serve Gigabit(Gi-Fi)w ireless *** design of M illimeter w ave(M m W)antennas has to cope w ith the unadorned influences of manufacturing tolerances and losses at 60 *** this paper,the concept of substrate Integrated Waveguide(sIW)and Exponentially Tapered slot(ETs)antenna w ere used together to design a high gain,efficient planar dielectric loaded antenna for M m W Gi-Fi w ireless communications at 60 *** sIW is used to feed the antenna and a dielectric is utilized in front of the antenna to increase the *** dielectric loaded ETs antenna and compact sIW feed w ere fabricated on a single substrate,resulting in low cost and easy *** antenna w ith elliptical shaped dielectric loaded w as fabricated using printed circuit board *** measured gain of the single element antenna is 10.2 dB,w hile the radiation efficiency of 96.84%is obtained at 60 *** Y-junction sIW pow er divider is used to form a 1×4 array structure.M easured gain of the 1×4 array antenna is 13.3 dB,w hile the measured radiation pattern and gain are almost constant w ithin the w ide bandw idth of the antenna.

关键词： millimeter waves 60 GHz exponentially tapered slot antenna dielectric loading substrate integrated waveguide

Design of Fuzzy Logic Control Framework for Qos Routing in MANET

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Intelligent Automation & soft Computing 2023年第3期35卷 3479-3499页

作者： M.Vargheese s.Vanithamani D.stalin David Ganga rama Koteswara Rao Department of Computer science and Engineering PSN College of Engineering and TechnologyTirunelveli627152Tamil NaduIndia Department of Master of Computer Applications M.Kumarasamy College of EngineeringKarur639113Tamil NaduIndia Department of Information Technology Veltech Multitech Dr.Rangarajan Dr.Sakunthala Engineering CollegeChennai600062Tamil NaduIndia Department of Computer science and Information Technology Koneru Lakshmaiah Education FoundationVaddeswaram522502Andhra PradeshIndia

Wireless networks with no infrastructure arise as a result of multiple wireless devices working *** Mobile Ad hoc Network(MANET)is a system for connecting independently located Mobile Nodes(MNs)via wireless links.A MANET is self-conﬁguring in telecommunications,while MN produces non-infrastructure networks that are entirely *** the MAC and routing layers of MANETs take into account issues related to Quality of service(Qos).When culling a line of optical discernment communication,MANET can be an effective and cost-saving route cull *** maintain Qos,however,more or fewer challenges must be *** paper proposes a Fuzzy Logic Control(FLC)methodology for specifying a probabilistic Qos guaranteed for *** framework uses network node mobility to establish the probabil-istic quality of *** Logic(FL)implementations were added to Network simulator-3(Ns-3)and used with the proposed FLC framework for *** have found that for a given node’s mobility,the path’s bandwidth decreases with time,hop count,and *** is resolutely based on this fuzzy rule that the priority index for a packet is ***,by avoiding sending pack-ets(PKT)out of source networks when there are no beneﬁcial routes,bandwidth is not *** FLC outperforms the scheduling methods with a wide range of *** improve Qos within MANETs,it is therefore recommended that FLC is used to synchronize ***,using these performance metrics,the Qos-responsible routing can opt for more stable *** on network simulation,it is evident that incorporating Qos into routing protocols is meant to improve traf-ﬁc performance,in particular authentic-time trafﬁc.

关键词： MANET quality of service fuzzy logic mobile node network trafﬁc

A silver-catalyzed[3+3]-annulation cascade of alkynyl alcohols andα,β-unsaturated ketones for the regioselective assembly of chromanes

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Organic Chemistry Frontiers 2022年第3期9卷 802-809页

作者： Ashwini K.Nakate sagar s.Thorat shailja Jain Gamidi rama Krishna Kumar Vanka Ravindar Kontham Organic Chemistry Division CSIR-National Chemical LaboratoryDr Homi Bhabha RoadPune-411008India Academy of scientific and Innovative Research(AcsIR) Ghaziabad-201002India Centre for Materials Characterization CSIR-National Chemical LaboratoryDr Homi Bhabha RoadPune-411008India Physical and Materials Chemistry Division CSIR-National Chemical LaboratoryDr Homi Bhabha RoadPune-411008India

An unprecedented Ag(I)-catalyzed[3+3]-annulation of alkynyl alcohols(5-hexyn-1-ols)andα,β-unsaturated ketones is reported to construct simple to complex *** transformation begins with hydroalkoxylation of alkynol through C-C triple bond activation to give cyclic-enol ether,followed by intermolecular 1,4-addition and intramolecular 1,2-addition of enol ethers onto the enone and oxidative aromatization or Grob-type elimination steps.

关键词： alcohols unsaturated catalyzed

Efficient Resource Allocation in Fog Computing Using QTCs Model

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Computers, Materials & Continua 2022年第2期70卷 2225-2239页

作者： M.Iyapparaja Naif Khalaf Alshammari M.sathish Kumar s.siva rama Krishnan Chiranji Lal Chowdhary school of Information Technology and Engineering Vellore Institute of TechnologyVellore632014India Mechanical Engineering University of HailSaudi Arabia

Infrastructure of fog is a complex system due to the large number of heterogeneous resources that need to be *** embedded devices deployed with the Internet of Things(IoT)technology have increased since the past few years,and these devices generate huge amount of *** devices in IoT can be remotely connected and might be placed in different locations which add to the network *** time applications require high bandwidth with reduced latency to ensure Quality of service(Qos).To achieve this,fog computing plays a vital role in processing the request locally with the nearest available resources by reduced *** of themajor issues to focus on in a fog service is managing and allocating *** theory is one of the most popular mechanisms for task *** this work,an efficient model is designed to improve Qos with the efficacy of resource allocation based on a Queuing Theory based Cuckoo search(QTCs)model which will optimize the overall resource management process.

关键词： Queuing theory Cuckoo search Qos resource allocation energy efficiency

sMO Algorithm to Unravel CEED Problem using Wind and solar

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Intelligent Automation & soft Computing 2023年第2期35卷 1857-1872页

作者： A.Prabha G.Themozhi rama Reddy sathi Faculty of Electrical Engineering Anna UniversityChennai600025India Department of Electrical and Electronics Engineering AMET Deemed UniversityChennai603112India Department of Electrical and Electronics Engineering Rajalakshmi Engineering CollegeChennai602105India

This research proposes a more advanced way to address Combined Economic Emission Dispatch(CEED)*** Load Dispatch(ELD)and Economic Emission Dispatch(EED)have been implemented to reduce generating unit fuel costs and *** both economics and emission tar-gets are taken into account,the dispatch of an aggregate cost-effective emission challenge *** research affords a mathematical modeling-based analyti-cal technique for solving economic,emission,and collaborative economic and emission dispatch problems with only one *** study takes into account both the fuel cost target and the environmental impact of *** bi-inten-tion CEED problem is converted to a solitary goal function using a price penalty factor *** this case,a metaheuristic and an environment-inspired,intel-ligent spider Monkey Optimization technique(sMO)are used to address the CEED *** following the generator’s scheduling process,the sMO meth-od is used to regulate the output from the power generation system in terms of pollution and fuel *** Fission-Fusion social(FFs)structure of spider mon-keys promotes them to utilize a global optimization method known as sMO dur-ing foraging *** emphasis is mostly on lowering the cost of generation and pollution in order to improve the efﬁciency of the power system and han-dle dispatch problems with *** economic dispatch has been reme-died,and the improved result demonstrates that the system’s performance is stable andﬂexible in real ***,the system’s output demonstrates that the system has improved in resolving CEED difﬁ*** compared to ear-lier investigations,the proposed model’sﬁndings have *** the gener-ating units,wind and solar are used to explore the CEED crisis in the IEEE 30 bus system.

关键词： Cost of generation emission CEED thermal power system bi-intention sMO wind and solar IEEE 30 bus system

ETP-AKEP: enhanced three-party authenticated key exchange protocols for data integrity in cloud environments

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Journal of Control and Decision 2023年第1期10卷 126-133页

作者： Kalluri rama Krishna C.V.Guru Rao Faculty of Informatics Osmania UniversityHyderabadIndia school of Computer science&Artificial Intelligence S.R.UniversityWarangalIndia

With key exchange protocols, a secure session key is generated between two remote users, andservers and exchanged between them. It is generally used to prevent unauthorised users fromgaining access to sensitive data. This article presents an enhanced three-party authenticated keyexchange protocols (ETP-AKE) protocol that does not depend on symmetric key encryption andinstead uses asymmetric key encryption. A key component of the proposed ETP-AKE protocol isusing elliptic curve encryption in conjunction with a one-way hash function. Its integrity certificationwas confirmed via the usage of the AVIsPA tool package. Our proposed protocol is intendedto protect against various security threats, including the man-in-the-middle assault, the parallelattack, and the key-compromise attack, among others.

关键词： ECC hash function cloud integrity third party key exchange