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HTR2A agonists play a therapeutic role by restricting ILC2 activation in papain-induced lung inflammation

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Cellular & Molecular Immunology 2023年第4期20卷 404-418页

作者： Zhishuo Wang Chenghua Yan Qizhen Du Yuying Huang Xuezhen Li Dan Zeng Ruizhi Mao rama krishna gurram Shipeng Cheng Wangpeng Gu Lin Zhu Weiguo Fan Liyan Ma Zhiyang Ling Ju Qiu Dangsheng Li Enmei Liu Yaguang Zhang Yiru Fang Jinfang Zhu Bing Sun state Key Laboratory of Cell Biology CAS Center for Excellence in Molecular Cell ScienceShanghai Institute of Biochemistry and Cell BiologyChinese Academy of SciencesUniversity of Chinese Academy of Sciences320 Yueyang RoadShanghai 200031China College of Life Sciences Jiangxi University of Chinese MedicineNanchang 330004China Department of Respiratory Medicine Children's Hospital of Chongqing Medical University National Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChongqing Key Laboratory of PediatricsChongqingChina Department of Allergy Chongqing General HospitalChongqingChina Clinical Research Center and Division of Mood Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghai 200030China Laboratory of Immune System Biology National Institute of Allergy and Infectious DiseasesNational Institutes of HealthBethesdaMD 20892USA CAS Key Laboratory of Tissue Microenvironment and Tumor Shanghai Institute of Nutrition and HealthUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China CAS Center for Excellence in Brain Science and Intelligence Technology Shanghai 200031China Shanghai Key Laboratory of Psychotic Disorders Shanghai 201108China.

Group 2 innate lymphoid cells(ILC2s)are a category of heterogeneous cells that produce the cytokines IL-5 and IL-13,which mediate the type 2 immune response.However,specific drug targets on lung ILC2s have rarely been reported.Previous studies have shown that type 2 cytokines,such as IL-5 and IL-13,are related to depression.Here,we demonstrated the negative correlation between the depression-associated monoamine neurotransmitter serotonin and secretion of the cytokines IL-5 and IL-13 by ILC2s in individuals with depression.Interestingly,serotonin ameliorates papain-induced lung inflammation by suppressing ILC2 activation.Our data showed that the serotonin receptor HTR2A was highly expressed on ILC2s from mouse lungs and human PBMCs.Furthermore,an HTR2A selective agonist(DOI)impaired ILC2 activation and alleviated the type 2 immune response in vivo and in vitro.Mice with ILC2-specific depletion of HTR2A(Il5^(cre/+)·Htr2a^(flox/flox)mice)abolished the DOI-mediated inhibition of ILC2s in a papain-induced mouse model of inflammation.In conclusion,serotonin and DOI could restrict the type 2 lung immune response,indicating a potential treatment strategy for type 2 lung inflammation by targeting HTR2A on ST2+ILC2s.

关键词： Serotonin(5-HT) HTR2A DOl Group 2 innate lymphoid cell Type 2 lung inflammation

ETP-AKEP: enhanced three-party authenticated key exchange protocols for data integrity in cloud environments

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Journal of Control and Decision 2023年第1期10卷 126-133页

作者： Kalluri rama krishna C.V.Guru Rao Faculty of Informatics Osmania UniversityHyderabadIndia School of Computer Science&Artificial Intelligence S.R.UniversityWarangalIndia

With key exchange protocols, a secure session key is generated between two remote users, andservers and exchanged between them. It is generally used to prevent unauthorised users fromgaining access to sensitive data. This article presents an enhanced three-party authenticated keyexchange protocols (ETP-AKE) protocol that does not depend on symmetric key encryption andinstead uses asymmetric key encryption. A key component of the proposed ETP-AKE protocol isusing elliptic curve encryption in conjunction with a one-way hash function. Its integrity certificationwas confirmed via the usage of the AVISPA tool package. Our proposed protocol is intendedto protect against various security threats, including the man-in-the-middle assault, the parallelattack, and the key-compromise attack, among others.

关键词： ECC hash function cloud integrity third party key exchange

Review Article on Condition Assessment of Structures Using Electro-Mechanical Impedance Technique

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Structural Durability & Health Monitoring 2022年第2期16卷 97-128页

作者： krishna Kumar Maurya Anupam Rawat rama Shanker Department of Civil Engineering MNNIT AllahabadPrayagraj211004India

Structural health monitoring(SHM)is a process for determination of presence,location,severity of damages and remaining life of the infrastructures.SHM is widely applied in aerospace,mechanical and civil engineering sys-tems to assess the conditions of structures to improve the operation,safety,serviceability and reliability,respec-tively.There are various SHM techniques for monitoring the health of structures such as global response based and local techniques.Damages occur in the structures due to its inability to withstand intended design loadings,physical environment and chemical environment.Therefore,damage identification is necessary to improve the durability of the structures for protection against catastrophic failure.The research paper is focused on elec-tro-mechanical impedance(EMI)technique which is one of the techniques based on smart materials.The smart materials are utilized for monitoring the health of the structures.These are used for damage determination and its quantification for the interrogated structures.Variation in admittance or impedance signature shows the existence of damage in the structures.Furthermore,the different statistical methods viz.,root mean square deviation(RMSD),mean absolute percentage deviation(MAPD),covariance(Cov),and correlation coefficient(CC)are used for the quantification of damage.Smart material such as piezoelectric materials,its properties and applica-tions are also considered.In this paper,the implementation of EMI technique based on different recent advances in smart materials and their appropriateness have been described.Subsequently,the reviewed investigations are significant for the monitoring of real-life infrastructures.The presented paper is the compact state-of-the-art for EMI technique which is used for SHM.This examination will be valuable to infrastructural health monitoring and engineering applications in respect to innovative research directions.

关键词： Structural health monitoring condition assessment EMI technique PZT patches damages

Additive manufacturing of biodegradable magnesium-based materials:Design strategies,properties,and biomedical applications

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Journal of Magnesium and Alloys 2023年第3期11卷 801-839页

作者： Farzad Badkoobeh Hossein Mostaan Mahdi Rafiei Hamid Reza Bakhsheshi-Rad Seeram rama krishna Xiongbiao Chen School of Metallurgy and Materials Engineering College of EngineeringUniversity of TehranTehranIran Faculty of Engineering Department of Materials and Metallurgical EngineeringArak UniversityArakIran Advanced Materials Research Center Department of Materials EngineeringNajafabad BranchIslamic Azad UniversityNajafabadIran Department of Mechanical Engineering National University of Singapore9 Engineering Drive 1Singapore 117576Singapore Department of Mechanical Engineering College of EngineeringUniversity of SaskatchewanSaskatoonSK S7N 5A9Canada

Magnesium(Mg)-based materials are a new generation of alloys with the exclusive ability to be biodegradable within the human/animal body.In addition to biodegradability,their inherent biocompatibility and similar-to-bone density make Mg-based alloys good candidates for fabricating surgical bioimplants for use in orthopedic and traumatology treatments.To this end,nowadays additive manufacturing(AM)along with three-dimensional(3D)printing represents a promising manufacturing technique as it allows for the integration of bioimplant design and manufacturing processes specific to given applications.Meanwhile,this technique also faces many new challenges associated with the properties of Mg-based alloys,including high chemical reactivity,potential for combustion,and low vaporization temperature.In this review article,various AM processes to fabricate biomedical implants from Mg-based alloys,along with their metallic microstructure,mechanical properties,biodegradability,biocompatibility,and antibacterial properties,as well as various post-AM treatments were critically reviewed.Also,the challenges and issues involved in AM processes from the perspectives of bioimplant design,properties,and applications were identified;the possibilities and potential scope of the Mg-based scaffolds/implants are discussed and highlighted.

关键词： Magnesium alloy Additive manufacturing 3D Printing Bone tissue engineering Scaffold Mechanical and biological properties

A silver-catalyzed[3+3]-annulation cascade of alkynyl alcohols andα,β-unsaturated ketones for the regioselective assembly of chromanes

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Organic Chemistry Frontiers 2022年第3期9卷 802-809页

作者： Ashwini K.Nakate Sagar S.Thorat Shailja Jain Gamidi rama krishna Kumar Vanka Ravindar Kontham Organic Chemistry Division CSIR-National Chemical LaboratoryDr Homi Bhabha RoadPune-411008India Academy of Scientific and Innovative Research(AcSIR) Ghaziabad-201002India Centre for Materials Characterization CSIR-National Chemical LaboratoryDr Homi Bhabha RoadPune-411008India Physical and Materials Chemistry Division CSIR-National Chemical LaboratoryDr Homi Bhabha RoadPune-411008India

An unprecedented Ag(I)-catalyzed[3+3]-annulation of alkynyl alcohols(5-hexyn-1-ols)andα,β-unsaturated ketones is reported to construct simple to complex chromanes.This transformation begins with hydroalkoxylation of alkynol through C-C triple bond activation to give cyclic-enol ether,followed by intermolecular 1,4-addition and intramolecular 1,2-addition of enol ethers onto the enone and oxidative aromatization or Grob-type elimination steps.

关键词： alcohols unsaturated catalyzed

Hydro-elastic computational analysis of a marine propeller using two-way fluid structure interaction

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Journal of Ocean Engineering and Science 2022年第3期7卷 280-291页

作者： V.rama krishna Srinivas Prasad Sanaka N.Pardhasaradhi B.Raghava Rao Naval Science&Technological Laboratory Visakhapatnam532007India Department of Mechanical Engineering V.R.Siddhartha Engineering CollegeVijayawada520007India

Marine propellers have complex geometry and their performance is determined by costly and time consuming open water experiments.Use of numerical techniques helps researchers in effective design of propellers.Several approaches are used that predicted either hydrodynamic and acoustic response or structural response.Two-way fluid-structure interaction(FSI)analysis is a very useful approach providing all three responses which helps in the design,analysis and optimization of a propeller.The objective of this paper is to predict the hydro-elastic response of a propeller using two-way FSI on a 0.2m diameter,DTMB-4119 propeller using ANSYS software.Two-way FSI analysis is carried out using system coupling approach that transfers the data between the structural and fluid solvers.The turbulence effects are captured using the large-eddy simulation(LES)model and the Ffowcs Williams Hawkings(FWH)acoustic model is used for evaluating the sound pressure level(SPL)generated by propeller.Analysis is extended to evaluate the hydro-elastic and acoustic response of the propeller after validating the hydrodynamic performance with the experimental result in the literature.The results from Two-way FSI analysis are in close agreement when compared with the one-way FSI analysis.Two-way FSI can accommodate the peak value of stress and deformation developed during the initial part of the transient solution which is important in the design of propeller.This study reveals that metallic(NAB)propeller can be replaced by a composite propeller.The acoustic response from two-way FSI analysis will be more realistic due to the consideration of hydro-elastic effect of propeller.

关键词： Advance ratio Coupled analysis CFD Marine propeller Hydrodynamic parameters Two-way fluid structure interaction

Structural,electrical and magnetic properties of cobalt ferrite with Nd^(3+) doping

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Rare Metals 2022年第1期41卷 240-245页

作者： Regaty Anitha Reddy Kattepogu rama Rao Bitra Rajesh Babu Guthikonda Kiran Kumar Cherukupalli Rajesh Anindita Chatterjee Nadella krishna Jyothi Department of Physics Koneru Lakshmaiah Education FoundationVaddeswaramGunturAndhra Pradesh 522502India Department of Physics Andhra UniversityVisakhapatnamAndhra Pradesh 530003India Department of Physics G.V.P.College of Engineering for WomenVisakhapatnamAndhra Pradesh 530048India Department of Physics Raghu College of Engineering(A)BheemunipatnamVisakhapatnamAndhra Pradesh 531162India Department of Physics Gayatri Vidya Parishad College of Engineering(Autonomous)VisakhapatnamAndhra Pradesh 530048India Department of Chemistry Raghu College of Engineering(A)BheemunipatnamVisakhapatnamAndhra Pradesh 531162India

A systematic study on the influence of Nd^(3+) substitution on structural,magnetic and electrical properties of cobalt ferrite nanopowders obtained by sol–gel auto-combustion routewas reported.The formation of spinel phasewas confirmed by X-ray diffraction(XRD)data,and percolation limit ofNd3?into the spinel lattice was also observed.Fourier transform infrared spectroscopy(FTIR)bands observed ≈580 and ≈390 cm^(-1 ) support the presence of Fe^(3+) at A andBsites in the spinel lattice.The variation in microstructure was investigated by scanning electronmicroscopy(SEM),and the average grain size varies from 5.3 to 3.3 lm.The substitution of Nd^(3+) significantly affects the formation of pores and grain size of cobalt ferrite.Room-temperature saturation magnetization and coercivity decrease from 60 to 30 mA·m^(2)·g^(-1) and 19.9–17.8 mT,respectively,with Nd^(3+) substitution increasing.These decreases in magnetic properties are explained based on the presence of non-magnetic nature of Nd^(3+) concentration and the dilution of super-exchange interaction in the spinel lattice.The room-temperature direct-current electrical resistivity increases with Nd^(3+) concentration increasing,which is due to the unavailability of Fe^(2+) at octahedral B sites.

关键词： Co-Nd ferrite Saturation magnetization DC resistivity

Tribological Properties of A356.2/RHA Composites

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Journal of Materials Science & Technology 2012年第4期28卷 367-372页

作者： D. Siva Prasad A. rama krishna Department of Mechanical Engineering GITAM University Visakhapatnam Andhra Pradesh India Department of Mechanical Engineering ANDHRA University Visakhapatnam Andhra Pradesh India

Rice husk ash （RHA） is one of the industrial waste byproduct available abundantly in the world. In the present work, an attempt is made to incorporate the RHA particles in the molten aluminum A356,2 alloy. The RHA particles were added into the matrix melt by creating a vortex with the help of a mechanical stirrer and the melt temperature was maintained between 800 and 850 ℃. Dry sliding wear experiments were performed in a pin on disc wear equipment against a chromium steel disc at 30 ℃. Scanning electron microscopy is used to study the wear characteristics of the unreinforced AI alloy and the A356.2/RHA composites. From the experiments it is observed that the composites exhibit higher hardness and resistance to wear as compared to unreinforced AI alloy,

关键词： Rice husk ash A356.2 Aluminum alloy Wear

Electrospun CNT embedded ZnO nanofiber based biosensor for electrochemical detection of Atrazine: a step closure to single molecule detection

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Microsystems & Nanoengineering 2020年第1期6卷 1353-1362页

作者： Patta Supraja Vikrant Singh Siva rama krishna Vanjari Shiv Govind Singh Department of Electrical Engineering Indian Institute of TechnologyHyderabadTelangana 502285India School of Medicine University of California DavisDavisCaliforniaUSA

In this study we have reported the design and development of a facile,sensitive,selective,and label-free electrochemical sensing platform for the detection of atrazine based on MWCNT-embedded ZnO nanofibers.Electrospun nanofibers were characterized using scanning electron microscope(SEM),transmission electron microscope(TEM),X-ray diffraction(XRD),X-ray photoelectron spectroscope(XPS),UV-Visible spectroscope(UV-VIS),and Fourier-transform infrared spectroscope(FTIR).Electrochemical properties of MWCNT-ZnO nanofiber-modified electrodes were assessed using electrochemical impedance spectroscopy(EIS)and cyclic voltammetry(CV).Binding event of atrazine to anti-atrazine antibody,which immobilized on nanofiber-modified electrode via EDC and NHS chemistry,was transduced with EIS.Due to high conductivity,surface area,and low bandgap of MWCNT-ZnO nanofibers,we have achieved the sensitivity and limit of detection(LoD)of sensor as 21.61(KΩμg^(−1) mL^(−1))cm^(−2) and 5.368zM for a wide detection range of 10 zM–1µM.The proposed immunosensing platform has good stability,selectivity,repeatability,and reproducibility,and are less prone to interference.

关键词： fiber fibers closure