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新疆单叶蔷薇居群表型变异及多样性研究

北京林业大学学报 2024年第2期46卷 51-61页

作者：刘学森李娜张雪云肖丽江律罗乐于超张启翔北京林业大学园林学院国家花卉工程技术研究中心城乡生态环境北京实验室花卉种质创新与分子育种北京市重点实验室北京100083

【目的】单叶蔷薇为蔷薇属唯一的单叶物种,是月季育种中的重要材料,在我国主要分布于新疆北部地区,但由于人为的破坏和环境的改变导致其面临濒危灭绝的风险。本研究通过分析单叶蔷薇表型多样性,探究其表型变异规律,旨在为更好地保护和... 详细信息

【目的】单叶蔷薇为蔷薇属唯一的单叶物种,是月季育种中的重要材料,在我国主要分布于新疆北部地区,但由于人为的破坏和环境的改变导致其面临濒危灭绝的风险。本研究通过分析单叶蔷薇表型多样性,探究其表型变异规律,旨在为更好地保护和利用单叶蔷薇种质资源提供理论指导。【方法】本研究以9个单叶蔷薇天然居群中270个单株为研究材料,对其19个表型性状数据进行收集,利用巢式方差分析、皮尔逊相关性分析、主成分分析和聚类分析方法,探究其表型变异规律与多样性水平。【结果】(1)9个单叶蔷薇天然居群表型多样性水平较高,19个表型性状的变异系数和香农多样性指数均值分别为15.90%和2.031;9个居群的表型变异系数在10.32%(P4)~13.19%(P8),表现出中等程度的变异,香农多样性指数在1.274(P5)~1.825(P8)之间,其中P8居群呈现出较高的多样性水平。(2)19个表型性状在居群间和居群内均存在极显著性差异(P<0.01),居群间的平均表型分化系数为41.23%,表型变异主要来源于居群内。(3)皮尔逊相关性分析发现,单叶蔷薇花径与叶面积、花瓣面积与花斑百分比等部分性状间存在显著相关性。(4)主成分分析共提炼出5个主成分,累计贡献率为80.463%,贡献率最大的2个主成分主要解释花与叶的性状。(5)聚类分析可将单叶蔷薇9个居群分为2类,第1类为大花类,包括P6、P7、P8;第2类为小花类,包括P1、P2、P3、P4、P5、P9。【结论】新疆单叶蔷薇具有较高的表型多样性和变异水平,且变异的来源主要集中在居群内。

关键词：单叶蔷薇居群表型变异表型多样性

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混配铜精矿对我国砷污染防治的影响与对策

化工环保 2024年第4期44卷 554-558页

作者：王玉晶韩伟王鹏程李娜聂晶磊生态环境部固体废物与化学品管理技术中心北京100029 云南铜业股份有限公司西南铜业分公司云南昆明650032 广西金川有色金属有限公司广西防城港538000

砷是我国重点防控的重金属之一,铜冶炼是主要的砷污染物排放源。基于实地调研、专家咨询及行业数据统计等方法,分析了我国混配铜精矿进口量的变化情况和铜冶炼过程中砷的流向,探讨了混配铜精矿进口量的增加对我国砷污染防治的影响,并提... 详细信息

砷是我国重点防控的重金属之一,铜冶炼是主要的砷污染物排放源。基于实地调研、专家咨询及行业数据统计等方法,分析了我国混配铜精矿进口量的变化情况和铜冶炼过程中砷的流向,探讨了混配铜精矿进口量的增加对我国砷污染防治的影响,并提出了相应的砷污染防治对策和建议,指出:应对配置混矿的企业进行全流程监管;加强对铜冶炼企业和含砷废物处理处置企业的环境监管;开展含砷废物的资源化利用研究,逐步提高含砷废物的资源化利用率;拓展含砷废物无害化处理路径,降低环境风险。

关键词：铜冶炼混配铜精矿含砷废渣砷污染

Schizophrenia with and without obsessive-compulsive symptoms:a comparative analysis of performance on trail making test and disability on WHOD AS

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General Psychiatry 2020年第6期33卷 406-412页

作者： Apala Singh ram Pratap Beniwal Triptish Bhatia Smita Neelkanth Deshpande Department of Psychiatry Govind Ballabh Pant Institute of Postgraduate Medical Education and Research(G.I.P.M.E.R.)New DelhiDelhiIndia Department of Psychiatry&Drug De-addiction Centre of Excellence in Mental HealthAtal Bihari Vajpayee Institute of Medical Sciences(ABVIMS)&Dr Ram Manohar Lohia HospitalNew DelhiDelhiIndia

Background Presence of obsessive-compulsive symptoms(0CS)affects performance on tests of some cognitive functions,such as the trail making test(TMT),and may affect the level of disability in schizophrenia(SZ).Aim s The aim of the present study was to compare performance on TMT and disability on WHO Disability Assessment Schedule(WHODAS)in persons with SZ with and without 0CS in a cross-sectional *** Persons with SZ(n=200)fulfilling DSM-V(Diagnostic and Statistical Manual)diagnostic criteria were assessed on Yale Brown Obsessive Compulsive Scale(YB0CS)and divided into two groups based on presence or absence of *** and WHODAS V.2.0 were *** two groups as a whole,as well as a subsample matched on age,gender and age of onset were *** Out of 200 persons with SZ,37(18.5%)reported *** OCS group took a significantly longer mean time to complete TMT-A(Z=-3.02,p=0.003)as well as TMT-B(Z=-3.551,p<0.001).Significant correlations were found between TMT-A and total YB0CS Scores(r=0.351,p=0.033),as well as TMT-A and YB0CS compulsion scores(r=0.404,p=0.013)but not with TMT-B *** OCS group reported greater disability in all domains separately as well as on average WHODAS Scores(Z=-5.969,p<0.001).Significant correlations were found between YB0CS obsession scores and YBOCS total scores with average WHODAS Scores(r=0.614,p<0.001 and r=0.406,p=0.013,respectively).We obtained essentially similar results with the matched subsample as well as with the entire *** Persons with SZ and comorbid OCS had significantly poorer performance on TMTs and greater disability in comparison to persons with SZ *** of disability correlated with severity of OCS.

关键词： trail performance matched

结节性硬化症患儿52例临床表型及基因型特点分析

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中华神经科杂志 2024年第4期57卷 359-365页

作者：徐那杨莉邱世彦张新李玉芬韩玉增徐丽云朱丽萍临沂市人民医院儿科临沂276000

目的分析52例结节性硬化症患儿的临床表型及TSC1/TSC2基因变异情况。方法收集2017年1月至2022年10月就诊于临沂市人民医院的59例结节性硬化症患儿的临床资料,对其主要家系成员进行TSC1及TSC2基因检测,分析致病性,并将基因检测阳性患儿分... 详细信息

目的分析52例结节性硬化症患儿的临床表型及TSC1/TSC2基因变异情况。方法收集2017年1月至2022年10月就诊于临沂市人民医院的59例结节性硬化症患儿的临床资料,对其主要家系成员进行TSC1及TSC2基因检测,分析致病性,并将基因检测阳性患儿分为TSC1基因变异组和TSC2基因变异组,比较两组的临床特征差异性。结果59例患儿中有52例检出TSC1或TSC2基因变异(包括TSC1基因变异17例,TSC2基因变异35例)。52例患儿中男性28例(53.8%),女性24例(46.2%);家族性病例17例(32.7%,包括TSC1基因变异10例,TCS2基因变异7例),散发病例35例(67.3%);皮肤色素脱失斑46例(88.5%),面部血管纤维瘤13例(25.0%),鲨革斑5例(9.6%),室管膜下结节/钙化49例(94.2%),皮质结节47例(90.4.%),室管膜下巨细胞星型细胞瘤2例(3.8%),智力障碍/发育迟缓39例(75.0%),癫痫发作49例(94.2%),心脏横纹肌瘤8例(15.4%),肾血管平滑肌脂肪瘤9例(17.3%),视网膜错构瘤4例(7.7%)。基因检测共检出49种变异,4种为大片段缺失/重复变异,45种为点变异。其中致病性变异41种,可能致病性变异7种,意义未明确1种。共发现国内外尚未见报道的变异位点16种、重复大片段1种。3个高频变异位点为***692*、***228*和***1200Try。TSC1基因变异组和TSC2基因变异组患儿在阳性家族史占比[10/17比7/35(20%),χ^(2)=7.838,P=0.005]、癫痫起病月龄[38.0(0.5~134.0)个月比8.0(0.1~63.0)个月,Z=3.506,P<0.001]及智力障碍/发育迟缓发生率[8/17比31/35(88.6%),χ_(adj)^(2)=8.423,P=0.004]上差异具有统计学意义。结论TSC临床表型谱广泛,可累及全身各个系统,主要为皮肤及神经系统。致病基因为TSC1/TSC2。TSC1基因变异患儿多有家族遗传,TSC2基因变异患儿癫痫起病年龄更早且智力障碍/发育迟缓发生率更高。本研究发现了未见报道的变异位点16种、重复大片段1种,热点变异3种,扩展了结节性硬化症的基因谱。

关键词：结节性硬化症儿童突变基因型 TSC1/TSC2基因

Prominently Promoting the Formation of Poly(butylene adipate) α-Form Crystals by Coalescing from Inclusion Complex

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Chinese Journal of Polymer Science 2018年第7期36卷 866-870页

作者： Hai-Mu Ye Xiao-Tong Chen Ping Liu na Yan Department of Materials Science and Engineering China University of PetroleumBeijing 102249China

We successfully use a co-precipitation method to prepare inclusion complex between poly（butylene adipate）（PBA） chains （guest component） and urea molecules （host component）. The PBA/urea inclusion complex is confirmed to adopt a hexagonal crystal modification with lattice parameters ofa = 8.14 A and c = 10.92 A, and the interaction between PBA chains and urea is van der Waals force. The singly isolated PBA chains are suggested to take some gauche conformation, which is different from the all-trans conformation in r-form PBA. Furthermore, we employ the isolated PBA chains which are uniformly pre-established in a specific conformation in urea channels to regulate the crystal form of PBA for the first time. After removing the host urea molecules, the coalesced PBA chains are found to solely crystallize into a-form crystals at different coalescing temperatures. By comparing the FTIR spectra, it is found that PBA chains in inclusion complex plausibly contain some similar conformers as those in a-form crystal, which is suggested to be the intrinsic reason for the sole formation of a-form crystals. This research proves that inclusion complex can be used as a very effective method to regulate polymorphism of semi-crystalline polymers.

关键词： Poly(butylene adipate) Inclusion complex Polymorphism Chain conformation

Dynamical Casimir effect in dissipative superconducting circuit system

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Science China(Physics,Mechanics & Astronomy) 2014年第12期57卷 2251-2258页

作者： ZHANG Yu na LUO Xi Wang ZHOU Zheng Wei Key Laboratory of Quantum Information University of Science and Technology of China Synergetic Innovation Center of Quantum Information and Quantum Physics University of Science and Technology of China

We investigate the possibility of observing in integrated solid-state systems the dynamical Casimir effect,in which photons are created out of *** use a transmission line resonator on a superconducting chip as the microwave cavity and modulate its properties by coupling it to carefully designed Josephson *** evaluate the effect of main decoherence sources and show that our design offers a promising system for experimentally demonstrating the dynamical Casimir ***,we also study the squeezing properties of the created photon field and how they depend on the dissipation.

关键词： dynamical Casimir effect superconducting circuit system dissipation squeezing

应用型医药卫生人才培养体系的构建及应用效果评价——以牡丹江医学院为例

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现代预防医学 2024年第16期51卷 3068-3072页

作者：马宏坤荣胜忠任凤云邹立娜牡丹江医学院公共卫生学院牡丹江医学院教师发展中心与教学评估中心牡丹江医学院附属红旗医院

应用型医药卫生人才是学术型人才的重要补充，更是健康中国建设服务基层最重要的生力军和主力军。因此，以提升岗位胜任能力为目标构建应用型医药卫生人才培养体系具有重要意义。本研究旨在从学校整体办学实践层面介绍应用型医药卫生人... 详细信息

应用型医药卫生人才是学术型人才的重要补充，更是健康中国建设服务基层最重要的生力军和主力军。因此，以提升岗位胜任能力为目标构建应用型医药卫生人才培养体系具有重要意义。本研究旨在从学校整体办学实践层面介绍应用型医药卫生人才培养体系的构建及取得的效果，以为其他学校办学实践提供借鉴。牡丹江医学院经过多年办学探索与实践，通过“做好顶层设计、强化专业建设、深化教育教学改革、完善教学条件保障”构建了行之有效的应用型医药卫生人才培养体系；体系的有效运用使得学校在“学科建设、专业建设、教材建设、课程建设、教师教学水平、教学改革成果”等方面取得良好效果，在校生获得省级、国家级竞赛奖励多项，毕业生就业满意度为93.55%～96.75%,基层医疗卫生用人单位对毕业生的整体满意度97%以上。学校构建的应用型医药卫生人才培养体系为新时期地方医学院校如何构建应用型医药卫生人才培养体系、培养党和国家需要的应用型医药卫生人才提供了良好的借鉴。

关键词：高等医学教育应用型医药卫生人才办学特色教育教学

Effects of interleukin-10 on activation and apoptosis of hepatic stellate cells in fibrotic rat liver

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World Journal of Gastroenterology 2006年第12期12卷 1918-1923页

作者： Li-Juan Zhana Wei-Da Zheng Mei-na Shi Department of Gastroenterology Union Hospital of Fujian Medical University.Fuzhou 350001.Fujian Province.China

AIM： TO study the effects of interleukin-10 （IL-10） on the expression of o-smooth muscle actin （α-SMA）, nuclear factor-κB（NF-κB） and Fas/Fas ligand （FasL） in hepatic stellate cells of experimental rats with hepatic fibrosis. METHODS： Sixty clean SD rats were randomly divided into control group （group N）, liver fibrotic group （group C） and IL-10 treatment group （group I）. Control group received intraperitoneal injection of saline （2ml·kg^-1）, twice a week. Fibrotic group was injected intraperitoneally with 50% carbon tetrachloride （CCh）（2 ml·kg^-1）, twice a week. IL-10 treatment group was given IL-10 at a dose of 4 pg·kg^-1 20 minutes before CCl4 administration from the third week. Hepatic stellate cells （HSCs） were isolated from these rats at the seventh and eleventh weeks during the course of liver fibrosis, respectively. The expression of α-SMA and NF-κB in HSCs was measured by S-P immunohistochemistry. The expression of Fas and FasL mRna was measured by RT-PCR. Furthermore, liver tissues were harvested from three groups at the same time. RESULTS： The CCh- induced experimental rat hepatic fibrosis model was established successfully. The purity of extracted hepatic stellate cells was about 95% and the yield of hepatic stellate cells was 1.2-2.3×10^6/g liver tissue averagely. The positive expression of α-SMA and NF-κB was 36.5% and 28.5% respectively in group N. The positive levels of α-SMA and NF-κB were increased significantly in group C compared to group N （P〈0.01）. The positive signals decreased significantly （P〈0.05） in group I. In the 11^th week, the HSCs of group I became round with visible pyknotic nuclei. The expression of NF-κB in group C was significantly increased in a timedependentmanner （P〈0.01）, but there was no difference in the α-SMA expression （P〉0.05）. The mRna of Fas and FasL in group C was significantly increased in a timedependent manner compared to that in control group. After treated with IL-10, the expression level of Fas and FasL was h

关键词： Liver fibrosis Hepatic stellate cell Znterleuldn-10 α-smooth muscle actin Nuclear factor-κB Rat

Single Image Super-Resolution via Dynamic Lightweight Database with Local-Feature Based Interpolation

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Journal of Computer Science & Technology 2019年第3期34卷 537-549页

作者： na Ding Ye-Peng Liu Lin-Wei Fan Cai-Ming Zhang School of Software Shandong UniversityJinan 250101China Shandong Co-Innovation Center of Future Intelligent Computing Yantai 264025China Digital Media Research Institute Shandong University of Finance and Economics Jinan 250061China

Single image super-resolution is devoted to generating a high-resolution image from a low-resolution one,which has been a research hotspot for its significant applications. A novel method that is totally based on the single input image itself is proposed in this paper. Firstly, a local-feature based interpolation method where both edge pixel property and location information are taken into consideration is presented to obtain a better initialization. Then, a dynamic lightweight database of self-examples is built with the aid of our in-depth study on self-similarity, from which adaptive linear regressions are learned to directly map the low-resolution patch into its high-resolution version. Furthermore, a gradually upscaling strategy accompanied by iterative optimization is employed to enhance the consistency at each *** without any external information, extensive experimental comparisons with state-of-the-art methods on standard benchmarks demonstrate the competitive performance of the proposed scheme in both visual effect and objective evaluation.

关键词： lightweight database linear regression local-feature interpolation super-resolution