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Genetic and epigenetic targets of natural dietary compounds as anti-Alzheimer's agents

neural Regeneration Research 2024年第4期19卷 846-854页

作者： Willian Orlando Castillo-Ordoñez nohelia Cajas-salazar Mayra Alejandra Velasco-Reyes Facultad de Ciencias naturales-Exactas y de la Educación Departamento de Biología.Universidad del Cauca Departamento de Estudios Psicológicos Universidad Icesi

Alzheimer’s disease is a progressive neurodegenerative disorder and the most common cause of dementia that principally affects older *** factors,such as oxidative stress,an increase in acetylcholinesterase activity,mitochondrial dysfunction,genotoxicity,and neuroinflammation are present in this syndrome,which leads to *** pathologies such as Alzheimer’s disease are considered late-onset diseases caused by the complex combination of genetic,epigenetic,and environmental *** are two main types of Alzheimer’s disease,known as familial Alzheimer’s disease(onsetnd late-onset or sporadic Alzheimer’s disease(onset≥65 years).Patients with familial Alzheimer’s disease inherit the disease due to rare mutations on the amyloid precursor protein(APP),presenilin 1 and 2(PSEn1 and PSEn2)genes in an autosomaldominantly fashion with closely 100%*** contrast,a different picture seems to emerge for sporadic Alzheimer’s disease,which exhibits numerous non-Mendelian anomalies suggesting an epigenetic component in its ***,the fundamental pathophysiological mechanisms driving Alzheimer’s disease are interfaced with epigenetic ***,the dynamic nature of epigenetics seems to open up new avenues and hope in regenerative neurogenesis to improve brain repair in Alzheimer’s disease or following injury or stroke in *** recent years,there has been an increase in interest in using natural products for the treatment of neurodegenerative illnesses such as Alzheimer’s *** epigenetic mechanisms,such as DnA methylation,non-coding RnAs,histone modification,and chromatin conformation regulation,natural compounds appear to exert neuroprotective *** we do not purport to cover every in this work,we do attempt to illustrate how various phytochemical compounds regulate the epigenetic effects of a few Alzheimer’s disease-related genes.

关键词： Alzheimer’s disease epigenetics genes methylation natural products

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Coffee Leaf Rust(Hemileia vastatrix)Disease in Coffee Plants and Perspectives by the Disease Control

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Phyton-International Journal of Experimental Botany 2024年第5期93卷 923-949页

作者： Alexis salazar-navarro Victor Ruiz-Valdiviezo Jose Joya-Dávila Daniel Gonzalez-Mendoza Instituto de Ciencias Agrícolas de la Universidad Autónoma de Baja California(ICA-UABC) Nuevo LeónBaja California21705México Laboratorio de Biología Molecular del Instituto Tecnológico nacional de Tuxtla Gutierrez(TecnM) Tuxtla GutierrezChiapas29050México Facultad de Ciencias Agronómicas Campus V.Universidad Autónoma de Chiapas(UnACH) VillafloresChiapas30470México

Coffee Leaf Rust(CLR)is caused by Hemileia vastatrix in Coffea *** is one of the most dangerous phytopathogens for coffee plantations in terms of coffee productivity and coffee cup *** this review,we resume the problem of CLR in Mexico and the pathogenesis of *** review abord plant-pathogen interactions which lead a compatible or incompatible interactions and result in CLR disease or resistance,*** review abord Coffea *** response pathways involved in *** ***,current measures to control *** proliferation and germination were aborded focused on phytosanitary actions,and biological and chemical ***,new trendlines to reduce the impact of CLR as nanoparticles and nanotechnology were analyzed.

关键词： Coffee leaf rust Coffea arabica pathogenesis nanoparticles biological control

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On Integration-based Methods for MOSFET Model Parameter Extraction

On Integration-based Methods for MOSFET Model Parameter Extr...

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2008 9th International Conference on Solid-State and Integrated-Circuit Technology

作者： Adelmo Ortiz-Conde Francisco J.García-Sánchez ramón salazar Solid State Electronics Laboratory Universidad Simon BolívarApartado Postal 89000Caracas 1080-AVenezuela

＜正＞This article reviews integration-based model-parameter extraction methods for *** comprises three different methods that use the transfer characteristics measured under linear regime operation *** two other methods are included for extraction under saturation *** integration-based method to evaluate the location of a maximum value of a given function is also included. Finally,the possibility of evaluating distortion is briefly introduced.

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Organ Abscission in Plants: With Special Emphasis on Bell Pepper

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Phyton-International Journal of Experimental Botany 2024年第7期93卷 1467-1484页

作者： ramiro Reyes-Castro Héctor G.núñez-Palenius Juan I.Valiente-Banuet María E.Sosa-Morales Blanca E.Orosco-Alcalá Rafael Guzmán-Mendoza Graciela M.L.Ruiz-Aguilar Rogelio Costilla-salazar Life Sciences Division Universidad de GuanajuatoIrapuato36500México School of Engineering and Sciences Tecnologico de MonterreyQuerétaro76130México

Bell pepper(Capsicum annuum L.),along with potato and tomato,is one of the three most cultivated vegetables in the *** pepper is worldwide accepted due to its characteristics of color,smell,ﬂavor,and *** pepper is also considered a nutritious food due to its vitamin and antioxidant *** Mexico,bell pepper production has a high value because it is grown for the international markets,particularly the United States of ***,the abscission ofﬂowers and fruits is a factor that limits the yield,hinders the planning of activities,and causes a variation in the prices of *** to the importance of this process,in this work we did a bibliometric analysis and literature review of scientiﬁc advances for the understanding of the abscission pro-cess in plants,and in particular for the bell ***,we introduce new perspectives that would help direct future research about organ abscission in ***,the lack of research that would further clarify abscis-sion process in the bell pepper plant is discussed.

关键词： Capsicum annuum abscission zone plant growth regulators environmental factors

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Hepatic rupture secondary to HELLP syndrome: outcomes in three cases

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World Journal of Emergency Medicine 2024年第1期15卷 56-58页

作者： Salvador Gomez-Carro Ruben R.Lozano-salazar Kassandra Santos-Zaldívar Victor Andres Villasuso-Alcocer nina Méndez-Domínguez O'Horan General Hospital Merida 97000Mexico Highly Specialized Hospital of the Yucatan Peninsula Merida 97134Mexico national Institute of Perinatology.Mexico City 11000 Mexico

Hypertensive disorders of pregnancy,including chronic hypertension,gestational hypertension,and preeclampsia,are the most common complications in pregnant women,affecting approximately 15%of pregnancies.[1,2]Hemolysis,elevated liver enzymes,and low platelet count(HELLP syndrome)can occur in 0.2%-0.6%of all pregnancies,and 10%-15%of patients are diagnosed with preeclampsia.[3,4]Among its severe complications,liver hematoma is remarkable and may lead to liver *** identification of HELLP syndrome is crucial for proper therapeutic management and to avoid fatal outcomes[4,5]since when a hepatic hematoma occurs,the risk of rupture increases to 12%.[3,5]

关键词： rupture HELLP hypertension pregnancy

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Pancreatic neuroendocrine tumors:Are tumors smaller than 2 cm truly indolent?

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1756-1762页

作者： Sergio Hoyos Pablo Posada-Moreno natalia Guzman-Arango Romario Chanci-Drago Jaime Chavez Alvaro Andrés-Duarte Santiago salazar-Ochoa Hepatobilary and Liver Transplant Unit Hospital Pablo Tobon Uribe and Gastrohepathology Group Universidad de AntioquiaMedellin 050034AntioquiaColombia Department of General Surgery Universidad Pontificia BolivarianaMedellín 050034AntioquiaColombia

BACKGROUnD Pancreatic neuroendocrine tumors(PnETs)are relatively rare but rank as the second most common pancreatic *** can be functional,causing early metabolic disturbances due to hormone secretion,or non-functional and diagnosed later based on tumor size-related *** diagnoses of PnETs under 2 cm in size have sparked debates about their management;some practitioners advocate for surgical removal and others suggest observation due to the tumors’lower potential for ***,it is unclear whether managing these small tumors expectantly is truly *** To evaluate poor prognostic factors in PnETs based on tumor size(>2 cm orn surgically treated *** This cohort study included 64 patients with PnETs who underwent surgical resection between 2006 and 2019 at a high-complexity reference hospital in Medellín,*** assess patient survival,quarterly follow-ups were conducted during the first year after surgery,followed by semi-annual con-sultations at the hospital's hepatobiliary surgery *** variables were described using absolute and relative frequencies,and quantitative variables were expressed using measures of central tendency and their corresponding measures of *** The presence of lymph node involvement,neural involvement,and lymphovascular invasion were all associated with an increased risk of mortality,with hazard ratios of 5.68(95%CI:1.26–25.61,P=0.024),6.44(95%CI:1.43–28.93,P=0.015),and 24.87(95%CI:2.98–207.19,P=0.003),*** involvement and lymphovascular invasion were present in tumors smaller than 2 cm in diameter and those larger than 2 cm in *** recurrence rates between the two tumor groups were furthermore similar:18.2%for tumors smaller than 2 cm and 21.4%for tumors larger than 2 *** survival was additionally comparable between the two tumor *** Tumor size does not dictate prognosis;lymph node and lymphovascular involvement a

关键词： neuroendocrine tumor Pancreatic neoplasm Pancreas Pancreatic neuroendocrine neoplasm Pancreatic neuroendocrine tumors

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从美声唱法视角下对女高音咏叹调《严刑酷罚千般万种》的诠释性建议

从美声唱法视角下对女高音咏叹调《严刑酷罚千般万种》的诠释性建...

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作者： MARIA GUADALUPE salazar GOMEZ 成都大学

学位级别：硕士

选自沃尔夫冈·阿玛多伊斯·莫扎特(Wolfgang Amadeus Mozart)的歌剧《后宫诱逃》(Die Entführung aus dem Serail)的咏叹调“Marten Aller Arten”,被认为是最具挑战性的女高音咏叹调之一。演唱这首咏叹调需要歌唱者具备较高的歌唱技... 详细信息

选自沃尔夫冈·阿玛多伊斯·莫扎特(Wolfgang Amadeus Mozart)的歌剧《后宫诱逃》(Die Entführung aus dem Serail)的咏叹调“Marten Aller Arten”,被认为是最具挑战性的女高音咏叹调之一。演唱这首咏叹调需要歌唱者具备较高的歌唱技术,包含歌唱中气息的灵活性、音与音之间的过渡和衔接、可长时间保持发声与音准的气息强度。此外,还需要歌唱者拥有宽广的音域和能够随时转换音高的能力。现今大众仍普遍认同的观点是,戏剧性的声音是沉重的、强烈的、甚至阴暗的,这与敏捷、灵活与明亮的声音几乎是对立的。通常情况下,敏捷、清晰的声音会更多地与闹剧或喜剧作品联系在一起,而沉重、强烈的声音则更多地与戏剧联系在一起。本文中,笔者尝试证明这两种音色可以同时存在于一个曲目中,由抒情花腔女高音扮演的康斯坦斯这一角色正好可以证明笔者的观点。本文提出了一些可供参考的观点,以帮助读者从不同的技术角度了解女高音如何处理声区转换,以支持其在主要音域中以饱满的嗓音演唱歌曲,使声音放开,并实现咏叹调“Marten Aller Arten”所要求的戏剧性。同时,本文以意大利美声学派的原则为基础,介绍了该咏叹调的技术方法——其重点集中于四个声区:胸声区、弱混声区、强混声区和头声区。本文比较了意大利美声学派的一些歌唱方法和关于声区的不同技术的概念。尽管这些概念仍会引起混淆,但这一新的视角有助于帮助人们理解女高音声区的结构,并将其更清晰地带入实践当中。了解了这四个音区的工作原理,女高音歌唱家就能更自如地去演绎这首咏叹调,并将嗓音发挥到极致,帮助歌唱家们更深入地了解自己的“乐器”,加强声音本身的柔韧性、肌肉和嗓音的调节能力,这些都是演唱咏叹调“Marten Aller Arten”所需要的。

关键词： Marten Aller Arten 美声学派音区女高音

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Amyotrophic lateral sclerosis,a neurodegenerative motor neuron disease with retinal involvement

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neural Regeneration Research 2022年第5期17卷 1011-1012页

作者： Ana I.ramírez Rosa de Hoz Pilar Rojas Juan J.salazar Instituto de Investigaciones Oftalmológicas ramón Castroviejo.Universidad Complutense de Madrid MadridSpain Facultad deÓptica y Optometría.Departamento de Inmunología Oftalmología y ORL.Universidad Complutense de MadridMadridSpain Hospital General Universitario Gregorio Marañón Instituto Oftálmico de MadridMadridSpain

Amyotrophic lateral sclerosis(ALS)is a neurodegenerative disease that damages the motor neurons,the spinal cord,the cerebellum,and some areas of the ***,more recent studies show that it can also affect the visual syst... 详细信息

关键词： visual problems involvement

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Retinal microglial activation in glaucoma:evolution over time in a unilateral ocular hypertension model

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neural Regeneration Research 2022年第4期17卷 797-799页

作者： JoséA.Fernández-Albarral Ana I.ramírez Rosa de Hoz Juan J.salazar Instituto de Investigaciones Oftalmológicas ramón Castroviejo Universidad Complutense de MadridMadridSpain Facultad deÓptica y Optometría Departamento de InmunologíaOftalmología y ORLUniversidad Complutense de MadridMadridSpain

Glaucoma is a neurodegenerative chronic pathology,characterized by the loss of retinal ganglion cells(RGC),which leads to an irreversible vision field *** increased intraocular pressure(IOP)constitutes its main risk ***,the main treatments for glaucoma are focused on decreasing IOP;nevertheless,the progression of the disease continues,despite IOP *** fact shows the existence of other factors that could contribute to the advance of glaucomatous *** early diagnostics,the use of neuroprotective therapies,and knowledge of the pathological processes are the major challenges associated with the management of this *** pathogenic mechanisms have been proposed to be responsible for RGC death,including oxidative stress,mitochondrial dysfunction,glutamate excitotoxicity,and neuroinflammation(Casson et al.,2012).

关键词： irreversible oxidative activation

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Unilateral rnurr1-V5 transgene expression in nigral dopaminergic neurons mitigates bilateral neuropathology and behavioral deficits in parkinsonian rats withα-synucleinopathy

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neural Regeneration Research 2024年第9期19卷 2057-2067页

作者： Bismark Gatica-Garcia Michael J.Bannon Irma Alicia Martínez-Dávila Luis O.Soto-Rojas David Reyes-Corona Lourdes Escobedo Minerva Maldonado-Berny ME Gutierrez-Castillo Armando J.Espadas-Alvarez Manuel A.Fernandez-Parrilla Juan U.Mascotte-Cruz CP Rodríguez-Oviedo Irais E.Valenzuela-Arzeta Claudia Luna-Herrera Francisco E.Lopez-Salas Jaime Santoyo-salazar Daniel Martinez-Fong Departamento de Fisiología Biofísica y NeurocienciasCentro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Department of Pharmacology Wayne State University School of MedicineDetroitMIUSA Laboratorio de Patogénesis Molecular Carrera Médico CirujanoFacultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla de BazMéxico Red de Medicina para la Educación y Desarrollo y la Investigación Científica de Iztacala(Red MEDICI) Carrera Médico CirujanoFacultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla de BazMéxico nanoparticle Therapy Institute AguascalientesMéxico Departamento de Biociencias e Ingeniería Centro Interdisciplinario de Investigaciones y Estudios sobre Medio Ambiente y DesarrolloInstituto Politécnico NacionalCiudad de MéxicoMéxico Escuela nacional de Medicina y Homeopatía Instituto Politécnico NacionalCiudad de MéxicoMéxico Departamento de Fisiología Escuela Nacional de Ciencias BiológicasInstituto Politécnico NacionalCiudad de MéxicoMéxico Departamento de Biología Molecular y Biotecnología Instituto de Investigaciones BiomédicasUniversidad Nacional Autónoma de MéxicoCiudad de MéxicoMéxico Departamento de Física Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Programa de nanociencias y nanotecnología Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico

Parkinsonism by unilateral,intranigralβ-sitosterolβ-D-glucoside administration in rats is distinguished in that theα-synuclein insult begins unilaterally but spreads bilaterally and increases in severity over time,thus replicating several clinical features of Parkinson’s disease,a typicalα-*** nurr1 repressesα-synuclein,we evaluated whether unilateral transfected of rnurr1-V5 transgene via neurotensin-polyplex to the substantia nigra on day 30 after unilateralβ-sitosterolβ-D-glucoside lesion could affect bilateral neuropathology and sensorimotor deficits on day 30 *** study found that rnurr1-V5 expression but not that of the green fluorescent protein(the negative control)reducedβ-sitosterolβ-D-glucoside-induced ***,a bilateral increase in tyrosine hydroxylase-positive cells and arborization occurred in the substantia nigra and increased tyrosine hydroxylase-positive ramifications in the *** addition,tyrosine hydroxylase-positive cells displayed less senescence markerβ-galactosidase and more neuron-cytoskeleton markerβIII-tubulin and brain-derived neurotrophic factor.A significant decrease in activated microglia(positive to ionized calcium-binding adaptor molecule 1)and neurotoxic astrocytes(positive to glial fibrillary acidic protein and complement component 3)and increased neurotrophic astrocytes(positive to glial fibrillary acidic protein and S100 calcium-binding protein A10)also occurred in the substantia *** effects followed the bilateral reduction inα-synuclein aggregates in the nigrostriatal system,improving sensorimotor *** results show that unilateral rnurr1-V5 transgene expression in nigral dopaminergic neurons mitigates bilateral neurodegeneration(senescence and loss of neuron-cytoskeleton and tyrosine hydroxylase-positive cells),neuroinflammation(activated microglia,neurotoxic astrocytes),α-synuclein aggregation,and sensorimotor *** neurotrophic astrocytes and

关键词： A1 astrocytes A2 astrocytes gene therapy microglia motor deficits nanoparticles neurodegeneration neuroinflammation senescence α-synuclein aggregates

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