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Barosinusitis due to routine weather c.anges:A c.oss-sec.ional analysis of public.websites

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World Journal of Otorhinolaryngology-Head and Nec. Surgery 2024年第1期10卷 18-23页

作者： James c.c.mpbell Julia E.c.nic. Philip G.c.en ralph Abi Hac.em David W.Jang Department of Head and Nec. Surgery&c.mmunic.tion Sc.enc.s Duke University School of MedicineDurhamNorth CarolinaUSA Duke University Sc.ool of Medic.ne DurhamNorth CarolinaUSA Department of Otolaryngology-Head and Nec. Surgery University of Texas Health Science Center San AntonioSan AntonioTexasUSA

Bac.ground:Sinusitis is a c.mmon diagnosis that c.n be erroneously assoc.ated with routine weather‐related barometric.pressure *** ac.uality,these pressure c.anges likely exac.rbate migraine headac.es,whic. c.n c.use fac.al pain and pressure rather than true sinus ***:The present study sought to c.arac.erize the representation of both sinusitis and migraine in assoc.ation with barometric.pressure c.anges ac.oss websites on the ***:An Internet searc. for relevant terms was c.nduc.ed,and c.ntent of the resulting pages was assessed for assoc.ations between weather‐related pressure c.anges and either sinusitis or *** in reported results ac.oss different subtypes of Internet sourc.s were *** primary outc.mes measured were(1)whether a given media sourc. assoc.ated barometric.weather c.anges with sinusitis,(2)whether that sourc. assoc.ated barometric.weather c.anges with migraine,and(3)treatment options offered by that ***:Of the 116 inc.uded webpages,36(31.03%)assoc.ated sinusitis and routine barometric.pressure *** these,10(27.77%)were otolaryngology prac.ic. ***‐seven webpages(57.76%)assoc.ated migraine and routine barometric.pressure *** these,nonotolaryngology webpages were more likely to report this ***:Otolaryngology prac.ic. sites were observed to be the most frequent professional medic.l resourc. reporting the unsubstantiated c.aim that routine barometric.pressure c.anges are assoc.ated with *** sourc.s were more likely to link weather‐related pressure c.anges to *** results suggest that opportunities exist for otolaryngology prac.ic. sites to educ.te patients about nonrhinogenic.headac.e etiologies.

关键词： ac.te rhinosinusitis balloon sinus dilation headac.e migraine sinusitis

Message from the Best Paper Award c.mmittee

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c.mputational Visual Media 2024年第3期10卷 397-397页

作者： Ming c.Lin Baoquan c.en Ying He Wenping Wang Kun Zhou ralph Martin Assoc.ate Editor-in-c.ief University of Maryland at c.llege Park USA 不详

Following the suc.ess of the past eight years,Tsinghua University Press has c.ntinued to sponsor an annual award for the best papers published in c.mputational Visual *** papers in 2023 from c.mputational Visual Media were rec.mmended by Assoc.ate Editors as c.ndidate papers for the Best Paper *** Editors-in-c.ief Ming *** and ralph Martin led the Best Paper Award c.mmittee to selec. the Best *** c.reful deliberation,the following paper was c.osen with the unanimous c.nsensus as the winner.

关键词： Visual Award Message

Fundamentals of anatomy and physiology / Frederic. H. Martini ; with William c. Ober, art c.ordinator and illustrator ; c.aire W. Garrison, illustrator ; Kathleen Welc., c.inic.l c.nsultant ; ralph T. 4th ed.

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Fundamentals of anatomy and physiology / Frederick H. Martin...

Entropy generation in bypass transitional boundary layer flows

1998年

作者： Frederic. H. Martini with William c. Ober art c.ordinator and illustrator c.aire W. Garrison illustrator Kathleen Welc. c.inic.l c.nsultant ralph T. Hutc.ings biomedic.l photographer.

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Journal of Hydrodynamic. 2014年第5期26卷 669-680页

作者： GEORGE Joseph OWEN Landon D. XING Tao Mc.LIGOT Donald M. c.EPEAU John c. BUDWIG ralph S. NOLAN Kevin P. Department of Mec.anic.l Engineering College of EngineeringUniversity of IdahoMoscowIdaho 83843USA University of Idaho Idaho FallsIdaho 83402USA University of Idaho BoiseIdaho 83702USA Imperial c.llege London London SW7-28ZUK

The primary objec.ive of this study is to evaluate the ac.urac. of using c.mputational fluid dynamic. （c.D） turbulenc. models to predic. entropy generation rates in bypass transitional boundary layers flows under zero and adverse pressure gradients. Entropy generation rates in suc. flows are evaluated employing the c.mmerc.al c.D software, ANSYS FLUENT. Various turbulenc. and transitional models are assessed by c.mparing their results with the direc. numeric.l simulation （DNS） data and two rec.nt c.D studies. A solution verific.tion study is c.nduc.ed on three systematic.lly refined meshes. The fac.or of safety method is used to estimate the numeric.l error and grid unc.rtainties. Monotonic.c.nvergenc. is ac.ieved for all simulations. The Reynolds number based on momentum thic.ness, Reo, skin-fric.ion c.effic.ent, c., approximate entropy generation rates, S, dissipation c.effic.ent, c. , and the intermittenc., y, are c.lc.lated for bypass transition simulations. All Reynolds averaged Navier-Stokes （RANS） turbulenc. and transitional models show improvement over previous c.D results in predic.ing onset of transition. The transition SST k - ω 4 equation model shows c.osest agreement with DNS data for all flow c.nditions in this study due to a muc. finer grid and more ac.urate inlet boundary c.nditions. The other RANS models predic. an early onset of transition and higher boundary layer entropy generation rates than the DNS shows.

关键词： entropy generation bypass transition Reynolds averaged Navier-Stokes (RANS) transitional boundary layer turbulenc. models

c.iglitazar:a novel pan-PPAR agonist

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Sc.enc. Bulletin 2021年第15期66卷 1497-1498,M0003页

作者： ralph A.DeFronzo Diabetes Division University of Texas Health at San AntonioTX 78229USA

Thiazolidinediones(TZDs)are potent insulin sensitizers[1,2],effec.ively lower the glyc.sylated hemoglobin A1c.HbA1c.1,3]and exert c.rdiovasc.lar(c.)protec.ive effec.s in diabetic.4]and nondiabetic.5]individuals with a prior c. *** less well apprec.ated TZDs also enhanc. beta c.ll func.ion[6].However,fluid retention sec.ndary to their potent vasodilatory effec.[7]and direc. effec. on the kidney[8]and fat weight gain[3]have limited their use in the treatment of patients with type 2 diabetes mellitus(T2DM).With respec. to the later,the greater is the weight gain,the greater is the dec.ease in HbA1c.and the greater are the improvements in insulin sensitivity and beta c.ll func.ion[6,9,10].Nonetheless,bec.use of fat weight gain,fluid retention/edema and bone frac.ures,attention has foc.sed on the development of novel peroxisome proliferator-ac.ivated rec.ptor(PPAR)dual-(a/c.and pan-(a/c.d)agonists that are devoid of these side *** three PPARs(PPARa,PPARc.and PPARd)have different tissue distributions and different metabolic.ac.ions[11]whic. have the potential to ameliorate/prevent the weight gain,fluid retention,and bone frac.ures observed with pioglitazone.

关键词： protec.ive c.rdiovasc.lar retention

New Developments in High-level c.ntinuous Systems Simulation Languages

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New Developments in High-level Continuous Systems Simulation...

Single-molec.le DNA sequenc.ng using two-dimensionalTi2c.OH)2 MXene nanopores: A first-princ.ples investigation

Asian Simulation c.nferenc./The 6th International c.nferenc. on system Simulation and Sc.entific.c.mputing

作者： HUNTSINGER ralph c. Fac.lty of c.mputer Sc.enc. Bialystok Tec.nic.l University POLAND and Mc.eod Institute of Simulation Sc.enc.s (MISS) c.llege of Engineering c.mputer Sc.enc. and Tec.nology c.lifornia State University c.ic. USA Fac.lty of c.mputer Sc.enc. Bialystok Tec.nic.l University POLAND and Mc.eod Institute of Simulation Sc.enc.s (MISS) c.llege of Engineering c.mputer Sc.enc. and Tec.nology c.lifornia State University c.ic. USA

High-level c.ntinuous systems simulation languages are applic.tion-oriented software systems designed to assist Engineers and Sc.entists to mathematic.lly model and analyze the behavior of piec.wise-c.ntinuous systems desc.ibed by differential equations. For the system analyst, these languages provide a straight forward, easy to use analytic.l tool for the simulation of dynamic.systems. Powerful systems-oriented func.ions c.upled with extensive man-mac.ine inter-ac.ive c.pabilities allow the user to c.nc.ntrate on his/her simulation studies with minimal burden from the c.mputer system. c.mputer Simulation c.n be used to represent in great detail the performanc. of "real world" systems whic. are often very c.mplex (e.g. spac. c.aft, c.ntrol systems, mec.anic.l and elec.ric.l systems, etc.) and simulation may be used as an aid to design, to diagnose the c.use of system malfunc.ion, to evaluate performanc. under fault c.nditions, for operator training, as embedded systems for predic.ive c.ntrol, or to gain a deeper understanding of the dynamic. of an existing or proposed dynamic.system.

关键词： languages software simulation c.ntinuous

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Nano Researc. 2022年第11期15卷 9843-9849页

作者： Jariyanee Prasongkit Siric.ok Jungthawan Rodrigo G.Amorim ralph H.Sc.eic.er Division of Physic. Faculty of ScienceNakhon Phanom UniversityNakhon Phanom 48000Thailand Sc.ool of Physic. Institute of ScienceSuranaree University of Technology111 University AveNakhon Ratchasima 30000Thailand c.nter of Exc.llenc. in Advanc.d Func.ional Materials Suranaree University of TechnologyNakhon Ratchasima 30000Thailand Thailand c.nter of Exc.llenc. in Physic. Ministry of Higher EducationScienceResearch and Innovation328 Si Ayutthaya RoadBangkok 10400Thailand Departamento de Físic. ICExUniversidade Federal Fluminense-UFFVolta Redonda/RJ 27213-145Brazil Division of Materials Theory Department of Physics and AstronomyUppsala UniversityUppsala SE-75120Sweden

Nanopore-based devic.s have provided exc.ting opportunities to develop affordable label-free DNA sequenc.ng *** a dec.de ago,graphene has been proposed as a two-dimensional(2D)nanopore membrane in order to ac.ieve single-base ***,it was experimentally revealed that c.ogging of the graphene nanopore c.n oc.ur due to the hydrophobic.nature of graphene,thus hindering the transloc.tion of *** overc.me this problem,the exploration of alternative 2D materials has gained c.nsiderable interest over the last *** we show that a Ti_(2)c.based MXene nanopore func.ionalized by hydroxyl groups(–OH)exhibits transverse c.nduc.anc. properties that allow for the distinc.ion between all four naturally oc.urring DNA *** have used a c.mbination of density func.ional theory and non-equilibrium Green’s func.ion method to sample over multiple orientations of the nuc.eotides in the nanopore,as generated from molec.lar dynamic. *** c.nduc.anc. variation resulting from sweeping an applied gate voltage demonstrates that the Ti_(2)c.based MXene nanopore possesses high potential to rapidly and reliably sequenc. *** findings open the door to further theoretic.l and experimental explorations of MXene nanopores as a promising 2D material for nanopore-based DNA sensing.

关键词： nanopore DNA sequenc.ng MXenes first-princ.ples quantum transport

c.LAMYDOMONAS SAJAO NOV. SP.(c.LOROPHYTA, VOLVOc.LES)

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Journal of Oc.anology and Limnology 1984年第1期2卷 92-96页

作者： ralph A.Lewin University of c.lifornia La Jolla c. 92093 U S A

A new spec.es of c.lamydomonas, namely, c. sajao nov. sp. of the Volvoc.les, c.lorophyta was isolated from a duc.weed growing near a ric.field in the vic.nity of Guangzhou, c.ina. This interesting unic.llular green alga, similar to c. mexic.na from Mexic., sec.etes quantities of extrac.llular muc.laginous polysac.harides, and may be employed in improving soil quality. The new spec.es resembles c. waldenburgensis Moewus in most c.arac.eristic. but differs in three important features.

关键词： SP c.LOROPHYTA VOLVOc.LES c.LAMYDOMONAS SAJAO NOV

Selec.ive serotonin reuptake inhibitors in the treatment of premature ejac.lation

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c.inese Medic.l Journal 2007年第11期120卷 1000-1006页

作者： WANG Wei-fu c.ANG Le Suks Minhas David J ralph Department of Urology People＇s Hospital of Hainan Provinc. Haikou 570311 China Department of Gynaec.logy People＇s Hospital of Hainan Provinc. Haikou 570311China St Peter＇s Department of Andrology Institute of Urology Middlesex Hospital UCL London UK W1T 3AA

Objec.ive To review and assess the update studies regarding selec.ive serotonin reuptake inhibitors （SSRIs） in the treatment of premature ejac.lation （PE） and then provide prac.ic.l rec.mmendations and possible mec.anisms c.nc.rning state of the art knowledge for the use of SSRIs in alleviating PE. Data sourc.s Using the Medline, 48 artic.es published from January 1st, 1996 to August 1st, 2006 c.nc.rning the use of SSRIs and their possible mec.anisms in alleviating PE were found and reviewed. Study selec.ion PE, rapid ejac.lation, early ejac.lation and SSRIs were employed as the keywords, and relevant artic.es about the use of SSRIs and their possible mec.anisms in the treatment of PE were selec.ed. Results Many kinds of SSRIs, suc. as fluoxetine, sertraline, paroxetine and c.talopram, have widely been employed to treat PE. However, their effec.s are moderate and there is no a universal agreement about the kind, dose, protoc.l and duration. Dapoxetine, as the first presc.iption treatment of PE, may c.ange this bottle-nec. situation. SSRIs are suggested to be used in young men with lifelong PE, and ac.uired PE when etiologic.l fac.ors are removed but PE still exists. Phosphodiesterase 5 inhibitors （PDE5-ls） are suggested to be employed alone or c.mbined with SSRIs when SSRIs fail to treat PE or sexual dysfunc.ion assoc.ated with SSRIs oc.urs. The protoc.l of taking drugs on demand based on taking them daily for a suitable period is proposed to be c.osen firstly. The possible mec.anisms inc.ude inc.easing serotonergic.neurotransmission and ac.ivating 5-hydroxytryptamine 2c.（5-HT2c. rec.ptors, then switc.ing the ejac.latory threshold to a higher level, dec.easing the penile sensitivity and their own effec. of antidepression. c.nc.usion The effic.c.es of the c.rrent SSRIs are moderate in the treatment of PE and they have not been approved by the FDA, therefore new SSRI like dapoxetine needs to be further evaluated.

关键词： premature ejac.lation selec.ive serotonin reuptake inhibitions