Single-molecule DNA sequencing using two-dimensionalTi2C(OH)2 MXene nanopores: A first-principles investigation

作     者：Jariyanee Prasongkit Sirichok Jungthawan Rodrigo G.Amorim Ralph H.Scheicher Jariyanee Prasongkit;Sirichok Jungthawan;Rodrigo G.Amorim;Ralph H.Scheicher

作者机构：Division of PhysicsFaculty of ScienceNakhon Phanom UniversityNakhon Phanom 48000Thailand School of PhysicsInstitute of ScienceSuranaree University of Technology111 University AveNakhon Ratchasima 30000Thailand Center of Excellence in Advanced Functional MaterialsSuranaree University of TechnologyNakhon Ratchasima 30000Thailand Thailand Center of Excellence in PhysicsMinistry of Higher EducationScienceResearch and Innovation328 Si Ayutthaya RoadBangkok 10400Thailand Departamento de FísicaICExUniversidade Federal Fluminense-UFFVolta Redonda/RJ 27213-145Brazil Division of Materials TheoryDepartment of Physics and AstronomyUppsala UniversityUppsala SE-75120Sweden 

出 版 物：《Nano Research》 (纳米研究（英文版）)

年 卷 期：2022年第15卷第11期

页      面：9843-9849页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 0702[理学-物理学] 

基　　金：support from the Thailand Research Fund(MRG6280150) S.J.is supported by Suranaree University of Technology(SUT) Thailand Science Research and Innovation(TSRI) National Science,Research and Innovation Fund(NSRF grant No.B05F640051) R.G.A.thanks for financial support from CNPq(Nos.437182/2018-5 and 313076/2020-0) also FAPERJ(Nos.E-26/010.101126/2018 and 26/202.699/2019).R.H.S.ackn 

主　　题：nanopore DNA sequencing MXenes first-principles quantum transport 

摘      要：Nanopore-based devices have provided exciting opportunities to develop affordable label-free DNA sequencing *** a decade ago,graphene has been proposed as a two-dimensional(2D)nanopore membrane in order to achieve single-base ***,it was experimentally revealed that clogging of the graphene nanopore can occur due to the hydrophobic nature of graphene,thus hindering the translocation of *** overcome this problem,the exploration of alternative 2D materials has gained considerable interest over the last *** we show that a Ti_(2)C-based MXene nanopore functionalized by hydroxyl groups(–OH)exhibits transverse conductance properties that allow for the distinction between all four naturally occurring DNA *** have used a combination of density functional theory and non-equilibrium Green’s function method to sample over multiple orientations of the nucleotides in the nanopore,as generated from molecular dynamics *** conductance variation resulting from sweeping an applied gate voltage demonstrates that the Ti_(2)C-based MXene nanopore possesses high potential to rapidly and reliably sequence *** findings open the door to further theoretical and experimental explorations of MXene nanopores as a promising 2D material for nanopore-based DNA sensing.