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An updated study of traditional medicines to the era of 1,3,4 oxadiazole derivatives for malaria treatment

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Traditional Medicine Research 2023年第1期8卷 36-42页

作者： Davinder kumar Harsh kumar Aakash Deep rakesh kumar marwaha Department of Pharmaceutical Sciences Maharishi Dayanand UniversityRohtak 124001HaryanaIndia Department of Pharmaceutical Sciences Chaudhary Bansi Lal UniversityBhiwani 127021HaryanaIndia.

Discovering potent drug candidates requires new antimalarial *** this reason,antimalarial drug researchers focus on developing new drug candidates on promising *** the identification of these targets,a basic understanding of the metabolism and biochemical processes of malaria parasites such as Plasmodium falciparum can prove ***,malarial resistant parasites are becoming more and more significant issues as antimalarial medications *** drugs are becoming increasingly resistant,thus the search for new molecules is very important *** based combination therapies are becoming more popular for treating *** will ultimately lead to the selection of resistance due to their extensive and indiscriminate *** artemisinin-based combination therapies are therefore *** is an interest in finding suitable antimalarial compounds based on their potential effectiveness against *** potential activity of 1,3,4 oxadiazole analogues against malarial infections is a major draw of the search for suitable antimalarial *** review identifies existing antimalarial drugs that have own therapeutic effects and evaluating their feasibility for developing novel synthetic antimalarial derivatives.

关键词： antimalarial Plasmodium falciparum 1,3,4 oxadiazoles traditional medicines

Critical Review on Balanites aegyptiaca Delile:Phytoconstituents,Pharmacological Properties and Nanointerventions

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Chinese Journal of Integrative Medicine 2024年第7期30卷 653-663页

作者： Surendra kumar Gautam rakesh kumar Paul Devesh M.Sawant Amita Sarwal Kaisar Raza Department of Pharmacy School of Chemical Sciences and PharmacyCentral University of RajasthanBandarsindriAjmerRajasthan305817India University Institute of Pharmaceutical Sciences Panjab UniversityChandigarh160014India

Balanites aegyptiaca Delile(BA)is an enduring xerophytic woody and spinous flowering tree and is commonly known as desert date or Ingudi(Hingot).It belongs to the family Zygophyllaceae,which is specific to be drought areas of Nigeria,Africa,South Asia and India(Rajasthan).In Ayurveda,this traditional medicinal plant is reported for the management of jaundice,syphilis,yellow fever,metabolic disorders,liver,and spleen *** main aim of the review is to compile its medicinal uses and further advancements to showcase the promises inherited in various parts of the plant for the benefit of *** per the literature survey,various researchers have focused on the detailed investigation of BA including the phytopharmacological evidence,chemical constituents,nano-formulations,commercialized products,and clinical *** remarkable scaffolds and isolated compounds like diosgenin,yamogenin,balanitin1/2,balanitin 3,bal4/5,bal6/7,rutin-3-glycosides,3,7-diglycosides,(3,12,14,16)–(12-hydroxycholest-5-ene-3,16-diyl-bis)-D-glucopyranoside and balanitoside have been ***,this traditional plant has been scientifically proven by in vitro and in *** on the complete review of this plant,most of the compounds have been isolated from the fruit and kernel ***,based on the literature,a histogram was developed for pharmacological activity in which antidiabetic study was found to be more compared to other pharmacological *** a spinous desert dates,this plant needs to be explored more to bring out newer phytochemicals in the management of various diseases.

关键词： Delile desert date phytochemicals nano-phytopharmaceutical pharmacological activities traditional medicine

Proposed numerical and machine learning models for fiber-reinforced polymer concrete-steel hollow and solid elliptical columns

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Frontiers of Structural and Civil Engineering 2024年第8期18卷 1169-1194页

作者： Tang QIONG Ishan JHA Alireza BAHRAMI Haytham F.ISLEEM rakesh kumar Pijush SAMUI School of Applied Technologies Qujing Normal UniversityQujing 655011China Department of Civil Engineering Indian Institute of Technology-BHUVaranasi 221005India Department of Building Engineering Energy Systems and Sustainability ScienceFaculty of Engineering and Sustainable DevelopmentUniversity of GävleGävle 80176Sweden Department of Civil Engineering National Institute of Technology-PatnaPatna 800005India

This study employs a hybrid approach,integrating finite element method(FEM)simulations with machine learning(ML)techniques to investigate the structural performance of double-skin tubular columns(DSTCs)reinforced with glass fiber-reinforced polymer(GFRP).The investigation involves a comprehensive examination of critical parameters,including aspect ratio,concrete strength,number of GFRP confinement layers,and dimensions of steel tubes used in DSTCs,through comparative analyses and parametric *** ensure the credibility of the findings,the results are rigorously validated against experimental data,establishing the precision and trustworthiness of the *** present research work examines the use of the columns with elliptical cross-sections and contributes valuable insights into the application of FEM and ML in the design and evaluation of structural systems within the field of structural engineering.

关键词： elliptical column fiber-reinforced polymer machine learning finite element method ABAQUS

Malignant pleural mesothelioma:The disdained member of thoracic oncology!

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World Journal of Experimental Medicine 2024年第3期14卷 1-10页

作者： Divya Khosla Pawan kumar Singh Bharath A Chhabria Vaishali Kataria Navneet Singh rakesh Kapoor Department of Radiotherapy and Oncology Postgraduate Institute of Medical Education and ResearchChandigarh 160012India Department of Pulmonary and Critical Care Medicine Pandit Bhagwat Dayal Sharma Postgraduate Institute of Medical SciencesRohtak 124001India Department of Pulmonary and Critical Care Medicine Ramaiah Memorial HospitalBengaluru 560054India Department of Pulmonary Medicine Postgraduate Institute of Medical Education and ResearchChandigarh 160012India

Pleural mesothelioma is a very aggressive malignancy that arises from the pleural mesothelial cell lining and is linked strongly to prior asbestos *** ban on asbestos has helped to lower the incidence,but in developing countries like India,it is expected to *** has an extended latency period usually progressing over decades and presents with nonspecific *** has a median survival ranging between 10-22 *** diagnosis of malignant pleural mesothelioma is challenging and is done using computed tomography(CT),magnetic resonance imaging,or positron emission tomography-CT,with the last two predicting the resectability of the tumor better than CT alone.A pleural biopsy along with an array of immunohistochemical markers,such as p16,BRCA1 associated protein 1,and claudin-4,are required for a definitive *** genetic alterations have prognostic significance as *** current histological subtype identification is indispensable for decision making because of the new therapeutic avenues being *** combination of nivolumab and ipilimumab-based immunotherapy outperformed platinum and pemetrexed-based chemotherapy in terms of survival benefit and improved quality of life especially for non-epithelioid ***,the latter continues to be a robust treatment option for patients with the epithelioid *** is recommended for resectable cases with radiotherapy being indicated in neoadjuvant,adjuvant,and palliative settings along with systemic *** review article provides an overview of epidemiology,etiology,clinical manifestations,diagnostic approaches(including immunohistochemical and genetic markers),staging,and multidisciplinary approaches to current treatment for malignant pleural mesothelioma using surgery,chemotherapy,immunotherapy,and *** also sheds light on some recent studies(EMPHACIS,CALGB30901,Checkmate-743,etc.)that have led to significant developments in recent years with clinically mean

关键词： Chemotherapy Diagnosis Immunotherapy Malignant pleural mesothelioma Radiotherapy

1,3,4-Oxadiazole as an emerging telomerase inhibitor-a promising anticancer motif

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Cancer Advances 2022年第18期5卷 1-6页

作者： Davinder kumar Virender kumar Harsh kumar Aakash Deep rakesh kumar marwaha Department of Pharmaceutical Sciences Maharishi Dayanand UniversityRohtak 124001 HaryanaIndia Department of Pharmaceutical Sciences Chaudhary Bansi Lal UniversityBhiwani 127021 HaryanaIndia

Currently,cancer is the most rapidly growing life-threatening disease after cardiovascular in the world,posing a major threat to human *** promotes tumorigenesis and development in most cancers and dyskerin plays a crucial role in telomere *** molecules are being developed continuously as a result of continuous research.A series of novel anticancer agents have been developed using telomerase inhibitors with improved specificity and *** medicinal chemistry advances,heterocyclic-based drugs find increasing applications,including anticancer *** properties have led to the development of five-membered aromatic rings of *** order to enhance their anticancer activity,oxadiazole scaffolds can be *** this review,we discuss the functions and mechanism of action of the telomerase *** paper also summarizes the interaction between 1,3,4-oxadiazole inhibitors and telomerase enzymes.

关键词： 1,3,4-Oxadiazole derivatives telomerase enzyme inhibitors anticancer drugs growth factors

1,3,4-oxadiazole-a bioactive scaffold for treating major depression-associated cognitive dysfunction

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Aging Communications 2023年第2期5卷 26-34页

作者： Davinder kumar Virender kumar Aakash Deep Harsh kumar rakesh kumar marwaha Department of Pharmaceutical Sciences Maharshi Dayanand UniversityRohtak 124001HaryanaIndia Department of Pharmaceutical Sciences Chaudhary Bansi UniversityBhiwani 127021India.

Background:Alzheimer’s disease affects millions of people worldwide,and one of its major characteristics is the accumulation of extracellular Aβpeptides in the human brain,leading to neuronal death and resulting in memory deficits,disorientation,and inappropriate *** and Methodology:This review study aims to develop new molecular targets for major depression-associated cognitive dysfunction and determine the mechanisms of action of 1,3,4-oxadiazole-based drug *** encourages scientists to develop and synthesize drugs with low side effects to treat Alzheimer’s ***,the drug has shown significant improvement in memory function among dementia patients,which is due to the increased production of acetylcholine in the *** derivatives show a high affinity to amyloid plaques,which are thought to cause cognitive damage in patients with Alzheimer’s *** review study emphasizes newly developed inhibitors of amyloid deposition using the enzymeα-secretase,which cleaves amyloid precursor protein into smaller fragments that are toxic to neurons.1,3,4-Oxadiazole compounds have demonstrated no significant toxicity to the central nervous *** antioxidant properties of 1,3,4-oxadiazoles can reduce free radicals,which play an active role in cell damage and ***:This review aims to provide readers with an overview of the current state of knowledge about oxadiazole-related drugs,emphasizing their biological *** aspects related to the discovery and development of these drug candidates are discussed in detail,including information on their structure,biological activity,chemistry,and pharmacological *** addition,different derivatives discovered for Alzheimer’s disease to enhance the therapeutic efficiency of oxadiazole drugs have been comprehensively discussed in this review.

关键词： 1,3,4-oxadiazole Alzheimer’s disease dementia amyloids antioxidant properties

Targeting brain tumors with innovative nanocarriers:bridging the gap through the blood-brain barrier

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Oncology Research 2024年第5期32卷 877-897页

作者： KARAN WADHWA PAYAL CHAUHAN SHOBHIT kumar rakesh PAHWA RAVINDER VERMA RAJAT GOYAL GOVIND SINGH ARCHANA SHARMA NEHA RAO DEEPAK KAUSHIK Department of Pharmaceutical Sciences Maharshi Dayanand UniversityRohtak124001India Department of Pharmaceutical Technology Meerut Institute of Engineering and Technology(MIET)NH-58Delhi-Roorkee HighwayMeerut250005India Institute of Pharmaceutical Sciences Kurukshetra UniversityKurukshetra136119India Department of Pharmaceutical Sciences Chaudhary Bansi Lal UniversityBhiwani127021India MM College of Pharmacy Maharishi Markandeshwar(Deemed to be University)Mullana-AmbalaHaryana133207India Delhi Pharmaceutical Sciences and Research University(DIPSAR) Delhi Pharmaceutical Sciences and Research UniversityNew Delhi110017India

Background:Glioblastoma multiforme(GBM)is recognized as the most lethal and most highly invasive *** high likelihood of treatment failure arises fromthe presence of the blood-brain barrier(BBB)and stemcells around GBM,which avert the entry of chemotherapeutic drugs into the ***:Recently,several researchers have designed novel nanocarrier systems like liposomes,dendrimers,metallic nanoparticles,nanodiamonds,and nanorobot approaches,allowing drugs to infiltrate the BBB more efficiently,opening up innovative avenues to prevail over therapy problems and radiation ***:Relevant literature for this manuscript has been collected from a comprehensive and systematic search of databases,for example,PubMed,Science Direct,Google Scholar,and others,using specific keyword combinations,including“glioblastoma,”“brain tumor,”“nanocarriers,”and several ***:This review also provides deep insights into recent advancements in nanocarrier-based formulations and technologies for GBM *** of various scientific advances in conjunction with encouraging findings concerning the future perspectives and challenges of nanocarriers for effective brain tumor management has also been discussed.

关键词： Glioblastoma Brain tumor Blood-brain barrier Liposomes Metallic nanoparticles Nanocarriers

Endoscopic ultrasound-guided pancreatic fluid collection drainage: Where are we?

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World Journal of Gastrointestinal Endoscopy 2024年第6期16卷 273-281页

作者： Anupam kumar Singh Manish Manrai rakesh Kochhar Department of Gastroenterology Postgraduate Institute of Medical Education and ResearchChandigarh 160012India Department of Gastroenterology Command HospitalLucknow 226002India Department of Gastroenterology Paras HospitalPanchkula 134109India

Pancreatic fluid collections(PFCs)result from injury to the pancreas from acute or chronic pancreatitis,surgery,or *** of these collections has evolved over the last 2 *** choice of interventions includes percu-taneous,endoscopic,minimally invasive surgery,or a combined *** drainage is the drainage of PFCs by creating an artificial communication between the collection and gastrointestinal lumen that is maintained by placing a stent across the fistulous *** this editorial,we endeavored to update the current status of endoscopic ultrasound-guided drainage of PFCs.

关键词： Pancreatic fluid collections Endoscopic ultrasound-guided drainage Endoscopic necrosectomy Lumen apposing metal stent Review

Emerging Novel Therapeutic Approaches for the Treatment of Alzheimer’s Disease

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Advances in Alzheimer's Disease 2024年第3期13卷 65-94页

作者： Amit Panwar Mohd. Imran Khan Rajesh kumar rakesh kumar Santosh kumar Rai Anil kumar New Drug Discovery Research Mankind Research Centre Mankind Pharma Limited Gurugram India

Alzheimer’s disease (AD) is caused by synaptic failure and the excessive accumulation of misfolded proteins especially Aβ and tau, and associated with memory loss and cognitive impairment. Treatment of AD mainly consists of symptomatic therapy and disease-modifying therapy (DMT). Several monotherapies including small molecules or antibodies have been evaluated through multiple clinical trials, but a very few have been approved by the USFDA to intervene the disease’s pathogenesis. Past research has shown multifactorial nature of AD, therefore, multi-target drugs were proposed to target different pathways at the same time, however, currently no rationally designed multi-target directed ligand (MTDL) has been clinically approved. Different combinations and bispecific antibodies are also under development. Novel approaches like stem cell-based therapies, microRNAs, peptides, ADCs and vaccines cast a new hope for AD treatment, however, a number of questions remained to be answered prior to their safe and effective clinical translation. This review explores the small molecules, MTDL, and antibodies (monospecific and bispecific) for the treatment of AD. Finally, future perspectives (stem cell therapy, PROTAC approaches, microRNAs, ADC, peptides and vaccines) are also discussed with regard to their clinical applications and feasibility.

关键词： Alzheimer’s Disease (AD) Disease-Modifying Therapy (DMT) MicroRNAs PROTAC