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The Development of Efficient Plant Promoters for Transgene Expression Employing Plant Virus Promoters

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Molecular Plant 2012年第4期5卷 941-944页

作者： Sunita Patro Deepak Kumar rajiv Ranjan Indu B.Maiti Nrisingha Dey Institute of Life Sciences Department of BiotechnologyGovernment of IndiaNalco SquareChandrasekherpurBhubaneswar 751023OrissaIndia Kentucky Tobacco Research and Development Center University of KentuckyLexingtonKY 40546-0236USA

Dear Editor, The structure of eukaryotic promoter is modular, consisting of different sub-domains （Benfey et al., 1990）. Cross-talk among these sub-domains and effective combinatorial interac- tions between the specific cis-element/s with respective trans- factor/s usually control the strength and tissue specificity of the promoter. Further, specificity/inducibility of promoter can be modified by altering its genetic architecture through ＇cis-rearrangement＇（Rushton et al., 2002） and ＇swapping of sub-domains＇（Bhullar et al., 2003）. The fundamental motiva- tion behind developing such modified promoters lies in thebelief that the swapping/shuffling of the upstream activation sequences carrying a specific set of cis-elements that bind to a particular trans-factor from one promoter to the other con- taininq a TATA seauence that miaht result in a novel chimericregu!atory module,

关键词： DELETION ANALYSIS ELEMENTS ENHANCER

3D printing applications for healthcare research and development

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Global Health Journal 2022年第4期6卷 217-226页

作者： Mohd Javaid Abid Haleem Ravi Pratap Singh rajiv Suman Department of Mechanical Engineering Jamia Millia IslamiaNew Delhi 110025India Department of Industrial and Production Engineering Dr B R Ambedkar National Institute of Technology JalandharPunjab 144011India Department of Industrial and Production Engineering G.B.Pant University of Agriculture and Technology PantnagarUttarakhand 263145India

There is a growing demand for customised,biocompatible,and sterilisable components in the medical busi-ness.3D Printing is a disruptive technology for healthcare and provides significant research and development *** 3D printing service gives patients low-cost individualised prostheses,implants,and gadgets,en-abling surgeons to operate more effectively with customised equipment and models;and assisting medical device manufacturers in developing new and faster goods.3D printed tissue pieces can overcome various challenges and may eventually allow medication companies to streamline research and *** the long run,it may also assist in lowering prices and making medicines more accessible and effective for *** is a growing corpus of research on the advantages of employing 3D printed anatomic models in teaching and *** capacity to 3D printing individual anatomical diseases for practical learning is one of the funda-mental contrasts between utilising 3D and regular anatomical models.3D printing is very appealing for producing patient-specific *** literature review-based paper explores the role of 3D printing and 3D bioprinting in *** briefs the need and progressive steps for implementing 3D printing in healthcare and presented various facilities and enablers of 3D printing for the healthcare ***,this paper identifies and discusses the significant applications of 3D printing for healthcare research and development.3D printing services can be deployed to easily construct complex geometries in plastic or metal with good *** results in improved prototypes,lower costs,and lower part processing *** can now physically create with natural materials,previously unattainable with prior *** hospital should have 3D printers in the future,allowing new organs/parts to be developed in-house.

关键词： 3D printing Healthcare Medical Research Development

Prognostic significance of red blood cell distribution width in gastrointestinal disorders

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World Journal of Gastroenterology 2017年第27期23卷 4879-4891页

作者： Hemant Goyal Giuseppe Lippi Altin Gjymishka Bijo John rajiv Chhabra Elizabeth May Department of Internal Medicine Mercer University School of Medicine Section of Clinical Biochemistry University of Verona Texas Digestive Disease Consultants Department of Gastroenterology Saint Luke’s HospitalSchool of MedicineUniversity of Missouri Kansas City Gastroenterology Attending Mc Laren Northern Hospital

The red blood cell distribution width(RDW) is a routinely measured and automatically reported blood parameter,which reflects the degree of anisocytosis. Recently,the baseline RDW was found to have clinical significance for assessing clinical outcome and severity of various pathological conditions including cardiovascular diseases,sepsis,cancers,leukemia,renal dysfunction and respiratory diseases. A myriad of factors,most of which ill-defined,have an impact on the red cell population dynamics(i.e.,production,maturation and turnover). A delay in the red blood cell clearance in pathological conditions represents one of the leading determinants of increased anisocytosis. Further study of RDW may reveal new insight into inflammation mechanisms. In this review,we specifically discuss the current literature about the association of RDW in various disease conditions involving the gastrointestinal and hepatobiliary systems. We also present some of the related measurements for their value in predicting clinical outcomes in such conditions. According to our data,RDW was found to be a valuable prognostic index in gastrointestinal disorders along with additional inflammatory biomarkers(i.e.,C reactive protein,erythrocyte sedimentation rate,and platelet count) and current disease severity indices used in clinical practice.

关键词： Red blood cell distribution width Hepatitis Pancreatitis Inflammatory bowel diseases Crohn’s disease Ulcerative colitis Colon cancer Hepatocellular carcinoma Acute mesenteric ischemia Gastrointestinal diseases

Double co-host emitter based top emitting white organic light emitting diodes with enhanced brightness and efficiency

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Optoelectronics Letters 2021年第10期17卷 581-585页

作者： Neha Jain Sujata Pandey rajiv Kr.Singh O.P.Sinha Department of ECE Amity School of Engineering and TechnologyAmity UniversityUPNoidaIndia Department ofEEE Galgotia College of Engineering and TechnologyGreater NoidaIndia CSIR-National Physical Laboratory New DelhiIndia Amity Institute of Nanotechnology Amity University UPNoidaIndia

Novel and simplified bi-layer top-emitting white organic light emitting diodes(OLEDs)with dual co-host emitters have been simulated and *** consist of yellow-green emitting layer(EML)as electron transport layer(ETL)and blue EML as hole transport layer(HTL).Novelty of the device lies in simplification of tri-layer white OLED to a bi-layered device which is done by merging yellow-green EML with ETL and blue EML with *** simulated devices show Commission Internationale de L’Eclairage(CIE)colour coordinates well within the emission range of white *** results show that device A with 5,6,11,12-tetraphenylnaphthacene(rubrene)doped ETL has achieved the lowest luminance but longest excited state *** D with tris-(8-hydroxyquinoline)aluminum:4-(dicyanomethylene)-2-t-butyle-6-(1,1,7,7-tetra-methyljulolidyl-9-enyl)4 H-pyran(Alq3:DCJTB)as ETL which emits yellow light and 2,7-bis[N,N-bis(4-methoxy-phenyl)amino]-9,9-spirobifluorene(MS-TPD):bis(2-methyl-8-quninolinato)-4-phenylphenolate alu-minium(BAlq)as HTL which is responsible for blue light emission is found to have best characteristics when compared to other simulated *** has a maximum luminance of 10000 cd/m2 and current efficiency of 15.25 cd/A,respectively,and CIE coordinates are at(0.329,0.319).The device is found to be compatible to be used in solid state lighting applications because of the low driving voltage of the device.

关键词： emitter diodes white

Elimination of extraordinarily high cracking susceptibility of aluminum alloy fabricated by laser powder bed fusion

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Journal of Materials Science & Technology 2022年第8期103卷 50-58页

作者： Holden Hyer Le Zhou Sharon Park Thinh Huynh Abhishek Mehta Saket Thapliyal rajiv S.Mishra Yongho Sohn Department of Materials Science and Engineering University of Central FloridaOrlandoFLUSA Center for Friction Stir Processing Department of Materials Science and EngineeringAdvanced Materials and Manufacturing Processes InstituteUniversity of North TexasDentonTXUSA Now Research Scientist Oak Ridge National LaboratoryOak RidgeTNUSA Now Assistant Professor Marquette UniversityMilwaukeeWIUSA Now PhD Candidate Johns Hopkins UniversityBaltimoreMDUSA

Using the calculation of phase diagrams approach and Scheil solidification modeling,the Al-2.5Mg-1.0Ni-0.4Sc-0.1Zr alloy was designed,intentionally with an extraordinarily high cracking susceptibility,making it prime for solidification cracking during laser powder bed *** study demonstrates the ability to mitigate even the most extreme solidification cracking tendencies in aluminum alloys with only minor alloying additions of Sc and Zr,0.5 wt.%***,by employing a simple direct ageing heat treatment,good tensile mechanical properties were observed with a yield strength of 308 MPa,an ultimate tensile strength of 390 MPa,and a total elongation of 11%.

关键词： Additive manufacturing Cracking susceptibility Aluminum alloy CALPHAD Mechanical properties

Double-sided friction stir welding of Nitronic-40 stainless steel for application in tokamak devices

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Journal of Materials Science & Technology 2023年第28期159卷 170-183页

作者： Supreeth Gaddam Ravi Sankar Haridas Deepthi Tammana Charlie Sanabria Christopher J.Lammi Diana Berman rajiv S.Mishra Center for Friction Stir Processing Department of Materials Science and EngineeringUniversity of North TexasDentonTX76207USA Advanced Materials and Manufacturing Processes Institute University of North TexasDentonTX76207USA Department of Mechanical Engineering University of North TexasDentonTX76207USA Commonwealth Fusion Systems CambridgeMAUSA

Nitrogen containing austenitic stainless steels(N-ASS)are widely utilized to fabricate various structural components in tokamak type fusion reactors owing to their suitable mechanical and functional *** components are exposed to a range of temperatures(4-500 K)and interact closely with the magnetic fields that are used to control and contain the plasma within the tokamak ***-40(N40)or XM-11 stainless steel is one such N-ASS used for fabricating structural components in the mag-netic and vacuum vessel systems in tokamak *** of most of the larger components in the magnetic and vacuum vessel systems typically involves some type of fusion-based welding *** study presents a double-sided friction stir welding(FSW)approach as an alternative to fusion welding processes to join 12 mm thick N40 plates to obtain joints with a low fraction ofδferrite(a detrimen-tal ferromagnetic phase),high joint efficiency,no sensitization and loss of hardness in the heat affected zone,and minimal nitrogen desorption from the weld *** double-sided FSW approach yielded superior weldments when compared to similar joints accomplished by fusion welding for application in tokamak devices.

关键词： Friction stir welding Nitronic-40 stainless steel XM-11 stainless steel Magnetic and vacuum vessel systems Tokamak devices

Bugbee flexible electrocautery facilitates choledochoscopic biopsy,fulguration,and debulking of a high grade intraductal papillary neoplasm of the bile duct

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Hepatobiliary & Pancreatic Diseases International 2018年第2期17卷 176-179页

作者： Ravi N Srinivasa rajiv N Srinivasa Joseph J Gemmete Jeffrey Forris Beecham Chick Department of Radiology Division of Vascular and Interventional Radiology University of Michigan Health System 1500 East Medical Center Drive Ann Arbor MI 48109 USA

To the Editor:Intraductal papillary neoplasm of the bile duct(IPNB)may occur in the setting of primary sclerosing cholangitis,choledochal cysts or hepatolithiasis[1].The entity may be a precursor of cancer or intrahepatic *** carcinoma,tubular or mucinous adenocarcinoma is present in approximately 40%-80%of IPNBs[1–3].IPNB is frequently found in the resection margins of patients undergoing hepatectomy for cholangiocarcinoma[4].

关键词： fulguration and debulking of a high grade intraductal papillary neoplasm of the bile duct Bugbee flexible electrocautery facilitates choledochoscopic biopsy flexible

Dietary synbiotic supplementation improves the growth performance,body antioxidant pool,serum biochemistry,meat quality,and lipid oxidative stability in broiler chickens

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Animal Nutrition 2020年第3期6卷 325-332页

作者： Kapil Dev Nasir Akbar Mir Avishek Biswas Jyoti Kannoujia Jubeda Begum rajiv Kant Asitbaran Mandal ICAR-Central Avian Research Institute IzatnagarBareilly 243122India Sam Higginbottom University of Agriculture Technology and SciencesAllahabad 211007India CSIR-Indian Institute of Chemical Technology Hyderabad 500007India G.B.Pant University of Agriculture&Technology College of Veterinary&Animal SciencesPantanagar 263145India

The present study investigated the effects of Lactobacillus acidophilus(LBA)and mannan-oligosaccharides(MOS)supplementation on the production performance,serum biochemistry,antioxidant profile,health indices,meat quality,and lipid oxidative stability of broiler chicken.A total of 252 commercial broiler chickens at 1 d old of uniform body weight were randomly allocated to 6 maize-soybean-based dietary treatments:T1(control diet),T2(antibiotic bacitracin methylene di-salicylate[BMD]at 20 mg/kg diet),T3(MOS at 0.1%+LBA at 10^6 CFU/g feed),T4(MOS at 0.1%+LBA at 10^7 CFU/g feed),T5(MOS at 0.2%+LBA at10^6 CFU/g feed),and T6(MOS at 0.2%+LBA at 10^7 CFU/g feed).Each treatment was assigned to 6 replicates of 7 *** samples for meat quality and serum biochemistry analysis were taken from 12 birds per treatment(2 birds/replicate).The results revealed better(P<0.01)growth performance and production efficiency of birds fed either T5 or T6 diet compared to control or BMD supplemented diet and BMD-supplemented birds superseded the control ***(P<0.01)serum and liver antioxidant enzyme activities,meat antioxidant capacity(2,2-azinobis-3-ethylbenzothiazoline-6-sulfonic acid[ABTS]and 1,1-diphenyl-2-picrylhydrazyl[DPPH]assays),serum total protein,high-density lipoproteins(HDL)cholesterol(P<0.05),and globulin levels(P<0.01)were observed in birds fed either T5 or T6 diet compared to control or BMD supplemented birds,whereas,lower lipid oxidation(P<0.01),cardiac risk ratio,atherogenic coefficient,atherogenic index of plasma,serum glucose,triglyceride,total cholesterol levels(P<0.01),and serum albumin-to-globulin ratio(P<0.05)were observed in the *** pH of meat from birds fed T4,T5 or T6 diet was lower(P<0.01)compared to control and other *** extract release volume(ERV),water holding capacity(WHC),and protein content of meat were higher(P<0.05)in birds fed either T5 or T6 diet compared to control or BMD supplemented ***,it was concluded that the sup

关键词： Lactobacillus acidophilus Manann-oligosaccharide Broiler chicken growth Antioxidant pool Meat quality Serum biochemistry

Empirical assessment of adaptation to climate change impacts of mountain households:development and application of an Adaptation Capability Index

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Journal of Mountain Science 2016年第8期13卷 1503-1514页

作者： rajiv PANDEY Nandini MAITHANI Roberta ARETANO Giovanni ZURLINI Kelli M ARCHIE Ajay K GUPTA Vishnu Prasad PANDEY Biodiversity and Climate Change Division ICFREDehradun 248 006India Forest Research Institute Dehradun 248006India Department of Biological and Environmental Sciences and Technologies University of SalentoLecee 73100Italy Climate Change Research Institute Victoria University of WellingtonWellington 6140New Zealand Asian Institute of Technology and Management(AITM) Lalitpur 44700Nepal

The present study proposes an index to assess the potential for adaptation to climate change for households in the mountainous regions. The index provides a realistic approach to recognize social and natural factors which contribute to successful adaptation and addresses several household functions, such as social networking, livelihood strategy, adjustment strategies, resource availability and accessibility. The proposed Adaptation Capability Index （ACI） is analytically defined, mathematically formulated and field tested on mountainous households in urban and semi-urban regions of the Uttarakhand Himalaya in India. To gather data on the topic relevant to the ACI, a household scale questionnaire was developed and administered to 12o heads of households through face-to-face interviews. The results highlight higher adaptive capability of urban households and low adaptation capacity of rural households due to poor farm productivity, low accessibility and availability of resources and technological input. Future programs and policies must include and implement regulations to remedy attributive factors responsible for higher adaptation. This paper may be applicable to other mountainous regions and may provide insights for effective adaptation strategies to climate change.

关键词： Adaptation strategy Adjustmentpractice Climate change Vulnerability Resilience Social networking