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Serum and glucocorticoid inducible protein kinases(SGKs):a potential target for cancer intervention

Acta Pharmaceutica Sinica B 2018年第5期8卷 767-771页

作者： rajesh basnet Grace Qun Gong Chenyao Li Ming-Wei Wang The National Center for Drug Screening and the CAS Key Laboratory of Receptor Research Shanghai Institute of Materia MedicaChinese Academy of Sciences (CAS) University of Chinese Academy of Sciences Department of Molecular Medicine and Pathology The University of Auckland School of Pharmacy Fudan University

The serum and glucocorticoid inducible protein kinase(SGK) family members share similar structure, substrate specificity and function with AKT and signal downstream of the phosphatidylinositol 3-kinase(PI3K) signalling pathway. They regulate a range of fundamental cellular processes such as cell proliferation and survival, thereby playing an important role in cancer development. This perspective intends to give an overview on the involvement of SGKs(particularly SGK3) in cancer progression, and compares the actions of SGK3 and AKT in cell cycle regulation, oncogenic signalling, and the potential as a therapeutic target for cancer.

关键词： SGK AKT PI3K Cancer Signalling Kinase Inhibitor

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Effect of plasma treatment on the seed germination and seedling growth of radish(Raphanus sativus)

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Plasma Science and Technology 2022年第1期24卷 95-107页

作者： rajesh Prakash GURAGAIN Hom Bahadur BANIYA Santosh DHUNGANA Ganesh Kuwar CHHETRI Binita SEDHAI Niroj basnet Aavash SHAKYA Bishnu Prasad PANDEY Suman Prakash PRADHAN Ujjwal Man JOSHI Deepak Prasad SUBEDI Department of Physics School of SciencesKathmandu UniversityDhulikhelKavre 45210Nepal Department of Physics Tri-Chandra Multiple CampusTribhuvan UniversityKathmandu 44600Nepal Department of Chemical Science and Engineering Kathmandu UniversityDhulikhelKavre 45210Nepal Department of Environmental Science and Engineering Kathmandu UniversityDhulikhelKavre 45210Nepal

The effect on the germination and seedling growth of radish(Raphanus sativus)seeds were examined employing a dielectric barrier discharge(DBD)at atmospheric pressure and room temperature for various treatment *** plasma using argon gas of flow rate 21 m^(-1)was employed in this *** seeds were treated with DBD plasma for 1-5 min,*** characteristics,seedling growth parameters,the contact angle of the seed coat,water uptake capacity,mass loss,the temperature of the seeds,chlorophyll,and carotenoid contents of the seedlings were measured before and after the DBD plasma *** treatment of radish seeds significantly increased germination-related characters,including germination percentage,fresh and dry weight,vigor index,and total carotenoids ***,the cumulative production rate was found to be *** from the experiment indicate an acceleration in the water uptake of the radish seeds and make the seed surface hydrophilic by plasma *** electron microscopy analysis showed that etching effects on the seed coat occurred after the argon plasma treatments,which affected the wettability of the radish *** experimental findings showed that seeds being treated by DBD plasma for 2 and 3 min had a positive effect on the germination and seedling growth of radish.

关键词： dielectric barrier discharge(DBD) electron temperature electron density germination growth parameters radish seeds

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