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Application of extracellular vesicles from mesenchymal stem cells promotes hair growth by regulating human dermal cells and follicles

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World Journal of Stem Cells 2022年第7期14卷 527-538页

作者： Ramya Lakshmi rajendran Prakash Gangadaran Mi Hee Kwack Ji Min Oh Chae Moon Hong Young KwanSung Jaetae Lee Byeong-Cheol Ahn Department of Nuclear Medicine School of MedicineKyungpook National UniversityDaegu 41944South Korea BK21 FOUR KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents Department of Biomedical SciencesSchool of MedicineKyungpook National UniversityDaegu 41944South Korea Department of Immunology School of MedicineKyungpook National UniversityDaegu 41944South Korea Department of Nuclear Medicine Kyungpook National University HospitalDaegu 41944South Korea

BACKGROUND Dermal papillae(DP)and outer root sheath(ORS)cells play important roles in hair growth and regeneration by regulating the activity of hair follicle(HF)*** To investigate the effects of human mesenchymal stem cell-derived extracellular vesicles(hMSC-EVs)on DP and ORS cells as well as *** are known to regulate various cellular ***,the effects of hMSC-EVs on hair growth,particularly on human-derived HF cells(DP and ORS cells),and the possible mechanisms underlying these effects are *** hMSC-EVs were isolated and characterized using transmission electron microscopy,nanoparticle tracking analysis,western blotting,and flow *** activation of DP and ORS cells was analyzed using cellular proliferation,migration,western blotting,and real-time polymerase chain *** growth was evaluated ex vivo using human *** Wnt3a is present in a class of hMSC-EVs and associated with the EV ***-EVs promote the proliferation of DP and ORS ***,they translocateβ-catenin into the nucleus of DP cells by increasing the expression ofβ-catenin target transcription factors(Axin2,EP2 and LEF1)in DP *** with hMSC-EVs also promoted the migration of ORS cells and enhanced the expression of keratin(K)differentiation markers(K6,K16,K17,and K75)in ORS ***,treatment with hMSC-EVs increases hair shaft elongation in cultured human *** These findings suggest that hMSC-EVs are potential candidates for further preclinical and clinical studies on hair loss treatment.

关键词： Mesenchymal stem cells Extracellular vesicles Hair growth Dermal papillae Outer root sheath cells

Evaluation of Medium Components by Plackett-Burman Statistical Design for Lipase Production by Candida rugosa and Kinetic Modeling

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生物工程学报 2008年第3期24卷 436-444页

作者： Aravindan rajendran anbumathi Palanisamy Viruthagiri Thangavelu Biochemical Engineering Laboratory Department of Chemical Engineering Annamalai University Annamalai nagar-608 002 Tamil Nadu India

Lipase production by Candida rugosa was carried out in submerged ***-Burman statisticalexperimental design was applied to evaluate the fermentation medium *** effect of twelve medium components was studied in sixteen experimental ***,olive oil,peptone and FeCl3·6H2O were found to have more significance on lipase production by Candida *** lipase activity of 3.8 u mL-1 was obtained at 50h of fermentation *** fermentation was carried out at optimized temperature of 3℃,initial pH of 6.8 and shaking speed of 120 r/*** kinetic models were used to simulate the experimental *** model,Luedeking-Piret model and modified Luedeking-Piret model were found suitable to efficiently predict the cell mass,lipase production and glucose consumption respectively with high determination coefficient(R2).From the estimated values of the Luedeking-Piret kinetic model parameters,α and β,it was found that the lipase production by Candida rugosa is growth associated.

关键词：脂肪酶假丝酵母动力学模型培养基深层发酵

Tertiary and Quaternary Marine Terraces and Planation Surfaces of Northern Oman:Interaction of Flexural Bulge Migration Associated with the Arabian-Eurasian Collision and Eustatic Sea Level Changes

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Journal of Earth Science 2016年第6期27卷 955-970页

作者： Ye Yuan Timothy M.Kusky Sankaran rajendran State Key Laboratory for Geological Processes and Mineral Resources Three Gorges Research Center for GeohazardsMinistry of EducationChina University of Geosciences Center for Global Tectonics School of Earth SciencesChina University of Geosciences Department of Earth Sciences Sultan Qaboos University

The northeastern Arabian passive margin is being subducted beneath the Zagros and Makran of Iran. A flexural bulge related to the weight of the Makran has migrated at 4 cm/a through the previously uplifted Hajar Mountains of Oman as this active convergence and collision between Arabia and Eurasia progresses, adding approximately another 500 meters of relief, and forming a series of uplifted marine terraces, alluvial terraces, and planation surfaces that record the passage of the bulge. We use a combination of field studies, remote sensing and GIS to map and better-understand these terraces, and elucidate how the tectonics of bulge migration, down-to-trench normal faulting, and eustatic sea level changes have interacted to produce the extant geomorphic features on the inner slope of the flexural bulge as it sinks into the foredeep of the Gulf of Oman. We speculate those terraces that were uplifted on the outer slope of the forebulge as it initially migrated through the passive margin （affected by ophiolite obduction in the Cretaceous） 3.75-7.5 Ma ago are now sinking on the inner slope of the forebulge （corresponding to the outer trench slope in the foredeep）, and have been partly covered by Quaternary marine terraces related to a Weichselian sea level high stand. Both the Tertiary and Quaternary terraces are cut by faults related to the active collision, confirming that there is a significant risk of moderate earthquakes in the region.

关键词： marine terraces flexural bulge Arabia-Eurasia collision Sultanate of Oman remote sensing image processing Quaternary sea level fluctuation.

Evaluation of biogenic markers-based phenotyping for resistance to Aphanomyces root rot in field pea

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Information Processing in Agriculture 2022年第1期9卷 1-10页

作者： Afef Marzougui Abirami rajendran D.Scott Mattinson Yu Ma Rebecca J.McGee Manuel Garcia-Perez Stephen P.Ficklin Sindhuja Sankaran Department of Biological Systems Engineering Washington State UniversityPullmanWAUnited States Department of Horticulture Washington State UniversityPullmanWAUnited States United States Department of Agriculture-Agricultural Research Service Grain Legume Genetics and Physiology Research UnitWashington State UniversityPullmanWAUnited States

Biogenic volatile organic compounds(VOCs)emitted by plants can reveal information about plant adaptation,defense processes,and biological ***,such VOC data may be utilized to capture phenotypic plant responses to the *** this study,the main objective was to evaluate the potential of biogenic compounds,including VOCs,to phenotype two pea cultivars,Ariel(susceptible)and Hampton(high levels of partial resistance)for resistance to Aphanomyces root rot *** were monitored non-destructively for VOC emission at three-time points(15,20,and 30 days after inoculation,DAI)using dynamic headspace sampling with gas chromatography-flame ionization detec-tion(GC-FID)system,as well as destructively at the end of the experiments,using solvent extraction and pyrolysis of both shoot and root tissues.A non-inoculated control(mock-inoculated with distilled water)was utilized to compare the plant responses within a *** common chemical peaks between control and inoculated samples of both culti-vars(RT_(cm))were analyzed after normalizing the relative peak intensity of inoculated samples with those of control samples,prior to a comparison between *** addi-tion,unique chemical peaks(RT_(uq))present in inoculated samples,but not in control sam-ples were also identified and their relative peak intensities were *** the released green leaf volatiles(RT_(cm)),the normalized relative peak intensity of hexanal emis-sion,at 20 DAI,was higher in Ariel than that of *** addition,several putative chemical peaks(both RT_(cm) and RT_(uq)),previously known as indicators for disease response,exhibited some differences in their emission rates between pea cultivars in at least one of the time *** destructive sampling revealed that shoot samples produced more putative unique biomarkers(RT_(uq))than the root *** on the differences in puta-tive chemical peaks between cultivars,this initial study supports the concept of utilizat

关键词： Plant breeding Pulse crop Volatile organic compounds Plant phenotyping Biotic stress

Green synthesized ZnO nanoparticles against bacterial and fungal pathogens

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Progress in Natural Science:Materials International 2012年第6期22卷 693-700页

作者： Sangeetha Gunalan Rajeshwari Sivaraj Venckatesh rajendran Department of Biotechnology School of Life sciencesKarpagain UniversityEachanari PostCoimhatore 641021Tamilnadu.India Department of Chemistry Government Arts College.Udumalpet 642126.TamilnaduIndia

Zinc oxide nanoparticles are known to be one of the multifunctional inorganic nanoparticles with effective antibacterial *** study aims to determine the antimicrobial efficacy of green and chemical synthesized ZnO nanoparticle against various bacterial and fungal *** microbiological tests were performed using varying concentrations of green and chemical ZnO NPs with sizes 40 and 25 nm *** prove that green ZnO nanoparticles show more enhanced biocidal activity against various pathogens when compared to chemical ZnO *** effectiveness of nanoparticles increases with increasing particle dose,treatment time and synthesis method. In addition,the current study has clearly demonstrated that the particle size variation and surface area to volume ratio of green ZnO nanoparticle are responsible for significant higher antimicrobial *** the results obtained it is suggested that green ZnO NPs could be used effectively in agricultural and food safety applications and also can address future medical concerns.

关键词： Green ZnO nanoparticle Chemical ZnO nanoparticle Antimicrobial potential Bacterial pathogen Fungal pathogen

High Prevalent Hypovitaminosis D Is Associated with Dysregulation of Calcium-parathyroid Hormone-vitamin D Axis in Patients with Chronic Liver Diseases

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Journal of Clinical and Translational Hepatology 2019年第1期7卷 15-20页

作者： Krishnasamy Narayanasamy rajendran Karthick A.Koodal Raj Department of Hepatology Madras Medical CollegeChennaiTamil NaduIndia Multidisciplinary Research Unit(MRU) Madras Medical CollegeChennaiTamil NaduIndia

Background and Aims:Although hypovitaminosis D is common among patients with chronic liver disease(CLD),the data are inconsistent on its prevalence and its relationship with *** study aimed to estimate the prevalence of hypovitaminosis D among patients with CLD and to determine the relationship between hypovitaminosis D and severity of liver dysfunction,and calcium(Ca),phosphate(PO4)and parathyroid hormone(PTH)levels in ***:The study included 236 CLD patients attending the Department of Hepatology,Rajiv Gandhi Government General Hospital(Chennai,India).Serum levels of 25-hydroxyvitamin D(25(OH)D),PTH,Ca,and PO4 were *** of liver dysfunction was graded using the Child-Turcotte-Pugh(CTP)***:The first report from our population showed that 162 of 236(68.6%)CLD patients had hypovitaminosis D(25(OH)D levels of<30 ng/mL),with higher frequency(124/162)76.5%among CTP B,C *** negative correlation(r=-0.288,p=0.0001)between 25(OH)D and CTP scores was noted in hypovitaminosis D *** of 25(OH)D was correlated negatively with PTH(r=-0.537,p=0.0001),positively with Ca(r=0.657,p=0.0001),and positively with PO4(r=0.477,p=0.0001)in sufficient vitamin D ***:Hypovitaminosis D is associated with higher CTP scores and is strongly associated with dysregulation of the Ca-PTH-vitamin D axis in *** measurement of vitamin D levels is essential,along with levels of PTH,Ca and PO4,to manage CLD patients.

关键词： Hypovitaminosis D Chronic liver disease Liver dysfunction Hypocalcemia Vitamin D

Electrochemical corrosion behavior of acid treated strip cast AM50 and AZX310 magnesium alloys in 3.5 wt.% NaCl solution

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Journal of Magnesium and Alloys 2017年第3期5卷 277-285页

作者： Srinivasan Arthanari rajendran Nallaiyan Shin Kwang Seon Magnesium Technology Innovation Center School of Materials Science and EngineeringSeoul National University1 Gwanak-roGwanak-guSeoul 08826Republic of Korea Department of Chemistry Anna UniversityChennai 600025TamilnaduIndia

The influence of acid treatments on the surface morphology and electrochemical corrosion behavior of strip-cast AM50 and AZX310 alloys have been studied in the present *** alloys were acid treated using H_(3)PO_(4)(AT-1),HF(AT-2)and HNO3(AT-3)for different treatment durations viz.,60,300 and 600 *** acid treatments produced a surface layer consisting of corresponding magnesium salts of the acids and were confirmed from the X-ray diffraction(XRD),scanning electron microscopy(SEM)and energy dispersive X-ray analysis(EDAX).AT-1 treatment produced cracked and network porous morphology for AM50 and AZX310 alloys respectively andAT-3 treatment exhibited dense creaked surface layer formation while AT-2 does not produce any significant change in the *** studies revealed that,the acid treatment significantly altered the corrosion process by altering anodic and cathodic reaction rates of AM50 and AZX310 *** HNO3(AT-3)treatment was effective compared to other treatments to control the corrosion rate in the studied treatment *** surface morphology and chemical composition of surface layer produced during the treatment was correlated to explain the corrosion results.

关键词： Magnesium Pretreatment Corrosion Acid treatment Polarization

2D-titanium carbide(MXene)based selective electrochemical sensor for simultaneous detection of ascorbic acid,dopamine and uric acid

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Journal of Materials Science & Technology 2021年第13期72卷 122-131页

作者： Nagaraj Murugan rajendran Jerome Murugan Preethika Anandhakumar Sundaramurthy Ashok K.Sundramoorthy Department of Chemistry SRM Institute of Science and TechnologyKattankulathur603203Tamil NaduIndia SRM Research Institute SRM Institute of Science and TechnologyKattankulathur603203Tamil NaduIndia

Two-dimensional(2 D)titanium carbide(MXene)nanosheets exhibited excellent conductivity,flexibility,high volumetric capacity,hydrophilic surface,thermal stability,***,it has been exploited in various ***,we report synthesis of mixed phase 2 D MXene as a catalytic material for simultaneous detection of important biomolecules such as ascorbic acid(AA),dopamine(DA)and uric acid(UA).Crystalline structure,surface morphology and elemental composition of mixed phase titanium carbide(Ti-C-T_(x))MXene(T_(x)=-F,-OH,or-O)nanosheets were confirmed by X-ray diffraction(XRD),Raman spectroscopy,high-resolution transmission electron microscopy(HR-TEM),high-re solution scanning electron microscopy(HR-SEM)and Energy-dispersive X-ray spectroscopy(EDS)mapping ***,Ti-C-T_(x) modified glassy carbon electrode(GCE)was prepared and its electrochemical properties are studied by cyclic voltammetry(CV)and diffe rential pulse voltammetry(DPV).It was found that Ti-C-T_(x) modified GCE(Ti-C-T_(x)/GCE)showed excellent electrocatalytic activity and separated oxidation peaks of important biomolecules such as AA(at 0.01 V),DA(at 0.21 V)and UA(at 0.33 V).Also,Ti-C-T_(x)/GCE sensor is enabled their simultaneous detection in physiological pH from 100 to 1000μM for AA,0.5-50μM for DA and 0.5-4μM&100-1500μM for *** limit of detection’s(LOD)was estimated as 4.6μM,0.06μM and 0.075μM for AA,DA and UA,***,real sample analysis indicated that spiked AA,DA and UA can be determined accurately by Ti-C-T_(x)/GCE with the recovery ratio in the range between 100.5%-103%in human urine *** proposed Ti-C-T_(x) modified electrode exhibited good stability,selectivity and reproducibility as an electrochemical sensor for the detection of AA,DA and UA molecules.

关键词： Titanium carbide Dopamine Uric acid Ascorbic acid Electrochemical sensor

Experimental Studies on the Thermal Performance of a Parabolic Dish Solar Receiver with the Heat Transfer Fluids SiC+ Water Nano Fluid and Water

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Journal of Thermal Science 2017年第3期26卷 263-272页

作者： D.R.rajendran E.Ganapathy Sundaram P.Jawahar Department of Mechanical Engineering Adhiparasakthi Engineering CollegeMelmaruvahur-603319Tamil NaduIndia Department of Mechanical Engineering Velammal Engineering CollegeChermai-600066Tamil NaduIndia Department of Production Engineering Velammal Engineering CollegeChennai-600066Tamil NaduIndia

An experimental investigation has been carried out with aa point focusing dish reflector of 12 square meters aperture area, exposed to the average direct normal irradiations of 810 W/m^2. This work focuses on enhancinge the energy and exergy efficiencies of the cavity receiver by minimizing the temperature difference between the wall and heat transfer fluids. Two heat transfer fluids Water and SiC + water nano fluid have been prepared from 50 nm particle size and 1% of volume fraction, and experimented separately for the flow rates of 0.2 lpm to 0.6 lpm with an interval of 0.1 lpm. The enhanced thermal conductivity of nano fluid is 0.800115 W/mK with the k_(eff)/k_b ratio of 1.1759 determined by using the Koo and Kleinstreuer correlation. The maximum attained energy and exergy efficiencies are 29.14% and 24.82% for water, and 32.91% and 39.83% for SiC+water nano fluid. The nano fluid exhibits enhanced energy and exergy efficiency of 12.94% and 60.48% than that of water at the flow rate of 0.5 lpm. The result shows that the system with SiC+Water produces higher exergy efficiency as compared to energy efficiency; in the case of water alone, the energy efficiency is higher than exergy efficiency.

关键词：指导正常照耀洞接收装置加热转移液体 nano 液体 exergy 因素