High Prevalent Hypovitaminosis D Is Associated with Dysregulation of Calcium-parathyroid Hormone-vitamin D Axis in Patients with Chronic Liver Diseases
作者机构：Department of HepatologyMadras Medical CollegeChennaiTamil NaduIndia Multidisciplinary Research Unit(MRU)Madras Medical CollegeChennaiTamil NaduIndia
出 版 物：《Journal of Clinical and Translational Hepatology》 (临床与转化肝病杂志（英文版）)
年 卷 期：2019年第7卷第1期
页 面：15-20页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
主 题：Hypovitaminosis D Chronic liver disease Liver dysfunction Hypocalcemia Vitamin D
摘 要：Background and Aims:Although hypovitaminosis D is common among patients with chronic liver disease(CLD),the data are inconsistent on its prevalence and its relationship with *** study aimed to estimate the prevalence of hypovitaminosis D among patients with CLD and to determine the relationship between hypovitaminosis D and severity of liver dysfunction,and calcium(Ca),phosphate(PO4)and parathyroid hormone(PTH)levels in ***:The study included 236 CLD patients attending the Department of Hepatology,Rajiv Gandhi Government General Hospital(Chennai,India).Serum levels of 25-hydroxyvitamin D(25(OH)D),PTH,Ca,and PO4 were *** of liver dysfunction was graded using the Child-Turcotte-Pugh(CTP)***:The first report from our population showed that 162 of 236(68.6%)CLD patients had hypovitaminosis D(25(OH)D levels of30 ng/mL),with higher frequency(124/162)76.5%among CTP B,C *** negative correlation(r=-0.288,p=0.0001)between 25(OH)D and CTP scores was noted in hypovitaminosis D *** of 25(OH)D was correlated negatively with PTH(r=-0.537,p=0.0001),positively with Ca(r=0.657,p=0.0001),and positively with PO4(r=0.477,p=0.0001)in sufficient vitamin D ***:Hypovitaminosis D is associated with higher CTP scores and is strongly associated with dysregulation of the Ca-PTH-vitamin D axis in *** measurement of vitamin D levels is essential,along with levels of PTH,Ca and PO4,to manage CLD patients.
维普期刊数据库