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Computational Identification of Sweet Wormwood (Artemisia annua) microRNA and Their mRNA Targets

Genomics, Proteomics & Bioinformatics 2011年第6期9卷 200-210页

作者： Alok Pani rajani kanta mahapatra Niranjan Behera Pradeep Kumar Naik School of Biotechnology Kalinga Institute of Industrial Technology (KIIT) UniversityBhubaneswar Odisha 751024 India School of Biotechnology Kalinga Institute of Industrial Technology (KIIT) University Bhubaneswar Odisha 751024 India School of Life Sciences Sambalpur UniversityBurla Odisha 768019 India Department of Biotechnology &Bioinformatics Jaypee University of Information TechnologySolan Himachal Pradesh 173215 India

Despite its efficacy against malaria, the relatively low yield （0.01%-0.8%） of artemisinin in Artemisia annua is a serious limitation to the commercialization of the drug. A better understanding of the biosynthetic pathway of artemisinin and its regulation by both exogenous and endogenous factors is essential to improve artemisinin yield. Increasing evidence has shown that microRNAs （miRNAs） play multiple roles in various biological processes. In this study, we used previously known miRNAs from Arabidopsis and rice against expressed sequence tag （EST） database of A. annua to search for potential miRNAs and their targets in A. annua. A total of six potential rniRNAs were predicted, which belong to the miR414 and miR1310 families. Furthermore, eight potential target genes were identified in this species. Among them, seven genes encode proteins that play important roles in artemisinin biosynthesis, including HMG-CoA reductase （HMGR）, amorpha-4,11-diene synthase （ADS）, farnesyl pyrophosphate synthase （FPS） and cytochrome P450. In addition, a gene coding for putative AINTEGUMENTA, which is involved in signal transduction and development, was also predicted as one of the targets. This is the first in silico study to indicate that miRNAs target genes encoding enzymes involved in artemisinin biosynthesis, which may help to understand the miRNA-mediated regulation of artemisinin biosynthesis in A. annua.

关键词： artemisinin microRNA EST computational prediction Artemisia annua

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Parents’s knowledge and awareness about hepatitis B can influence the vaccination of their children

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World Journal of Virology 2024年第2期13卷 96-106页

作者： Nanda Chhavi Geetika Srivastava Mariya Waseem Abhishek Yadav Surender Singh rajani Singh Amit Goel Department of Paediatrics Era’s Lucknow Medical CollegeLucknow 226003Uttar PradeshIndia Medical Consultant National Disease Control ProgramNational Health MissionLucknow 226003Uttar PradeshIndia Department of Hepatology Sanjay Gandhi Postgraduate Institute of Medical SciencesLucknow 226014Uttar PradeshIndia

BACKGROUND Birth-dose(Hep-BD)followed by three additional doses(Hep-B3)of hepatitis B virus(HBV)vaccine are key to eliminating HBV by ***,Hep-BD and Hep-B3 coverage in our country is *** To studied the parent’s knowledge and awareness about HBV infection,its prevention,consequences and *** Parents of 6 months to 8 years old children were interviewed to assess their knowledge&awareness about hepatitis B,its transmission,prevention,illness caused by this,and *** close-ended questions were admini-stered,and responses were recorded as‘yes’,‘no’,or‘not sure’.HBV knowledge score was calculated based on the sum of correct *** correct response scored one point and incorrect,missing or‘not sure’responses received no *** data are presented as number(%)and numerical data are expressed as *** were compared using Chi2 tests and level of significance was kept as P<*** Parents(58.3%mothers)of 384 children(89.9%age<5 years;82%age-appropriately vaccinated)were *** hundred and twenty-two(83.9%)children were Hep-B3 vaccinated.94.3%,87.5%,and 29.2%parents knew about polio,tetanus,and hepatitis B ***,41.2%,15.8%,and 23%parents knew about hepatitis B transmission,consequences of infection,and prevention *** 7.6%parents knew about three-dose schedule of hepatitis B *** 23%parents believed that vaccine could prevent HBV,15.7%knew that HBV affects *** of Hep-B3 vaccinated children were significantly more aware about HBV than the parents of unvaccinated children(P<0.05 for 17/18 questions).CONCLUSION The knowledge and awareness among the parents about hepatitis B is *** Increasing knowledge/awareness about HBV among parents may improve Hep-B3 vaccination coverage.

关键词： Hepatitis B Viral hepatitis Cirrhosis Hepatocellular carcinoma Hepatotropic viruses Transfusion transmitted infection Mother to child transmission

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Reconfiguration of PV Arrays(T-C-T,B-L,H-C)Considering Wiring Resistance

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CSEE Journal of Power and Energy Systems 2022年第5期8卷 1408-1416页

作者： Kandipati rajani Tejavathu Rame Electrical and Electronics Engineering Department National Institute of Technology Andhra PradeshWest Godavari-534101India

Partial shadings on the photovoltaic(PV)array causes reduction in maximum power *** of PV arrays plays an important role in increasing the maximum power generation from PV array configurations under partial *** general,partial shadings on the PV arrays are concentrated on a group of ***,the distribution of shading over the array increases the maximum power *** paper uses a modified Sudoku pattern to increase the maximum power generation from the PV array *** PV array configurations are analyzed by considering column wiring resistance and cross ties *** modified Sudoku pattern is applied to Total-Cross-Tied(T-C-T),Bridge-Link(B-L)and Honey-Comb(H-C)configurations and their performances are analyzed under various shading patterns,such as short narrow,short wide,long narrow,long wide,middle and *** specifications,such as Global Maximum Power(GMP),Mismatch losses,Fill Factor,Efficiency are considered to see the efficacy of various PV array configurations and their *** the results,it can be concluded that reconfigured T-C-T PV array generates the highest GMP compared to other configurations under considered shading patterns.

关键词： Bridge-link efficiency fill factor global maximum power honey-comb photovoltaic array reconfiguration Sudoku Total-Cross-Tied

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Exposure to Electromagnetic Fields from Mobile Phones and Fructose consumption Coalesce to Perturb Metabolic Regulators AMPK/SIRT1-UCP2/FOXO1 in Growing Rats

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Biomedical and Environmental Sciences 2023年第11期36卷 1045-1058页

作者： Ruchi Tripathi Sanjay Kumar Banerjee Jay Prakash Nirala rajani Mathur Department of Pharmacology Delhi Institute of Pharmaceutical Sciences & ResearchDelhi Pharmaceutical Sciences and Research University(DPSR-U))New DelhiINDIA Drug Discovery Research Centre Translational Health Science and Technology InstituteFaridabadINDIA Department of Biotechnology National Institute of Pharmaceutical Education and ResearchGuwahatiINDIA School of Environmental Sciences Jawaharlal Nehru UniversityNew DelhiINDIA

Objective In this study,the combined effect of two stressors,namely,electromagnetic fields(EMFs)from mobile phones and fructose consumption,on hypothalamic and hepatic master metabolic regulators of the AMPK/SIRT1-UCP2/FOXO1 pathway were elucidated to delineate the underlying molecular mechanisms of insulin *** Weaned Wistar rats(28 days old)were divided into 4 groups:Normal,Exposure Only(ExpO),Fructose Only(FruO),and Exposure and Fructose(EF).Each group was provided standard laboratory chow ad libitum for 8 ***,the control groups,namely,the Normal and FruO groups,had unrestricted access to drinking water and fructose solution(15%),***,the respective treatment groups,namely,the ExpO and EF groups,received EMF exposure(1,760 MHz,2 h/day x 8 weeks).In early adulthood,mitochondrial function,insulin receptor signaling,and oxidative stress signals in hypothalamic and hepatic tissues were assessed using western blotting and biochemical *** In the hypothalamic tissue of EF,SIRT1,FOXO 1,p-PI3K,p-AKT,ComplexⅢ,UCP2,MnSOD,and catalase expressions and OXPHOS and GSH activities were significantly decreased(P<0.05)compared to the Normal,ExpO,and FruO *** hepatic tissue of EF,the p-AMPKα,SIRT1,FOXO1,IRS1,p-PI3K,ComplexⅠ,Ⅱ,Ⅲ,Ⅳ,Ⅴ,UCP2,and MnSOD expressions and the activity of OXPHOS,SOD,catalase,and GSH were significantly reduced compared to the Normal group(P<0.05).Conclusion The findings suggest that the combination of EMF exposure and fructose consumption during childhood and adolescence in Wistar rats disrupts the closely interlinked and multi-regulated crosstalk of insulin receptor signals,mitochondrial OXPHOS,and the antioxidant defense system in the hypothalamus and liver.

关键词： EMF-mobile phone Fructose Childhood-adolescence Insulin receptor signal Mitochondrial OxPHOS Antioxidant system Hypothalamic insulin resistance Hepatic insulin resistance

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Solar Supergranular Fractal Dimension Dependence on the Solar Cycle Phase

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Research in Astronomy and Astrophysics 2022年第4期22卷 55-61页

作者： G.rajani G.M.Sowmya U.Paniveni R.Srikanth PES College of Engineering Mandya-571401KarnatakaIndia GSSS Institute of Engineering and Technology for Women KRS RoadMetagalli Mysuru-570016KarnatakaIndia Bangalore University JnanabharathiBengaluru-560056India Poornaprajna Institute of Scientific Research DevanahalliBangalore-562110KarnatakaIndia

We study the complexity of the supergranular network through fractal dimension by using the Ca II K digitized data archive obtained from the Kodaikanal Solar *** data consist of 326 visually selected supergranular cells spread across the 23rd solar *** cells that were well-defined were chosen for the analysis and we discuss the potential selection effect thereof,mainly that it favors cells of a smaller size(<20 Mm).Within this sample,we analyzed the fractal dimension of supergranules across the solar cycle and find that it is anticorrelated with the activity level.

关键词： Sun:chromosphere Sun:granulation Sun:activity

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Supergranular Fractal Dimension and Solar Rotation

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Research in Astronomy and Astrophysics 2022年第9期22卷 239-244页

作者： G.M.Sowmya G.rajani U.Paniveni R.Srikanth GSSS Institute of Engineering and Technology for Women Mysuru-570016KarmatakaIndia PES College of Engineering Mandya-571401KarnatakaIndia Bangalore University JnanabharathiBengaluru-560056India Poornaprajna Institute of Scientific Research DevanahalliBangalore-562110KamatakaIndia

We present findings from an analysis of the fractal dimension of solar supergranulation as a function of latitude,supergranular cell size and solar rotation, employing spectroheliographic data in the Ca II K line of solar cycle no.23. We find that the fractal dimension tends to decrease from about 1.37 at the equator to about 1 at 20° latitude in either hemisphere, suggesting that solar rotation rate has the effect of augmenting the irregularity of supergranular boundaries. Considering that supergranular cell size is directly correlated with fractal dimension, we conclude that the mechanism behind our observation is that solar rotation influences the cell outflow strength, and thereby cell size, with the latitude dependence of the supergranular fractal dimension being a consequence thereof.

关键词： Sun:chromosphere Sun:rotation Sun:magnetic fields

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OKRA (HIBISCUS ESCULENTUS) AND FENUGREEK (TRIGONELLA FOENUM GRACEUM) MUCILAGE:CHARACTERIZATION AND APPLICATION AS FLOCCULANTS FOR TEXTILE EFFLUENT TREATMENTS

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Chinese Journal of Polymer Science 2008年第6期26卷 679-687页

作者： rajani Srinivasan Anuradha Mishra Blackland Research and Extension Centre Texas A&M University System720East Blackland RoadTempleTX76502USA Department of Chemistry University Institute of Engineering and TechnologyCSJM UniversityKanpur-208 024India

The use of new food grade polysaccharides (mucilage) obtained from Hibiscus esculentus and Trigonella foenum graceum,commonly called Okra and Fenugreek,respectively,as flocculants was *** polysaccharides were used for removal of solids (suspended solids (SS) and total dissolved solids (TDS)) and dyes from real textile effluents and aqueous solutions of different class of synthetic *** of varying polysaccharide concentration,contact time and pH on removal of pollutant from the textile...

关键词： Fenugreek Okra Natural polysaccharides Flocculation Wastewater treatment Textile effluent Bridging Hibiscus esculentus Trigonella foenum graceum.

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Maximum Power Enhancement Under Partial Shadings Using a Modified Sudoku Reconfiguration

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CSEE Journal of Power and Energy Systems 2021年第6期7卷 1187-1201页

作者： Kandipati rajani Tejavathu Ramesh the Electrical Engineering Department National Institute of Technology Andhra PradeshWest Godavari-534101India

Partial shading is one of the important factors in reducing maximum power generation from PV(Photovoltaic)*** power generation can be improved by selecting a PV array through a Total-Cross-Tied(T-C-T)***,maximum power generated from T-C-T can still be improved by distribution of shading over various *** to distribution of shading,the current entering the node increases and results in improved maximum power *** can be done effectively by using Sudoku reconfiguration *** techniques are economical,since they don’t require any sensors and switching *** technique only changes the physical location of the PV panel but the electrical connection between the panels remains the *** paper proposes a Modified Sudoku reconfiguration pattern which enhances the maximum power from the T-C-T connected PV ***,the theoretical calculation of row current and power output have been done for existing and proposed topologies under various shading *** performance of the proposed pattern has been analyzed and compared using specifications,such as Global Maximum Power(GMP),Fill Factor(FF),mismatch losses,and *** the results,it can be concluded that the Modified Sudoku reconfiguration enhances the GMP under all shading conditions.

关键词： Efficiency fill factor global maximum power point mismatch losses partial shadings PV array reconfiguration shading patterns sudoku and total-cross-tied

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Pu-erh tea: A review of a healthful brew

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Journal of Traditional Chinese Medical Sciences 2022年第2期9卷 95-99页

作者： Wei Jia Cynthia rajani Aiping Lv Tai-Ping Fan Xiaojiao Zheng The Traditional Chinese Medicine Phenome Research Centre School of Chinese MedicineHong Kong Baptist UniversityHong Kong Special Administrative Region of China University of Hawaii Cancer Center HonoluluHI96813USA Angiogenesis and Traditional Chinese Medicine Laboratory Department of PharmacologyUniversity of CambridgeCambridgeCB21PDUnited Kingdom Center for Translational Medicine Shanghai Jiao Tong University Affiliated Sixth People's HospitalShanghai200233China

Pu-erh tea has been used for thousands of years to treat metabolic *** in Shen Nong's Herbal Classic,a compendium kept by the first traditional Chinese practitioners,it is still highly valued for its hypocholesterolemic and hypolipidemic *** review reports the processing and bioactive components of pu-erh *** human and animal studies of pu-erh tea and its potential therapeutic mechanisms have also been *** interaction of liver and gut microbiome regulates the puerh tea biotransformation and endogenous metabolism,and thus contributes to the health benefits.

关键词： Pu-erh tea Theabrownin Gut microbiome Hypocholesterolemic effects Hypolipidemic effects

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Bile acids and their effects on diabetes

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Frontiers of Medicine 2018年第6期12卷 608-623页

作者： Cynthia rajani Wei Jia University of Hawaii Cancer Center HonoluluHI 96813USA Shanghai Key Laboratory of Diabetes Mellitus and Center for Translational Medicine Shanghai Jiao Tong University Affiliated Sixth People's HospitalShanghai 200233China

Diabetes is a widespread, rapidly increasing metabolic disease that is driven by hyperglycemia. Early glycemic control is of primary importance to avoid vascular complications including development of retinal disorders leading to blindness, end-stage renal disease, and accelerated atherosclerosis with a higher risk of myocardial infarction, stroke and limb amputations. Even after hyperglycemia has been brought under control, “metabolic memory,” a cluster of irreversible metabolic changes that allow diabetes to progress, may persist depending on the duration of hyperglycemia. Manipulation of bile acid (BA) receptors and the BA pool have been shown to be useful in establishing glycemic control in diabetes due to their ability to regulate energy metabolism by binding and activating nuclear transcription factors such as farnesoid X receptor (FXR) in liver and intestine as well as the G-protein coupled receptor, TGR5, in enteroendocrine cells and pancreatic -cells. The downstream targets of BA activated FXR, FGF15/21, are also important for glucose/insulin homeostasis. In this review we will discuss the effect of BAs on glucose and lipid metabolism and explore recent research on establishing glycemic control in diabetes through the manipulation of BAs and their receptors in the liver, intestine and pancreas, alteration of the enterohepatic circulation, bariatric surgery and alignment of circadian rhythms.

关键词： bile acids metabolic memory diabetes circadian rhythm bariatric surgery

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