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Unraveling quad fever:Severe hyperthermia after traumatic cervical spinal cord injury

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Chinese Journal of Traumatology 2023年第1期26卷 27-32页

作者： Carlton C.L.Watson Dooniya Shaikh Jody C.DiGiacomo Aaron C.Brown raina Wallace Shridevi Singh Lisa Szydziaka Sara Cardozo-Stolberg LD.George Angus Department of Surgery Nassau University Medical CenterEast MeadowNY1155USA American University of the Caribbean School of Medicine Pembroke PinesFL33027USA

Purpose:There are many infectious and inflammatory causes for elevated core-body temperatures,though they rarely pass 40℃(104℉).The term"quad fever"is used for extreme hyperpyrexia in the setting of acute cervical spinal cord injuries(SCIs).The traditional methods of treating hyperpyrexia are often ineffective and reported morbidity and mortality rates approach 100%.This study aims to identify the incidence of elevated temperatures in SCIs at our institution and assess the effectiveness of using a non-invasive dry water temperature management system as a treatment modality with ***:A retrospective analysis of acute SCI patients requiring surgical intensive care unit admission who experienced fevers≥40℃(104℉)were compared to patients with maximum temperatures<40℃.Patients≥18 years old who sustained an acute traumatic SCI were included in this *** who expired in the emergency department;had a SCI without radiologic abnormality;had neuropraxia;were admitted to any location other than the surgical intensive care unit;or had positive blood cultures were *** 9.4 was used to conduct statistical ***:Over the 9-year study period,35 patients were admitted to the surgical intensive care unit with a verified *** patients experienced maximum temperatures of≥40℃.Six of those patients were treated with the dry water temperature management system with an overall mortality of 57.1%in this *** mortality rate for the 28 patients who experienced a maximum temperature of≤40℃was 21.4%(p=0.16).Conclusion:The diagnosis of quad fever should be considered in patients with cervical SCI in the presence of *** this study,there was no significant difference in mortality between quad fever patients treated with a dry water temperature management system versus SCI patients without quad *** early use of a dry water temperature management system appears to decrease the mortality rate of quad fever.

关键词： Spinal cord injuries Fever Quadriplegia Therapeutic hypothermia

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中国与澳大利亚医学教育培养模式的比较研究

中华医学教育探索杂志 2015年第1期14卷 1-6页

作者：莫佳瑜孔宪明王春鸣 raina MacIntyre Joanne Travaglia Chinthaka Balasooriya 上海交通大学医学院附属仁济医院绩效管理办公室 200127 上海交通大学医学院附属仁济医院院长办公室 200127 2052 New South Wales AustraliaThe University of New South Wales

中国医疗卫生体制正面临重大改革，医学教育也随之进行了快速调整，以满足我国卫生服务和医药卫生事业发展的需要。然而，医学教育体制的调整以及全国不同地区的学制设置的差异，导致我国医学教育学制和与之相对应学位的定义很难进行国... 详细信息

中国医疗卫生体制正面临重大改革，医学教育也随之进行了快速调整，以满足我国卫生服务和医药卫生事业发展的需要。然而，医学教育体制的调整以及全国不同地区的学制设置的差异，导致我国医学教育学制和与之相对应学位的定义很难进行国际的同步比较，也使我国医学学位和学制很难被国际上许多国家教育部门所理解。结合澳大利亚高等医学教育的理论和实践经验，从招生、学制建设、课程设置和教学模式等方面，与中国的医学教育培养模式进行系统性对比和分析，为完善我国高等医学教育体系提供参考，更为我国医学教育体制与国外成熟体制间的相互参照奠定基础。

关键词：医学教育教育体系培养模式

Molecular and epidemiologic characterization of Wilms tumor from Baghdad, Iraq

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World Journal of Pediatrics 2018年第6期14卷 585-593页

作者： Hannah M.Phelps Mazin F.Al-Jadiry Natasha M.Corbitt Janene M.Pierce Bingshan Li Qiang Wei raina R.Flores Hernan Correa Stefania Uccini Haydar Frangoul Adel R.Alsaadawi Safaa A.F.Al-Badri Amir F.Al-Darraji Raghad M.Al-Saeed Salma A.Al-Hadad Harold N.LovvornⅢ Vanderbilt University School of Medicine 2215 Garland AvenueNashvilleTN 37232-9780USA Oncology Unit Children’s Welfare Teaching HospitalBaghdad University Medical CityBaghdadIraq Department of P ediatric Surgery Vanderbilt University Medical CenterNashvilleUSA Department of Molecular Physiology and Bioph ysics Vanderbilt University School of MedicineNashvilleUSA Division of P ediatric Pathology Vanderbilt University Medical CenterNashvilleUSA Department of Clinical and Molecular Medicine Sapienza UniversityRomeItaly Division of P ediatric Hematology and Oncology Vanderbilt University Medical CenterNashvilleUSA Department of P athology Baghdad University Medical CityBaghdadIraq Oncology Unit Children’s Welfare Teaching HospitalWasit University College of MedicineWasitIraq

Background Wilms tumor (WT) is the most common childhood kidney cancer worldwide, yet its incidence and clinical behavior vary according to race and access to adequate healthcare resources. To guide and streamline therapy in the war-torn and resource-constrained city of Baghdad, Iraq, we conducted a first-ever molecular analysis of 20 WT specimens to characterize the biological features of this lethal disease within this challenged population. Methods Next-generation sequencing of ten target genes associated with WT development and treatment resistance (WT1, CTNNB1, WTX, IGF2, CITED1, SIX2, p53, N-MYC, CRABP2, and TOP2A) was completed. Immunohistochemistry was performed for 6 marker proteins of WT (WT1, CTNNB1, NCAM, CITED1, SIX2, and p53). Patient outcomes were compiled. Results Mutations were detected in previously described WT 'hot spots' (e.g., WT1 and CTNNB1) as well as novel loci that may be unique to the Iraqi population. Immunohistochemistry showed expression domains most typical of blastemal-predominant WT. Remarkably, despite the challenges facing families and care providers, only one child, with combined WT1 and CTNNB1 mutations, was confirmed dead from disease. Median clinical follow-up was 40.5 months (range 6–78 months). Conclusions These data suggest that WT biology within a population of Iraqi children manifests features both similar to and unique from disease variants in other regions of the world. These observations will help to risk stratify WT patients living in this difficult environment to more or less intensive therapies and to focus treatment on cell-specific targets.

关键词： Iraq Low- and middle-income countries Next-generation sequencing Pediatric cancer Wilms tumor

Genomics-driven derivatization of the bioactive fungal sesterterpenoid variecolin:Creation of an unnatural analogue with improved anticancer properties

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Acta Pharmaceutica Sinica B 2024年第1期14卷 421-432页

作者： Dexiu Yan Jemma Arakelyan Teng Wan Ritvik raina Tsz Ki Chan Dohyun Ahn Vladimir Kushnarev Tsz Kiu Cheung Ho Ching Chan Inseo Choi Pui Yi Ho Feijun Hu Yujeong Kim Hill Lam Lau Ying Lo Law Chi Seng Leung Chun Yin Tong Kai Kap Wong Wing Lam Yim Nikolay S.Karnaukhov Richard Y.C.Kong Maria V.Babak Yudai Matsuda Department of Chemistry City University of Hong KongHong Kong SARChina iGEM Team“VarieCure” City University of Hong KongHong Kong SARChina Department of Biomedical Engineering City University of Hong KongHong Kong SARChina Moscow Clinical Research Center Named After A.S.Loginov Moscow 111123Russian Federation

A biosynthetic gene cluster for the bioactive fungal sesterterpenoids variecolin(1)and variecolactone(2)was identified in Aspergillus aculeatus ATCC *** production of 1 and 2 was achieved in Aspergillus oryzae by expressing the sesterterpene synthase VrcA and the cytochrome P450 ***,the replacement of VrcB with homologous P450s from other fungal terpenoid pathways yielded three new variecolin analogues(5-7).Analysis of the compounds’anticancer activity in vitro and in vivo revealed that although 5 and 1 had comparable activities,5 was associated with significantly reduced toxic side effects in cancer-bearing mice,indicating its potentially broader therapeutic *** study describes the first tests of variecolin and its analogues in animals and demonstrates the utility of synthetic biology for creating molecules with improved biological activities.

关键词： Animal studies Anticancer properties Biosynthesis Natural products Sesterterpenoids Synthetic biology Terpene synthases Variecolin

Filtration efficiency of face masks against aerosolized surrogate SARS-CoV-2 at different social distances

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Science Bulletin 2022年第6期67卷 565-568页

作者： Song Tang Xia Li Pei Ding Yixin Mao Fuchang Deng Yu’e Cha Siqi Zhuang Cheng Ding Jiao Wang Youbin Wang Xiaoning Zhao Rachael M.Jones Biao Kan C.raina MacIntyre Dongqun Xu Xiaoming Shi China CDC Key Laboratory of Environment and Population Health National Institute of Environmental HealthChinese Center for Disease Control and PreventionBeijing 100021China Center for Global Health School of Public HealthNanjing Medical UniversityNanjing 211166China Section of Ecological Environment&Energy Resources Beijing Institute of MetrologyBeijing 100012China Department of Family and Preventive Medicine School of MedicineUniversity of UtahSalt Lake City 84108USA State Key Laboratory for Infectious Disease Prevention and Control National Institute of Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China The Kirby Institute Faculty of MedicineThe University of New South WalesSydney 2052Australia

The coronavirus disease 2019(COVID-19)pandemic is an unpreedented global *** has become clear that COVID-19 is transmitted by virus-containing droplets(>5μm)and aerosols(<5μm),and that all human exhalatory activities(e.g.,breathing,speaking,singing,shouting,coughing,and sneezing)result in the emission of suspended droplets/aerosols of various *** an example,COVID-19 patients exhale millions of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)RNA copies into the air per hour[1].SARS-CoV-2-laden aerosols play a profound role in disease transmission,as they can linger and remain viable in the air for a long duration(~16 h)[2]and travel a long distance(~4.8 m)due to their smaller size[3].

关键词：过滤效率气溶胶替代物

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适合医用非织造材料生产的梳理机

国际纺织导报 2011年第12期39卷 28-28,30页

作者： D．Pirkl K．Schweizer M．raina T．Gries 张慧（译）亚琛工业大学纺织研究所德国不详

医疗器械法严格限制了医用纺织品生产使用的材料以及医用纺织品生产机器的操作环境。德国亚琛工业大学纺织研究所在开发制造适合医用非织造材料的梳理机时已经考虑到这些限制和要求。使用这项非织造材料生产技术,在未来可以生产实验室... 详细信息

医疗器械法严格限制了医用纺织品生产使用的材料以及医用纺织品生产机器的操作环境。德国亚琛工业大学纺织研究所在开发制造适合医用非织造材料的梳理机时已经考虑到这些限制和要求。使用这项非织造材料生产技术,在未来可以生产实验室规模的组织工程支架。

关键词：医用要求梳理机非织造材料

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生物高分子短纤维加工走向新市场

国际纺织导报 2011年第12期39卷 22-24页

作者： S．Ramaswamy S．Ray M．A．raina T．Gries 王倩妮（译）亚琛工业大学纺织技术研究所德国不详

原材料发展和以再生资源为主的能源方面的研究和创新现已成为世界关注的焦点。生物高分子在纺织产品上的应用应进一步朝着可持续和绿色的方向发展。介绍了目前生物高分子发展水平,讨论了生物高分子材料在纺织品上的应用预测。创新问题... 详细信息

原材料发展和以再生资源为主的能源方面的研究和创新现已成为世界关注的焦点。生物高分子在纺织产品上的应用应进一步朝着可持续和绿色的方向发展。介绍了目前生物高分子发展水平,讨论了生物高分子材料在纺织品上的应用预测。创新问题解决理论(TRIZ)的应用是讨论以最少的资源为代价开发一些生物高分子纤维纺纱技术的基本思路。

关键词：生物高分子短纤维纺纱创新问题解决理论

医务人员呼吸道感染影响因素的巢式病例对照研究

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国际病毒学杂志 2011年第5期18卷 129-133页

作者：张奕 Chandini raina MacIntyre 杨鹏 Holly Seale 王小莉刘文婷 Simon Cauchemez Neil Ferguson 王全意北京市疾病预防控制中心传染病地方病控制所 100013 澳大利亚新南威尔士大学公共卫生和社区医学学院 2052 SW7 2AZ英国帝国理工大学传染病流行病学所

目的探索医务人员在院内感染呼吸道传染病的影响因素，针对性的提出院感防范重点及感染控制改进建议。方法本研究采用巢式病例对照研究的方法。选取北京市东城区和西城区的9家二级以上医院，将符合条件的医务人员作为一个队列，对其医... 详细信息

目的探索医务人员在院内感染呼吸道传染病的影响因素，针对性的提出院感防范重点及感染控制改进建议。方法本研究采用巢式病例对照研究的方法。选取北京市东城区和西城区的9家二级以上医院，将符合条件的医务人员作为一个队列，对其医疗行为进行为期一个月的观察。依据咽拭子病原学检测结粜削定研究对象的呼吸道感染状况，并将他们分为病例组和对照组。通过问卷调查了解并比较肼组人员在职、眦暴露与防护行为等方面的差异。数据分析应用STATA11．0软件完成，危险因素的分析采用非条件Logistic回归。结果共有481名医务人员完成本次研究，随访率为100％。在481名研究对象中有40例经实验室确诊为呼吸道感染，纳入病例组，其他441人纳入对照组。单因素分析显示，医院级别、工作科室、高危操作、接触病人后洗手等四个因素可能与医务人员发生呼吸道感染相关。多因素非条件logistic回归分析发现，共有2个因素进入回归方程，其中从事高危操作（OR=2．42，95％CI1．06～5．50）为发生呼吸道感染的危险因素，接触病人后洗手（OR=0．41，95％CI0．19—0．89）为保护性因素。结论为防止医务人员在院内感染呼吸道传染病，针对其危险因素所采取的干预措施亟待开展。

关键词：医务人员呼吸道感染危险因素巢式病例对照研究

The Relationship between Human Papillomavirus and Oesophageal Squamous Cell Carcinoma in China—A Review of the Evidence

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Advances in Infectious Diseases 2013年第1期3卷 17-34页

作者： Surabhi S. Liyanage Qian Li Yang Zheng Holly Seale Philip J. Crowe Anthony T. Newall Bayzidur Rahman Eva Segelov Chenxu Qu Fanghui Zhao Junfeng Liu Zhanhai Gao Weixian Shi Peng Yang Aye Moa Chandini raina MacIntyre Centre for Disease Control and Prevention Beijing China Department of Cancer Epidemiology Cancer Institute Chinese Academy of Medical Sciences Peking Union Medical College Beijing China Department of Medicine St. Vincent’s Hospital Clinical School The University of New South Wales Sydney Australia Department of Surgery Fourth Hospital Shijiazhuang China Department of Surgery Prince of Wales Hospital Clinical School The University of New South Wales Sydney Australia School of Public Health and Community Medicine The University of New South Wales Medicine The University of New South Wales Sydney Australia

Background: China has one of the highest incidence rates of oesophageal cancer in the world. The role of human papillomavirus (HPV) has been extensively researched in oesophageal squamous cell carcinoma (OSCC) with indeterminate results. The majority of these studies have been conducted in the Chinese population. Evidence for a definitive HPV-OSCC association could potentially support prophylactic vaccination in target populations, highlighting the need for ongoing investigation. The aim of this review is to summarise the findings of HPV DNA in OSCC tissue in Chinese subjects, with a view to informing further research in this area. Methods: A systematic literature search of the Chinese National Knowledge Infrastructure (CNKI) database, Medline, Embase and PubMed was conducted for all studies in English and Chinese language, examining OSCC tissue for HPV DNA in China. Reference lists of retrieved articles were reviewed and hand searches of relevant, key journals were conducted, to source articles which were not electronically indexed. Sixty-four studies met our selection criteria. Data from case-control and cross-sectional studies were analysed separately for any HPV-OSCC association, using the Epi InfoTM 3.5.3 software program. Results: From all studies conducted in the Chinese population, 2166/5953 (36%) of all OSCC tissue and 478/1684 (28%) of healthy control tissue, tested positive for HPV. We found that 11/16 case-control and cross-sectional studies had a statistically significant crude odds ratio, which supported a potential HPV-OSCC association. The largest study, carried out in the high incidence County of Anyang in Henan Province, reported 207/265 (78%) OSCC tissues testing positive for HPV DNA against 203/357 (57%) controls and had an unadjusted odds ratio of 2.71 (p-value Conclusion: A rigorous meta-analysis would improve interpretation of the data and a well-designed large-scale case-control study is warranted. If a link is found between HPV and OSCC, pro

关键词： Human Papillomavirus Oesophageal Carcinoma Squamous Cell Carcinoma HPV Vaccine China