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Raman spectroscopy as a promising noninvasive tool in brain cancer detection

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Journal of Innovative Optical Health Sciences 2017年第5期10卷 39-46页

作者： piyush Kumar Amity Institute of Biotechnology Amity University Mumbai Bhatan Post-SomatanePanvel Navi MumbaiMaharashtra 410206India

Despite intensive therapy regi men,brain cancers present with a poor prognosis,with an esti-mated median survival time of less than 15 months in case of *** detection and improved surgical resctions are suggested to enhance prognosis;several tools are being explored to achieve the *** spectroscopy(RS),a nondestructive and noninv asive technique,has been extensively explored in brain *** review summarizes RS based studies in brain cancers,categorized into studies on animal models,ex tivo human samples,and in tito human *** suggest RS as a promising tool which can aid in improving the accuracy of brain tumor *** adv ancements in instrumentation,market assessment,and clinical trials can facilitate translation of the technology as a noninvasive intraopenative guidance tool.

关键词： Ramnan spectroscopy brain cancers intraoperative glioma

Seismic analysis of nailed vertical excavation using pseudo-dynamic approach

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Earthquake Engineering and Engineering Vibration 2016年第4期15卷 621-631页

作者： piyush Sarangi Priyanka Ghosh Department of Civil Engineering Indian Institute of Technology

An attempt has been made to study the behavior of nailed vertical excavations in medium dense to dense cohesionless soil under seismic conditions using a pseudo-dynamic approach. The effect of several parameters such as angle of internal friction of soil （φ）, horizontal （kh） and vertical （kv） earthquake acceleration coefficients, amplification factor （fa）, length of nails （L）, angle of nail inclination （a） and vertical spacing of nails （S） on the stability of nailed vertical excavations has been explored. The limit equilibrium method along with a planar failure surface is used to derive the formulation involved with the pseudo-dynamic approach, considering axial pullout of the installed nails. A comparison of the pseudo-static and pseudo-dynamic approaches has been established in order to explore the effectiveness of the pseudo-dynamic approach over pseudo-static analysis, since most of the seismic stability studies on nailed vertical excavations are based on the latter. The results are expressed in terms of the global factor of safety （FOS）. Seismic stability, i.e., the FOS of nailed vertical excavations is found to decrease with increase in the horizontal and vertical earthquake forces. The present values of FOS are compared with those available in the literature.

关键词： earthquake factor of safety pseudo-dynamic approach soil nailing vertical excavation

Modeling protein-protein interactions in axon initial segment to understand their potential impact on action potential initiation

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Neural Regeneration Research 2021年第4期16卷 700-706页

作者： piyush Bhardwaj Don Kulasiri Sandhya Samarasinghe Centre of Advanced Computational Solutions(C-fACS) Lincoln UniversityChristchurchNew Zealand Department of Molecular Biosciences Lincoln UniversityChristchurchNew Zealand

The axon initial segment(AIS)region is crucial for action potential initiation due to the presence of high-density AIS protein voltage-gated sodium channels(Nav).Nav channels comprise several serine residues responsible for the recruitment of Nav channels into the structure of AIS through interactions with ankyrin-G(AnkG).In this study,a series of computational experiments are performed to understand the role of AIS proteins casein kinase 2 and AnkG on Nav channel recruitment into the *** computational simulation results using Virtual cell software indicate that Nav channels with all serine sites available for phosphorylation bind to AnkG with strong *** the low initial concentration of AnkG and casein kinase 2,the concentration of Nav channels reduces significantly,suggesting the importance of casein kinase 2 and AnkG in the recruitment of Nav channels.

关键词： Alzheimer’s disease ankyrin-G axon initial segment casein kinase-2 microtubules voltage-gated potassium channel voltage-gated sodium channel

Multivariable regression model for Fox depth correction factor

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Frontiers of Structural and Civil Engineering 2019年第1期13卷 103-109页

作者： Ravi Kant MITTAL Sanket RAWAT piyush BANSAL Department of Civil Engineering Birla Institute of Technology & SciencePilani 333031India Department of Civil and Environmental Engineering Virginia TechBlacksburgVA 24061USA

This paper presents a simple and efficient equation for calculating the Fox depth correction factor used in computation of settlement reduction due to foundation *** solution of Boussinesq theory was used originally to develop the Fox depth correction factor equations which were rather complex in *** equations were later simplified in the form of graphs and tables and referred in various international code of practices and standard texts for an unsophisticated and quick ***,these tables and graphs provide the factor only for limited values of the input variables and hence again complicates the process of automation of ***,this paper presents a non-linear regression model for the analysis of effect of embedment developed using "IBM Statistical Package for the Social Sciences" *** multiple iterations,the value of coefficient of determination is found to reach *** equation is straightforward,competent and easy to use for both manual and automated calculation of the Fox depth correction factor for wide range of input *** the developed equation,parametric study is also conducted in the later part of the paper to analyse the extent of effect of a particular variable on the Fox depth factor.

关键词： settlement embedment Fox depth correction factor regression multivariable

The rheological model of biodiesels at elevated pressures and temperatures

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Clean Energy 2022年第3期6卷 438-445页

作者： piyush Kuchhal Rajnish Garg Department of Physics School of EngineeringUPESIndia Department of Mechanical Engineering School of EngineeringUPESIndia

In the present study,an approximation is used to study viscosity as a function of pressure at different *** correlation so obtained is applied to study the viscosity of biodiesels extracted from soybean,Vistive soybean,canola,used canola,coconut and *** computed values of viscosity from the proposed model were found to be in good agreement with experimental data throughout the range of pressure and temperature *** maximum average absolute relative deviation(AARD%)and mean AARD%are found to be 0.52 and 0.20,respectively,over the entire range of pressure(0.1-140 MPa)and temperature(283.15-373.15 K)for all biodiesels except rapeseed biodiesel,for which the values are 1.1 and 0.62,***,this work includes the very first investigation conducted so far on the variation of the pressure-viscosity coefficient(PVC)with pressure at different temperatures for *** variation in PVC with the temperature is more sensitive at elevated pressures as compared to atmospheric pressure whereas the variation in PVC with pressure is more sensitive at elevated temperatures as compared to room temperature.

关键词： renewable fuel biodiesels viscosity pressure-viscosity coefficient pressure temperature

Frequency dependent electrical properties of Na_(2)Pb_(2)R_(2)W_(2)Ti_(4)Nb_(4)O_(30)(R=Nd,Sm)ceramics

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Journal of Advanced Ceramics 2014年第3期3卷 215-223页

作者： Lalatendu BISWAL piyush RDAS Banarji BEHERA Department of Physics SOTKIIT UniversityBhubaneswar-751024OdishaIndia Department of Physics Veer Surendra Sai University of TechnologyBurla-768018SambalpurIndia School of Physics Sambalpur UniversityJyoti ViharBurla-768019OdishaIndia

In the present research work,frequency dependent electrical properties of tungsten bronze structured compounds Na2Pb2R2W2Ti4Nb4O30(R=Nd,Sm)are reported.X-ray diffraction(XRD)study of polycrystalline ceramic samples confirms the formation of compounds with orthorhombic *** of frequency dependent electrical data in the framework of modulus and conductivity formalism suggests the presence of thermally activated relaxation process in the compounds,which show Arrhenius *** magnitudes of activation energies give the nature of the relaxing *** real and imaginary parts of complex modulus trace the depressed semicircle in complex plane,suggesting non-Debye type relaxation process in the *** power law behavior of admittance data is successfully modeled by introducing constant phase element(CPE)to the equivalent circuit.A large value of power law parameter(n)of CPE below ferroelectric transition temperature(Tc)is attributed to the cooperative response of the dipoles which is reduced above *** behavior is correlated with the frequency dependence of CPE,suggesting a physical meaning to *** frequency dependent AC conductivity at different temperatures follows Jonscher’s universal power *** and West formalism is used to estimate the hopping rate,activation enthalpy and charge carrier concentration in the materials.

关键词： ceramics electrical properties microstructure electrical conductivity

A shake table investigation of dynamic behavior of pile supported bridges in liquefiable soil deposits

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Earthquake Engineering and Engineering Vibration 2021年第1期20卷 1-24页

作者： piyush Mohanty Xu Dan Suryakant Biswal Subhamoy Bhattacharya CSIR-Central Building Research Institute Roorkee247667India Fluor Ltd. 140 Pinehurst RoadFarnboroughGU147BFUK Institute of Engineering Mechanics China Earthquake AdministrationSanhe 065201China University of Surrey GuildfordGU27XHUK

Bridges are a part of vital infrastructure,which should operate even after a disaster to keep emergency services *** have been numerous bridge failures during major past earthquakes due to *** other categories of failures,mid span collapse(without the failure of abutments)of pile supported bridges founded in liquefiable deposits are still observed even in most recent *** mechanism of collapse is attributed to the effects related to the differential elongation of natural period of the individual piers during liquefaction.A shake table investigation has been carried out in this study to verify mechanisms behind midspan collapse of pile supported bridges in liquefiable *** this investigation,a typical pile supported bridge is scaled down,and its foundations pass through the liquefiable loose sandy soil and rest in a dense gravel *** noise motions of increasing acceleration magnitude have been applied to initiate progressive liquefaction and to characterize the dynamic features of the *** has been found that as the liquefaction of the soil sets in,the natural frequency of individual bridge support is reduced,with the highest reduction occurring near the central *** a result,there is differential lateral displacement and bending moment demand on the *** has also been observed that for the central pile,the maximum bending moment in the pile will occur at a higher elevation,as compared to that of the interface of soils of varied stiffness,unlike the abutment *** practical implications of this research are also highlighted.

关键词： bridges midspan failure liquefaction bridge collapse earthquake pile shake table test natural frequency

Assessing foundation behaviour under complex loading near tunnels

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Journal of Mountain Science 2024年第10期21卷 3503-3520页

作者： piyush KUMAR Vinay Bhushan CHAUHAN Aayush KUMAR Civil Engineering Department Madan Mohan Malaviya University of TechnologyGorakhpur 273010India

The stability of strip footings subjected to eccentrically inclined loads is critical for reliable foundation *** study investigates the effect of a circular unlined tunnel in a rock mass on the ultimate bearing capacity(UBC)of a foundation with width B under inclined and eccentric *** finite element limit analysis was employed to evaluate the reduction in UBC of the footing resting above a *** examined critical parameters include normalized load eccentricity(e/B),load inclination(β),and horizontal and vertical distances of the tunnel from the foundation(P/B and Q/B,respectively),along with rock mass *** results reveal that for e/B≥0.25 and β≤60°,the reduction coefficient,R_(c)≥0.90,suggesting that the presence of a tunnel has a minimal impact on the load-bearing capacity of the footing,with failure primarily governed by load eccentricity and ***,potential failure mechanisms are explored,showing that at lower e/B,higher β,and lower Q/B,the tunnel significantly affects footing's failure ***,at higher e/B and lower β,failure is due to rotational effects of footing,regardless of the tunnel's *** predict the Rc more accurately,due to the time-consuming nature of direct calculations,both MLR and ANN models were *** MLR model provided a baseline for comparison,while the ANN model,with a coefficient of determination(R2)of 0.98,demonstrated superior accuracy compared to the R2=0.96 of *** both approaches ensured robust and efficient predictions of *** Rc does not directly provide the reduced UBC of footing due to presence of tunnel,the study introduced bearing capacity factor(Nc)to enable direct calculation of the reduced UBC of *** findings offer theoretical guidelines for preliminary design and provide practitioners with an effective tool for evaluating UBC reduction in complex loading scenarios involving tunnels.

关键词： Unlined tunnel Shallow foundation FELA Rock Mass ANN MLR

Trade Destruction and Trade Diversion： Evidence from China

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China & World Economy 2017年第3期25卷 31-59页

作者： piyush Chandra Associate Professor Economics Department Stonehill College USA.

Over the past three decades, we have seen a dramatic increase in the incidence oftemporary trade barriers such as antidumping duties and countervailing duties. Chinahas been at the receiving end of a large number of such measures. In this paper, we studyhow China＇s exports to its major trade partners have been affected when its major tradepartners have used these measures either against China or against other countries. Wefind that Chinese exports to the country that imposed an antidumping duty decreased byapproximately 35 percent. At the same time, an antidumping duty used by the importingcountry that was directed towards other countries but not against China led to anapproximate 30-percent increase in China＇s exports to the policy-imposing *** results remain robust across various specifications. Our findings have importantpolicy implications. In particular, the magnitude of these effects highlights why it isimportant to curb the recent widespread use of these barriers.

关键词： antidumping duties, China, temporary trade barriers, trade destruction, trade diversion