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World Journal of Diabetes 2019年第3期10卷 137-139页

作者： Taru Dutt rahul Kashyap Salim Surani Department of Neurology Research Mayo Clinic Rochester MN 55902 United States Department of Anesthesiology and Peri-operative Medicine Critical Care IMP Mayo Clinic Rochester MN 55902 United States Health Science Center Texas A and M University Corpus Christi TX 78404 United States

Diabetes mellitus (DM) is marked as global health care challenge with almost 10% of the United States population being diagnosed with DM. A sizeable percentage of patients are oblivious of their disease, in spite of easily accessibility knowledge about its early signs and symptoms and rapid diagnostic modalities. Critically ill patients with undiagnosed DM are likely to have an increased mortality as compared to intensive care unit (ICU) patients with diagnosed DM. DM may have adverse effect on ICU patients causing organ failure and complications. Early Screening of patients at the risk of developing disease may prevent long term complications. Early screening and management may be beneficial as controlled DM patients have similar morbidity as non DM patients in ICU. An intense glycaemic and blood pressure control improves retinopathy and albuminuria, but may not affect the macrovascular outcomes.

关键词： Diabetes mellitus Intensive care unit Microvascular Macrovascular Diabetes screening

Variability of Nonionellina labradorica Dawson in Surface Sediments from Kongsfjorden,West Spitsbergen

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Acta Geologica Sinica(English Edition) 2011年第3期85卷 549-558页

作者： Suhas SHETYE rahul MOHAN Sunil Kumar SHUKLA Sudhakar MARUTHADU Rasik RAVINDRA National Centre for Antarctic and Ocean Research Goa India Ministry of Earth Sciences New Delhi India

Kongsfjorden is a fjord in Spitsbergen（Svalbard archipelago）that lies adjacent to both Arctic and Atlantic water masses and is therefore a suitable site to understand the effects of climate change on *** decipher the effect of the lateral advection of transformed Atlantic water （TAW）within the fjord,spatial variations of foraminiferal tests,their test size variations and stable isotopic composition（δ^（13）C andδ^（18）O）in the surface sediments were *** organic carbon and textural analyses were also carried *** dominant benthic foraminifera included Nonionellina labradorica,Elphidium excavatum,Cassidulina reniforme,Quinqueloculina stalkeri and Islandiella *** labradorica was the predominant species in the outer fjord,whereas Elphidium excavatum and Cassidulina reniforme were dominant in the inner *** organic carbon and the test size of Nonionellina labradorica within the fjord were highly correlated（r=0.97）and both showed a decreasing trend towards the inner *** on the distribution and abundance of Nonionellina labradorica as well as temperature profiles,we suggest that there was little or no major change in the lateral advection of TAW within the fjord in the immediate past.

关键词： West Spitsbergen Current Kongsfjorden Nonionellina labradorica grain size organic carbon stable isotopes temperature

Alcoholic Liver Disease and COVID-19 Pneumonia:A Case Series

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Journal of Clinical and Translational Hepatology 2020年第4期8卷 463-466页

作者： Devika Kapuria Shubhra Upadhyay rahul Shekhar Euriko Torrazza-Perez Department of Gastroenterology University of New Mexico Health Science CenterAlbuquerqueNMUSA Department of Internal Medicine University of New Mexico Health Science CenterAlbuquerqueNMUSA

The novel coronavirus 2019(COVID-19)was reported by the World Health Organization in December 2019,and since then it has progressed into a worldwide pandemic,causing significant morbidity and *** symptoms of COVID-19 and elevated liver chemistries are seen in up to 50%of infected *** reports have suggested a high mortality rate for COVID-19 in patients with pre-existing liver disease,having an associated mortality of 39.8%.Alcoholic liver disease is a significant cause of morbidity and mortality in New Mexico(USA),and we report here the clinical course and characteristics of three cases of patients with alcoholic cir-rhosis who were admitted to our hospital with COVID-19.

关键词： COVID-19 Alcoholic liver disease ARDS Acute kidney injury

A randomized controlled trial of peeling and aspiration of Elschnig pearls and neodymium: yttrium-aluminiumgarnet laser capsulotomy

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International Journal of Ophthalmology(English edition) 2015年第3期8卷 590-596页

作者： rahul Bhargava Prachi Kumar Shiv Kumar Sharma Avinash Kaur Department of Ophthalmology Laser Eye Clinic Department of Pathology Santosh Medical College and Hospital Department of Ophthalmology Rotary Eye Hospital Department of Ophthalmology Santosh Medical College and Hospital

AIM: To compare surgical peeling and aspiration and neodymium yttrium garnet laser capsulotomy for pearl form of posterior capsule opacification(PCO).METHODS: A prospective, randomized, double blind,study was done at Rotary Eye Hospital, Maranda,Palampur, India, Santosh Medical College Hospital,Ghaziabad, India and Laser Eye Clinic, Noida *** patients with pearl form of PCO following surgery, phacoemulsification, manual small incision cataract surgery and conventional extracapsular cataract extraction(ECCE) for age related cataract, were randomized to have peeling and aspiration or neodymium yttrium garnet laser capsulotomy. Corrected distance visual acuity(CDVA), intra-operative and postoperative complications were ***: A total of 634 patients participated in the study, and 314(49.5%) patients were randomized to surgical peeling and aspiration group and 320(50.5%) to the Nd:YAG laser group. The mean pre-procedural log MAR CDVA in peeling and neodymium: yttrium-aluminium-garnet(Nd:YAG) laser group was 0.80 ±0.25 and 0.86 ±0.22, respectively. The mean final CDVA in peeling group(0.22 ±0.23) was comparable to Nd:YAG group(0.24 ±0.28; t-test, P =0.240). There was a significant improvement in vision after both the procedures(P <0.001). A slightly higher percentage of patients in Nd:YAG laser group(283/88.3%) than in peeling group(262/83.4%) had a CDVA of 0.5(20/63) or better at 9mo(P <0.001). On the contrary, patients havingCDVA worse than 1.00(20/200) was also significantly higher in Nd:YAG laser group as compared to peeling group(25/7.7% vs 15/4.7%, respectively). On application of ANCOVA, there was less than 0.001% risk that PCO thickness and total laser energy had no effect on rate of complications in Nd:YAG laser group and less than 0.001% risk that PCO thickness had no effect on complications in peeling group respectively. Sum of square analysis suggests that in the Nd:YAG laser group,thick PCO had a stronger impact on complication

关键词： posterior capsule neodymium Elschnig pearls yttrium-aluminium-garnet capsulotomy

Metabolic complications of hepatitis C virus infection

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World Journal of Gastroenterology 2021年第13期27卷 1267-1282页

作者： rahul Chaudhari Sherouk Fouda Ashik Sainu Joseph M Pappachan Department of Medicine Pennsylvania Hospital of the University of PennsylvaniaPennsylvaniaPA 19104United States School of Health and Biomedical Sciences RMIT UniversityMelbourne VIC 3000Australia Department of Gastroenterology and Hepatology Aster Oman HospitalAl GhubraMuscat OM 133Oman Department of Endocrinology and Metabolism Lancashire Teaching Hospitals NHS TrustPreston PR29HTUnited Kingdom Faculty of Science Manchester Metropolitan UniversityManchester M156BHUnited Kingdom Faculty of Biology Medicine and HealthThe University of ManchesterManchester M139PLUnited Kingdom

Hepatitis C virus(HCV) infection is a systemic disease that is implicated in multiple extrahepatic organ dysfunction contributing to its protean manifestations. HCV is associated with diverse extrahepatic disorders including atherosclerosis, glucose and lipid metabolic disturbances, alterations in the iron metabolic pathways, and lymphoproliferative diseases over and above the traditional liver manifestations of cirrhosis and hepatocellular carcinoma. The orchestration between HCV major proteins and the liver-muscle-adipose axis, poses a major burden on the global health of human body organs, if not adequately addressed. The close and inseparable associations between chronic HCV infection, metabolic disease, and cardiovascular disorders are specifically important considering the increasing prevalence of obesity and metabolic syndrome, and their economic burden to patients, the healthcare systems, and society. Cellular and molecular mechanisms governing the interplay of these organs and tissues in health and disease are therefore of significant interest. The coexistence of metabolic disorders and chronic hepatitis C infection also enhances the progression to liver fibrosis and hepatocellular carcinoma. The presence of metabolic disorders is believed to influence the chronicity and virulence of HCV leading to liver disease progression. This comprehensive review highlights current knowledge on the metabolic manifestations of hepatitis C and the potential pathways in which these metabolic changes can influence the natural history of the disease.

关键词： Chronic hepatitis C infection Insulin resistance Metabolic syndrome Cardiovascular diseases Fatty liver Diabetes mellitus

Thrombotic thrombocytopenic purpura in a HIV-positive patient:A hematological emergency

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Journal of Acute Disease 2023年第2期12卷 87-88页

作者： Majed Abdul Basit Momin Rathore rahul Dev Singh Rubina Hassan Department of Laboratory Medicine Yashoda HospitalHyderabadTelanganaIndia

Dear editor,Thrombotic thrombocytopenic purpura(TTP)is an acute non-immune acquired microangiopathic hemolytic *** is characterized by the classic pentad features of fever,thrombocytopenia,hemolytic anemia,neurological symptoms and renal dysfunction,although all five clinical features are seen in less than 10%of patients[1].The diagnosis of TTP is frequently neglected since thrombocytopenia is a common hematological finding in patients with TTP and human immunodeficiency virus(HIV)*** peripheral blood film composed of schistocytes(fragmented red blood cells)plays a crucial role in diagnosing TTP associated with a chronic infection such as HIV.

关键词： diagnosis acute patients

Association of COVID-19 with hepatic metabolic dysfunction

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World Journal of Virology 2022年第5期11卷 237-251页

作者： Ramesh Kumar Vijay Kumar rahul Arya Utpal Anand Rajeev Nayan Priyadarshi Department of Gastroenterology All India Institute of Medical SciencesPatnaPatna 801507BiharIndia Department of Medicine All India Institute of Medical SciencesPatnaPatna 801507BiharIndia Department of Surgical Gastroenterology All India Institute of Medical SciencesPatnaPatna 801507BiharIndia Department of Radiodiagnosis All India Institute of Medical SciencesPatnaPatna 801507BiharIndia

The coronavirus disease 2019(COVID-19)pandemic continues to be a global problem with over 438 million cases reported so *** it mostly affects the respiratory system,the involvement of extrapulmonary organs,including the liver,is not *** the beginning of the pandemic,metabolic comorbidities,such as obesity,diabetes,hypertension,and dyslipidemia,have been identified as poor prognostic *** metabolic and lipidomic studies have identified several metabolic dysfunctions in patients with *** metabolic alterations appear to be linked to the course of the disease and inflammatory reaction in the *** liver is an important organ with high metabolic activity,and a significant proportion of COVID-19 patients have metabolic comorbidities;thus,this factor could play a key role in orchestrating systemic metabolic changes during *** suggests that metabolic dysregulation in COVID-19 has both short-and long-term metabolic ***,COVID-19 has adverse associations with metabolic-associated fatty liver *** to the ensuing effects on the renin-angiotensin-aldosterone system and ammonia metabolism,COVID-19 can have significant implications in patients with advanced chronic liver disease.A thorough understanding of COVID-19-associated metabolic dysfunction could lead to the identification of important plasma biomarkers and novel treatment *** this review,we discuss the current understanding of metabolic dysfunction in COVID-19,focusing on the liver and exploring the underlying mechanistic pathogenesis and clinical implications.

关键词： COVID-19 Coronavirus Metabolism Metabolic syndrome Metabolic inflammation Hepatic dysfunction

Disentangling the spin-parity of a resonance via the gold-plated decay mode

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Chinese Physics C 2016年第3期40卷 12-28页

作者： Tanmoy Modak Dibyakrupa Sahoo rahul Sinha Hai-Yang Cheng Tzu-Chiang Yuan The Institute of Mathematical Sciences Taramani Chennai 600113 Institute of Physics Academia Sinica Taipei 11529

Searching for new resonances and finding out their properties is an essential part of any existing or future particle physics experiment. The nature of a new resonance is characterized by its spin, charge conjugation,parity, and its couplings with the existing particles of the Standard Model. If a new resonance is found in the four lepton final state produced via two intermediate Z bosons, the resonance could be a new heavy scalar or a Z boson or even a higher spin particle. In such cases a step by step methodology as enunciated in this paper can be followed to determine the spin, parity and the coupling to two Z bosons of the parent particles, in a fully model-independent way. In our approach we show how three uni-angular distributions and a few experimentally measurable observables can conclusively tell us about the spin, parity as well as the couplings of the new resonance to two Z bosons. We have performed a numerical analysis to validate our approach and showed how the uni-angular observables can be used to disentangle the spin parity as well as the coupling of the resonance.

关键词： general spin-parity analysis angular distributions angular asymmetries

Truck and Passenger Car Connected Vehicle Penetration on Indiana Roadways

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Journal of Transportation Technologies 2022年第4期12卷 578-599页

作者： rahul Suryakant Sakhare Margaret Hunter Justin Mukai Howell Li Darcy Michael Bullock Lyles School of Civil Engineering Purdue University West Lafayette Indiana

Commercially available connected vehicle (CV) probe data has been demonstrated to provide scalable and near-real-time methodologies to evaluate the performance of road networks for various applications. However, one of the major concerns of probe data for agencies is data sampling, particularly during low-volume overnight hours. This paper reports on an evaluation that looked at both connected passenger cars and connected trucks. This study analyzed 40 continuous count stations in Indiana that recorded more than 10.8 million vehicles and more than 13 million trips (3 billion records) from CV data over a 1-week period from May 9th to 15th in 2022. The average truck penetration was observed to be 3.4% during overnight hours from 1 AM to 5 AM when the connected passenger car penetration was at the lowest. When both connected trucks and connected car penetration were analyzed, the overall CV penetration was 6.32% on interstates and 5.30% on non-interstate roadways. The paper concludes by recommending that both connected car and connected truck data be used by agencies to increase penetration and reduce the hourly variation in CV penetration. This is particularly important during overnight hours.

关键词： Connected Vehicle Data Trucks Penetration Big Data

Root-associated fungi of Arabidopsis thaliana and Microthlaspi perfoliatum

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Fungal Diversity 2014年第3期66卷 99-111页

作者： Jessica Keim Bagdevi Mishra rahul Sharma Sebastian Ploch Marco Thines Department of Biological Sciences Institute of EcologyEvolution and DiversityGoethe UniversitySiesmayerstr.7060323 Frankfurt am MainGermany Biodiversity and Climate Research Centre(BiK-F) Senckenberganlage 2560325 Frankfurt am MainGermany Senckenberg Gesellschaft für Naturforschung Senckenberganlage 2560325 Frankfurt am MainGermany Integrative Fungal Research Cluster(IPF) Senckenberganlage 2560325 Frankfurt am MainGermany

Root-associated fungi,with the focus on endophytic species,were isolated from healthy Arabidopsis thaliana and Microthlaspi perfoliatum plants collected at different locations in Germany.A large number of fungal taxa were discovered with a small-scale *** provides additional evidence that root-associated and endophytic fungi are common in *** most prevalent genera associated with *** roots were Trichoderma and Fusarium,while the roots of *** were dominated by different species of Fusarium and *** in species composition and richness might be due to preferences and lifecycle of the two plant *** of endophyte species that did not have closely related species in GenBank searches and those already known as root endophytes were chosen for preliminary co-cultivation experiments using germinating host plants on agar medium to observe effects on plant growth and *** these conditions several fungal isolates had an adverse effect on plant growth and health,especially on Arabidopsis *** isolates did not adversely affect biomass during initial plant growth,while they altered the shoot-root ratio in favour of the shoot,especially in Microthlaspi *** strains are promising candidates for future research on endophytes as they might have some effects in Brassicaceae that are similar to mycorrhizal *** are also promising candidates for investigating interactions with their host plants.

关键词： Arabidopsis thaliana Brassicaceae Cultivation Endophytes Microthlaspi perfoliatum Mycorrhiza-like endophytes Phylogeny