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Trends of obesity and overweight among children and adolescentsin China

World Journal of Pediatrics 2023年第12期19卷 1115-1126页

作者： Ye Hong rahim ullah Jian‑Bing Wang Jun‑Fen Fu Department of Endocrinology Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthNational Children’s Regional Medical CenterHangzhou 310052China Zhejiang University School of Medicine Hangzhou 310052China

Background Recent decades have shown a rapid increase in the prevalence of overweight and obesity among Chinese children based on several national *** due to the coronavirus disease 2019 outbreak have worsened its *** review updates the trends in the prevalence of overweight and obesity among Chinese children and adolescents and analyzes the underlying reasons to provide evidence for better policy *** Studies published in English and Chinese were retrieved from PubMed,Google Scholar,China National Knowl-edge Infrastructure *** The prevalence of overweight and obesity has been increasing for decades and varies with age,sex and geography but is more pronounced in primary school *** increase in obesity in boys appeared to be slower,whereas that in girls showed a declining *** northern areas of China have persistently maintained the highest levels of obesity with a stable trend in recent ***,the prevalence in eastern regions has dramatically ***,the overall prevalence of obesity in children has shown a stabilizing trend in recent ***,the occurrence of obesity-related metabolic diseases *** effect of migrants floating into east-coast cities should not be *** The high prevalence of overweight and obesity among Chinese children and adolescents persists but with vary-ing ***-related metabolic diseases occur more frequently despite a stable trend of *** factors are responsible for the changing ***,comprehensive and flexible policies are needed to effectively manage and prevent the burden of obesity and its related complications.

关键词： Adolescents Children Obesity Overweight Policy

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FTO gene polymorphisms and obesity risk in Chinese population: a meta-analysis

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World Journal of Pediatrics 2019年第4期15卷 382-389页

作者： Ning-Ning Zhao Guan-Ping Dong Wei WU Jin-Ling Wang rahim ullah Jun-Fen Fu Department of Endocrinology Children's HospitalZhejiang University School of Medicine3333Binsheng RoadHangzhou 310052China

Background There is tremendous increase in obesity *** factors including diet,life style,genetic,and epigenetic changes contribute to *** fat mass and obesity-associated (FTO) gene polymorphisms are strongly associated with *** has been reported that FTO single-nucleotide polymorphisms (SNPs) are associated with obesity in European populations;however,it was controversial in Chinese *** present meta-analysis study was designed to investigate the association between FTO polymorphisms and obesity risk in Chinese *** The investigators searched studies using the following databases:PubMed,web of science,and Cochrane Central Register of Controlled Trials.A random-effects model was used to calculate the pooled odds ratios (ORs).The heterogeneity among the studies was measured by I2 *** analysis was used to find out the potential factors influencing the *** A total of 18 articles including 26 studies were included in the present ***,the FTO SNPs were significantly associated with obesity in Chinese population (OR 1.30;95% CI 1.19-1.42;P < 0.001) under per-allele *** subgroup analysis also showed strong association between four FTO SNPs (rs9939609,rs6499640,rs8050136,and rs 1558902) and obesity ***,subgroup analysis stratified by children/adolescent and adult groups showed same *** The present meta-analysis indicated that FTO SNPs are associated with obesity risk in both children/adolescents and adults in Chinese population.

关键词： FTO SNPs Obesity Chinese population

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Postnatal feeding with high-fat diet induces obesity and precocious puberty in C57BL/6J mouse pups： a novel model of obesity and puberty

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Frontiers of Medicine 2017年第2期11卷 266-276页

作者： rahim ullah Yan Su Yi Shen Chunlu Li Xiaoqin Xu Jianwei Zhang Ke Huang Naveed Rauf Yang He Jingjing Cheng Huaping Qin Yu-Dong Zhou Junfen Fu Department of Endocrinology Children's Hospital Zhejiang University School of Medicine Hangzhou 310051 China Department of Neurobiology Institute of Neuroscience and the Collaborative Innovation Center for Brain Science Key Laboratory of Medical Neurobiology of the Ministry of Health of China Zhejiang University School of Medicine Hangzhou 310058 China

Childhood obesity and obesity-related metabolic complications are induced by a high-fat postnatal diet. The lack of a suitable animal model, however, remains a considerable challenge in obesity studies. In the current study, we provided high-fat diet （HFD） to dams during lactation and to pups after weaning. We also developed a novel model of C57BL/6J mouse pups with HFD-induced postnatal obesity. Results showed that feeding with HFD induces fat deposition and obesity in pups. Furthermore, HFD more potently increased the body weight （BW） of male than female pups. HFD-fed female pups were obese, underwent precocious puberty, and showed increased kisspeptin expression in the hypothalamus. However, parental obesity and precocious puberty exerted no synergistic effects on the HFD-induced postnatal weight gain and puberty onset of the pups. Interestingly, some HFD-fed litters with normal BW also exhibited precocious puberty. This finding suggested that diet composition but not BW triggers puberty onset. Our model suggests good construction validity of obesity and precocious puberty. Furthermore, our model can also be used to explore the mutual interactions between diet-induced postnatal childhood obesity and puberty.

关键词： postnatal HFD feeding obesity kisspeptin HPG axis precocious puberty

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Big Data of Home Energy Management in Cloud Computing

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Journal of Quantum Computing 2020年第4期2卷 193-202页

作者： Rizwan Munir Yifei Wei rahim ullah Iftikhar Hussain Kaleem Arshid Umair Tariq Beijing University of Posts and Telecommunications Beijing10086China Higher Education Department PeshawarKhyber Pakhtunkhwa25000Pakistan School of Computer and Information Technology Beaconhouse National UniversityLahore53700Pakistan Faculty of Information Technology Beijing University of TechnologyBeijing100124China

A smart grid is the evolved form of the power grid with the integration of sensing,communication,computing,monitoring,and control *** technologies make the power grid reliable,efficient,and ***,the smartness boosts the volume of data in the smart *** obligate full benefits,big data has attractive techniques to process and analyze smart grid *** paper presents and simulates a framework to make sure the use of big data computing technique in the smart *** offered framework comprises of the following four layers:(i)Data source layer,(ii)Data transmission layer,(iii)Data storage and computing layer,and(iv)Data analysis *** a proof of concept,the framework is simulated by taking the dataset of three cities of the Pakistan region and by considering two cloud-based data *** results are analyzed by taking into account the following parameters:(i)Heavy load data center,(ii)The impact of peak hour,(iii)High network delay,and(iv)The low network *** presented framework may help the power grid to achieve reliability,sustainability,and cost-efficiency for both the users and service providers.

关键词： Cloud computing virtual machine data centers internet of things big data in smart grid

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Continuous age-and sex-specific reference ranges of liver enzymes in Chinese children and application in pediatric non-alcoholic fatty liver disease

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World Journal of Pediatrics 2024年第9期20卷 949-956页

作者： Zhao-Yuan Wu Si-Wei Chi Liu-Jian Ouyang Xiao-Qin Xu Jing-Nan Chen Bing-Han Jin rahim ullah Xue-Lian Zhou Ke Huang Guan-Ping Dong Zhe-Ming Li Ying Shen Jie Shao Yan Ni Jun-Fen Fu Qiang Shu Wei Wu Department of Endocrinology Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child Health3333 Binsheng RoadHangzhou310051China Department of Data and Information Children’s HospitalZhejiang University School of MedicineHangzhouChina Department of Child Health Care Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhouChina Department of Thoracic&Cardiovascular Surgery Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthNational Children’s Regional Medical Center3333 Binsheng RoadHangzhou310051China

Background Alanine aminotransferase(ALT)is widely used to screen patients with hepatic ***,the current reference ranges(<50 U/L)were developed by laboratories and have not been validated in populations with a large number of healthy *** This study collected venous blood and anthropometric data from a total of 13,287 healthy children aged 3 months to 18 years who underwent routine physical examinations in the Department of Pediatric *** applied the least mean square algorithm to establish age-and sex-related reference percentiles of serum levels of *** validation,we recruited 4276 children and adolescents with obesity/overweight who underwent evaluation and metabolic tests in the *** receiver operating characteristic curves,we determined age-and sex-specific upper limit percentiles of liver enzymes for fatty liver *** This study revealed a significant correlation between serum transaminase levels and age and sex(P<0.01).These transaminase levels exhibited age-and sex-specific *** individuals in the non-alcoholic fatty liver disease(NAFLD)cohort,elevated ALT levels displayed a positive association with clinical markers of disease severity,including homeostatic model assessment of insulin resistance,waist-hip ratio,and serum uric acid levels(P<0.01).According to the receiver operating characteristic curves,ALT levels at the 92.58th percentile for boys and the 92.07th percentile for girls yielded the highest accuracy and *** This study provides age-and sex-specific reference ranges for ALT,aspartate aminotransferase,andγ-glutamyltransferase in Chinese children and adolescents,making it the largest population study to ***,the study establishes a precise upper limit for ALT levels,facilitating their use in NAFLD screening.

关键词： Alanine aminotransferase Childhood Fatty liver diseases

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New models of High Fat Diet induced Obesity and Early Puberty in C57 mice babies

New models of High Fat Diet induced Obesity and Early Pubert...

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2015年浙江省医学会儿科学分会学术年会暨儿内科疾病诊治新进展国家级继续教育学习班

作者： ullah rahim Shen Yi Zhou Yu-dong Li Chunlu Cheng Jin Jing Zhu Qian Dong Can He Yang Xu Xiaoqin Huang Ke Fu Jun-fen children's hospital of Zhejiang University Key Laboratory of Medical Neurobiology of Ministry of Health and Zhejiang Province Department of NeurobiologySchool of MedicineZhejiang University

Objectives:The present study was designed to study whether high fat diet(HFD)induces obesity and early puberty in C57 mice babies or *** synergistic effects of maternal obesity on puberty onset and obesity of mice babies were also ***:We have used two different methods to produce mice babies with early puberty and *** first method,while eating on control chow food before and during pregnancy,adult female mice(n=3)gave ***-

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Secure Transmission of Compressed Medical Image Sequences on Communication Networks Using Motion Vector Watermarking

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Computers, Materials & Continua 2024年第3期78卷 3283-3301页

作者： Rafi ullah Mohd Hilmi bin Hasan Sultan Daud Khan Mussadiq Abdul rahim Computer and Information Sciences Department Universiti Teknologi PETRONASBandar Seri Iskandar Perak32610Malaysia Department of Computer Science National University of TechnologyIslamabad46000Pakistan Interdisciplinary Research Center for Intelligent Secure Systems King Fahd University of Petroleum and MineralsDammam31261Saudi Arabia

Medical imaging plays a key role within modern hospital management systems for diagnostic *** methodologies are extensively employed to mitigate storage demands and enhance transmission speed,all while upholding image ***,an increasing number of hospitals are embracing cloud computing for patient data storage,necessitating meticulous scrutiny of server security and privacy ***,considering the widespread availability of multimedia tools,the preservation of digital data integrity surpasses the significance of compression *** response to this concern,we propose a secure storage and transmission solution for compressed medical image sequences,such as ultrasound images,utilizing a motion vector watermarking *** watermark is generated employing an error-correcting code known as Bose-Chaudhuri-Hocquenghem(BCH)and is subsequently embedded into the compressed sequence via block-based motion *** the process of watermark embedding,motion vectors are selected based on their magnitude and phase *** embedding watermarks,no specific spatial area,such as a region of interest(ROI),is used in the *** embedding of watermark bits is dependent on motion *** reversible watermarking allows the restoration of the original image sequences,we use the irreversible watermarking *** reason for this is that the use of reversible watermarks may impede the claims of ownership and legal *** restoration of original data or images may call into question ownership or other legal *** peak signal-to-noise ratio(PSNR)and structural similarity index(SSIM)serve as metrics for evaluating the watermarked image *** all images,the PSNR value exceeds 46 dB,and the SSIM value exceeds *** results substantiate the efficacy of the proposed technique in preserving data integrity.

关键词： Block matching algorithm(BMA) compression full-search algorithm motion vectors ultrasound image sequence watermarking

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Analysis of various semi-numerical schemes for magnetohydrodynamic(MHD)squeezing fluid flow in porous medium

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Propulsion and Power Research 2019年第1期8卷 69-78页

作者： Inayat ullah M.T.rahim Hamid Khan Mubashir Qayyum Department of Mathematics Edwardes College PeshawarKhyber Pakhlunkhwa(KPK)25000Pakistan Department of Humanities FAST NUCES Peshawar CampusKhyber Pakhlunkhwa(KPK)25000Pakistan

In this article comparative analysis of various semi-numerical schemes has beenmade for the case of squeezing flow of an incompressible viscous fluid between two largeparallel plates having no-slip at the *** medium of flow contains magnetohy-drodynamic(MHD)effect and having small *** boundary value problem is solvedanalytically using Optimal homotopy asymptotic method(OHAM),homotopy perturbationmethod(HPM),differential transform method(DTM),Daftardar Jafari method(DIM)andAdomian decomposition method(ADM).For comparison purpose,residuals of these schemeshave been found and analyzed for *** study indicates that DTM and DJM arequite good in tem of accuracy near the center of domain[—1,1]but the accuracy reducesconsiderably near the start and end of the given *** and OHAM residuals indicatethat OHAM surpasses HPM in terms of accuracy in the present case.

关键词： Optimal homotopy asymptotic method Homotopy perturbation method Differential transform method Daftardar Jafari method Adomian decomposition method Residual

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Correction of array failure using grey wolf optimizer hybridized with an interior point algorithm

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Frontiers of Information Technology & Electronic Engineering 2018年第9期19卷 1191-1202页

作者： Shafqat ullah KHAN M.K.A.rahim Liaqat ALI Advanced RF ＆ Microwave Research Group Department of Communication EngineeringFaculty of Electrical EngineeringUniversiti Teknologi Malaysi Department of Electrical Engineering University of Science and Technology Bann

We design a grey wolf optimizer hybridized with an interior point algorithm to correct a faulty antenna array. If a single sensor fails, the radiation power pattern of the entire array is disturbed in terms of sidelobe level（SLL） and null depth level（NDL）, and nulls are damaged and shifted from their original locations. All these issues can be solved by designing a new fitness function to reduce the error between the preferred and expected radiation power patterns and the null limitations. The hybrid algorithm has been designed to control the array＇s faulty radiation power pattern. Antenna arrays composed of 21 sensors are used in an example simulation scenario. The MATLAB simulation results confirm the good performance of the proposed method, compared with the existing methods in terms of SLL and NDL.

关键词： Failure correction Grey wolf optimizer Interior point algorithm Sidelobes Deeper null depth level

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Development of bis-thiobarbiturates as successful urease inhibitors and their molecular modeling studies

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Chinese Chemical Letters 2016年第5期27卷 693-697页

作者： Fazal rahim Muhammad Ali Shifa ullah Umer Rashid Hayat ullah Muhammad Taha Muhammad Tariq Javed Wajid Rehman Aftab Ahmad Khan Obaid Ur Rahman Abid Muhammad Bilal Department of Chemistry Hazara University Department of Chemistry COMSATS Institute of Information Technology Department of Biochemistry and Biotechnology The Islamia University of Bahawalpur Atta-ur-Rahman Institute for Natural Product Discovery Universiti Teknologi MARA (UiTM)Puncak Alam Campus Faculty of Applied Science UiTM Department of Environmental Science COMSATS Institute of Information Technology

Bis-thiobarbiturate derivatives 1-15 have been synthesized, characterized by 1HNMR and El-MS and screened for urease inhibition. All compounds showed various degree of urease inhibitory activity with iC50 values ranging 7.45 ± 0.12 - 74.24 ± 0.81 μmol/L while the standard thiourea behaved normally （ICso = 21.10 ±0.12）. Compounds I （IC50= 7.45 ± 0.12 ]μmol/L）, 9 （IC50 =18,17 ± 1.03 bmol/L） and 13 （IC50= 8.61 ± 0.45 bmol/L） showed excellent urease inhibitory activity in the series. Molecular modeling studies were performed to understand the binding site with the bimetallic nickel center of the enzyme. Structure-activity relationship has also been established for these compounds. This study identified bis- thiobarbiturate as a novel class of urease inhibitors.

关键词： Thiobarbituric acid Synthesis Urease inhibition Molecular docking studies

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