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Methyl gallate isolated from Mangifera pajang kernel induces proliferation inhibition and apoptosis in MCF-7 breast cancer cells via oxidative stress

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Asian Pacific Journal of Tropical Biomedicine 2022年第4期12卷 175-184页

作者： Ranneh Yazan Abu Bakar Mohd Fadzelly rahim azlen-che Kassim Nur Kartinee Stanslas Johnson Teh Yuan-Han Fadel Abdulmannan Ellulu Mohammed S Department of Technology and Natural Resources Faculty of Applied Science and TechnologyUniversiti Tun Hussein Onn MalaysiaPagoh CampusKM1 Panchor RoadMuar JohorMalaysia Department of chemistry Faculty of ScienceUniversiti Putra MalaysiaSerdang 43300Malaysia Department of Medicine Faculty of Medicine and Health SciencesUniversiti Putra MalaysiaSelangorMalaysia Sport and Exercises Sciences School Faculty of ScienceLiverpool John Moores UniversityLiverpoolUK Department of Clinical Nutrition Faculty of Applied Medical SciencesAl-Azhar University of GazaGaza CityState of Palestine

Objective:To determine the lead bioactive compound in kernel extract of Mangifera pajang and its anti-cancer activity against human breast cancer cell lines with positive estrogen receptor(MCF-7).Methods:The methanolic extract of dried powder kernel of Mangifera pajang was exposed to column chromatography for *** structural elucidation of the isolated compound was characterized using infrared,nuclear magnetic resonance,mass ***,cytotoxicity,morphological changes,flow cytometry and cell cycle arrest analyses were performed to examine the mechanism of anti-proliferation and apoptosis induced by methyl gallate against ***:One compound was isolated from the methanolic extract of Mangifera pajang kernel and identified as methyl *** flow cytometric results demonstrated induction of apoptosis in MCF-7 cells by three concentrations of methyl *** cell cycle arrest showed a significant(P<0.05)decrease in cell progression at G2/M phase of MCF-7 after treatment with 100μM of methyl *** cell percentage of early and late apoptosis was significant at 10 and 100μM of methyl ***,methyl gallate treatment induced up-regulation of reactive oxygen species levels in MCF-7 cells with a reduction in superoxide dismutase ***:These findings indicate that isolated methyl gallate from Mangifera pajang kernel extracts induces growth inhibition and apoptosis in MCF-7 cells via up-regulating oxidative stress pathway.

关键词： Mangifera pajang Methyl gallate Breast cancer Cell cycle Apoptosis Oxidative stress

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Extraction and Characterization of Litopenaeus vannamei’s Shell as Potential Sources of Chitosan Biopolymers

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Journal of Renewable Materials 2023年第3期11卷 1181-1197页

作者： che Engku Noramalina che Engku Chik Amyra Suryatie Kamaruzzan Ahmad Ideris Abdul rahim Fathurrahman Lananan Azizah Endut Siti Aslamyah Nor Azman Kasan Higher Institution Centre of Excellence(HICoE) Institute of Tropical Aquaculture and Fisheries(AKUATROP)Universiti MalaysiaTerengganuMalaysia East Coast Environmental Research Institute(ESERI) Universiti Sultan Zainal Abidin(UniSZA)Terengganu Darul ImanMalaysia Faculty of Bioresources and Food Industry Universiti Sultan Zainal Abidin(UniSZA)Terengganu Darul ImanMalaysia Faculty of Innovative Design and Technology Universiti Sultan Zainal AbidinTerengganu Darul ImanMalaysia Faculty of Marine Science and Fisheries Hasanuddin UniversityMakassarIndonesia

Chitin is the second most abundant polysaccharide,produced mainly as an industrial waste stream during crustacean *** can be derived into chitosan through the deacetylation *** of shrimp waste into chitosan via the deacetylation process could be considered a practical approach for shell waste *** this study,chitosan’s physicochemical characteristics extracted from two types of Pacific white leg shrimp,***’s shell(i.e.,rough and smooth),were compared with commercial *** yield,moisture,ash,solubility,water and fat binding capacity were *** degree of deacetylation(DDA)was calculated using FTIR,and their chemical Structure was confirmed using XRD and *** extracted chitosan showed no significant difference in yield,moisture,ash,solubility and water binding capacity but showed a significant difference with commercial ***,the fat binding capacity of commercial chitosan showed the lowest percentage(408.34±0.83%)as compared to extracted chitosan(smooth shell 549.59±12.48%;rough shell 500.55±12.10%).The DDA indicated that extracted chitosan from the smooth and rough shell was considered good chitosan as compared to commercial chitosan with 84.08±1.27%,80.78±0.79%and 74.99±1.48%,***,the presence of hydroxyl and amino groups from FTIR and a good crystallinity index was recorded using XRD of extracted *** on observed characteristics,shrimp shell waste from *** can achieve chitosan standard quality as a biopolymer and highly potential to be applied in various industrial applications.

关键词： Chitin chitosan degree of deacetylation L.vannamei shrimp shell surface morphology

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A review on 3D terrain visualization of GIS data:techniques and software

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Geo-Spatial Information Science 2012年第2期15卷 105-115页

作者： che Mat RUZINOOR Abdul Rashid Mohamed SHARIFF Biswajeet PRADHAN Mahmud RODZI AHMAD Mohd Shafry Mohd rahim Geospatial Information Science Research Centre(GISRC) Faculty of EngineeringUniversiti Putra Malaysia43400 UPM SerdangSelangorMalaysia College of Arts and Sciences Universiti Utara Malaysia06010 UUM SintokKedahMalaysia Department of Civil Engineering Faculty of EngineeringUniversiti Putra Malaysia43400 UPM SerdangSelangorMalaysia Faculty of Computer Science&Information Systems Universiti Teknologi Malaysia81310 UTM SkudaiJohorMalaysia

3D terrain visualization of geographic information systems(GIS)data has become an important issue in recent *** is due to the emergence of new geo-browsers such as Google Earth,widely popular among *** availability of 3D representation tools has increased the demand for 3D terrain *** aim of this paper is to review the literature related to the 3D terrain visualization of GIS data from the first map produced until the online mapping *** reviews are divided into four different sections:manual visualization of 3D terrain,automated visualization of 3D terrain,online visualization of 3D terrain,and software for visualizing 3D ***,the paper compares between the different types of systems developed by various authors based on the capabilities and the limitations of the *** of the techniques have their own strengths and limitations which solve the problem in 3D terrain ***,the research on improving 3D terrain visualization is still *** is due to the popularity of online environments and mobile devices that render 3D *** review paper will help interested users understand the current state of 3D terrain visualization of GIS data in a better way.

关键词： terrain visualization geographic information systems(GIS) 3D terrain visualization online 3D terrain visualization remote sensing Malaysia

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Effect of residual structural strain caused by the addition of Co3O4 nanoparticles on the structural, hardness and magnetic properties of an Al/Co3O4 nanocomposite produced by powder metallurgy

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International Journal of Minerals,Metallurgy and Materials 2020年第3期27卷 384-390页

作者： Seyed rahim Kiahosseini Hossein Ahmadian Department of Engineering Damghan Branch Islamic Azad University

Al composites are of interest due to their appropriate ratio of strength to *** our research,an Al/Co3O4 nanocomposite was generated using a sintering *** powders of Al with various Co3O4 nanoparticle contents(0 wt%,0.5 wt%,1.0 wt%,1.5 wt%,2.0 wt%,and2.5 wt%)were first blended using planetary milling for 30 min,and compressed in a cylindrical steel mold with a diameter of 1 cm and a height of5 cm at a pressure of 80 *** samples were evaluated with X-ray diffractometry(XRD),scanning electron microscopy(SEM),Vickers hardness,and a vibrating sample magnetometer(VSM).Although the crystallite size of the Al particles remained constant at 7–10 nm,the accumulation of nanoparticles in the Al particle interspace increased the structural tensile strain from 0.0045 to 0.0063,the hardness from HV 28 to HV 52 and the magnetic saturation from 0.044 to 0.404 emu/g with an increase in Co3O4 nanoparticle content from 0 wt%to 2.5 wt%.

关键词： Residual strain Vickers hardness vibrating sample magnetometer scanning electron microscopy

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Investigation of the Effects of Baffles on the Shallow Water Sloshing in A Rectangular Tank Using A 2D Turbulent ISPH Method

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China Ocean Engineering 2019年第1期33卷 94-102页

作者： rahim SHAMSODDINI Bahador ABOLPUR Department of Mechanical Engineering Sirjan University of Technology Department of chemical Engineering Sirjan University of Technology

Liquid sloshing is a common phenomenon in the liquid tanks transportation. Liquid waves lead to fluctuating forces on the tank wall. Uncontrolled fluctuations lead to large forces and momentums. Baffles can control these fluctuations. A numerical method, which has been widely used to model this phenomenon, is Smoothed Particle Hydrodynamics(SPH). The Lagrangian nature of this method makes it suitable for simulating free surface flows. In the present study, an accurate Incompressible Smoothed Particle Hydrodynamics(ISPH) method is developed and improved using the kernel gradient correction tensors, particle shifting algorithms, k–ε turbulence model, and free surface particle detectors. Comparisons with the experimental data approve the ability of the present algorithm for simulating shallow water sloshing. The main aim of this study is to investigate the effects of the vertical baffle on the damping of liquid sloshing. Results show that baffles number has a major role in sloshing fluctuation damping.

关键词： SPH k–ε vertical baffle shallow water sloshing free surface

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Neural network and principal component regression in non-destructive soluble solids content assessment:a comparison

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第2期13卷 145-151页

作者： Kim-seng CHIA Herlina ABDUL rahim Ruzairi ABDUL rahim Department of Control and Instrumentation Faculty of Electrical EngineeringUniversiti Teknologi Malaysia

Visible and near infrared spectroscopy is a non-destructive,green,and rapid technology that can be utilized to estimate the components of interest without conditioning it,as compared with classical analytical *** objective of this paper is to compare the performance of artificial neural network(ANN)(a nonlinear model)and principal component regression(PCR)(a linear model)based on visible and shortwave near infrared(VIS-SWNIR)(400-1000 nm)spectra in the non-destructive soluble solids content measurement of an ***,we used multiplicative scattering correction to pre-process the spectral ***,PCR was applied to estimate the optimal number of input ***,the input variables with an optimal amount were used as the inputs of both multiple linear regression and ANN *** initial weights and the number of hidden neurons were adjusted to optimize the performance of *** suggest that the predictive performance of ANN with two hidden neurons outperforms that of PCR.

关键词： Artificial neural network (ANN) Principal component regression (PCR) Visible and shortwave nearinfrared (VIS-SWNIR) Spectroscopy Apple Soluble solids content (SSC)

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Full-Quantum Simulation of Graphene Self-Switching Diodes

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Chinese Physics Letters 2019年第6期36卷 53-56页

作者： Ashkan Horri rahim Faez Department of Electrical Engineering Arak Branch Islamic Azad University Arak Department of Electrical Engineering Tehran Sharif University of Technology

We present a quantum study on the electrical behavior of the self-switching diode(SSD). Our simulation is based on non-equilibrium Green's function formalism along with an atomistic tight-binding model. Using this method,electrical characteristics of devices, such as turn-on voltage, rectification ratio, and differential resistance, are investigated. Also, the effects of geometrical variations on the electrical parameters of SSDs are simulated. The carrier distribution inside the nano-channel is successfully simulated in a two-dimensional model under zero,reverse, and forward bias conditions. The results indicate that the turn-on voltage, rectification ratio, and differential resistance can be optimized by choosing appropriate geometrical parameters.

关键词： Full-Quantum Simulation Graphene Self-Switching Diodes

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Cohen-Macaulay Lexsegment Complexes in Arbitrary Codimension

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Algebra Colloquium 2017年第3期24卷 401-406页

作者： Siamak Yassemi rahim Zaare-Nahandi School of Mathematics Statistics & Computer Science University of Tehran Tehran Iran

We characterize pure lexsegment complexes which are Cohen-Macaulay in arbitrary codimension. More precisely, we prove that any lexsegment complex is Cohen- Macaulay if and only if it is pure and its 1-dimensional links are connected, and that a lexsegment flag complex is Cohen-Macaulay if and only if it is pure and connected. We show that any non-Cohen-Macaulay lexsegment complex is a Buchsbaum complex if and only if it is a pure disconnected flag complex. For t≥2, a lexsegment complex is strictly Cohen-Macaulay in codimension t if and only if it is the join of a lexsegment pure discon- nected flag complex with a （t - 2）-dimensional simplex. When the Stanley-Reisner ideal of a pure lexsegment complex is not quadratic, the complex is Cohen-Macaulay if and only if it is Cohen-Macaulay in some codimension. Our results are based on a characterization of Cohen-Macaulay and Buchsbaum lexsegment complexes by Bonanzinga, Sorrenti and Terai.

关键词： squarefree lexsegment ideal Cohen-Macaulay complex Buchsbaum complex,flag complex CMt complex

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Correction of failure in antenna array using matrix pencil technique

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Chinese Physics B 2017年第6期26卷 491-498页

作者： S U Khan M K A rahim Advanced RF & Microwave Research Group Department of Communication Engineering Faculty of Electrical Engineering Universiti Teknologi Malaysia 81310 Skudai Johor Malaysia

In this paper a non-iterative technique is developed for the correction of faulty antenna array based on matrix pencil technique（MPT）. The failure of a sensor in antenna array can damage the radiation power pattern in terms of sidelobes level and nulls. In the developed technique, the radiation pattern of the array is sampled to form discrete power pattern information set. Then this information set can be arranged in the form of Hankel matrix（HM） and execute the singular value decomposition（SVD）. By removing nonprincipal values, we obtain an optimum lower rank estimation of HM. This lower rank matrix corresponds to the corrected pattern. Then the proposed technique is employed to recover the weight excitation and position allocations from the estimated matrix. Numerical simulations confirm the efficiency of the proposed technique, which is compared with the available techniques in terms of sidelobes level and nulls.

关键词： array correction low rank estimation matrix pencil technique singular value decomposition

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Rare Earth Elements in the Water Column of Sungai Balok, Pahang, Malaysia as Monsoon Event Proxies

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Journal of Environmental Protection 2020年第5期11卷 421-440页

作者： Zolhizir Daud che Abd rahim Mohamed Department of Earth Sciences & Environment Faculty of Science and Technology Universiti Kebangsaan Malaysia Bangi Selangor Malaysia

Sampling of surface water at seven stations along the Sungai Balok, Pahang was conducted from 2013 to 2015 to investigate the distribution of dissolved rare earth elements (REE) in river systems. The whole concentration of ΣREE in the dissolved phase recorded during this study ranged from 368 to 9121 pmol?L?1 with a mean of 2328 ± 1442 pmol?L?1 that was dominantly influenced by the concentration of Ce ranging from 84 to 3237 pmol?L?1. Similarly, the large ranged value of La/YbN (0.69 - 11.57) might be due to the fluctuating rainfall events during samplings as well as input from lithogenic sources that suggests the influence of monsoon events. The highly significant statistical correlation of Al and Fe (R2 = 0.65;p < 0.01) also suggests the resuspension and mixing of REEs in the water column. However, the lower ratio of Y/Ho < 55 might be due to the large volume of freshwater input especially during the Northeast monsoon (November to March). Therefore, the highest inventories of Ce were during 15th January 2014 and 1st November 2014 with 586.5 pmol?cm?2 and 643.4 pmol?cm?2, accordingly. Subsequently, results showed an increasing flux of Ce occurring in the dissolved phase from November 2013 to January 2014 and November 2014 to January 2015, with 39.14 nmol?cm?2?yr?1 and 59.78 nmol?cm?2?yr?1, respectively.

关键词： Rainfall Sediment Water Column Monsoon Dissolved Phase

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