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Exercised blood plasma promotes hippocampal neurogenesis in the Alzheimer's disease rat brain

Journal of Sport and Health Science 2024年第2期13卷 245-255页

作者： Cecilie Skarstad n.revik Aleksi M.Huuha ragnhild n.rфsbjфrgen Linda Hildegard Bergersen Kamilla Jacobsen.rodrigo Miguel-dos-Santos Liv ryan Belma Skender Jose Bianco n.Moreira Asgeir Kobro-Flatmoen Menno P.Witter nathan Scrimgeour Atefe r.Tari Cardiac Exercise research Group(CErG) Department of Circulation and Medical ImagingNorwegian University of Science and Technology7491TrondheimNorway Department of neurology and Clinical neurophysiology St.Olavs University Hospital7030TrondheimNorway Institute of Oral Biology University of Oslo0372OsloNorway Department of Physiology Federal University of SergipeS~ao Cristov~ao49100-000SergipeBrazil Cen.re of Molecular Inflammation.research Department of Clinical and Molecular MedicineNorwegian University of Science and Technology7491TrondheimNorway Kavli Institute for Systems neuroscience Centre for Neural Computationand Egil and Pauline Braathen and Fred Kavli Centre for Cortical MicrocircuitsNorwegian University of Science and Technology7030TrondheimNorway K.G.Jebsen Cen.re for Alzheimer’s Disease Norwegian University of Science and Technology7030TrondheimNorway

Background:Exercise training promotes brain plasticity and is associated with protection against cognitive impairment and Alzheimer’s disease(AD).These beneficial effects may be partly mediated by blood-borne *** we used an in vitro model of AD to investigate effects of blood plasma from exercise-trained don.rs on neuronal viability,and an in vivo rat model of AD to test whether such plasma impacts cognitive function,amyloid pathology,and ***:Mouse hippocampal neuronal cells were exposed to AD-like stress using amyloid-βand treated with plasma collected from human male don.rs 3 h after a single bout of high-intensity *** in vivo studies,blood was collected from exercise-trained young male Wistar rats(high-intensity intervals 5 days/week for 6 weeks).Transgenic AD rats(McGill-r-Thyl-APP)were inj ected 5 times/fortnight for 6 weeks at2 months or 5 months of age with either(a)plasma from the exercise-trained rats,(b)plasma from sedentary rats,or(c)*** function,amyloid plaque pathology,and neurogenesis were *** plasma used for the treatment was analyzed for 23 ***:Plasma from exercised don.rs enhanced cell viability by 44.1%(p=0.032)and reduced atrophy by 50.0%(pn amyloid-β-treated *** vivo exercised plasma treatment did not alter cognitive function or amyloid plaque pathology but did in.rease hippocampal neurogenesis by~3 fold,regardless of pathological stage,when compared to saline-treated *** of 7 cytokines were significantly reduced in exercised plasma compared to sedentary ***:Our proof-of-concept study demonstrates that plasma from exercise-trained don.rs can protect neuronal cells in culture and promote adult hippocampal neurogenesis in the AD rat *** effect may be partly due to reduced pro-inflammatory signaling molecules in exercised plasma.

关键词： Cytokines High-intensity interval training Inflammation neurons Plasma transfusion

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丹麦国家海事博物馆

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城市环境设计 2019年第2期118卷 142-159页

作者： John Pries Jensen Henrik Kania Ariel Joy n.rback Walln.r rasmus Pedersen Annette Jensen Dennis rasmussen Jan Magasanik Jeppe Ecklon Karsten Hammer Hansen.rasmus rodam rune Hansen Alina Tamosiunaite Alysen Hiller Ana Merino Armen Menendian Andy Yu An.reas Johansen Baptiste Blot Christian Alvarez Christin Svensson Claudia Hertrich Claudio Moretti Cory Mattheis Eskild n.rdbud Felicia Guldberg Finn n.rkj?r Gül Ertekin Jan Borgstr?m James Schrader Johan Cool Jonas M?nster Kirstine ragnhild Malte Kloe Michael Andersen Michal Kristof Marc Jay Maria Mavriku Masatoshi Oka Oana Simionescu Pablo Labra Peter rieff Qianyi Lim Sara Sosio Sebastian Latz Tina Lund H?jgaard Tina Troster Todd Bennet Xi Chen Xing Xiong Xu Li Zoltan Kalaszi Iwan Baan.rasmus Hjortshoj Luca Santiago Mora Dragoer Luftfoto Jens Lindhe Lorenzon Boddi Thiks Wolzak 陈子钰

丹麦海事博物馆位于独特的历史和空间环境中:在丹麦最重要和最著名的建筑之一克伦堡城堡和文化庭院——一个新的、雄心勃勃的文化中心之间。BIG建议将博物馆放在地下,就在船坞的墙壁外侧,以便将船坞保留为开放的户外展示空间,保存其强... 详细信息

丹麦海事博物馆位于独特的历史和空间环境中:在丹麦最重要和最著名的建筑之一克伦堡城堡和文化庭院——一个新的、雄心勃勃的文化中心之间。BIG建议将博物馆放在地下,就在船坞的墙壁外侧,以便将船坞保留为开放的户外展示空间,保存其强有力的结构作为海事博物馆中心。将博物馆这样设置,使它在成为与克伦堡城堡和邻近的文化庭院相联系的文化环境的一部分的同时,彰显自身,成为一个独立

关键词：海事博物馆铝覆层 Section 重钢结构

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