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Growth differentiation factor 15 as an emerging novel biomarker in SARS-CoV-2 infection

World Journal of Methodology 2022年第5期12卷 438-447页

作者： Deepak Parchwani Sagar Dholariya CDS Katoch ragini singh Department of Biochemistry All India Institute of Medical SciencesRajkot 360001GujaratIndia Department of Pulmonary Medicine All India Institute of Medical SciencesRajkot 360001GujaratIndia

BACKGROUND Growth differentiation factor(GDF)-15 is a member of a transforming growth factor-βcytokine superfamily that regulates metabolism and is released in response to inflammation,hypoxia and tissue *** has evolved as one of the most potent cytokines for predicting the severity of infections and inflammatory conditions,such as severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)*** To investigate the utility of GDF-15 in predicting the severity of SARS-CoV-2 *** PubMed,Reference Citation Analysis,CNKI,and Goggle Scholar were explored by using related MeSH keywords and data such as the first author’s name,study duration,type and place of study,sample size and subgroups of participants if any,serum/plasma GDF-15 level in pg/mL,area under the curve and cut-off value in receiver operating characteristic analysis,method of measurement of GDF-15,and the main conclusion were *** In all studies,the baseline GDF-15 level was elevated in SARS-CoV-2-infected patients,and it was significantly associated with severity,hypoxemia,viral load,and worse clinical *** addition,GDF-15 levels were correlated with C-reactive protein,D-dimer,ferritin and procalcitonin,and it had superior discriminatory ability to detect severity and in-hospital mortality of SARS-CoV-2 ***,GDF-15 might be used to predict the severity and prognosis of hospitalized patients with *** Serial estimation of GDF-15 levels in hospitalized patients with SARS-CoV-2 infection appeared to have useful prognostic value and GDF-15 can be considered a clinically prominent sepsis biomarker for SARS-CoV-2 infection.

关键词： SARS-CoV-2 Growth differentiation factor 15 Biomarker Risk-stratification Prognosis

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Tapered Optical Fiber-Based LSPR Biosensor for Ascorbic Acid Detection

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Photonic Sensors 2021年第4期11卷 418-434页

作者： Guo ZHU Lokendra singh Yu WANG ragini singh Bingyuan ZHANG Fengzhen LIU Brajesh Kumar KAUSHIK Santosh KUMAR Shandong Key Laboratory of Optical Communication Science and Technology School of Physics Science and Information TechnologyLiaocheng UniversityLiaocheng 252059China Department of Robotics and Automation Engineering PARK College of Engineering and TechnologyKaniyur 641659India School of Agriculture Science Liaocheng UniversityLiaocheng 252059China Liaocheng People's Hospital Medical College of Liaocheng UniversityLiaocheng 252000China Department of Electronics and Communication Engineering Indian Institute of Technology-RoorkeeRoorkee 247667India Department of Electrical and Electronics&Communication Engineering DIT UniversityDehradim 248009India

The ascorbic acid(AA)is a biomarker that can be used to detect the symptoms of severe disorders such as scurvy,Parkinson’s,Alzheimer’s,and cardiovascular *** this work,a simple and effective sensor model is developed to diagnose the presence of AA *** develop the sensor,a tapered single-mode optical fiber has been used with the well-known phenomenon of localized surface plasmon resonance(LSPR).For LSPR,the tapered region is immobilized with synthesized gold nanoparticles(AuNPs)and zinc oxide nanoparticles(ZnO-NPs)whose absorbance peak wavelengths appear at 519nm and 370nm,*** the basis of nanoparticles(NPs)configurations,two different biosensor probes are *** the first one,the sensing region is immobilized with AuNPs and named Probe *** the second probe,the immobilized layer of AuNPs is further coated with a layer of ZnO-NPs,and a resultant probe is termed as Probe *** characterizations of synthesized AuNPs and developed fiber probes are done by the ultraviolet-visible(UV-vis)spectrophotometer,high-resolution transmission electron microscope(HR-TEM),atomic force microscopy(AFM),and scanning electron microscope(SEM).To enhance the selectivity,a sensing region of probes is functionalized with ascorbate oxidase enzyme that oxidizes the AA in the presence of *** response of developed sensor probes is authenticated by sensing the samples of AA in the range from 500 nM to 1 mM,which covers the range of AA found in human bodies,i.e.,40μM-120μ*** performance analysis of the developed sensor probes has been done in terms of their stability,reproducibility,reusability,and *** observe the stability of AA,a pH-test has also been done that results in a better solubility of AA molecules in phosphate-buffered saline(PBS)solution.

关键词： Ascorbic acid localized surface plasmon resonance gold nanoparticlcs zinc oxide nanoparticles tapered fiber optical fiber sensor

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Antioxidative study of Cerium Oxide nanoparticle functionalised PCL-Gelatin electrospun fibers for wound healing application

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Bioactive Materials 2018年第2期3卷 201-211页

作者： Hilal Ahmad Rather Ria Thakore ragini singh Dhwani Jhala Sanjay singh Rajesh Vasita Biomaterials&Biomimetics Laboratory School of Life SciencesCentral University of GujaratGandhinagar382030GujaratIndia Division of Biological and Life Sciences School of Arts and ScienceAhmedabad UniversityNavrangpuraAhmedabad380009GujaratIndia

Skin wound healing involves a coordinated cellular response to achieve complete *** levels of reactive oxygen species(ROS)in the wound environment often pose a hindrance in wound healing resulting in impaired wound healing *** oxide nanoparticles(CeNPs)have the ability to protect the cells from oxidative damage by actively scavenging the ***,matrices like nanofibers have also been explored for enhancing wound *** the current study CeNP functionalised polycaprolactone(PCL)-gelatin nanofiber(PGNPNF)mesh was fabricated by electrospinning and evaluated for its antioxidative *** angle XRD analysis of randomly oriented nanofibers revealed^2.6 times reduced crystallinity than pristine PCL which aided in rapid degradation of nanofibers and release of ***,bioactive composite made between nanoparticles and PCLgelatin maintained the fibrous morphology of PGNPNF upto 14 *** PGNPNF mesh exhibited a superoxide dismutase(SOD)mimetic activity due to the incorporated *** PGNPNF mesh enhanced proliferation of 3T3-L1 cells by^48%as confirmed by alamar blue assay and SEM micrographs of cells grown on the nanofibrous ***,the PGNPNF mesh scavenged ROS,which was measured by relative DCF intensity and fluorescence microscopy;and subsequently increased the viability and proliferation of cells by three folds as it alleviated the oxidative ***,the results of this study suggest the potential of CeNP functionalised PCL-gelatin nanofibrous mesh for wound healing applications.

关键词： Electrospinning Ce nanoparticles Antioxidative Nanofiber

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World Journal of Virology 2023年第1期12卷 53-67页

作者： Deepak Parchwani Amit D Sonagra Sagar Dholariya Anita Motiani ragini singh Department of Biochemistry All India Institute of Medical SciencesRajkot 360001India

BACKGROUND Empirical use of potentially hepatotoxic drugs in the management of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection is considered as one of the major etiopathogenetic factors for liver *** evidence has shown that an underlying genetic factor may also ***,it is important to understand the host genetics and iatrogenic-based mechanisms for liver dysfunction to make timely remedial *** To investigate drug-induced and genetic perspectives for the development of coronavirus disease 2019(COVID-19)-related liver *** Reference Citation Analysis,PubMed,Google Scholar and China National Knowledge Infrastructure were searched by employing the relevant MeSH keywords and pertaining data of the duration,site and type of study,sample size with any subgroups and drug-induced liver injury *** aspects were extracted from the most current pertinent *** In all studies,the hepatic specific aminotransferase and other biochemical indices were more than their prescribed upper normal limit in COVID-19 patients and were found to be significantly related with the gravity of disease,hospital stay,number of COVID-19 treatment drugs and worse clinical *** addition,membrane bound O-acyltransferase domain containing 7 rs641738,rs11385942 G>GA at chromosome 3 gene cluster and rs657152 C>A at ABO blood locus was significantly associated with severity of livery injury in admitted SARS-CoV-2 *** Hepatic dysfunction in SARS-CoV-2 infection could be the result of individual drugs or due to drug-drug interactions and may be in a subset of patients with a geneticpropensity. Thus, serial estimation of hepatic indices in hospitalized SARS-CoV-2 patients shouldbe done to make timely corrective actions for iatrogenic causes to avoid clinical *** molecular and translational research is warranted in this regard.

关键词： SARS-CoV-2 Liver injury Genetic prospective Drug-induced liver injury Prognosis COVID-19

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Cyanobacteria,Lyngbya aestuarii and Aphanothece bullosa as antifungal and antileishmanial drug resources

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Asian Pacific Journal of Tropical Biomedicine 2013年第6期3卷 458-463页

作者： Maheep Kumar Manoj Kumar Tripathi Akanksha Srivastava Jalaj Kumar Gour Rakesh Kumar singh ragini Tilak Ravi Kumar Asthana Department of Botany Faculty of ScienceBanaras Hindu University Department of Biochemistry Faculty of ScienceBanaras Hindu University Department of Microbiology Institute of Medical SciencesBanaras Hindu University

Objective:To investigate two cyanobacteria isolated from different origins *** aestuarii(***)from brackish water and Aphanothece bullosa(***)from fresh water paddy fields for antifungal and antileishmanila activity taking Candida albicans and Leishmania donovain as ***:Biomass of *** and *** were harvested after 40 and60 d respectively and lyophilized twice in methanol(100%)and redissolved in methanol(5%)for *** bioassay was done by agar well diffusion method while antileishmanial,by counting cell numbers and flageller motility observation of promastigotes and amastigotes from *** and 5%methanol were used as ***:Both the cyanobacteria were found to be potent source of antifungal activity keeping fluconazole as positive control,however,methanolic crude extract(15 mg/mL)of *** was found more potent(larger inhibition zone)over that of methanolic crude extract of ***,Similarly antileishmanial activity of crude extract(24.0 mg/mL)of *** was superior over that of methanolic crude extract of ***(25.6 mg/mL).Conclusions:Antifungal and antileishmanial drugs are still limited in the *** of microbes possessing antifungal and antileishmanial activity drug is of prime *** are little explored in this context because most of the drugs in human therapy are derived from microorganisms,mainly bacterial,fungal and *** in the present study two cyanobacterial strains from different origins showed potent source of antifungal and antileishmanial biomolecules.

关键词： Antifungal Antileishmanial Secondary metabolite Cyanobacteria

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